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8133883 Compositions containing piperacillin and tazobactam useful for injection  
An aminocarboxylic acid chelating agent, preferably EDTA, or a salt thereof has been found to be useful for inhibiting particulate formation in piperacillin/tazobactam parenteral combinations. The...
8071535 Guanidinium derivatives for improved cellular transport  
Reagents and methods useful for the synthesis of conjugates comprising guanidinylated cyclic acetals are provided. Also provided are methods for increasing the cellular uptake of various...
7943118 Aerosolized fosfomycin/aminoglycoside combination for the treatment of bacterial respiratory infections  
A fosfomycin plus tobramycin combination formulation for delivery by aerosolization is described. The concentrated fosfomycin tobramycin combination formulation containing an efficacious amount of...
7915229 Compositions containing piperacillin and tazobactam useful for injection  
An aminocarboxylic acid chelating agent, preferably EDTA, or a salt thereof has been found to be useful for inhibiting particulate formation in piperacillin/tazobactam parenteral combinations. The...
7749971 Aminoglycoside treatment for lysosomal storage diseases  
The present invention provides a method of treating lysosomal storage diseases such as Hurler syndrome and Batten disease in individuals in need of such treatment, comprising the step of...
7612045 Compounds, compositions and methods for controlling biofilms and bacterial infections  
The present invention provides compounds and compositions useful for controlling bacterial biofilms as well as for controlling and/or preventing bacterial infections. The compounds of the invention...
7498312 Compositions containing piperacillin and tazobactam useful for injection  
An aminocarboxylic acid chelating agent, preferably EDTA, or a salt thereof has been found to be useful for inhibiting particulate formation in piperacillin/tazobactam parenteral combinations. The...
7368102 Pulmonary delivery of aminoglycosides  
The present invention is directed to the administration of aminoglycosides. In particular, the present invention is directed to compositions and methods for the pulmonary administration of...
7244712 Aminoglycoside antibiotics and methods of using same  
The present invention relates to aminoglycoside compounds having antibiotic activity. Moreover, the present invention relates to L-aminoglycoside compounds and diastereomers thereof which posses...
7094431 Method of healing skin wounds in mammals and a composition therefor  
This invention pertains to therapeutic antibacterial/antifungal-wound healing compositions comprising a therapeutically effective amount of antibacterial agents and/or antifungal agents and/or...
6974798 Treatment of balance impairments  
Compositions and methods are provided for prophylactic or therapeutic treatment of balance impairments involving neuronal damage, loss, or degeneration, preferably of vestibular ganglion neurons,...
6900184 Compositions containing pipercillin and tazobactam useful for injection  
The invention pertains to pharmaceutical compositions of Zosyn® piperacillin with tazobactam in the presence of a buffer, preferably citrate, a particulate formation inhibitor, preferably EDTA ...
6706290 Methods for eradication of nanobacteria  
Nanobacteria contribute to pathological calcification in the human and animal body, including diseases such as kidney stones, salivary gland stones, dental pulp stones and atherosclerosis. The...
6620782 Substituted 2-aminobenzamide caspase inhibitors and the use thereof  
The present invention is directed to novel 2-aminobenzamide thereof, represented by the general Formula I: where R1-R3, X, and A—D are defined herein. The present invention also relates to the d...
6620794 Guerbet functionalized phospholipids  
The present invention relates to novel compositions and, more particularly, to a class of compounds having specific quaternized amine based upon a guerbet amido amine linked to specific phosphate...
6475993 Treatment of hereditary diseases with gentamicin  
This invention relates to a method of treating an inherited disease due to a point mutation producing a stop codon by administering an effective dose of an aminoglycoside antibiotic or a derivative...
6387886 Method for the treatment of severe chronic bronchitis (bronchietasis) with an aerosolized antibiotic  
The present invention is directed to a method for the treatment of severe chronic bronchitis, i.e., bronchiectasis, using a concentrated aminoglycoside antibiotic formulation delivering the...
6290962 Urease-based vaccine and treatment for helicobacter infection  
Method of eliciting in a mammalian host a protective immune response to Helicobacter infection and treatment of Helicobacter infection by administering to the host an immunogenically effective...
6262073 Pharmaceutical methods of use of 5-substituted and 5,5 disubstituted-3,4-dihydroxy-2(5H)-furanones  
The present invention relates to synthetic methods for the production of both optically active and racemic 5,5-disubstituted-3,4-dihydroxy-2(5H)-furanones;...
6255288 Certain methanebisphosphonic acid derivatives in fracture healing  
The invention relates to the use of methanebisphosphonic acid derivatives of formula I ##STR1##for the treatment of fractures. These compounds have surprisingly been found to promote a more rapid...
6123966 Stabilized two-part disinfecting system and compositions and methods related thereto  
A stabilized two-part disinfecting system comprising a first part and a second part adapted to be mixed to yield an aqueous disinfecting composition. The first part contains a non-esterifying acid...
5972336 Urease-based vaccine against helicobacter infection  
Method of eliciting in a mammalian host a protective immune response to Helicobacter infection by administering to the host an immunogenically effective amount of a Helicobacter urease or urease...
5929039 Method for treating cardiac dysfunction and pharmaceutical compositions useful therefor  
The present invention relates generally to a method for, and pharmaceutical compositions useful in, the prophylaxis and/or treatment of cardiac dysfunction in a mammal by the administration of an...
5900406 Use of antibiotics of the type 2-deoxystreptamine substituted with aminosugars to inhibit growth of microorganisms containing group I introns  
The invention described herein provides for methods of screening for compounds that can be used to prevent or inhibit the growth of microbial eukaryotes, particularly plant or animal pathogens. The...
5827543 Methods and compositions for the prevention and treatment of urogenital disorders  
The subject invention encompasses methods for prevention and treatment of a human or lower animal subject having a urogenital disorder caused or mediated by one or more parasitic protozoa...
5595977 Salts of amino glycosides  
The present invention relates to novel amino glycoside salts of sucrose-octa-O-sulfonic acid of formula I: ([sucrose-octa-O-sulfonic acid8- ]-[R-(NH3+)x ]y -Mzn+) (I) (xy)+(zn)=8 xy...
5534408 2-deoxystreptamine aminoglycoside inhibition of HIV RRE/Rev binding  
Disclosed is a method for the inhibition of binding of a ligand to an RNA, the inhibition being mediated by a small organic molecule which binds to the RNA, thereby inhibiting ligand binding. A...
5527781 4-O-(aminoglycosyl)- or 4,6-di-O-(aminoglycosyl)-2,5-dideoxy-5,5-difluorostreptamine derivatives  
As new compounds are now synthetized 5-deoxy-5,5-difluoro derivatives of aminoglycosidic antibiotics of neamine, kanamycin A-series, kanamycin B-series, gentamicin-series and seldomycin-series....
5312813 Biofilm reduction method  
A method of killing microorganisms which form a biofilm on a tissue or implant surfaces in a patient, and which are refractory to a biocide at a dose which is effective to kill the microorganism in...
5256684 Methods and compositions for the treatment of gastrointestinal disorders  
Methods, for the treatment of humans and lower animal subjects having a gastrointestinal disorder, comprising administering bismuth and administering an antimicrobial. From about 50 to about 5000...
5169637 Stable plurilamellar vesicles  
A new and substantially improved type of lipid vesicle, called stable plurilamellar vesicles (SPLVs), are described, as well as the process for making the same and X-ray diffraction methods for...
4959358 Drug administration  
Compositions and methods useful for the prevention or treatment of a human or animal disorder or for the regulation of the human or animal physiological condition are provided. The compositions...
4888327 Topical antibiotic compositions  
Disclosed are antibiotic compositions for topical administration comprising an aminoglycoside, a benzylpyrimidine and a sulfonamide.
4886781 Substituted 2,3-diphenyl-1,2-dihydroquinoxalines and antibiotics for growths promoting  
Novel substituted 2,3-diphenyl-1,2-dihydroquinoxalines are useful for promoting growth and improving feed conversion efficiencies in meat-producing animals. In addition, the novel compounds are...
4877775 Polymeric aminosaccharides as antihypercholesterolemic agents  
Crosslinked copolymers of monomeric aminosaccharides such as aminoglycosidic antibiotics, e.g. neomycin, or of polymeric aminosaccharides, e.g., chitosan, with dialdehydes are useful...
4873225 1-n-(4-amino-3-fluoro-2-hydroxybutyryl)-kanamycins  
As new compound are now provided ten compounds, namely 1-N-{(2R,3R)-4-amino-3-fluoro-2-hydroxybutyryl}kanamycin A; 1-N-{(2R,3R)-4-amino-3-fluoro-2-hydroxybutyryl}-2',3'-dideox ykanamycin A;...
4855287 Aminoglycoside compounds, processes for production thereof, and pharamaceutical composition containing the same  
An aminoglycoside compound represented by the following formula (I) ##STR1## wherein one of R1 and R2 represents a hydrogen atom, and the other represents a methyl group, R3 represents a hydrogen...
4845082 3'4'-dideoxy-3'-fluorokanamycin B and production thereof  
New compound, 3',4'-dideoxy-3'-fluorokanamycin B is now provided, which is useful as antibacterial agent.3',4'-Dideoxy-3'-fluorokanamycin B is prepared by a process comprising halogenating an...
4749694 Novel lysine esters used as absorption  
Novel lysine esters used as absorption enhancing agents for gastrointestinally and rectally administered drugs. Also provided are processes for preparation of said lysine ester compounds as well as...
4661474 2',3'-dideoxy-2'-fluorokanamycin A and 1-N-(α-hydroxy-ω-aminoalkanoyl) derivatives thereof  
New compounds, 2',3'-dideoxy-2'-fluorokanamycin A and 1-N-(α-hydroxy-ω-aminoalkanoyl) derivatives thereof, particularly 1-N-(DL- or L-3-amino-2-hydroxypropionyl)- and 1...
4656160 Aminoglycoside derivatives  
Aminoglycoside derivatives and pharmaceutically acceptable salts thereof which are useful as prophylactic and therapeutic agents for infectious diseases caused by pathogenic microorganisms, and a...
4654209 Preparation for percutaneous administration  
A preparation for percutaneous administration of nitroglycerine, said preparation comprising nitroglycerine incorporated in a cream base in an amount not less than about 0.05% by weight based on...
4650790 Drug combinations having synergistic effect  
The invention relates to a synergistic antibiotic composition useful for the treatment of respiratory, gastrointestinal or urinary infections and septicaemia of domestic animals. The composition...
4645760 Activated aminoglycosides and aminoglycoside-aminocyclitols pharmaceutical compositions and method of use  
Aminoglycosides and aminoglycoside-aminocyclitols which have been oxygen-radical activated show a broad spectrum of antibacterial activity. The activated compounds are able to penetrate the cell...
4634688 3'-fluoro-3'-deoxykanamycin A  
A new compound, 3'-fluoro-3'-deoxykanamycin A is now provided, which is active against gram-negative and gram-positive bacteria, including kanamycin-resistant strains of bacteria and is useful as...
4617293 Flavonoid phosphate salts of aminoglycoside antibiotics  
Flavonoid phosphates of aminoglycoside antibiotics are useful sparingly soluble salts, e.g., for achieving a depot effect.
4547492 1-N-(ω-Amino-α-hydroxyalkanoyl-2',3'-dideoxykanamycin A and pharmaceutical composition containing same  
1-N-(L-3-amino-2-hydroxypropionyl)-2',-3'-dideoxykanamycin A and 1-N-(L-4-amino-2-hydroxybutyryl)-2',3'-dideoxykanamycin A are now provided which each is a new compound useful as antibacterial...
4486419 5,2',3',4',4",6"-Hexadeoxykanamycin and its 1-N-acylated derivative  
5,2',3',4',4",6"-Hexadeoxykanamycin and 1-N-[(S)-4-amino-2-hydroxybutyryl]-5,2',3',4',4",6"-hexadeox ykanamycin are now provided, which are each a new compound useful as antibacterial agent. The...
4421741 Pharmaceutical compositions  
An anti-inflammatory pharmaceutical composition is described which is adapted for topical application to the eye and contains as active principle a compound of formula ##STR1## or a...
4410516 1-N(αHydroxy-ω-aminoalkanoyl) derivatives of 5,3',4'-trideoxy- or 5,3', 4'-trideoxy-6'-N- methyl- or 5, 3', 4',6"-tetradeoxykannamyci B and production thereof  
New antibacterial compounds are provided, including a 1-N-(α-hydroxy-ω-aminoalkanoyl)-5,3',4'-trideoxykanamycin B; a 1-N(α-hydroxy-ω-aminoalkanoyl)-5,3',4',641 -tetradeoxykanamycin B; and a 1-N...
Matches 1 - 50 out of 85 1 2 >