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7618967 |
Indane compounds
The invention provides novel indane compounds which are useful in the treatment of affective disorders, pain disorders, attention deficit hyperactivity disorder (ADHD), cognitive disorders,...
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7612099 |
Vinylogous acid derivatives
The invention is concerned with vinylogous acids derivatives of formula (I)
wherein A and R 1 to R 6 are as defined in the description and in the claims, as well as physiologically acceptable...
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7612066 |
Composition containing benzamidine derivative and method for stabilizing benzamidine derivative
The present invention provides a composition containing a benzamidine derivative that does not decompose even when placed under humidification conditions and a method for stabilizing a benzamidine...
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7605168 |
PDE4B inhibitors
Compounds are described that are active on PDE4. Also described are crystal structures of PDE4B determined using X-ray crystallography, the use of PDE4B crystals and structural information for...
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7605156 |
Methods for the use of inhibitors of cytosolic phospholipase A2
This invention provides methods for the use of substituted indole compounds of the general formula:
and pharmaceutically acceptable salt forms thereof. The invention provides methods for the...
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7601749 |
Indole acetic acids exhibiting CRTH2 receptor antagonism and uses thereof
The invention relates to indole acetic acid compounds which function as antagonists of the CRTH2 receptor. The invention also relates to the use of these compounds to inhibit the binding of...
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7598288 |
Inhibitors of glycogen synthase kinase-3 (GSK-3) for treating glaucoma
The use of inhibitors of GSK-3 useful for treating glaucoma is disclosed.
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7582770 |
Viral polymerase inhibitors
An enantiomer, diastereoisomer or tautomer of a compound, represented by formula I:
wherein A, B, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , and R 10 are as defined herein, or a...
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7582671 |
Therapeutic use of N-(1H-indolyl)-1H-indole-2-carboxamide derivatives
The invention relates to therapeutic use of compounds of general formula (I):
in which X 1 , X 2 , X 3 , X 4 , X 5 , Z 1 , Z 2 , Z 3 , Z 4 and Z 5 , R, Y and n are as defined herein.
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7582670 |
Methods of treating an inflammatory-related disease
The invention relates to pharmaceutical compositions and methods of treating inflammatory-related diseases associated with pro-inflammatory cytokine expression and/or reduced expression of...
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7582658 |
Bicyclic compound
A novel compound represented by the following formula (1) or a salt thereof:
wherein symbol “A” represents a saturated heterocyclic group, a 5-membered heteroaromatic group having two...
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7579370 |
Fused heterocycles
This invention provides fused heterocycles having the formula:
in which R 1 is a member selected from the group consisting of H, substituted or unsubstituted arylalkyl and substituted or...
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7572923 |
Indirubin derivatives having anticancer property against human cancer cell line
The present invention relates to an indirubin derivative having anticancer property by inhibiting cell proliferation as to human cancer cell line. More particularly, this invention provides the...
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7566791 |
Substituted 3-carbonyl-1h-indol-1yl acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1)
Substituted 3-carbonyl-1H-indol-1-yl acetic acid derivatives of formula I are provided:
wherein: R 1 , R 2 , R 3 , R 4 and R 5 are as defined herein which are useful as inhibitors of...
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7560481 |
Indoles are cannabinoid receptor ligands
The present invention provides novel compounds of Formula (I)
which are CB 2 selective ligands useful for the treatment of pain.
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7557138 |
5-phenoxyalkoxypsoralens and methods for selective inhibition of the voltage gated Kv1.3 potassium channel
Compositions of matter comprising 5-phenoxyalkoxypsoralen compounds and their method of synthesis and use. The compounds are useable to treat diseases or disorders in human or animal subjects,...
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7557134 |
N-(heteroaryl)-1H-indole-2-carboxamide derivatives and their use as vanilloid TRPV1 receptor ligands
The invention concerns therapeutic uses of compounds of general formula (I), wherein n, X 1 , X 2 , X 3 , X 4 , Z 1 , Z 2 , Z 3 , Z 4 , Z 5 and W are as defined herein.
Said compounds are...
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7547722 |
Chemical compounds
The invention relates to a group of novel thieno-pyrrole compounds of Formula (I):
wherein: R 1 , R 2 , R 3 , R 4 and R 5 are as defined in the specification, which are useful as...
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7547703 |
Indoline derivatives substituted in the 6-position, their preparation and their use as medicaments
The present invention relates to indolinone derivatives, substituted in the 6-position, of the formula
in which
R 1 to R 6 and X are as defined in claim 1 , to their tautomers,...
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7544698 |
Indoles and benzoimidazoles as modulators of the histamine H4 receptor
Benzoimidazole and indole compounds are described, which are useful as H 4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease...
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7541358 |
1-aryl-or 1-alkylsulfonylbenzazole derivatives as 5-hydroxytryptamine-6 ligands
The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor.
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7531670 |
Methods for treating cognitive/attention deficit disorders using tetrahydroindolone analogues and derivatives
Methods for treating cognitive/attention deficit disorders in general using tetrahydroindolone derivatives and analogues, particularly tetrahydroindolone derivatives or analogues in which the...
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7531568 |
PPAR active compounds
Compounds are described that are active on at least one of PPARα, PPARδ, and PPARγ, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPARα,...
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7531552 |
Indole, azaindole and related heterocyclic pyrrolidine derivatives
This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with amido piperazine...
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7528124 |
1,3-dihydro-2H-indol-2-one derivative
A 1,3-dihydro-2H-indol-2-one derivative expressed by Formula 1 (wherein R 1 is a halogen atom, a C 1 to C 4 alkyl group, etc., and R 2 is a hydrogen atom, a halogen atom, etc., or R 2 is in...
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7524883 |
Eponemycin and epoxomicin analogs and uses thereof
The present invention provides compounds having formula (1): wherein R 1 -R 6 , A, J, D, E, G, Q, w, x, y, and z are as described generally and in classes and subclasses herein, and additionally...
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7524842 |
Compounds for the treatment of inflammatory disorders
This invention relates to compounds of the Formula (I):
or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions...
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7524839 |
Compounds, their use and preparation
The invention-provides 2, 3-, 4- or 5-substituted-N1-(arylsulfonyl)indole and (heteroaryl)indole compounds of the general formula (I):
in which Ar, R 2 , R 3 , R 4 and R 5 are as defined in...
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7514466 |
Purification of progesterone receptor modulators
Methods for purifying a compound of formula I are provided, wherein A, B X, Q, and R 1 are defined herein.
The methods include mixing the compound of formula I and a solvent; adding a base to...
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7514452 |
2-furancarboxylic acid hydrazides and pharmaceutical compositions containing the same
The present invention provides 2-furancarboxylic acid hydrazide compounds represented by General Formula (I) below, and prodrugs, physiologically acceptable salts, hydrates, solvates thereof:
...
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7511071 |
Thioamide derivatives as progesterone receptor modulators
Thioamide compounds, and specifically, thioamide pyrrole compounds, and preparation thereof are provided. These thioamide compounds can be used as progesterone receptor modulators, in...
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7504424 |
Compounds for the treatment of inflammatory disorders
This invention relates to compounds of the Formula (I):
or a pharmaceutically acceptable salt, solvate, ester or isomer thereof, which can be useful for the treatment of diseases or...
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7504401 |
Anti-cancer agents and uses thereof
The present invention is in the area of novel compounds and salts thereof, their syntheses, and their use as anti-cancer agents. The compounds include compounds of Formula I:
and solvates,...
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7498328 |
Derivatives of sulphonamides, their preparation and use as medicaments
The present invention relates to new derivatives of sulphonamides, with the general formula (I), as well as to their physiologically acceptable salts, the processes for their preparation, their...
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7495109 |
Nociceptin analogs
A compound of the formula (I), (II), (III) or (IV)
wherein
Z, A, B, C, R, R 1 , R 2 , Q, and n are as described herein.
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7488725 |
Pyrrolidinyl beta-amino amide-based inhibitors of dipeptidyl peptidase IV and methods
Compounds are provided having the formula:
wherein R 1 , R 2 , R 2′ , R 3 , R 3′ , R 4 , R 4′ , R 5 , X, Y and Z are as defined herein.
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7485652 |
Indolyl derivatives as liver-X-receptor (LXR) modulators
The invention relates to compounds of formula (I):
and pharmaceutically acceptable salts and pharmaceutically acceptable esters thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , A, m, n and...
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7482472 |
Substituted isoindoles and their use
The invention relates to coagulation of the blood. Disclosed are novel compounds of formula (I),
a method for the production of these compounds, pharmaceutical compositions containing them, and...
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7479503 |
Photodynamic therapy in selective cell inactivation in blood and treating immune dysfunction diseases
Multiple sclerosis and rheumatoid arthritis can be treated effectively using photodynamic therapy. In this protocol, a photoactive compound is administered, allowed to distribute in the effected...
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7462638 |
Use of IκB-kinase inhibitors in pain therapy
The present invention relates to the use of IκB-kinase Inhibitors and methods for the prophylaxis and therapy for treating pain comprising administering such compounds.
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7462631 |
Thiophene-2-carboxamide derivatives, preparation and therapeutic application thereof
The invention discloses and claims a compound of formula (I):
Wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and R 11 are as defined herein. Further embodiments of the invention...
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7456183 |
Guanidino compounds
Compounds having the general structure I are provided. X and Y are independently selected from the group consisting of CH 2 , N, NR 9 , C═O, C═S, S═O, SO 2 , S, O, (CR 6 R 7 ) n ,...
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7452913 |
Polymorphs of pyrrole substituted 2-indolinone protein kinase inhibitors
The present invention relates to polymorphs of the 3-pyrrole substituted 2-indolinone compound 5-(5-fluoro-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-2,4-dim
ethyl-1H-pyrrole-3-carboxylic acid...
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7449481 |
Thio-substituted biaryl-methanesulfinyl derivatives
The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions that...
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7449459 |
Inhibitors of soluble adenylate cyclase
The invention relates to compounds of general formula I as well as the production and use thereof as a medication.
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7449453 |
Compositions of ezetimibe and methods for the treatment of cholesterol-associated benign and malignant tumors
A method of prevention or treatment of a cholesterol-associated tumor is provided which comprises administering a therapeutically effective amount of an azetidinone-based cholesterol absorption...
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7446118 |
3-amino-1-arylpropyl indoles and aza-substituted indoles and uses thereof
The present invention provides compounds of the formula:
or pharmaceutically acceptable salts, solvates or prodrugs thereof,
wherein p, Ar, R 1 , R 2 , R 3 , R a , R b , R c , R d and R e ...
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7429611 |
Indole inhibitors of 15-lipoxygenase
The present invention provides indole inhibitors of 15-LO, pharmaceutical compositions containing such inhibitors and methods for treating diseases related to the 15-LO cascade using such compounds...
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7425574 |
Benzofuran oxyethylamines as antidepressants and anxiolytics
Novel benzofuranoxyethylamines of the formula (I), in which R 1 , R 2 , R 3 , R 4 , m and n have the meanings indicated in Patent Claim ( 1 ), which have a strong affinity to the 5 HT 1A receptors...
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7425553 |
Triheterocyclic compounds, compositions, and methods for treating cancer or viral diseases
The present invention relates to novel Triheterocyclic Compounds, compositions comprising a Triheterocyclic Compound, and methods useful for treating or preventing cancer or a neoplastic disorder...
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