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5686459 |
Dioxopyrrolo pyrrole derivatives
Novel dioxopyrrolo-pyrrole derivatives of the formula ##STR1## as well as hydrates or solvates thereof, which inhibit thrombin-induced or Factor Xa-induced platelet aggregation and fibrinogen...
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5681812 |
Methods and compositions for reducing multidrug resistance
The present invention comprises methods and compositions for reducing or eliminating multidrug resistance in cancers or certain infections by drug resistant microorganisms in patients. According to...
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5677328 |
Ethylamino carbazole melatonergic agents
Novel substituted carbazole compounds of Formula I are active as melatonergic agents: ##STR1## wherein: R 1 is C(O)R 3 or SO 2 R 4 ; R 2 is H or C 1 -6 alkoxy; R 3 is C 1 -6 alkyl, (CH...
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5670492 |
DC-89 derivatives
Provided are DC-89 derivatives represented by the formula: ##STR1## wherein X represents Cl or Br, R represents hydrogen or COR 1 , and W represents ##STR2## and pharmaceutically acceptable salts...
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5668167 |
Methods of treating microbial infections
The present invention provides methods for treating Cryptococcus neoformans, Cryptosporidium parvum, and Candida albicans in a subject in need of such treatment. The methods comprises administering...
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5668166 |
Methods of inhibiting pneumocystis carinii pneumonia and compounds useful therefor
The present invention provides methods for treating Pneumocystis carinii pneumonia. The method comprises administering to the subject a compound of Formula I: ##STR1## wherein: X is located in the...
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5665727 |
Use of 11,28-dioxa-4-azatricyclo[22.3.1.0.sup.4,9 ]octacos-18-ene derivatives and pharmaceutical compositions containing them
The compounds of formula I, ##STR1## have been found to have excellent topical activity. They are thus indicated for use in the topical treatment of inflammatory and hyperpoliferative skin diseases...
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5663190 |
Memory enhancing and analgesic 1,2,3,3a,8,8a-Hexahydro-3a,8(and 1,3a,8)-Di (and Tri)methylpyrrolo(2,3-b) indoles
There are described compounds of the formula ##STR1## where (a) X is O or S; (b) R is H, loweralkyl, ##STR2## where Y is O or S; R 2 is alkyl, cycloalkyl, bicycloalkyl, cycloalkenyl, aryl,...
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5663191 |
Benzopyran compounds as 5HT.sub.2C receptor antagonists
Compounds of formula (I): ##STR1## in which: n represents 1 or 2, R 1 represents hydrogen or alkyl, benzyl, acetyl, benzoyl, allyl, pyridinecarbonyl, pyridinemethyl, acylaminoalkyl (optionally...
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5654312 |
Treatment of inflammatory and/or autoimmune dermatoses with thalidomide alone or in combination with other agents
Methods of treatment for inflammatory and autoimmune dermatoses which comprises topical and/or systemic administration of a therapeutically-effective amount of thalidomide alone or in combination...
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5654319 |
N-[(4-heteroaryl-1-piperidinyl)alkyl]-2,3-naphthalimides and related compounds and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a...
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5650426 |
Enantiomers of carbazole derivatives as 5-HT.sub. 1-like agonists
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5650427 |
Centrally acting 6,7,8,9-tetrahydro-3H-benz(e) indole heterocyclics
A compound of Formula I ##STR1## or pharmaceutically acceptable salts of Formula I, where R 1 is H, C 1 -C 3 alkyl, --(CH 2 ) n CONH 2 where n is 2 to 6, (CH2) n ...
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5646173 |
Tricyclic pyrrole derivatives useful as 5-HT selective agents
The invention relates to tricyclic pyrrole derivatives useful as 5-HT selective agents of the formula ##STR1## wherein R 1 to R 4 are, independently, hydrogen, halogen, lower alkyl, phenyl,...
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5643918 |
Marcrocyclic amide and urea immunomodulators
Immunomodulatory macrocyclic compounds having the formula: ##STR1## and pharmaceutically-acceptable salts, esters, amides and prodrugs thereof, as well as pharmaceutical compositions containing the...
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5643915 |
Treatment of ischemia/reperfusion injury with thalidomide alone or in combination with other therapies
In accordance with the present invention, a method is provided for treating reperfusion injury, ischemia and runaway inflammatory conditions with thalidomide alone or in combination with other...
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5643939 |
Use of, and method of treatment using, carbazolyl-(4)-oxypropanolamine compounds for inhibition of smooth muscle cell proliferation
A new use of, and method of treatment using, a compound selected from the group consisting essentially of compounds of Formula I: ##STR1## wherein: R 1 is hydrogen, lower alkanoyl of up to 6...
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5639764 |
2-[(4-heteroaryl)-1-piperidinyl)alkyl]-1,3-indandiones and related compound and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents, the compounds are especially useful for treating psychoses by administering to a mammal a...
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5639778 |
Indoletetralins having dopaminergic activity
A compound of formula (I) and pharmaceutically acceptable salts thereof, where Z is R 3 and X and Y form (a), or X is R 3 and Y and Z form (a) or (b); R 1 and R 2 are independently hydrogen, C...
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5633277 |
Sulfonamide aminomethylene derivatives as immunosuppressants
Compounds which suppress human T-lymphocyte proliferation are disclosed. The active compounds essentially contain at least the following structure: ##STR1##
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5633276 |
Indoline derivatives, method of preparation and use
A compound of formula (I) ##STR1## wherein, R 1 is hydrogen, halogen or C 1 -6 alkyl; R 2 is a group of formula --CR 3 R 4 (CH 2 ) p NR 5 COR 6 ; R 3 , R 4 and R 5 , which may be the...
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5633265 |
***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analgetics
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a...
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5629326 |
4-(heteroaryl)-1-[(2,3-dihydro-1H-indol-1-yl)alkyl]piperidines and related compounds and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a...
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5627203 |
Tricyclic oxime ethers
The present invention relates to compounds of formula (I): ##STR1## wherein A, x, y, R 1 , R 2 and R 3 are as defined in the description. The compounds are useful for treating diseases requiring...
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5621000 |
Nitric esters having a pharmacological activity and process for their preparation
Nitric esters with pharmacological activity having general formula (I), their pharmaceutical utilisation and process for their preparation. ##STR1##
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5616603 |
Enantiomers of carbazole derivatives as 5-HT.sub.1 -like agonists
A (+)or (-) enantiomer of a compound of formula (I) wherein R 4 is methyl or ethyl, or a salt, solvate or hydrate thereof, processes for preparing said compounds and pharmaceutical compositions...
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5614543 |
1-(aryloxyalkyl)-3- (heteroaryl) pyrrolidines and related compounds useful as antipsychotics and analgesics
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a...
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5612342 |
***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
[(4-heteroaryl-1-piperindyl)alkoxy]-3,4-dihydro-1(2H)-naphthalenones and related compounds and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a...
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5612331 |
Tetrahydrocarbazole derivatives as 5-HT1-like agonists
Compounds of formula (I), wherein R 1 represents halogen, C 1 -4 alkyl, C 1 -4 alkoxy, hydroxy, NO 2 , --NR 4 R 5 , R 4 R 5 NCO(CH 2 ) m --, R 4 R 5 NSO 2 (CH 2 ) m --, R 6 CONH(CH 2 )- m...
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5612343 |
N-[(4-heteroaryl-1-piperazinyl)alkyl]-2,3-naphthalimides and related compounds and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a...
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5607945 |
N-[(4-(heteroaryl)-1-piperidinyl)alkyl]-1,2,3,4-tetrahydroisoquinolines and related compounds and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a...
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5607938 |
Medicament for treating or preventing cerebrovascular infarction
The present invention is drawn to methods for treating cerebral infarction by administering to a patient in need thereof an effective amount of a compound of the formulae (I, II or III): ##STR1##
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5607955 |
Tricyclic compounds on angiotensin II receptor antagonists
A tricyclic compound represented by the following formula (I): ##STR1## exhibits antagonism to angiotensin II receptors.
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5605913 |
***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
1-(arylthioalkyl, arylaminoalkyl or arylmethylenealkyl)-4-(heteroaryl) piperidines and related compounds useful as antipsychotics and analgesics
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a...
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5604234 |
Substituted thiol macrolactam immunomodulators
Immunomodulatory macrocyclic compounds having the formula: ##STR1## and pharmaceutically acceptable salts, esters, amides and prodrugs thereof, as well as pharmaceutical compositions containing...
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5597842 |
3-heteroaryl-1-pyrrolidinealkanols and derivatives thereof and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a...
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5591745 |
(4-heteroaryl)-1-[(2,3-dihydro-1H-isoindol-2-yl)alkyl] piperidines and related compounds and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a...
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5589495 |
2-[(3-heteroaryl-1-pyrrolidinyl)alkyl]-1,3- indandiones and related compounds and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents, the compounds are especially useful for treating psychoses by administering to a mammal a...
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5589494 |
2-[(3-heteroaryl-1-pyrrolidinyl)alkyl]-1,3-dioxanes and related compounds and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a...
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5587367 |
Pharmaceutical or cosmetic composition containing a combination of a retinoid and a sterol
A pharmaceutical or cosmetic composition is disclosed comprising in combination a retinoid and a sterol capable of inhibiting the biosynthesis of cholesterol resulting in a synergistic effect in...
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5580879 |
N-[(4-heteroaryl-1-pyrrolidinyl)alkyl]-1H-benz[DE]isoquinoline-1;3(2H)-di ones and related compounds and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a...
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5578624 |
Heteroarylpyrrolidines and their use as antipsychotics and analgesics
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a...
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5574039 |
Antiproliferative compounds having nitrogen-containing tricyclic ring systems and phenyl substituents
The invention relates to TS-inhibiting compounds of the formula ##STR1## where W is an alkylene group; D is a structure having two rings that are unsubstituted or substituted, where (i) one ring is...
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5571828 |
N-[(3-heteroaryl-1-pyrrolidinyl)alkyl]-2,3-napthalimides and related compounds and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a...
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5569666 |
Anti-neoplastic, anti-viral and ribonucleotide reductase activity affecting pharmaceutical conpositions and methods of treatment
A method for treating a human or non-human animal afflicted with malignant cells sensitive to parabactin or vibriobactin or a pharmaceutically acceptable salt or complex thereof comprising...
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5561137 |
Thio-heterocyclic macrolactam immunomodulators
Immunomodulatory macrocyclic compounds having the formula: ##STR1## and pharmaceutically acceptable salts, esters, amides and prodrugs thereof, where R 8 and R 9 are selected such that one of...
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5561151 |
Antipyretic and analgesic methods of using optically pure R-etodolac
Methods are disclosed utilizing optically pure R(-) etodolac for the treatment of pain, including but not limited to pain associated with toothaches, headaches, sprains, joint pain and surgical...
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5545656 |
2-Oxidole-1-carboxamide pharmaceutical agents for the treatment of alzheimer's disease
This invention relates to the use of certain 3-substituted 2-oxindole-1-carboxamides and their pharmaceutically acceptable base salts for the treatment or prevention of Alzheimer's disease in...
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5543407 |
Preparation and application of scopolamine and chlorpromazine as a drug-withdrawal agent
An empirical efficacy appears in the drug-withdrawal treatment of drug dependence with a novel drug-withdrawal scopolamine agent(DSA) which contains scopolamine hydrobromide as a subsidiary...
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5543433 |
Azine-substituted phenylacetic acid derivatives and fungicides containing these
Compounds of the formula I ##STR1## where X is hydrogen, halogen, alkyl, alkoxy, trifluoromethyl, cyano or nitro, Y is an amino, methylamino or dimethylamino group, Z is a group CHCH 3 ,...
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