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7582770 |
Viral polymerase inhibitors
An enantiomer, diastereoisomer or tautomer of a compound, represented by formula I:
wherein A, B, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , and R 10 are as defined herein, or a...
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7579338 |
Methods and compositions for treating atheroma, tumors and other neoplastic tissues
The radiation sensitization potential of a candidate compound can be screened by determine its ability to generate one or more reactive oxygen species under appropriate conditions. Compounds...
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7547689 |
Methods and compositions for treating atheroma, tumors and other neoplastic tissues
Compositions comprising motexafin gadolinium, as well as methods for using these compositions in the treatment of brain metastases, are described herein.
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7534807 |
De novo synthesis of bacteriochlorins
A method of making a bacteriochlorin is carried out by condensing a pair of compounds of Formula II
to produce the bacteriochlorin, wherein R is an acetal or aldehyde group. The condensing may...
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7491831 |
PPAR active compounds
Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile.
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7488817 |
Metal complex protein kinase inhibitors
This inventive subject matter relates to novel metal complex protein kinases inhibitors, methods for making such compounds, and methods for using such compounds for treating diseases and disorders...
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7485320 |
Liposome for incorporating large amounts of hydrophobic substances
A liposome formulation for stably incorporating high content of hydrophobic substance is disclosed. The liposome includes two phospholipids with different phase transition temperatures such as...
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7482472 |
Substituted isoindoles and their use
The invention relates to coagulation of the blood. Disclosed are novel compounds of formula (I),
a method for the production of these compounds, pharmaceutical compositions containing them, and...
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7449454 |
Metallotexaphyrin derivatives
Novel derivatives of metallotexaphyrins are prepared by modifying the apical ligands associated with the central metal component of a metallotexaphyrin.
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RE40558 |
Therapeutic uses of di-aryl acid derivatives
The use of diaryl acid derivatives of formula (I)
or pharmaceutically acceptable salts, N-oxides, hydrates or solvates thereof, wherein the variables shown are defined in the disclosure, and...
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7423056 |
Tricyclic heteroaryl piperazines, pyrrolidines and azetidines as serotonin receptor modulators
The present invention generally relates to a series of compounds, to pharmaceutical compositions containing the compounds, and to use of the compounds and compositions as therapeutic agents. More...
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7414069 |
Antituberculosis compounds, Hirsutellones A, B, and C
Three new alkaloids, Hirsutellones A, B, and C, are produced in cultures of fungus such as Hirsutella nivea strain BCC 2594 and Trichoderma sp. strain BCC 7579. The Hirsutellones exhibited...
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7410978 |
Once daily dosage forms of trospium
A pharmaceutical composition of a pharmaceutically acceptable trospium salt, with upon administration to a human patient generates an average steady state blood levels of trospium with a minimum (C...
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7390821 |
Methods of reducing angiogenesis
The present invention provides methods of reducing angiogenesis in an individual. The methods generally involve administering to the individual an effective amount of a nicotinic acetyl choline...
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7388024 |
Indeno[2,1A]indenes and isoindolo[2,1-A]indoles
The present invention provides indeno[2,1a]indene and isoindolo[2,1-a]indole derivatives of the Formula I, its salts and its stereoisomers, wherein X, R 1 , R 2 , R 3 , R 4 , R 6 , R 7 , R 8 , R 9...
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7371742 |
Porphyrin derivatives for photodynamic therapy
This invention relates to porphyrin compounds used to destroy or impair the functioning of a target biological material in photodynamic therapy, in particular against virus, tumoral cells,...
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7354947 |
Isothiazoloanthrones, isoxazoloanthrones, isoindolanthrones and derivatives thereof a JNK inhibitors and compositions and methods related thereto
Isaothiazoloanthrones, isooxazoloanthrones, isoindolanthrones, and derivatives thereof having the general formula:
and pharmaceutically acceptable salts thereof, wherein R 0 is —CH 2...
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7348361 |
Solution for diagnosing or treating tissue pathologies
The invention concerns a 5-aminolevulinic acid ester (E-ALA) solution for producing a pharmaceutical preparation useful for diagnosing and/or treating tissue and/or cell pathologies by local...
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7348352 |
Diindolylmethane for the treatment of HPV infection
New methods and compositions are disclosed that comprise the phytochemical Diindolylmethane, alone or in combination with immune potentiating steroids. These methods and compositions are utilized...
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7345034 |
Azacyclosteroid histamine-3 receptor ligands
Azacyclosteroid histamine-3 receptor ligands, pharmaceutical compositions comprising such compounds, and methods for using such compounds and compositions are described herein.
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7338973 |
Tetracyclic heteroatom containing derivatives useful as sex steroid hormone receptor modulators
The present invention is directed to novel tetracyclic heteroatom containing derivatives, pharmaceutical compositions containing them, their use in the treatment of disorders mediated by one or...
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7317035 |
Tetracyclic arylcarbonyl indoles having serotonin receptor affinity useful as therapeutic agents, process for their preparation and pharmaceutical compositions containing them
The present invention relates to novel tetracyclic arylcarbonyl indoles, their derivatives, their analogues, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically...
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7312203 |
1-aza-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof
The present invention relates to 1-aza-dibenzoazulene derivatives, to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to...
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7307080 |
Compounds, methods and pharmaceutical compositions for treating cellular damage, such as neural or cardiovascular tissue damage
The disclosure relates to compounds, pharmaceutical compositions and methods for inhibiting PARP by use of the disclosed compositions. The compounds of the disclosure have the following structures...
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7297711 |
Arylalkyl indoles having serotonin receptor affinity useful as therapeutic agents, process for their preparation and pharmaceutical compositions containing them
The present invention relates to novel tetracyclic arylalkyl indoles, their derivatives, their analogues, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically...
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7294646 |
Maxi-k channel blockers, methods of use and process for making the same
This invention relates to the use of potent potassium channel blockers or a formulation thereof in the treatment of glaucoma and other conditions related to elevated intraocular pressure in the eye...
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7276494 |
Photosensitisers
A compound for use as a photosensitiser in PDT, in photochemical internalisation in the production of a cancer vaccine or in the diagnosis or detection of medical conditions, the compound having a...
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7268155 |
Photosensitizer conjugates for pathogen targeting
Conjugate molecules which include photosensitizer compositions conjugated to non-antibody non-affinity pair targeting moieties and methods of making and using such conjugates are described.
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7267990 |
Chelation of charged and uncharged molecules with porphyrin-based compounds
Porphyrins containing one or more neutral or negatively-charged, closo- or nido-carborane substituents are useful as chelators. The carbon-carbon bonds linking the boron-containing groups to the...
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7265100 |
Separation of regioisomers of metal phthalocyanines
The present invention refers to a process for the separation of regioisomeric mixtures of metal phthalocyanines of formula (I), to the regioisomers obtained by this process, and their use as...
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7262215 |
N-carbacycle monosubstituted indolocarbazoles as protein kinase inhibitors
This invention relates to N-carbacycle monosubstituted indolocarbazole compounds. Furthermore, this invention relates to medicaments comprising N-carbacycle monosubstituted indolocarbazoles...
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7241796 |
Inhibitors of serine proteases, particularly HCV NS3-NS4A protease
The present invention relates to peptidomimetic compounds that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3–NS4A protease. As such, they act by interfering...
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7232842 |
Kinase inhibitors and associated pharmaceutical compositions and methods of use
The invention provides novel compounds useful as kinase inhibitors or as starting materials And/or intermediates in the synthesis of compounds useful as kinase inhibitors. The compounds have The...
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7230026 |
Selected fused pyrrolocarbazoles
The present invention relates generally to selected fused pyrrolocarbazoles, including pharmaceutical compositions thereof and methods of treating diseases therewith. The present invention is also...
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7214703 |
Pyrrolidinohydrochinazolines
Disclosed are compounds of formula (I):
or stereoisomers or pharmaceutically acceptable salts thereof, wherein the groups Ar 1 , Ar 2 , A, R 1 , R 2 , R 3 , E 1 , E 2 , X and n are as defined...
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7214701 |
Active substance combinations having insecticidal and acaricdal properties
The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising
(a) compounds of the formula (I)
in which W, X, Y, Z, A, B, D and G...
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7202255 |
Substituted [1,4] benzodioxino[2,3-e] isoindole derivatives, method for preparing and pharmaceutical compositions containing same
Compounds of formula (I):
wherein:
A is as defined in the description, Y represents a group selected from an oxygen atom and a methylene group, R 2 represents a hydrogen atom and in...
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7192650 |
Element having porphyrin polymer fixed on a substrate and method of preparing the same
A photo-functional molecule element having, on a substrate, a porphyrin polymer containing covalently-fixed porphyrin units, and the method of preparing the same. The photo-functional molecule...
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7189707 |
Substituted porphyrins
The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby...
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7169802 |
Fused pyrrolocarbazoles
The present invention relates generally to selected fused pyrrolocarbazoles, including pharmaceutical compositions thereof and methods of treating diseases therewith. The present invention is also...
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7163956 |
Substituted fullerene compositions and their use as antioxidants
This patent discloses a substituted fullerenes, compositions comprising the same, and their use as antioxidants. The substituted fullerenes comprise a fullerene core (Cn) and at least one of: (i)...
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7160873 |
Texaphyrin coordination compounds and uses thereof
Novel coordination polymers, their pharmaceutical formulations, useful for treating atheroma, tumors and other neoplastic tissue, as well as other conditions that are responsive to the induction of...
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7153848 |
Inhibitors of HCV replication
Indole compounds of Formula I are described. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV. Different forms and compositions...
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7151108 |
[3,4-a:3,4-c]carbazole compounds
A compound selected from those of formula (I):
wherein:
W 1 represents, together with carbon to which it is bonded, phenyl, pyridyl, Z represents a group of formula U—V as defined in...
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7147840 |
Oxo-bacteriopyropheophorbide-a carboxylic acid and esters thereof
A compound having the structural formula:
where R is H or lower alkyl of 1 through 12 carbon atoms. In general, the compounds of the invention are 13 2 -Oxo-bacteriopyropheophorbide—a...
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7144912 |
Pyrrole-type compounds, compositions, and methods for treating cancer, treating viral diseases and causing immunosuppression
The present invention relates to novel Pyrrole-Type compounds, compositions comprising Pyrrole-Type compounds, and methods useful for treating or preventing cancer or a neoplastic disorder...
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7144879 |
Substituted metal-phthalocyanines, their preparation and the use thereof
The present invention is directed to metal-phthalocyanines of general formula (I) to the corresponding conjugates, the processes for their preparation and use in the photodynamic therapy of...
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7138391 |
Hydrophilizable and hydrophilic cyanine dyes
The present invention provides an IR-absorbing dye of formula (I) or (II):
wherein
Q 1 , Q 2 , Q 3 and Q 4 are the same or different and are independently selected from a C 3-20 ...
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7135193 |
Liposome compositions of porphyrin photosensitizers
Liposomal pharmaceutical formulations incorporating porphyrin photosensitizers useful for photodynamic therapy or diagnosis of malignant cells. The liposomal formulations comprise a porphyrin...
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7125862 |
Porphyrin-metal complexes and oxygen infusions containing the same
A porphyrin metal complex that can form a stable oxygen complex and acts effectively as an oxygen infusion, which comprises:
a transition metal ion M of period 4 or 5 coordinating to a porphyrin...
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