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6342516 |
Phenylazole compounds, process for producing the same and drugs for hyperlipemia
Phenylazole compounds represented by general formula (1) or pharmaceutically acceptable salts thereof and drugs for hyperlipemia which contain these compounds as the active ingredient, wherein A...
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6340694 |
Diarylbenzopyran derivatives as cyclooxygenase-2 inhibitors
The diarylbenzopyran derivatives represented by formula I, and the pharmaceutically acceptable salts thereof, are disclosed. The composition comprising the compound of formula I, or a...
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6329373 |
Metalloproteinase inhibitors
A compound of formula (I) ##STR1## wherein X is a --CONHOH group and the R groups are defined in the claims. The compounds are inhibitors of matrix metalloproteinases involved in tissue degradation...
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6322775 |
Cosmetic compositions containing pyrazolin-4,5-diones, novel pyrazolin-4,5-diones, preparation methods therefor and uses thereof
The present invention relates to novel cosmetic compositions, in particular for coloring the skin and/or the hair, comprising, in a cosmetically acceptable support, at least one...
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6316485 |
1,5-diphenylpyrazole derivatives
A compound of the formula (I): ##STR1## wherein: R 1 is chlorine, difluoromethyl, trifluoromethyl or cyano; and R 2 is a group having the formula: ##STR2## wherein: X is halogen,...
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6313157 |
Insecticidal method
A method of control of fleas by applying a 1-arylpyrazole of formula (1) to a locus where the fleas are located or expected to be located.
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6310049 |
Nematicidal pyrazoles
##STR1## Novel pyrazoles of formula (1) wherein R 1 represents halogen, C 1 -6 alkyl, C 1 -5 haloalkyl, C 2 -6 alkoxy, C 1 -4 alkylthio, C 2 -5 alkenyloxy, C 3 -5 alkynyloxy, C 2 -6 (total carbon...
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6306890 |
Esters derived from indolealkanols and novel amides derived from indolealkylamides that are selective COX-2 inhibitors
A compound of the formula ##STR1## where: n, and X are as defined in the specification, and the compound possesses selectivity for inhibition of cyclooxygenase-2.
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6306891 |
HIV integrase inhibitors
Nitrogen-containing heteroaryl dioxo-butyric acid derivatives are described as inhibitors of HIV integrase and inhibitors of HIV replication. These compounds are useful in the prevention or...
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6300359 |
(E)-3-[1-n-Butyl-5-[2-(2-carboxyphenyl)methoxy-4-chlorophenyl]-1H-pyrazol-4 -yl]-2-[(5-methoxy-2,3-dihydrobenzofuran-6-yl)methyl]-prop-2-enoic acid monoargininyl salt
This invention relates to a new monoargininyl salt form of the endothelin receptor antagonist (E)-3-[1-n-Butyl-5-[2-(2-carboxyphenyl)methoxy-4-chloropheny
l]-1H-pyrazol-...
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6277849 |
N-sulphonyl and N-sulphinyl amino acid amides as microbiocides
The invention relates to novel pesticidally active compounds of the general formula I ##STR1## as well as possible isomers and isomeric mixtures thereof, wherein n is a number zero or one; and ...
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6277847 |
Herbicidal isoindolinonyl-and 3,4-dihydroisoquinolonyl-substituted heterocycles
This invention relates to herbicidal compounds of formula (I), methods of making such herbicidal compounds and methods of using such herbicidal compounds. It has been found that compounds of...
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6271237 |
Nitrogen containing heteromatics with ortho-substituted P1s as factor Xa inhabitors
The present application describes nitrogen containing heteroaromatics with ortho-substituted P1's and derivatives thereof of formula I: ##STR1## or pharmaceutically acceptable salt or prodrug forms...
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6265429 |
Method for treating congestive heart failure
The present invention relates to methods for treating congestive heart failure in a mammal by administering a congestive heart failure treating amount of a compound which inhibits phosphodiesterase...
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6265428 |
Substituted phenyl compounds and derivatives thereof that modulate the activity of endothelin
Methods, compositions, and compounds for modulating the activity of an endothelin peptide are provided. The methods use compositions that contain compounds of formula (1): ##STR1## where X and Y...
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6265430 |
3-thiocarbamoylpyrazole derivatives as pesticides
The invention relates to new 3-thiocarbarnoylpyrazole derivatives of the formula (I) ##STR1## in which Ar represents in each case optionally substituted phenyl or pyridyl, R 1 represents H 2...
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6262040 |
Indazole derivatives and their use as inhibitors of phosphodiesterase (PDE) type IV and the production of tumor necrosis factor (TNF)
The invention relates to compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R, R 1 , and R 2 , are as defined herein. The invention further relates to pharmaceutical...
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6262103 |
Thienycyclohexanone derivatives as ligands of the GABAA α5 receptor subtype
A pharamceutical composition comprises a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein A is C 1 -6 alkyl, C 2 -6 alkenyl, C 2 -6 -alkynyl, C 3 -6 -cycloalkyl, arylC...
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6261996 |
Pregerminated rice seed
A pregerminated rice seed comprising a plant growth regulator, optionally further comprising a phytoprotection product, especially an insecticide.
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6255333 |
Parasiticidal compounds
Parasiticidal pyrazole derivatives of formula (I) wherein: R 1 represents CN, C 1 -6 alkoxycarbonyl, NO 2 , CHO, C 1 -6 alkanoyl, phenyl optionally substituted by one or more halogen, or C 1 -6...
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6248745 |
Pharmaceutical combination comprising a COX-2 inhibitor and a iNOS inhibitor
The invention relates to the co-administration of an inhibitor of induced nitric oxide synthase and an inhibitor of cyclooxygenase-2 for the treatment of inflammation and inflammatory disorders.
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6245797 |
Combination therapy for reducing the risks associated with cardio-and-cerebrovascular disease
The instant invention provides a drug combination comprised of an HMG-CoA reductase inhibitor in combination with a COX-2 inhibitor, which is useful for treating, preventing, and/or reducing the...
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6214834 |
Integrin inhibitor prodrugs
This invention relates to novel heterocycles which are useful as antagonists of the α v β 3 integrin and related cell surface adhesive protein receptors, to pharmaceutical compositions...
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6204283 |
Parasitic mite control on beneficial insects
The present invention provides a method to control parasitic mites on beneficial insects, such as honeybees, via the application of a parasiticidally effective amount of tebufenpyrad.
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6200979 |
Methods of administering CRF antagonists
Substituted pyrrazoles of the formula ##STR1## wherein R 1 , R 2 , R 3 , X, Y, Z and A are as defined herein with reference to formula I; pyrazoles and pyzazolopyrimidines of the formula ##STR2##...
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6184241 |
Aspartic protease inhibitors
The present invention is directed to aspartic protease inhibitors, in particular to HIV protease, renin, pepsin and cathepsin D inhibitors. Inhibitors of the present invention have a 3 to...
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6180656 |
Use of condensated (hetaryl-substituted) 1-benzal-3-pyrazol derivates for treating special diseases of the cardiovascular and the central nervous systems
The present invention relates to the new use of 1-benzyl-3-(substituted hetaryl)-fused pyrazole derivatives, some of which are known, of the general formula (I) ##STR1## in which R 1 to R 4 have...
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6177427 |
Treatment of glaucoma and ocular hypertension
Compositions of non-steroidal glucocorticoid antagonists for treating glaucoma or ocular hypertension and methods for their use are disclosed.
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6169105 |
Potentiation of drug response
The power of citalopram, fluvoxamine and paroxetine to increase the availability of sarotonin, norepinephrine and dopamine, particularly serotonin, is augmented by administration in combination...
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6156782 |
Parasiticidal compounds
A compound of the formula ##STR1## useful as a parasiticidal agent, are disclosed.
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6150393 |
Small molecule modulators of non-endogenous, constitutively activated human serotonin receptors
Disclosed herein are non-endogenous, constitutively activated forms of the human 5-HT 2A and human 5-HT 2C receptors and uses of such receptors to screen candidate compounds. Further disclosed...
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6147104 |
Fluoropyrazole-biphenylamide fungicides
The invention relates to biphenylamides having general formula (I), and their salts, in which R 1 is H or F; R 2 is H, halogen, alkyl, halogen methyl, alkoxy, alkylthio; R 3 is CH 3 , CHF 2 , CF...
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6143745 |
Process and agent for controlling harmful fungi
Compositions for controlling harmful fungi, containing in a solid or liquid carrier pyridaben of the formula: ##STR1## or fenpyroximate of the formula: ##STR2## or tebufenpyrad of the formula:...
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6133261 |
Amino acid derivatives useful to treat stroke
The invention provides a therapeutic method for treating or preventing stroke and other ischemic disorders, as well as novel compounds and pharmaceutical compositions useful for carrying out such...
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6127399 |
Certain pyrazole derivatives as cortiocotropin-releasing factor receptor CRF1 specific ligands
Disclosed are compounds that are highly selective partial agonists or antagonists at human CRF 1 receptors that are useful in the diagnosis and treatment of treating stress related disorders such...
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H001900 |
Method of combating insect eggs
A method of destroying insect eggs and a method of protecting crops from the insects resulting from the eggs wherein a compound of formula (I) is applied to the eggs
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6124333 |
Metalloproteinase inhibitors
Therapeutically active hydroxamic acid derivatives, processes for their preparation, pharmaceutical compositions containing them, and the use of such compounds in medicine. The compounds are...
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6124305 |
Use of N-(substituted glycyl)-2-cyanopyrrolidines in inhibiting dipeptidyl peptidase-IV
N-(N'-substituted glycyl)-2-cyanopyrrolidines of formula I ##STR1## wherein R is as defined herein. Compounds of formula I inhibit DPP-IV (dipeptidyl-peptidase-IV) activity. They are therefore...
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6107324 |
5-HT2A receptor inverse agonists
Disclosed herein is a new class of pyrazole compounds which act at the 5HT 2A receptors.
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6103750 |
Fluorinated dihydrobenzofuranyl and dihydroisobenzofuranyl compounds useful as insecticidal and acaricidal agents
A heterocyclic compound represented by the formula (I) ##STR1## wherein X and Y, which may be same or different, represent a hydrogen atom, a halogen atom, a nitro group or a cyano group, the...
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6103744 |
4-aminoalkoxy-1,3-dihydrobenzoimidazol-2-one dopamine autoreceptor agonists
Disclosed are compounds of the formula ##STR1## wherein: R 1 is hydrogen or C 1 -C 6 alkyl; R 2 is selected from hydrogen, straight-chain and branched C 1 -C 10 alkyl, cyclohexylmethyl or...
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6096747 |
Phenylaminocarbonyl derivatives and processes for their preparation
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6096766 |
3-benzylaminopiperidines as tachykinin receptor antagonists
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6075023 |
Method for combatting fish mycoses and one-celled ectoparasites
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6063783 |
Analgesic use of triazolo-pyridazine derivatives
A class of substituted 7,8-ring fused 1,2,4-triazolo[4,3-b]pyridazine derivatives as shown in Formula I, possessing an optionally substituted cycloalkyl, phenyl or heteroaryl substituent at the...
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6054473 |
1,3-dimethyl-5-fluoro-pyrazole-4-carboxamide derivatives, their preparation and their use as microbicides
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6051593 |
3-(cycloalkanoheteroarylidenyl)-2- indolinone protein tyrosine kinase inhibitors
The present invention relates to novel 3-(cycloalkanoheteroarylidenyl)-2-indolinone compounds and physiologically acceptable salts and prodrugs thereof which are expected to modulate the activity...
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6043240 |
3-heteroaryl-1-pyrrolidinealkylamines and derivatives thereof and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents the compounds are especially useful for treating psychoses by administering to a mammal a...
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6040329 |
Substituted indazole analogs
The invention relates to compounds of the formula I ##STR1## and pharmaceutically acceptable salts thereof, wherein R, R 1 , and R 2 , are as defined herein. The invention further relates to...
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6030993 |
2-hydroxypropionic acid derivative and its manufacturing method
This invention relates to a novel 2-hydroxypropionic acid derivative and its manufacturing method. Based on its mechanism to inhibit the CPT I, 2-hydroxypropionic acid derivative of this invention...
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