Matches 201 - 250 out of 305 < 1 2 3 4 5 6 7 >
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5602167 4-arylcyclohepta[c] pyrrole analgesics  
The 4-arylcyclopenta[c]pyrroles of the following formula are effective analgesics: ##STR1## including stereoisomers and pharmaceutically acceptable salts thereof, wherein ##STR2## with the proviso...
5591766 Solid oral formulations of pyridone carboxylic acids  
A solid oral pharmaceutical formulations of novel pyridone carboxylic acid compounds and esters or salts thereof having powerful antibacterial activities is disclosed.
5547978 Derivatives of pyrrolidin-2-ylcarbonylheterocyclic compounds  
The invention relates to derivatives of pyrrolidin-2-ylcarbonylheterocyclic compound of the general formula ##STR1## in which R 1 represents C 1 -6 alkyl, C 1 -20 cycloalkyl, aryl or heteroaryl, ...
5541217 4-arylcyclopenta[c]pyrrole analgesics  
The 4-arylcyclopenta[c]pyrroles of the following formula are effective analgesics: ##STR1## including stereoisomers and pharmaceutically acceptable salts thereof, wherein ##STR2## with the proviso...
5532243 Antipsychotic nitrogen-containing bicyclic compounds  
There are provided nitrogen-containing bicyclic compounds, pharmaceutical compositions containing these compounds and methods of using these compounds to treat physiological or drug-induced...
5506257 Aminocyclohexylamides for antiarrhythmic and anaesthetic uses  
The present invention provides methods for blocking sodium channels in cardiac or neuronal tissue using aminocyclohexylamides. This invention also provides kits including aminocyclohexylamides and...
5498625 Substantially pure enantieners of 2-azabicyclo(2.2.1)hept-5-en-3-one  
Lactams of 1-amino-3-carboxylic acid cyclic compounds are produced in enantiomeric form, together with an enantiomer of the corresponding ring-opened amino-acid or ester, by reaction of the racemic...
5461072 Use of aryl hydroxyurea compounds for the treatment of atherosclerosis  
The present invention is concerned with the use of a compound of formula (I): Ar--Y--Q, wherein Ar is either (i) furyl, thienyl, thienyl 1,1-dioxide, pyrryl, pyridyl, benzofuryl, benzothienyl,...
5457121 Cis-hexahydro-5-(1,2,3,4-tetrahydro-2-naphthalenyl)pyrrolo<3,4-c> pyrroles as inhibitors of serotonin reuptake  
This invention provides ring-substituted cis-hexahydro-5-(1,2,3,4-tetrahydro-2-naphthalenyl)pyrrolo&l t;3,4-c>pyrroles which are selective inhibitors of serotonin reuptake.
RE34918 Azaazulene compounds which are useful as antiallergic and antiinflammatory agents  
An azaazulene derivative having the general formula (I): ##STR1## wherein R 1 is hydrogen atom or isopropyl group; the bond C N between C at the 2-position and N at the 1-position is single bond...
5395840 Heterocyclically substituted phenyl-cyclohexane-carboxylic acid derivatives  
Heterocyclically substituted phenyl-cyclohexanecarboxylic acid derivatives are prepared by reacting appropriate heterocyclic compounds with cyclohexanebenzyl halides. The compounds can be employed...
5366994 Use of a combination of angiotensin-converting enzyme inhibitor and calcium antagonist for the treatment of proteinuria  
A combination of angiotensin-converting enzyme inhibitors and calcium antagonists for the treatment of proteinuria is disclosed. The invention relates to the prevention and therapy of proteinuria...
5356910 Use of N-(pyridinyl)-1H-indol-1-amines for the treatment of obsessive-compulsive disorder  
There is disclosed a method of alleviating obsessive compulsive disorders which comprises administration of an effective amount of a compound of the formula. ##STR1## where m is 1 or 2; R is H,...
5348944 Carboxyalkyl dipeptides  
Compounds of the formula ##STR1## useful as antihypertensive agents are disclosed.
5225401 Treatment of congestive heart failure  
Congestive heart failure is treated by administration of a selective inhibitor of neutral endopeptidase and an angiotensin converting enzyme inhibitor. Captopril, fosinopril sodium, enalapril...
5223528 Anticholinergic compounds, composititons and methods of treatment  
Compounds of the formula ##STR1## wherein the variables are defined in the specification. The compounds and their salts are soft anticholinergic/antisecretory agents especially useful as mydriatics...
5221689 Prostaglandin analogues, processes for their preparation and pharmaceutical compositions containing them  
The present invention relates to novel isomers of 6,9α-nitrilo-PGI 1 s having a specific steric configuration, which are replaced by an alkyl (C 1 to C 8 )-substituted cycloalkyl (C 4 to C 7 )...
5202335 Succinic acid compounds  
Succinic acid compounds of the formula: ##STR1## wherein A represents a heterocyclic group, a 3 to 8-membered cycloalkyl group or a phenyl group which may have one or more substituents selected...
5196423 Unsaturated cyclohexylacetic acid derivatives, and crop-protection agents containing same  
Unsaturated cyclohexylacetic acid derivatives of the formula I ##STR1## where U isNOCH 3 , CHOCH 3 , CH 2 , CH--CH 3 , CH--CH 2 --CH 3 , N--NH--CH 3 or CH--S--CH 3 , n is...
5196454 Method of treating disorders of the dopaminergic systems using 2,5-diaminotetralines  
The invention relates to novel 2,5-diaminotetralines of the formula: ##STR1## wherein R1, R2, R3 and R4 are defined herein, processes for preparing them and their use in pharmaceutical...
5190938 Derivatives of 2-hydroxythiophene and -furan fused with a nitrogen-containing ring and their application in therapy  
The invention relates to compounds of formula ##STR1## in which R 1 is selected from the groups R 3 and OR 3 , R is selected from H and a group CHR 2 R', in which R 2 is selected from H, alkyl,...
5179093 Quinoline-diones  
Compounds of the formula ##STR1## or a pharmaceutically acceptable salt thereof wherein, R is H, halogen, (C 1 -C 6 ) alkyl, N(C 1 -C 6 alkyl/aryl) 2 , OH, O--(C 1 -C 6 ) alkyl/aryl, CH 2 OH,...
5162370 Treatment of cataract with prostacyclin compounds  
A method for treatment of cataract which comprises administering, to a subject in need of such treatment, a prostacyclin compound in an amount effective in treatment of cataract.
5139740 Polyprenyl compound composition for soft capsules  
A pharmacological composition for soft capsules, containing a polyprenyl compound having the formula (1) and a surfactant and/or an unsaturated aliphatic acid, has improved absorbability. ##STR1##...
5114962 New amino acid esters, a process for their preparation, medicaments containing them, and the use thereof  
New amino acid esters, a process for their preparation, medicaments containing them, and the use thereof The invention relates to amino acid esters of the formula I ##STR1## in which n is 1 or 2,...
5068242 Pyrrolidine-2-carboxylic acid derivatives and their use for psychotropic action  
The present invention relates to compounds of the formula I ##STR1## in which R 1 to R 4 are defined in the description, processes for their preparation, their use for the treatment and...
5063231 Method of treatment of visceral pain  
A method of treatment of visceral pain in mammals, including humans, which method comprises the administration to the mammal in need of such treatment, an effective amount of a compound of formula...
5061722 Cis, endo-2-azabicyclo-[3.3.0]-octane-3-carboxylic acids, a process for their preparation, agents containing these compounds and their use  
Compounds of the formula I ##STR1## in which the carboxyl group on carbon atom 3 is orientated in the endo-position relative to the bicyclic ring system of cis-configuration, and in which R 1 ...
5055483 Novel amino acid glycerides, learning medicaments containing them and their use  
The invention relates to amino acid esters of the formula ##STR1## in which n=1 or 2, R, R 1 , R 2 and R 3 denote hydrogen or a defined radical, R 4 together with R 5 and the atoms carrying...
5043346 Amino acid esters, pharmaceuticals containing them, and the use thereof in learning disorders  
The invention relates to amino acid esters of the formula I ##STR1## in which n is 2 and R, R 1 , R 2 , R 3 , R 4 and R 5 have the meaning indicated in the description, to a process and...
5021448 Method of reducing serum uric acid and/or increasing renal uric acid clearance with thromboxane synthetase inhibitor inhibitor and/or thromboxane receptor antagonist  
A method of reducing serum uric acid and/or increasing renal clearance of uric acid in a mammal in need thereof comprising administering to such mammal a uricosuric effective amount of a...
5021427 Novel pyrrolizidine alkaloid  
The present invention involves a purified bioactive compound of the formula: ##STR1## wherein at least one of R 1 , R 2 , R 3 and R 4 are H or an acyl having less than about five carbon atoms....
5008273 Amino acid derivatives and their pharmaceutical use  
Amino acid derivatives of general formula ##STR1## (the definitions of the various symbols being explained in the specification) are suitable for treating high blood pressure and for...
4999370 Compounds with a psychotropic action, agents containing them, and the use thereof for the treatment and prophylaxis of disorders of the central nervous system  
Compounds with a psychotropic action, agents containing them, and the use thereof for the treatment and prophylaxis of disorders of the central nervous system. The invention relates to the use of...
4987130 Substituted amine derivatives, their production and use  
Substituted amino derivatives represented by the formula: ##STR1## wherein R 1 and R 2 each stand for an acyclic hydrocarbon residue or an alicyclic hydrocarbon residue; R 3 and R 4 each stand...
4957938 Nutritional formulation for the treatment of renal disease  
A novel nitritional formulation comprising mixtures of mixed salts formed between branched-chain α-keto-acids and basic L-amino acid is disclosed which provides optimal nutrition when consumed...
4920144 Derivatives of bicyclic amino acids, agents containing them and their use as hypotensives  
The invention relates to new derivatives of the bicyclic amino acids of the formula I ##STR1## in which n denotes 0, 1 or 2, R denotes hydrogen, alkyl or aralkyl, R 1 denotes hydrogen or alkyl,...
4886827 Cis,endo-2-azabicycloalkane-3-carboxylic acid derivatives, their use and intermediates in their preparation  
The invention relates to compounds of the formula I ##STR1## in which n is 1, 2 or 3, Z 1 and Z 2 , and Z 3 and Z 4 , in each case together represent a chemical bond or Z 1 , Z 2 , Z 3 and...
4877785 Non-peptidyl beta-succinamidoacyl aminodiols as anti-hypertensive agents  
Non-peptidyl compounds characterized generally as β-succinamidoacyl aminodios are useful as renin inhibitors for the treatment of hypertension.
4876269 Benoz-fused cycloalkane trans-1,2-diamine derivatives  
Benzo-fused cycloalkane and oxa- and thia-cycloalkane trans-1,2-diamine compounds of the formula: ##STR1## wherein A, B, C, D, n, X, Y, R, R 1 , R 2 and R 3 are as defined in the specification,...
4839379 Substituted azabicycloalkanes, the use thereof, pharmaceutical compositions containing them  
1-Phenyl-3-azabicyclo[3.1.0]hexane-2,4-diones of the formula ##STR1## wherein R 1 is hydrogen, R 2 is hydrogen, sulfo or acyl and R 3 is hydrogen, or R 1 is a saturated or unsaturated...
4818749 Carboxyalkyl dipeptides and medical use thereof in treating hypertension and congestive heart failure  
The present invention relates to carboxyalkyl dipeptides which are inhibitors of angiotensin-converting enzyme and are useful as antihypertensive agents and in the treatment of congestive heart...
4812475 New method of treatment using prostaglandin analogues  
The invention relates to a new method for the treatment of anoxia of brain cells using a PGI 1 derivative of the formula: ##STR1## (wherein R represents an alkyl group of 1 to 4 carbon atoms.) or...
4797387 Certain pharmaceutically useful ureas  
Compounds of formula (I), and pharmaceutically acceptable salts thereof: ##STR1## wherein L is NH or O; X is a moiety capable of hydrogen bonding to the NH group depicted in formula (I); R 1 ...
4767757 Acyloxythiophene-carboxamide fungicides, compositions and use  
Novel fungicidally active acyloxythiophene-carboxamides of the formula ##STR1##
4761247 Phenol-stabilized microbiocidal compositions  
Solutions of microbiocides in cosolvents having alkanol moieties and concentrate compositions of carriers, microbiocides and cosolvents having alkanol moieties are stabilized against UV-catalyzed...
4760077 Pyrrothine derivatives and pharmaceutical use thereof  
There is described the use of pyrrothine derivatives of the general formula I ##STR1## wherein R 1 and R 3 signify hydrogen or methyl, R 2 hydrogen, methyl or an acyl group with 1 to 5 carbon...
4758585 Saturated cycloalkyl (B) pyrrol-1 (2H)- acetic acid amides and derivatives thereof  
A unique series of saturated cycloalkyl[b]pyrrol-1(2H)-acetic acid amides are useful as agents for the reversal of amnesia. Intermediates for preparing the compounds, pharmaceutical composition...
4751231 Substituted thieno[2,3-b]pyrrole-5-sulfonamides as antiglaucoma agents  
Thieno[2,3-b]pyrrole-5-sulfonamides are carbonic anhydrase inhibitors useful in the treatment of elevated intraocular pressure and glaucoma.
4735959 Carboxylic acid amides and pharmaceutical compositions containing them  
There are described novel carboxylic acid derivatives of the formula ##STR1## and derivatives of the formula ##STR2## and the addition salts thereof, which exhibit an effect on the intermediary...
Matches 201 - 250 out of 305 < 1 2 3 4 5 6 7 >