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6017946 |
Serotonin containing formulation for oral administration and method of use
A medicament containing serotonin and an antioxidant useful in the treatment of pain, including migraines and premenstrual syndrome(PMS); chronic fatigue symptoms; depression and eating disorders;...
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6011054 |
Method for treating depression, obsessive compulsive disorder, and anxiety with N--acetyl serotonin
The present invention relates to a method of treatment of depression in a human being identified as having depression. This method comprises the administration of a therapeutically effective...
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6004991 |
Acylated derivatives of melationin and its analogues, useful as medicaments
The invention relates to derivatives of general formula I ##STR1## as defined in the description. The invention also relates to a process for their preparation and to their therapeutic use, in...
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6004988 |
Carboxylic acid derivatives, their preparation and their use
Carboxylic acid derivatives of the formula I ##STR1## here R 1 is a tetrazole [sic], nitrile [sic], a group COOH or a radical which can be hydrolyzed to COOH, and the other substituents have the...
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6001824 |
Butyryl-tyrosinyl spermine, analogs thereof and methods of preparing and using same
The present invention provides a compound having the structure: ##STR1## wherein R 1 is a saturated or unsaturated linear or branched chain alkyl group, or a cholestanyl group; wherein R 2 is a...
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5998438 |
5-cyclo indole compounds
Described herein are compounds selective for a 5-HT 1D -like receptor, which have the general formula: ##STR1## wherein A is selected from a six-membered, non-aromatic, optionally substituted...
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5998421 |
Lipid metabolism ameliorants
The present invention relates to a food and a feed having lipid metabolism improving activity or anti-obesity activity, and a lipid metabolism improving agent or an anti-obesity agent for humans or...
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5994387 |
Pyrrolidinyl methyl indole salt
The fumarate salt of (R)-5-(methylaminosulphonylmethyl)-3-(N-methylpyrrolidin-2-y
lmethyl)-1H-in dole, useful in the treatment of migraine.
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5993859 |
Pharmaceutical agents
The invention provides a pharmaceutical composition comprising a particular physical form of N-[4-[5-(cyclopentyloxycarbonyl)amino-1-methylindol-3-yl-met
hyl]-3-methoxy...
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5994379 |
Bisaryl COX-2 inhibiting compounds, compositions and methods of use
The present invention relates to inhibitors of COX-2, compositions which contain such compounds and methods of use. The compounds are represented by formula I: ##STR1## and include pharmaceutically...
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5985907 |
Method for inhibiting growth of methanogens
Methods and compositions for decreasing the production of methane in ruminant animals, thereby increasing feed utilization efficiency, are disclosed. The methods employ HMG-CoA reductase inhibitors...
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5985293 |
Antioxidative dermocosmetic compositions comprising very low dosages of melatonin/analogs
Topically applicable dermocosmetic compositions for improving or maintaining the appearance of human skin or the scalp, comprise a minor antioxidant effective amount of melatonin or analog thereof,...
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5985910 |
3- [4- (2- Phenyl-Indole-1-ylmethyl) Phenyl]- Acrylamides as estrogenic agents
The present invention relates to new 3-[4-(2-Phenyl-Indole-1-ylmethyl)-Phenyl]-Acrylamide compounds which are useful as estrogenic agents, as well as pharmaceutical compositions and methods of...
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5977154 |
Selective β3 adrenergic agonist
The present invention is in the field of medicine, particularly in the treatment of Type II diabetes and obesity. More specifically, the present invention relates to selective β3 adrenergic...
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5972988 |
Method for treatment of chronic bronchitis using indole compounds
A method is disclosed for the treatment of chronic bronchitis by administering to a mammal in need thereof a therapeutically effective amount of a 1H-indole-3-glyoxylamide compound.
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5972937 |
Heterocyclic compounds possessing 5HT.sub.2C receptor antagonist activity
The invention relates to heterocyclic families of compounds having pharmacological activity, in particular possessing 5HT 2C receptor antagonist activity processes for their preparation, to...
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5972982 |
Heteroaryl-substituted deoxy glycerols and antibacterial and antiviral compositions containing the same
Heteroaryl-substituted deoxy glycerols represented by the general Formulas Ia, Ib and Ic: ##STR1## wherein: X is oxygen (--O--) or sulfur (--S--); R is substituted or unsubstituted straight or...
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5965582 |
N-benzylindole and benzopyrazole derivatives with anti-asthmatic, anti-allergic, anti-inflammatory and immunemodulating effect
The N-benzylindole- and benzopyrazole derivatives of the general formula 1 ##STR1## possess anti-asthmatic, anti-allergic, anti-inflammatory and immunomodulating effect and are suitable for the...
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5962463 |
Methods of stimulating non-amyloidogenic processing of the amyloid precursor protein
Stimulating non-amyloidogenic processing by the activation of cell surface serotonin receptors linked to phospholipase and protein kinase C is described. Activation of the cell surface serotonin...
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5962502 |
Polyamidic acid derivatives with antigastrin activity, a method for their preparation, and their pharmaceutical use
Derivatives of glutamic and aspartic of formula (I) are described ##STR1## where the compounds are potent receptor antagonists of gastrin at the peripheral level and of cholecystokinin at the level...
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5958964 |
Use of melatonin to prevent cytotoxic effects of amyloid beta protein
The present invention is directed to a method of preventing cytotoxic effects of amyloid beta protein on cells. The method comprises exposing the cells to an effective amount of melatonin. The...
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5958965 |
4-aminoethoxy indoles
Compounds of the formula: ##STR1## in which R 1 is hydrogen, alkyl, cycloalkylalkyl, arylalkyl, (haloaryl)alkyl, (alkoxyaryl)alkyl, thienylmethyl, furanylmethyl, pyridinylmethyl, alkylphenyl,...
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5955491 |
Method for treating osteoporosis
The present invention provides a cathepsin L inhibitor containing a compound of the formula: ##STR1## wherein R 1 is a hydrogen atom or an arylalkyl, heterocyclic-alkyl or lower alkyl group which...
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5952346 |
Use of non-peptide bradykinin antagonists for the treatment or prevention of Alzheimer's disease
The invention relates to the use of non-peptide bradykinin antagonists for the production of pharmaceuticals for the prevention and treatment of Alzheimer's disease. Suitable Compounds are...
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5948808 |
Indole-3-carbinol, diindolylmethane and substituted analogs as antiestrogens
Provided in the present invention are compounds and compositions of substituted indole-3-carbinols and diindolylmethane suitable for treating estrogen-dependent tumors. Also provided are methods of...
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5948813 |
Method of preventing allograft rejection
A method for suppressing the rejection of allogeneic transplants in a mammal, including a human, comprising administering to said mammal an effective amount of the compound of the formula ##STR1##...
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5942536 |
N- 2-substituted-3-(2-aminoethyl)-1H-indol-5-YL!-Amides: new 5-HT.sub.1F agonists
The invention provides novel 5-HT 1f agonists of formula (I) where X, R 1 , R 2 , and R 3 are defined in the specification, which are useful for the treatment of migraine and associate disorders....
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5939425 |
Method for treating a migraine
The migraine-treating effectiveness of a local anesthetic drug is significantly enhanced by coadministering dextromethorphan or dextrorphan.
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5939084 |
Aqueous phase dermatological/cosmetic compositions comprising solubilized melatonin values
Stable, recrystallization-resistant dermatological/cosmetic compositions, well suited for preventing/treating oxidative stress of the skin, comprise a substantially ethanol-free aqueous phase, the...
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5939429 |
Cardiovascular uses of cannabinoid compounds
Hemorrhagic shock and in other conditions associated with excessive vasoconstriction, such as hypertension, peripheral vascular disease, cirrhosis of the liver, or certain forms of angina pectoris...
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5939076 |
Composition and method for treating or alleviating migraine headaches
A method of preventing or alleviating a migraine headache in a patient subject to migraine headaches comprises administering to the patient daily, for an effective period of time, a daily effective...
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5932608 |
Melatonin derivative dermocosmetic compositions for whitening/depigmenting the skin
Topically applicable dermocosmetic compositions for whitening/depigmenting human skin, comprise a skin-whitening/depigmenting effective amount of at least one melatonin derivative having the...
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5922582 |
Indole alkaloid type compound 0089-D
The present invention relates to compound 0089-D having excellent antitumor activity and antimicrobial activity, represented by the general formula (I): ##STR1## or pharmaceutically acceptable...
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5912260 |
Gastrin and CCK antagonists
Described herein are compounds of formula (I) or a pharmaceutically acceptable salt thereof, ##STR1## wherein L is N or C, one of X and Y is --NH--CH 2 --R 2 and the other is the substituent of...
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5908835 |
Anti-tumor compositions containing taxane derivatives
Disclosed are antitumor compositions comprising taxol, taxotere or their derivatives in combination with an anthracycline antibiotic, the combination having a pharmacologic activity greater than...
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5902811 |
Method for preventing intervention-associated stenosis and other symptoms associated with stenosis of blood vessels following non-bypass, invasive interventions
The present invention relates to method for reducing stenosis after non-bypass invasive intervention comprising administering a daily amount of a dopamine-potentiating/prolactin-reducing compound...
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5895787 |
Treatment of fibromyalgia and related disorders
A method of treating fibromyalgia-like complaints (i.e., fibromyalgia, chronic fatigue syndrome and irritable bowel syndrome) in a patient, the method comprising: administering to the patient an...
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5891903 |
Use of melatonin in a composition for stabilizing hydrophilic gelling polymers
The present invention relates to the use of melatonin or analogues thereof in a composition as an agent for stabilizing hydrophilic gelling polymers. The invention relates more particularly to...
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5891902 |
Indole derivatives
The present invention relates to indole derivatives represented by formula (I): ##STR1## wherein R 1 and R 2 independently represent hydrogen, lower alkyl, hydroxy, lower alkoxy, halogen,...
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5889038 |
Methods and products for treating diarrhea and scours: use of clotrimazole and related aromatic compounds
A method and product for treating and preventing diarrhea and scours is provided. The method involves treating a subject who has diarrhea, or scours, or is at risk of getting diarrhea or scours...
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5877198 |
Treatment of urinary incontinence
The present invention relates to a treatment for patients having urinary incontinence by administering a composition comprising histamine, serotonin or a combination thereof in an amount effective...
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5874477 |
Method of treatment for malaria utilizing serotonin receptor ligands
The invention provides a method of preventing or treating malaria comprising administering a therapeutically effective amount of serotonin receptor ligand to reduce the pathological consequences of...
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5872133 |
Method of regulating the immune response
Methods for upregulating abnormal responses of the mammalian immune system are provided. Also disclosed are methods for modifying normal responses of the mammalian immune system. Further disclosed...
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5872145 |
Formulation of 5-HT agonist and NSAID for treatment of migraine
This invention comprises a method of treating migraine in a human comprising co-timely administering of a therapeutically effective amount of a 5-HT agonist coordinated with a therapeutically...
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5866594 |
Indole-2-carboxylate derivatives and fungicidal compositions for agricultural or horticultural use containing the derivatives as active component
An object of the invention is to provide an indole-2-carboxylic acid ester derivative which shows a selectively high fungicidal effect on fungicide-resistant fungi. The indole-2-carboxylic acid...
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5855920 |
Total hormone replacement therapy
A hormone replenishment method particularly useful in maintaining the body's neuroendocrine clock at optimal levels and combating conditions associated with advancing age is disclosed. The method...
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5852049 |
Aromatic ethers derived from indoles which are useful as medicaments
The present invention relates to new aromatic ethers derived from indole and having general formula (I) as well as to their preparation methods, pharmaceutical compositions containing them and...
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5849782 |
Methods of inhibiting neurodegenerative diseases
Methods for inhibiting a nitric oxide-mediated pathological condition and a neurodegenerative disease such as Parkinson's disease, Huntington's disease, Alzheimers's disease, and amyotrophic...
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5849756 |
Pharmaceutical composition and method for modulating the immune reaction
Pharmaceutical compositions for the modulation of the immune reaction of warm blooded animals that are derivatives of the 2-oxindole-3-acetic acid or the...
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5846973 |
Methods of treating pulmonary hypertension
This invention provides methods of inhibiting pulmonary hypertensive disease which comprise administering to a mammal in need thereof a compound having activity as a tachykinin receptor antagonist.
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