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7098234 |
Indole derivatives, process for preparation of the same and use thereof
Indole derivatives represented by formula (I):
(wherein all symbols are described in the description), a process for the preparation of the same and a DP receptor antagonist comprising it as an...
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7091220 |
Substituted indole Mannich bases
The present invention relates to substituted indole Mannich bases, processes of preparing substituted indole Mannich base, a medicament containing the same, and a pharmaceutical composition...
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7091234 |
Thio-oxindole derivatives
This invention relates to compounds which are agonists of the progesterone receptor which have the general structure:
wherein:
R 1 , R 2 , R 3 , R 4 , R 5 and Q 1 are as defined herein, or a...
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7091204 |
Sulfonamides
The present invention relates to sulfonamides, pharmaceutical compositions containing them, and their use as antagonists of urotensin II.
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7084167 |
Calcium receptor active molecules and method for preparing same
The invention concerns compounds of general formula (I) wherein: the group X represents a —NR4, —CH═N or —CHR5-NR4-group; the group Y represents an oxygen or sulphur atom or a NR, —CR5,...
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7081473 |
Agent for preventing/ameliorating obesity comprising methylidene hydrizide compound as active ingredient
The present invention provides a low-molecular inhibitor of GIP functions and, further, an agent for preventing/ameliorating obesity based on inhibition of GIP functions, which comprises, as an...
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7081254 |
Skin preparations for external use
The invention relates to a skin preparation for external use, which contains a lamellar structure containing a fatty acid monoglyceride as a main component, and vitamin A or a derivative thereof....
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RE39197 |
Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds
The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions comprising these compounds, and to methods...
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7078425 |
Preparation of phosphatase inhibitors
Disclosed are compounds of the Formula (I) and pharmaceutically acceptable salts and prodrugs thereof, wherein A, B, R 1 , R 2 , R 3 , and R 4 are as defined in the specification. Such compounds...
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7074782 |
Carbamate caspase inhibitors and uses thereof
This invention provides caspase inhibitors of formula I:
wherein Z is oxygen or sulfur; R 1 is hydrogen, —CHN 2 , R, CH 2 OR, CH 2 SR, or —CH 2 Y; Y is an electronegative leaving group; R 2...
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7049336 |
Method for diagnosing neuronal diseases and for treating primary hemostasis deficiency
Pharmaceutical compositions for treatment of primary hemostasis deficiency and methods of treatment of primary hemostasis deficiency are disclosed. Also, methods for diagnosing neuronal diseases...
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7049308 |
C-nitroso compounds and use thereof
A C-nitroso compound having a molecular weight ranging from 225 to 1,000 (from 225 to 600 for oral administration) on a monomeric basis wherein a nitroso group is attached to a tertiary carbon,...
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7045543 |
Covalent conjugates of biologically-active compounds with amino acids and amino acid derivatives for targeting to physiologically-protected sites
This invention herein describes a method of facilitating the entry of drugs into cells and tissues at physiologically protected sites at pharmacokinetically useful levels and also a method of...
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7037932 |
Heteroaryloxy 3-substituted propanamines as serotonin and norepinephrine reuptake inhibitors
There is provided a heretoaryloxy 3-substituted propanamine compound of formula (I): wherein A is selected from —O— and —S—; X is selected from phenyl optionally substituted with up to 5...
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7034050 |
Pseudopeptides growth hormone secretagogues
The present invention relates to novel growth hormone releasing pseudopeptides capable of stimulating the release of growth hormone from the pituitary and of promoting growth in mammals. The...
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7030123 |
Indole derivatives with vascular damaging activity
The invention provides a compound of Formula (I).
Wherein R1, R2, R3, R10 and R11 have the meanings given in the description. Such compounds are predicted to cause the selective destruction of...
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7026348 |
Indole sPLA2 inhibitors
A class of novel acylsulfonamide substituted indole compounds is disclosed together with the use of such compounds for inhibiting sPLA 2 mediated release of fatty acids for treatment of...
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7026344 |
Treating sickle cell disease
Sickle cell disease is treated by administering a 5-lipoxygenase inhibitor.
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7019003 |
Peptide deformylase inhibitors
Novel PDF inhibitors and novel methods for their use are provided.
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7015241 |
Appetite-stimulating agents and remedies for anorexia
An appetite-stimulating agent and a therapeutic agent for anorexia, each comprising, as an active ingredient, a sulfonamide derivative or sulfonic acid ester derivative represented by the following...
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7008636 |
2,3,5-substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia
This invention provides compounds of Formula I having the structure
or a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disorders related to insulin resistance...
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7001905 |
Substituted diarylamines as MEK inhibitors
Diarylamines, such as 5-amide substituted diarylamines of formula (I) or formula (II) wherein A is hydroxy, C 1-6 alkoxy, or NR 6 OR 7 ; X is OR 12 , NR 13 R 12 , or NR 14 ; inhibitors of MEK and...
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7001611 |
Compositions normalizing circadian rhythm
The present invention provides a circadian rhythm normalizing composition containing astaxanthin and/or its ester as an active ingredient, and a composition having the action of enhancing the...
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6998419 |
3,4,5-trisubstituted aryl nitrone compounds and pharmaceutical compositions containing the same
Disclosed are 3,4,5-trisubstituted aryl nitrone compoundsd and pharmaceutical compositions containing such compounds. The 3,4,5-trisubstituted aryl nitrone compounds have formula (I); where R 1...
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6995184 |
3-arylindole derivatives and their use as CB2 receptor agonists
A subject-matter of the present invention is compounds of formula:
and their preparation and the pharmaceutical compositions comprising them. These compounds are agonists for CB 2 cannabinoid...
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RE38970 |
Indolyl or indolinyl derivatives and medicinal use thereof as ACAT or lipid peroxidation inhibitors
A heterocyclic derivative of the formula (I)
wherein each symbol is as defined in the specification, and pharmaceutically acceptable salts thereof. The compound (I) of the present invention...
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6989362 |
Methods of treating dopamine dysregulation using agents that regulate phosphorylation/dephosphorylation in dopamine signaling
The present invention discloses that DARPP-32 is substrate for the cyclin dependent kinase Cdk5. The phosphorylation takes place at a specific threonine residue of DARPP-32 (Threonine 75). The Cdk5...
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6987122 |
2-(1H-indol-3-yl)-2-oxo-acetic acid amides with antitumor activity
2-(1H-Indol-3-yl)-2-oxo-acetamide derivatives of formula (I) having antitumor activity in particular against solid tumors, specifically colon and lung tumors.
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6969729 |
Use of isatin derivatives as ion channel activating agents
The present invention relates to ion channel activating agents. More particularly, the present invention relates to a particular class of chemical compounds that has proven useful as openers of...
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6964980 |
Method of reducing serum glucose and triglyceride levels and for inhibiting angiogenesis using substitute indolealkanoic acids
Disclosed are methods of reducing serum glucose and triglyceride levels and for inhibiting angiogenesis, the methods comprising administration of substituted indolealkanoic acids to patients in...
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6960611 |
Sulfonyl-containing 2,3-diarylindole compounds, methods for making same, and methods of use thereof
The present invention relates to sulfonyl-containing 2,3-diarylindole, especially to new compounds of general Formula, to a preparation method for their preparation, to pharmaceutical compositions...
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6956054 |
Compositions and methods for use in targeting vascular destruction
Treatment of warm-blooded animals having a tumor or non-malignant hypervascularation, by administering a sufficient amount of a cytotoxic agent formulated into a phosphate prodrug form having...
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6951881 |
(1-substituted-indol-3-yl) alkylidenehydrazinecarboximidamide derivatives as 5-hydroxytryptamine-6 ligands
The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of a disorder relating to or affected by the 5-HT6 receptor.
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6951869 |
Use of leukotriene receptor antagonist for treatment of scarring
A method of preventing or treating either scarring or capsular contractures in subjects in need of such treatment comprising the administration of leukotriene receptor antagonists to said subject...
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6951848 |
Functionalized heterocycles as modulators of chemokine receptor function and methods of use therefor
Disclosed are novel compounds having the formula
or a physiologically acceptable salt, amide, ester or prodrug thereof. The compounds can be used to modulate (antagonize, agonize) chemokine...
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6949574 |
(Oxime)carbamoyl fatty acid amide hydrolase inhibitors
The present invention relates to novel oxime carbamyl derivatives and pharmaceutical compositions comprising said derivatives which inhibit fatty acid amide hydrolase. These pharmaceutical...
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6946462 |
N-monoacylated derivatives of o-phenylenediamines, their analogs and their use as pharmaceutical agents
New compounds represented by the formula
or pharmaceutically acceptable salts or prodrugs thereof,
wherein
X 1 and X 2 are each independently selected from a CH group or a nitrogen atom;...
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6939897 |
Method and composition for inhibiting arteriosclerosis
The present invention has for its object to provide a method and a composition for achieving a more efficient recovery of the antioxidant activity of plasma LDL, or even augmentation thereof, which...
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6939889 |
Quarternary ammonium compounds
Novel compounds and pharmaceutical compositions containing such compounds and possessing anti-tussive activity, and a method of administering the same to warm-blooded animals, including humans.
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6933291 |
Cholesterol lowering supplement
The invention provides a composition and a method for lowering blood serum cholesterol levels or for preventing elevated blood serum cholesterol levels, as well as suitable composition comprising...
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6924304 |
Cell proliferation inhibitors
Compounds having formula (I)
inhibit cellular proliferation. Processes for the preparation of the compounds, pharmaceutical compositions containing the compounds, and methods of treatment...
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RE38761 |
Styryl compounds which inhibit EGF receptor protein tyrosine kinase
A method of inhibiting cell proliferation in a patient suffering from such disorder comprising administering to said patient an effective amount of a composition comprising, in admixture with a...
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6914070 |
Ophthalmic compositions for treating ocular hypertension
This invention relates to the use of potent potassium channel blockers or a formulation thereof in the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in...
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6906094 |
1,2,4-tribsubstituted benzenes as inhibitors of 15-lipoxygenase
The present invention provides compounds of formula (I) wherein R, Z, Y, W, R 5 , V, and X are as defined in the description, and pharmaceutically acceptable salts thereof, which are useful for the...
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6906095 |
Indolylalkylidenehydrazine-carboximidamide derivatives as 5-hydroxytryptamine-6 ligands
The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of a disorder relating to or affected by the 5-HT6 receptor.
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6894042 |
Azabicyclic compounds for the treatment of disease
The invention provides compounds of Formula I:
wherein Azabicyclo is
These compounds may be in the form of pharmaceutical salts or compositions, may be in pure enantiomeric form or...
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6887887 |
Asymmetric synthesis of (S,S,R)-(-)-actinonin and its analogs and uses therefor
The present invention provides methods for the asymmetric synthesis of (S,S,R)-(−)-actinonin and its analogs and the compounds thereby synthesized having a structural formula:
where R 1 is...
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6887890 |
Compounds exhibiting thrombopoietin-like activities
The compounds of the invention are compounds represented by the following general formula (1):
wherein E represents one selected from the group consisting of a methylidyne group and a nitrilo...
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6878712 |
Amides as inhibitors for pyruvate dehydrogenase
A compound of formula (I):
wherein:
Ring A is a nitrogen linked mono or bicyclic heterocyclic ring as defined within; R 1 and R 2 are independently C 1-3 alkyl optionally substituted...
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6878700 |
Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds
The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immunune diseases, to pharmaceutical compositions containing these compounds, and to methods...
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