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7608635 Pyrazole compounds that modulate HSP90 activity  
Compounds of formula (I), pharmaceutical compositions comprising compounds of formula (I) and methods of inhibiting Hsp90 in a cell, treating or preventing a proliferation disorder in a mammal and...
7582121 Composition for dyeing keratin fibers, comprising at least one diamino-N,N-dihydropyrazolone derivative, at least one coupler, and at least one heterocyclic direct dye  
Disclose herein is a composition for dyeing keratin fibers, for example, human keratin fibers such as the hair, comprising at least one oxidation base chosen from diamino-N,N-dihydropyrazolones and...
7541378 Condensed heterocyclic pyrazole derivatives as kinase inhibitors  
Bicyclo-pyrazole compound of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, processes for their preparation, combinatorial libraries comprising a...
7538135 Benzenesulfonylamino compounds and pharmaceutical compositions containing these compounds  
Compounds of the formula provide pharmacological agents which bind to Peroxisome Proliferator-Activated Receptors (PPARs). Accordingly, the compounds of the instant invention are useful for the...
7531186 Topical formulations comprising 1-N-arylpyrazole derivatives and amitraz  
The present invention provides for, inter alia, novel topical formulations comprising at least one 1-N-arypyrazole derivative and amitraz and to methods for treating, controlling, or preventing...
7524838 Pyrazolyl derivatives, preparation process and intermediates of this process as medicinal products and pharmaceutical compositions containing them  
The present invention relates to the novel derivatives of formula (I) in which A is, if it is present, a (C1-C6) alkyl, a (C3-C6) alkenyl, a (C3-C6) alkynyl, a (C3-C7) cycloalkyl or a (C5-C7)...
7514570 Derivatives of 3-hydroxy-4-(cyclyl-alkylaminoalkyl)-5-phenyl-1h-pyrazole as antagonists of the gonadotropin releasing hormone (GnRH) for use in the treatment of sex hormone related conditions, such as prostatic of uterine cancer  
The invention relates to a group of novel pyrazole compounds of Formula (I): wherein: R 1 , R 2 , R 3 , M and R 5 are as defined in the specification, which are useful as gonadotrophin releasing...
7504362 Pesticidal compositions  
5-Substituted-sulfonylaminopyrazole derivatives of formula (I): or salts thereof, wherein the various symbols are as defined in the description, and pesticidal compositions thereof, processes...
7501449 2H -or 3H-benzo[e]indazol-1-yl carbamate derivatives, the preparation and therapeutic use thereof  
Compounds corresponding to the formula (I) as defined in the disclosure as well as methods for making such compounds, intermediates employed in such methods, pharmaceutical compositions...
7488831 Process for producing 5-hydroxy-4-thiomethylpyrazole compound  
A pyrazole compound represented by general formula (1) is reacted with a sulfur compound represented by general formula (2) in the presence of a base and formaldehyde, to thereby produce a...
7488355 Composition for dyeing keratin fibers, comprising a diamino-N,N-dihydropyrazolone compound, a coupler, and a polyol  
The present disclosure relates to a composition for dyeing keratin fibers, for instance human keratin fibers such as the hair, comprising at least one oxidation base chosen from...
7482375 Compounds useful in therapy  
Compounds of formula (I), or pharmaceutically acceptable derivatives thereof, wherein: R 1 represents H, C 1-6 -alkyl, C 1-6 alkyloxy, C 3-8 cycloalkyl, or halo; R 2 represents H, C...
7468386 Pyrazole-amine compounds for the treatment of neurodegenerative disorders  
The present invention relates to compounds of the Formula wherein R 1 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 are as defined. Compounds of the Formula I have activity inhibiting production...
7468381 Control of arthropods in animals  
A method of controlling parasites in or on an animal comprising administering to the animal a parasiticidally effective, substantially non-emetic 1-arylpyrazole.
7452874 Thrombopoietin mimetics  
Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating...
7452873 Inhibitors of GSK-3 and uses thereof  
The present invention relates to compounds of formula I that are useful as GSK-3 inhibitors. The invention also relates to methods of using compounds of formula I or pharmaceutical compositions...
7439242 PPARγ modulators  
Modulators of PPARγ activity are provided which are useful in pharmaceutical compositions and methods for the treatment of conditions such as type II diabetes and obesity.
7435728 Pyrazole derivatives  
This invention relates to pyrazole derivatives of formula (I) or pharmaceutically acceptable salts, solvates or derivative thereofs, wherein R1 to R4 are defined in the description, and to...
7432287 Heteroarylcarbamoylbenzene derivative  
Compounds represented by formula (I): as well as their pharmaceutically acceptable salts are disclosed. The compounds are useful as glucokinase activating agents for the treatment of diabetes...
7425640 Substituted 5-carboxyamide pyrazoles and [1,2,4]triazoles as antiviral agents  
The present invention provides compounds of formula I wherein X, Y, R 1 -R 7 are as defined herein. Compositions containing these compounds, and methods for inhibiting HCV RNA-dependent RNA...
7407971 Substituted pyrrolo-pyrazole derivatives as kinase inhibitors  
A new class of pyrazolo derivative compounds having the formula where R and R 1 have the meanings given herein. The pyrazolo derivative compounds are useful in treating cell proliferative...
7399766 Soluble amide & ester pyrazinoylguanidine sodium channel blockers  
The present invention provides a pyrazinoylguanidine compound represented by formula (I): where the structural variables are as defined herein. The compounds are useful for promoting hydration...
7354944 Thiadiazole compounds and methods of use  
The invention relates to thiadiazole compounds useful for treating diseases mediated by protein kinase B (PKB). The invention also relates to the therapeutic use of such thiadiazole compounds and...
7329670 Inhibition of RAF kinase using aryl and heteroaryl substituted heterocyclic ureas  
The compounds are aryl and heteroaryl substituted heterocyclic ureas of the formula A—NH—C(O)—NH—B where A is the aryl or hetaryl substituted heterocyclic group and B is an aryl or...
7317024 Heterocyclic modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof  
The invention relates to a class of novel non-steroidal compounds which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity...
7307097 Chemical compounds  
Pyrazole derivatives are described herein. The described invention also includes methods of making such pyrazole derivatives as well as methods of using the same in the treatment of diseases.
7285137 Composition for dyeing keratinous fibers comprising at least one diamino-N,N-dihydropyrazolone derivative  
Disclosed herein are a composition for dyeing keratinous fibers, for example, human keratinous fibers such as hair, comprising at least one oxidation base chosen from diamino-N,N-dihydropyrazolone...
7282212 Control of wood-destroying pests with thiamethoxam  
There are described a method for the control of wood pests which comprises applying to the pests or to their habitat a pesticidally active amount of a pesticidal composition comprising, as active...
7271191 Pyrazole derivatives as gamma-secretase inhibitors useful in the treatment of Alzheimer's disease  
The compounds of formula I: inhibit gamma secretase and hence are of utility in the treatment or prevention of Alzheimer's Disease.
7268139 Methods of promoting osteogenesis  
The invention is directed to methods of bone healing by administering a p38 MAP kinase inhibitor. The invention is directed to methods of treating bone fractures, bone diseases, bone grafting,...
7268135 Biaryl sulfonamides and methods for using same  
The present invention relates to biaryl sulfonamides and their use as, for example, metalloproteinase inhibitors.
7265102 Substituted pyrazoles  
Substituted pyrazoles of general formula methods of manufacturing them, compositions containing them, and methods of using them to, for example, treat autoimmune diseases mediated by cathepsin...
7262214 1-N-arylpyrazole derivatives in prevention of arthropod-borne and mosquito-borne diseases  
This invention provides for a method for preventing or interrupting the transmission of anthropod and mosquito-borne diseases from a first actual or putative amplifying or incipient host to a...
7256209 Pyrazole derivatives and diabetic medicine containing them  
The present invention provides pyrazole-O-glycoside derivatives represented by the following formulae, used as a diabetic medicine
7253169 Aza compounds, pharmaceutical compositions and methods of use  
The present invention relates to N-substituted cyclic aza compounds, pharmaceutical compositions comprising such compounds, and methods of their use for effecting neuronal activities.
7241793 Phenyloxyalkanonic acid derivatives as hPPAR activators  
A compound of formula (I) or a pharmaceutically acceptable salt, solvate, or hydrolysable ester thereof, wherein:
7230025 Pyrazole derivatives  
This invention relates to pyrazole derivatives of formula (I) or pharmaceutically acceptable salts, solvates or derivative thereof, wherein R 1 to R 4 are defined in the description, and to...
7220772 Pyrazole derivatives  
This invention relates to pyrazole derivatives of formula (I) or pharmaceutically acceptable salts, solvates or derivative thereof, wherein R 1 to R 4 are defined in the description, and to...
7214701 Active substance combinations having insecticidal and acaricdal properties  
The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising (a) compounds of the formula (I) in which W, X, Y, Z, A, B, D and G...
7211597 Substituted pyrazolyl compounds for the treatment of inflammation  
The present invention relates to compounds of Formula I: wherein A is (CH 2 ) m -Q-(CH 2 ) n , wherein each CH 2 may be independently substituted with one or more substitution selected from...
7205289 Combinations of active ingredients with insecticidal and acaricidal properties  
The invention relates to novel active compound combinations of certain cyclic ketoenols and certain insecticidally active compounds that together have very good insecticidal and acaricidal properties.
7195773 Pesticidal composition  
A pesticidal composition comprising a pesticidally effective amount of at least one of a pyridic compound of the formula (I) or it salt and at least one of other pesticides: wherein Y is a...
7195756 Control of arthropod vectors of parasitic diseases  
The present invention provides a method for controlling ectoparasites of small rodents, thereby preventing the transmission of diseases by arthropod vectors. The invention further provides an...
7183306 Pyrazole derivatives  
A compound of the formula (I): wherein R 1 is hydrogen or lower alkyl; R 2 is lower alkyl, etc.; R 3 is lower alkoxy, etc.; R 4 is hydroxy, etc.; X is O, S, etc.; Y is CH or N; Z is...
7183296 Anti-HIV pyrazole derivatives  
The present invention comprises novel and known pyrazole derivatives having anti-HIV activity, a process for their manufacture, pharmaceutical compositions and the use of such compounds in...
7179825 Retinoic acid mimetic anilides  
The present invention is concerned with compounds of formula the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein X represents...
7173055 Pyrazolecarboxamide and pyrazolethioamide as fungicide  
Novel pyraole derivatives of formula (I), wherein: X is oxygen or sufu, R 1 is C 1 –C 3 alkyl, C 1 –C 3 haloalkyl, C 1 –C 3 alkoxy-C 1 –C 3 alkyl or C 1 –C 3 haloalkoxy-C 1 –C 3 alkyl;...
7169802 Fused pyrrolocarbazoles  
The present invention relates generally to selected fused pyrrolocarbazoles, including pharmaceutical compositions thereof and methods of treating diseases therewith. The present invention is also...
7166294 Control of arthropods in rodents  
The present invention provides a method for controlling ectoparasites of small rodents, thereby preventing the transmission of diseases by arthropod vectors.
7157078 Devices and methods for eliminating termite colonies  
This invention relates to devices, kits, and methods for eliminating termite colonies. The kits, devices, and methods employ a termiticidal bait matrix containing a) a termiticide selected...
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