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6323234 |
Methods to treat gastrointestinal lesions and to reduce drug-induced gastrointestinal or renal toxicity
Nonsteroidal antiinflammatory drugs which have been substituted with a nitrogen monoxide group; composition comprising (i) a nonsteroidal antiinflammatory drug, which can optionally be substituted...
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6323216 |
Basic derivatives of benz[E]isoindol-1-ones and pyrrolo[3,4-c]quinolin-1-ones with 5-HT3-antagonistic activity, their preparation and their therapeutic use
Novel basic derivatives of benz[e]isoindol-1-ones and pyrrolo[3,4-c]quinolin-1-ones which can be represented by the general formula (I) indicated below are described: ##STR1## in which X is CH...
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6291506 |
Method of reducing retinal ganglion cell degeneration
Disclosed is a method of reducing intraocular pressure or retinal ganglion cell death caused by specific reactive oxygen species by delivering carvedilol or a derivative or metabolite thereof...
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6284800 |
Methods and compositions for treatment of asthma
The present invention comprises methods and compositions for the treatment of bronchorestrictive disorders, including asthma, in humans or animals. The methods and compositions are effective in...
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6271264 |
Polymers containing spirobicyclic ammonium moieties as bile acid sequestrants
The present invention relates to a method for sequestering bile acids in a patient and to particular polymers for use in the method. The method comprises administering a therapeutically effective...
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6271251 |
Substituted guanidine derivatives, process for production thereof, and pharmaceutical uses thereof
A substituted guanidine derivative represented by the general formula: ##STR1## or a pharmaceutically acceptable acid addition salt thereof, is useful as a therapeutic or prophylactic agent for...
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6265431 |
Cycloalkano-indole and -azaindole derivatives
Cycloalkano-indole and -azaindole derivatives are prepared by reaction of appropriately substituted carboxylic acids with amines. The cycloalkano-indole and -azaindole derivatives are suitable as...
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6264974 |
Buccal and sublingual administration of physostigmine
Physostigmine, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo[2,3-b] indol-5ol methylcarbamate, administered buccally or sublingually in non-sustained release dosage form provides extremely...
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6239128 |
Indole-2,3-dione-3-oxime derivatives for therapeutic use
The present invention relates to the use of indole-2,3-dione-3-oxime derivatives in a method of combating diseases and disorders associated with or mediated by the release of excitatory amino acids.
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6225306 |
Biphenyl derivatives and drug composition
A biphenyl derivative represented by the following general formula (1) and a pharmaceutically acceptable salt thereof: ##STR1## [In the formula (1), A represents a single bond, --CH 2 --, --CO--,...
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6221884 |
Carboxamides useful as 5-HT1F agonists
The present invention provides novel 2-amino-1,2,3,4-tetrahydro-9H-carbazole-6-carboxamides and 3-amino-10H-cyclohepta[7,6-b]indole-7-carboxamides of Formula I: ##STR1## where R 1 , R 2 , R 3 and...
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6214831 |
Pharmaceutical composition containing evodiamine compound and method for improving lipid metabolism or antiobesity
The present invention relates to a food and a feed having lipid metabolism improving activity or anti-obesity activity, and a lipid metabolism improving agent or an anti-obesity agent for humans or...
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6214854 |
Method for inhibiting stress-activated protein kinases
This invention relates to a method for inhibiting stress-activated protein kinases (SAPKs) which comprises administering to a mammal in need thereof an effective amount of a compound which is a...
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6204245 |
Treatment of narcolepsy with immunosuppressants
The invention provides compositions and methods for treatment of narcolepsy or isolated cataplexy. Such methods entail administering a therapeutically effective regime of at least one...
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6201005 |
Method for inhibiting lymphokine production
This invention relates to tricyclo compounds useful for treatment and prevention of resistance by transplantation, graft-versus-host diseases by medulla ossium transplantation autoimmune diseases,...
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6201004 |
Dioxino derivatives and their use as therapeutic agents
Compounds of formula I ##STR1## and pharmaceutically acceptable salts thereof in which A is methylene or --O--; B is methylene or --O--; G 1 --G 2 --G 3 form a heteroaromatic or heteroaliphatic...
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6194439 |
Tricyclic polyhydroxylic tyrosine kinase inhibitors
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6174878 |
Topical use of kappa opioid agonists to treat otic pain
Compositions and methods for treating otic pain are disclosed. In particular, the invention discloses compositions and methods of using kappa opioid agonists locally for the prevention or...
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6172099 |
Tricyclic compounds having saturated rings and medicinal compositions containing the same
Compounds represented by general formula (I) or their salts, having β 3 -adrenoceptor agonism and being efficacious when employed in drugs for treating and preventing diabetes, obesity,...
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6166008 |
Treatment of schizophrenia with ampakines and neuroleptics
This invention relates to treatment of schizophrenia and related psychotic disorders, including enhancement of receptor functioning in synapses in brain networks responsible for higher order...
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6153640 |
Benzo[3,4]cyclobuta[1,2-c]pyrrole compounds
A compound of formula (I): ##STR1## wherein: R 1 , R 2 and R 3 , which may be the same or different, represent a group as defined in the description, R 4 represents hydrogen, alky, alkenyl,...
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6140352 |
Carbazolyl-substituted ethanolamines as selective β-.sub.3 agonists
Disclosed herein are selective beta 3 adrenergic agonists represented by the following structural formula: ##STR1## The variables in the structural formula shown above are defined in the...
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6130237 |
Condensed N-aclyindoles as antitumor agents
The invention provides compounds of general formula (I), wherein: X is halogen or OSO 2 R, where R represents H or is unsubstituted or hydroxy-or amino-substituted lower alkyl; Y is a nitro or...
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6121271 |
Naphtho[2,3-B]heteroar-4-yl derivatives
This invention provides compounds of Formula I having the structure wherein R 1 , R 2 , R 3 , R 4 , R 5 , W, R 9 , X, R 6 , p, Y, Z, R 7 , and R 8 are as defined in the specification, or a...
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6121257 |
Sulfamate containing macrocyclic immunomodulators
The present invention relates to novel compounds of formula I: ##STR1## which are useful as immunomodulators, in particular, macrolide immunosuppressants. The invention also relates to the...
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6114347 |
Pharmaceutical formulation for the prophylaxis and pretreatment of a poisoning caused by organophosphorus cholinesterase inhibitors
A pharmaceutical formulation for the prophylaxis and preliminary treatment of a poisoning caused by organophosphorus cholinesterase inhibitors is characterized in that it consists of an active...
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6110955 |
Metabolically stabilized oxyalkylene esters and uses thereof
This invention relates to compositions for and methods of treating, preventing or ameliorating cancer and other proliferative diseases as well as methods of inducing wound healing, treating...
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6107328 |
Use of 5HT.sub.1B receptor antagonist for the treatment of vascular disease
The present application is directed to the use of 5HT 1B or 5HT 1D receptor antagonists in the treatment of vascular diseases, in particular angina, Raynaud's syndrome, peripheral vascular...
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6107327 |
Therapeutic treatment for HIV infection
A method for treating HIV infection is disclosed, particularly using the isozyme selective PKC inhibitor, (S)-3,4-[N, N'-1,1'-((2"-ethoxy)-3'"(O)-4'"-(N,N-dimethylamino)-butane)-
bis-(3,3'-indo...
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6096777 |
Method for inhibiting the expression of Fas
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6083971 |
Certain oxopyrolo-pyrrole derivatives having thrombin inhibiting activity
Compounds of the formula ##STR1## wherein R 1 is lower-alkyl, cycloalkyl or phenyl, R 2 is H, OH or C(O)O-A, wherein A is lower-alkyl, cycloalkyl or phenyl, and R 3 , R 4 and R 5 are...
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6080752 |
Tricyclic amine derivatives
A compound of formula (I): ##STR1## wherein R 1 represents a group of formula (A) or (B): ##STR2## R 2 , R 3 , Ar, Y Ar 1 are as defined herein; or a pharmaceutically acceptable salt thereof,...
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6077840 |
Tetrahydrobenzindolone derivatives
Compounds represented by the following formula (I) or pharmaceutically acceptable salts thereof and a process for producing the same are disclosed. The compounds have progesterone receptor binding...
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6071945 |
8H-thieno-[2,3-b]pyrrolizin-8-one compounds
A compound selected from those of formula (I): ##STR1## wherein: R 1 represents hydrogen, halogen, alkyl, nitro, hydroxy, alkoxy, trihaloalkyl, trihaloalkoxy or optionally substituted amino, R...
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6071946 |
Tricyclic urea compounds
A compound selected from those of formula (I): ##STR1## in which A, Y, R 1 , R 2 and R 3 are as defined in the Specification, and pharmaceutical compositions containing the same, which are useful...
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6051583 |
2,3,3a,4,9,9a-hexahydro-8-hydroxy-1H-benz[f]indoles, processes for preparing them and their use as pharmaceutical compositions
The present invention relates to new substituted 2,3,3a,4,9,9a-hexahydro-8-hydroxy-1H-benz[f]indole derivatives, processes for preparing them and their use as pharmaceutical compositions. The...
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6048877 |
Tetralone derivatives as antiarrhythmic agents
Tetralone derivatives of the formula ##STR1## where R 1 is halo, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, (aryl)alkenyl, (aryl)alkynyl, alkoxy, O-alkenyl, O-aryl, O-alkyl(heterocyclo),...
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6040331 |
Nerve cell protective agents
The invention provides novel benzindole derivatives, processes for producing them, as well as a neuroprotective agent, an agent to prevent or treat diseases involving the degeneration, retraction...
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6037371 |
Insecticidal/acaricidal composition
An insecticidal/acaricidal composition which comprises 2-methoxycarbonyl-4-chlorotrifluoromethanesulfonanilide and N-(2-ethylhexyl)bicyclo[2.2.1]hept-5-ene-2,3-dicarboximide as an active...
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6037361 |
Fluorinated butyric acids and their derivatives as inhibitors of matrix metalloproteinases
Fluorinated butyric acid compounds and derivatives are described as well as acid methods for the preparation and pharmaceutical compositions of same, which are useful as inhibitors of matrix...
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6034117 |
Methods of treating and diagnosing sleep disordered breathing and means for carrying out the method
This invention relates to a method for treating snoring, sleep apnea and other form of sleep-disordered breathing, which comprises administration of a therapeutically effective dose of an acetyl...
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6030984 |
Pyridone compounds useful in treating Alzheimer's disease
The invention is concerned with the use of bi- and tricyclic pyridone compounds of the formula where A, R 1 , R 3 , R 4 , and R 7 are described herein and of their pharmaceutically acceptable...
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6030967 |
Naphtholactams and lactones as bone morphogenetic protein active agents
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6028097 |
Method of immunosuppression
This invention relates to tricyclo compounds useful for treatment and prevention of resistance by transplantation, graft-versus-host diseases by medulla ossium transplantation, autoimmune diseases,...
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6020358 |
Substituted phenethylsulfones and method of reducing TNFα levels
Phenethylsulfones substituted in the position α to the phenyl group with a 1-oxoisoindoline or 1,3-dioxoisoindoline group reduce the levels of TNFα in a mammal. Typical embodiments are...
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5998460 |
Phenylcarbamates of (-)-eseroline, (-)-N1-noreseroline and (-)-N1-benzylnoreseroline: selective inhibitors of acetyl and butyrylcholinesterase, pharmaceutical compositions and method of use thereof
The present invention relates to eseroline, N 1 -noreseroline, and N 1 -benzylnoreseroline phenyl carbamate analogues which provide highly potent and selective cholinergic agonist and blocking...
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5998461 |
Tricyclic amide compounds
This invention relates to benzofuran/pyran derivatives of a new tricyclic amide compound, their composition and method of use for treating disorders of the melatoninergic system.
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5998421 |
Lipid metabolism ameliorants
The present invention relates to a food and a feed having lipid metabolism improving activity or anti-obesity activity, and a lipid metabolism improving agent or an anti-obesity agent for humans or...
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RE36419 |
Use of ketorolac for treatment of squamous cell carcinomas of the oral cavity or oropharynx
The present invention provides novel methods for prevention or treatment of primary and recurring squamous cell carcinoma of the oral cavity or oropharynx comprising topical administration, to the...
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5990104 |
Polycyclic alcaloid-derivatives as NMDA-receptor antagonists
Polycyclic alkaloids of formula (I), wherein R 1 is H, C 1 -6 alkyl, or C 6 -12 aryl optionally substituted with polar groups; R 2 and R 3 are independently H, OH, C 1 -6 alkyl, --C(NH)--NH 2 ,...
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