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6358994 |
2-acylaminopropanamines as tachykinin receptor antagonists
This invention provides compounds of the Formula I: which are useful as tachykinin receptor antagonists. This invention also provides methods employing these compounds, as well as pharmaceutical...
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6353014 |
15-ketal postaglandins for the treatment of glaucoma or ocular hypertension
A method of treating glaucoma or ocular hypertension in a patient, which comprises administering to the patient a pharmaceutically effective amount of a compound of formula I:
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6339100 |
Methods for inhibiting mastocytosis
A method of preventing or treating in a subject mastocytosis which comprises administering to the subject a therapeutically effective amount of a compound having the structure: or a...
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6323234 |
Methods to treat gastrointestinal lesions and to reduce drug-induced gastrointestinal or renal toxicity
Nonsteroidal antiinflammatory drugs which have been substituted with a nitrogen monoxide group; composition comprising (i) a nonsteroidal antiinflammatory drug, which can optionally be substituted...
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6300366 |
Aminopyrroline compounds
Compound of formula (I): ##STR1## in which: n is 1 or 2, X represents alkylene, alkenylene, alkynylene or optionally substituted arylene or heteroarylene, R 10 represents hydrogen or...
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6288077 |
2,3-methano-amino acid compounds
Compound of formula (I): ##STR1## wherein: n represents 2 or 3, R 1 represents optionally substituted alkyl, cycloalkyl or optionally substituted phenyl, R 2 represents amino, optionally...
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6271264 |
Polymers containing spirobicyclic ammonium moieties as bile acid sequestrants
The present invention relates to a method for sequestering bile acids in a patient and to particular polymers for use in the method. The method comprises administering a therapeutically effective...
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6268377 |
Method for treating androgen-related conditions
The present invention provides for the combined use of 5α-reductase inhibitors together with calcium channel blockers for the treatment of benign prostatic hyperplasia (BPH), prostate cancer,...
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6221377 |
Administration media for analgesic, anti-inflammatory and anti-pyretic drugs containing nitrous oxide and pharmaceutical compositions containing such media and drugs
Administration mediums comprising solutions of nitrous oxide in water, alcohols, ethers or oils, and optionally including essential fatty acids or C 1 -C 6 alkyl esters thereof enhance the action...
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6218417 |
Ace-inhibitor nitric salts
Compounds having platelet anti-aggregating activity and antihypertension activity having reduced branchial side effects.
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6214857 |
Substituted alkanohydroxamic acids and method of reducing TNFα levels
Imido and amido substituted alkanohydroxamic acids reduce the levels of TNFα and inhibit phosphodiesterase in a mammal. A typical embodiment is...
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6204284 |
Use of 1-(substitutedphenyl)-3-azabicyclo[3.1.0]hexanes for the treatment of chemical dependencies
The invention is a method of treatment for the relief of an addictive, compulsive disorder which comprises the administration to a human or animal suffering from such a disorder an effective amount...
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6200987 |
Cyclic amides
Cyclic amides are inhibitors of tumor necrosis factor and can be used to combat cachexia, endotoxic shock, and retrovirus replication. A typical embodiment is...
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6180601 |
Low molecular weight hyaluronic acid with peptide or protein
The invention relates to freeze-dried soft, flexible and continous matrix of low-molecular weight hyaluronic acid or salt thereof, in which the molecular weight of the hyaluronic acid is preferably...
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6177450 |
Synergizing combination having an antagonist effect on NKI and NK2 receptors
Synergising associations characterized in that they are comprised of at least one product having an antagonist activity on NK1 receptors and at least one product having an antagonist activity on...
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6174878 |
Topical use of kappa opioid agonists to treat otic pain
Compositions and methods for treating otic pain are disclosed. In particular, the invention discloses compositions and methods of using kappa opioid agonists locally for the prevention or...
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6160003 |
1,3,6-trihydro-6-aza-3-oxapentalen-2-one derivatives for the treatment of neoplasia
1,3,6-Trihydro-6-Aza-3-Oxapentalen-2-One Derivatives of Formula I are useful for inducing or promoting apoptosis and for arresting uncontrolled neoplastic cell proliferation, and are specifically...
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6124305 |
Use of N-(substituted glycyl)-2-cyanopyrrolidines in inhibiting dipeptidyl peptidase-IV
N-(N'-substituted glycyl)-2-cyanopyrrolidines of formula I ##STR1## wherein R is as defined herein. Compounds of formula I inhibit DPP-IV (dipeptidyl-peptidase-IV) activity. They are therefore...
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6110934 |
Substituted benzamide derivatives and their use as anticonvulsants
This invention relates to substituted benzamido-heterocyclic compounds of general formula (I) having an alkoxy substituent at the C2 position of the benzamido group and various substituents at...
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6106821 |
Fly attractant compositions
The invention relates to fly attractant compositions that comprise at least one volatile short chain carboxylic acid, at least one organic sulfide and at least one nitrogen heterocycle. In a...
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6083971 |
Certain oxopyrolo-pyrrole derivatives having thrombin inhibiting activity
Compounds of the formula ##STR1## wherein R 1 is lower-alkyl, cycloalkyl or phenyl, R 2 is H, OH or C(O)O-A, wherein A is lower-alkyl, cycloalkyl or phenyl, and R 3 , R 4 and R 5 are...
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6048886 |
Compositions and delivery systems for the topical treatment of psoriasis and other conditions of the skin
The invention provides compositions and methods for the application of those compositions in order to treat biological surfaces, especially the skin. The compositions contain a ubiquinone, may...
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6042842 |
Cosmetic composition comprising a novel pigment
The present invention relates to cosmetic compositions, in particular make-up cosmetic compositions, comprising a novel red pigment with an intense and saturated color which does not generate free...
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6028106 |
Treatment of urinary incontinence with nitric oxide synthase substrates and/or nitric oxide donors alone or in combination with estrogen or progesterone and/or other agents
The invention provides a method for the treatment and prevention of urinary incontinence in mammals, e.g., human males and females, especially nonpregnant female mammals, by administering a nitric...
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6017946 |
Serotonin containing formulation for oral administration and method of use
A medicament containing serotonin and an antioxidant useful in the treatment of pain, including migraines and premenstrual syndrome(PMS); chronic fatigue symptoms; depression and eating disorders;...
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5990106 |
Bicyclic amino group-substituted pyridonecarboxylic acid derivatives, esters thereof and salts thereof, and bicyclic amines useful as intermediates thereof
This invention relates to bicyclic amino group-substituted pyridonecarboxylic acid derivatives of the general formula A--Pri esters thereof and salts thereof, wherein: Pri is a pyridonecarboxylic...
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5972973 |
Sulfonylurea-glitazone combinations for diabetes
Combinations of a sulfonylurea antidiabetic agent and a glitazone antidiabetic agent are useful for treating diabetes mellitus and improving glycemic control.
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5965529 |
Treatment of preeclampsia and preterm labor with combination of progestational agent and a nitric oxide synthase substrate and/or donor
Preeclampsia and preterm labor in a pregnant female mammal are treated by administering thereto a combination of a progestin and a nitric oxide synthase substrate, a nitric oxide donor or both,...
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5962413 |
Treatment of uterine contractility disorders with a nitric oxide synthase substrate and/or donor, or a nitric oxide inhibitor
Dysmenorrhea, disfunctional uterine bleeding, preterm labor and postpartum labor in female mammals are treated by inhibiting uterine contractility by administering thereto a nitric oxide synthase...
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5958878 |
Treatment of climacteric disorders with nitric oxide synthase substrates and/or donors
The symptoms of the climacterium are ameliorated by the administration to an afflicted individual one or both of a nitric oxide substrate and/or nitric acid donor, alone or optionally in...
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5939357 |
Fungicide compositions
This invention provides a novel fungicide composition which has a bicarbonate-containing inorganic salt ingredient which enhances the efficacy of a fungicide ingredient for the treatment of...
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5919790 |
Hydroxamate inhibitors of interleukin-1β converting enzyme
The present invention relates to compounds that are inhibitors of interleukin-1β converting enzyme that have the Formula II ##STR1## This invention also relates to a method of treatment of stroke,...
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5889022 |
Indole, indoline and quinoline derivatives with 5HT.sub.1D (anti-depressive) activity
Novel indole, indoline and quinoline derivatives of formula (I) processes for their preparation, pharmaceutical compositions containing them, and their use in medicine is disclosed. A structurally...
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5869518 |
Azacycloalkane derivatives, their preparation and their application in therapy
Azacyloalkane derivatives of general formula ##STR1## in which: R 1 and R 2 represent a hydrogen atom, an alkyl group or a phenyl group, or R 1 and R 2 together form an oxo group, R 3 ...
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5801023 |
Antiparasitic pyrrolobenzoxazine compounds
This invention provides compounds of the following chemical formula or their pharmaceutically-acceptable salts: ##STR1## wherein R is hydrogen or chloro. Also, the present invention provides a...
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5780494 |
Piperidinyl-terminated alkylamino ethynl alanine amino diol compounds for treatment of hypertension
Compounds characterized generally as piperidinyl-terminated alkylamino ethynyl alanine amino diol derivatives are useful as renin inhibitors for the treatment of hypertension. Compounds of...
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5776963 |
3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a...
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5753690 |
N-substituted azobicycloheptane derivatives, the preparation and use thereof
A compound of the formula ##STR1## in which A, R 1 and n have the meanings stated in the description are described. The novel compounds are suitable for controlling diseases.
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5747520 |
Topoisomerase II inhibitors and therapeutic uses therefor
Azatoxin and derivatives thereof are illustrative of a new class of antitumor drugs that are topoisomerase II (top 2) inhibitors. The pharmacophore inhibits the catalytic activity of the purified...
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5721244 |
Combination of angiotensin-converting enzyme inhibitors with calcium antagonists as well as their use in drugs
The invention relates to combinations of angiotensin-converting enzyme inhibitors with calcium antagonists, processes for their preparation and their use as medicaments.
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5688826 |
Excitatory amino acid derivatives
Compounds for formula I ##STR1## in which X represents O, NR a , S, SO or SO 2 and R is as defined in the specification; and non-toxic metabolically labile esters or amides thereof; and...
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5679670 |
Sulfonamides useful as carbonic anhydrase inhibitors
Sulfonamides and pharmaceutical compositions containing the compounds useful in controlling intraocular pressure are disclosed. Methods for controlling intraocular pressure through administration...
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5663188 |
Synergistic therapeutic compositions of angiotensin I converting enzyme inhibitors and angiotensin II antagonists and methods
This invention relates to compositions and methods for achieving a therapeutic effect such as lowering blood pressure and treating congestive heart failure in a mammal. More specifically, this...
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5656654 |
Arylidene and heteroarylidene oxindole derivatives and process for their preparation
Arylidene and heteroarylidene oxindole derivatives of formula (I) ##STR1## wherein, subject to provisos, Y is a bicyclic ring system chosen from naphthalene, tetralin, quinoline and isoquinoline; ...
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5654319 |
N-[(4-heteroaryl-1-piperidinyl)alkyl]-2,3-naphthalimides and related compounds and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a...
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5643888 |
Regulating retroviral replication, infection, and pathogenesis
Glucosidase I inhibitors as therapeutic agents for combatting nondefective retroviral pathogens, including the aetiological agents of AIDS and feline leukemia. Administration of a processing...
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5641798 |
Bicyclic compounds and their use as excitatory amino acid receptor antagonists
This invention provides novel bicyclic compounds which are useful as excitatory amino acid receptor antagonists and in the treatment of neurological disorders. This invention also provides...
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5639764 |
2-[(4-heteroaryl)-1-piperidinyl)alkyl]-1,3-indandiones and related compound and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents, the compounds are especially useful for treating psychoses by administering to a mammal a...
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5635537 |
8-substituted-2-aminotetralins
A compound of the formula ##STR1## Z is hydrogen or halogen, Q is COR 1 or 5-or 6-membered aryl which may contain 1 or 2 heteroatoms selected from N, 0 or S and may be substituted or fused wherein...
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5629326 |
4-(heteroaryl)-1-[(2,3-dihydro-1H-indol-1-yl)alkyl]piperidines and related compounds and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a...
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