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7612099 |
Vinylogous acid derivatives
The invention is concerned with vinylogous acids derivatives of formula (I)
wherein A and R 1 to R 6 are as defined in the description and in the claims, as well as physiologically acceptable...
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7560483 |
Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof
The present invention provides a method for synthesizing 1-(acyloxy)-alkyl derivatives from 1-acyl-alkyl derivatives, which typically proceeds stereospecifically, in high yield, does not require...
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7553836 |
Melanin concentrating hormone receptor-1 antagonists
The present application provides compounds, including all stereoisomers, solvates, prodrugs and pharmaceutically acceptable forms thereof according to Formula I
wherein R 1a , R 1b , R 1c...
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7476689 |
Therapeutic compositions for intranasal administration which include KETOROLAC
An analgesic/anti-inflammatory pharmaceutical dosage form which comprises an effective amount of an active ingredient selected from the group consisting of racemic...
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7425573 |
Use of annellated pyrrole compounds in the treatment of articular cartilage or subchondral bone degeneration
Treating or preventing degeneration or destruction of articular cartilage and/or subchondral bone in the affected joint of a mammal is accomplished by administering a compound of formula (I),...
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7410978 |
Once daily dosage forms of trospium
A pharmaceutical composition of a pharmaceutically acceptable trospium salt, with upon administration to a human patient generates an average steady state blood levels of trospium with a minimum (C...
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7388027 |
Bicyclic compounds as modulators of androgen receptor function and method
The present invention relates to bicyclic compounds according to formula I, pharmaceutical compositions containing such compounds and methods of using such compounds in the treatment of androgen...
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7378437 |
Drugs for diabetes
Use for the diabetes treatment of compounds or salts thereof, having the following general formula (I): A-(B) b0 —(C) c0 —NO 2 wherein A contains the radical of a drug having an...
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7375128 |
Inhibitors of α1 β2 integrin mediated cell adhesion
The present invention relates to a compound of formula (I): wherein R is hydrogen atom, hydroxyl group or carbamoyl group, and n is 1 or 2, or a pharmaceutically acceptable salt thereof.
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7338971 |
Treatment of inflammatory, cancer, and thrombosis disorders
This invention provides for the treatment of inflammatory, cancer and thrombotic disorders through the administration, in combination, of a COX2 inhibitor, low dose aspirin, and antioxidant...
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7214703 |
Pyrrolidinohydrochinazolines
Disclosed are compounds of formula (I):
or stereoisomers or pharmaceutically acceptable salts thereof, wherein the groups Ar 1 , Ar 2 , A, R 1 , R 2 , R 3 , E 1 , E 2 , X and n are as defined...
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7214701 |
Active substance combinations having insecticidal and acaricdal properties
The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising
(a) compounds of the formula (I)
in which W, X, Y, Z, A, B, D and G...
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7176198 |
1H-pyrazole and 1H-pyrrole-azabicyclic compounds for the treatment of disease
The invention provides compounds of Formula I:
wherein Azabicyclo is
where the variables have the definitions discussed herein. These compounds may be in the form of pharmaceutical salts or...
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7160876 |
Fused bicycloheterocycle substituted quinuclidine derivatives
Compounds of formula (I)
wherein n is 0, 1, or 2; X is O, S, —NH—, and —N-alkyl-; Ar 1 is a 6-membered aromatic ring; and Ar 2 is a fused bicycloheterocycle. The compounds are useful in...
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7138423 |
Arylpyrrolidine derivatives as NK-1 /SSRI antagonists
The present disclosure relates to chemical compounds and their use in treatment of human diseases. A particular embodiment relates to compounds of Formula (I) or an isomer, a pharmaceutically...
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7109210 |
Quinuclidine derivatives and medicinal compositions containing the same
Compounds of the formula
wherein: {circle around (C)} is phenyl, C 4 to C 9 heteroaromatic, naphthalenyl, 5,6,7,8-tetrahydronaphthalenyl or biphenyl;
R 1 , R 2 and R 3 are hydrogen or a...
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7105507 |
Cyclohexane derivatives and their use as therapeutic agents
The present invention relates compounds of formula (I), wherein ring A is a phenyl or pyridyl ring; X represents a linker selected from the group consisting of formulae: (a), (b), (c), (d), and...
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7094800 |
Cyanopyrrolidides, process for their preparation and their use as medicaments
The invention relates to compounds of the formula I
in which the radicals have the meanings stated in the text, their stereoisomeric forms, and their physiologically tolerated salts,...
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RE39128 |
Pleuromutilin derivatives as antimicrobials
The present invention relates to pleuromutilin derivatives, to processes for their preparation, to pharmaceutical compositions containing them and to their use in medical therapy, particularly...
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7041696 |
Interleukin-1β converting enzyme inhibitors
The present invention relates to interleukin-1β converting enzyme inhibitors having the formula:
R is a carbocyclic or heterocyclic ring; R 1 is a cysteine trap; R 2a , R 2a′ , R 2b , and R...
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7022706 |
Pharmaceutical compositions and methods for use
Pharmaceutical compositions incorporate compounds that are capable of affecting nicotinic cholinergic receptors. A wide variety of conditions and disorders, and particularly conditions and...
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6936632 |
Fused pyrrole compounds, pharmaceutical agents containing the same, and the use thereof
The present invention relates to fused pyrrole compounds of the formula 1.
in which at least one of the radicals R1, R2, R3 is 4-sulphur-substituted phenyl.
These compounds are in particular...
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6894042 |
Azabicyclic compounds for the treatment of disease
The invention provides compounds of Formula I:
wherein Azabicyclo is
These compounds may be in the form of pharmaceutical salts or compositions, may be in pure enantiomeric form or...
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6878738 |
Anti-inflammatory oxo derivatives and hydroxy derivatives of pyrrolizines, and their pharmaceutical use
The present invention relates to compounds of the formula I
in which one of the radicals R8 and R9 is a hydrogen atom or an alkyl group and the other is hydroxyl, alkoxy or acyloxy or where R8...
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6869971 |
UCS1025 derivatives
UCS 1025 derivatives having antitumor activity or antibacterial activity which are represented by formula (I):
wherein R 1 represents hydrogen, lower alkyl, etc.; R 2 represents hydrogen, or...
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6869946 |
Substituted azabicyclic moieties for the treatment of disease
The invention provides compounds of Formula I:
wherein m 1 is 0 or 1; m 2 is 1 or 2; R 1 is —H, alkyl, halogenated alkyl, substituted alkyl, cycloalkyl, or phenyl; R 2 is —H,...
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6852716 |
Substituted-aryl compounds for treatment of disease
The invention provides compounds of Formula I:
These compounds may be in the form of pharmaceutical salts or compositions, racemic mixtures, or pure enantiomers thereof. The compounds of...
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6849620 |
N-(azabicyclo moieties)-substituted hetero-bicyclic aromatic compounds for the treatment of disease
The invention provides compounds of Formula I:
wherein Azabicyclo is
W 0 is a bicyclic moiety and is
These compounds may be in the form of pharmaceutical salts or...
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6821993 |
Triazepine derivatives as neurotrophic agents
This invention relates to a series of triazepines of Formula I and II, and pharmaceutical compositions containing them. The compounds of the invention have neurotrophic activity and are useful...
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6686358 |
Bicyclic amino-pyrazinone compounds
A compound of formula (I): wherein: R 1 represents hydrogen, or linear or branched (C 1 -C 6 )alkyl optionally substituted by one or more identical or different groups selected from aryl,...
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6586426 |
β-sheet mimetics and use thereof as protease inhibitors
There are disclosed β-sheet mimetics and methods relating to the same for imparting or stabilizing the β-sheet structure of a peptide, protein or molecule. In one aspect, the β-sheet mimetics...
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6579878 |
Pharmaceutical compositions and methods for use
Pharmaceutical compositions incorporate compounds that are capable of affecting nicotinic cholinergic receptors. A wide variety of conditions and disorders, and particularly conditions and...
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6562816 |
Substituted-heteroaryl-7-aza&lsqb 2.2.1&rsqb bicycloheptanes for the treatment of disease
The invention provides compounds of Formula I: compounds of the Formula I: wherein R 1 , R 2 , R 4 , R 6 , X, and W are defined herein. These compounds may be in the form of pharmaceutical salts...
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6514981 |
Methods of modulating tyrosine protein kinase function with indolinone compounds
The invention relates to certain indolinone compounds, their method of synthesis, and a combinatorial library consisting of the indolinone compounds. The invention also relates to methods of...
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6492332 |
Irrigation solution and methods for inhibition of tumor cell adhesion, pain and inflammation
This invention relates to a method of inhibiting tumor cell adhesion, pain, and inflammation at a wound during a surgical procedure by delivering an irrigation solution containing a tumor cell...
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6472433 |
Method for treatment of inflammation with R-NSAIDS
This invention relates to the use of enantiomerically pure R-NSAIDs for the treatment of inflammation. Preferably, the R-NSAID used is R-flurbiprofen and is administered in a dose of at least 5...
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6462071 |
Agents for intravitreal administration to treat or prevent disorders of the eye
Methods and preparations for treating disorders of the eye and/or causing posterior vitreous disconnection or disinsertion. Preparations containing a) urea, b) urea derivatives (e.g., hydroxyurea,...
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6462065 |
Use of 5-HT3 receptor antagonists for treating musculoeskeletal diseases
The present invention relates to a new use for compounds having 5-HT 3 (serotonin M) receptor antagonist activity, especially tropisetron, for the manufacture of a pharmaceutical composition for...
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6395746 |
Methods of treating ophthalmic, otic and nasal infections and attendant inflammation
Methods of treating or preventing ophthalmic, otic, and nasal infections and attendant inflammation are described. The methods utilize ophthalmic, otic, and nasal compositions containing a new...
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6376508 |
Treatments for spinal muscular atrophy
The invention features a method of modulating SMN exon 7 expression in a subject by administering a histone deacetylase inhibitor.
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6329369 |
Methods of treating pain and other conditions
Methods of treating glaucoma or elevated pressure and other diseases with reduced side effects by treating a mammal in need thereof an agonist of the alpha 2B or alpha 2B/2C adrenergic receptor(s)....
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6323234 |
Methods to treat gastrointestinal lesions and to reduce drug-induced gastrointestinal or renal toxicity
Nonsteroidal antiinflammatory drugs which have been substituted with a nitrogen monoxide group; composition comprising (i) a nonsteroidal antiinflammatory drug, which can optionally be substituted...
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6271264 |
Polymers containing spirobicyclic ammonium moieties as bile acid sequestrants
The present invention relates to a method for sequestering bile acids in a patient and to particular polymers for use in the method. The method comprises administering a therapeutically effective...
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6214855 |
Method for the treatment of stroke using N-heterocyclic glyoxlyamide compounds
A method and composition for the treatment and/or prevention of stroke is disclosed using N-heterocyclic glyoxamide compounds having the following general formula: ##STR1## wherein X, E, F, R 11...
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6191126 |
Topical use of κ opioid agonists to treat ocular pain
The present invention relates to the pharmaceutical treatment of pain. In particular, the present invention relates to the topical use of kappa opioid receptor agonists and partial agonists for the...
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6177451 |
Epibatidine and derivatives thereof as nicotine cholinergic receptor agonists
The present invention provides methods of treatment utilizing pharmaceutical compositions comprising an effective nicotine agonist amount of epibatidine (1) or a synthetic...
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6150371 |
Method for preventing and for treating autoimmune disease
A method for preventing or treating autoimmune diseases (excluding type I diabetes) by administering an insulin resistance improving substance as an active ingredient.
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6143734 |
Nitroso esters of β-oxo-amides and aryl propionic acid derivatives of non-steroidal antiinflammatory drugs
A compound comprising a non-steroidal antiinflammatory agent to which is directly or indirectly linked an NO group, a compound comprising an enolic anilide non-steroidal antiinflammatory agent to...
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6136820 |
Isolation of castanospermine and its use as an antidiabetic agent
A method for inhibiting the formation of glucose by the administration of castanospermine is described herein. In addition, a new process for the isolation of castanospermine from Castanospermum...
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6121306 |
Method of making (1S, 4R)-1-azabicyclo[2.2.1]heptan-3-one and (1R, 4S), 1-azabicyclo[2.2.1]heptan-3-one
Racemic (±)-1-azobicyclo[2.2.1]heptan-3-one may be efficiently resolved into its (1S,4R)- and (1R,4S)-1-azabicyclo[2.2.1]heptan-3-one isomers by formation of di-p-toluoyl hemitartrate salts by...
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