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6797724 |
Direct spot-on antiparasitic skin solution for domestic animals
A spot-on composition for the treatment or protection of a domestic animal against parasitic infestation comprising, (a) an insecticidal active substance of the formula (X): (b) an organic...
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6797708 |
Inhibitors of cytosolic phospholipase A2
This invention provides substituted indole compounds of the general formula: and pharmaceutically acceptable salt forms thereof, and methods for using the compounds as inhibitors of the activity...
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6797723 |
Heterocycle substituted diphenyl leukotriene antagonists
The invention relates to novel heterocycle substituted diphenyl leukotriene B 4 (LTB 4 ) antagonists, to compositions containing such compounds, and to methods of using such compounds for...
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6794400 |
4-substituted-1-(arylmethylidene)thiosemicarbazide, 4-substituted-1-(arylcarbonyl)thiosemicarbazide and analogs as activators of caspases and inducers of apoptosis and the use thereof
The present invention is directed to optionally substituted 4-substituted-1-(arylmethylidene)thiosemicarbazide, 4-substituted-1-(arylcarbonyl)thiosemicarbazide and analogs thereof, represented by...
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6777418 |
Retinoid compounds (I)
The current invention provide novel retinoid compounds and methods for their synthesis, methods of treating or preventing emphysema, cancer and dermatological disorders and pharmaceutical...
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6762182 |
Converting cox inhibition compounds that are not COX-2 selective inhibitors to derivatives that are COX-2 selective inhibitors
A method of altering specificity of cyclooxygenase-inhibiting compounds that have a COOH moiety by changing the various COOH containing compounds, such as indomethacin, into ester derivatives or...
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6759412 |
Acylated 6,7,8,9-tetrahydro-5H-benzocycloheptenyl amines and their use as pharmaceutical agents
The present invention relates to compounds according to the general formula (I), wherein R 1 -R 4 have the meanings given in the description, A is CH 2 , CHOH or CH—(C 1 -C 3 -alkyl), B, C...
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6750230 |
Pyrazole derivatives
This invention relates to the use of pyrazole derivatives of the formula and pharmaceutically acceptable salts and solvates thereof, in the manufacture of a reverse transcriptase inhibitor or...
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6743817 |
Substituted fused pyrroleimines and pyrazoleimines
Disclosed are compounds of the formula and the pharmaceutically acceptable salts thereof wherein R, Ar, A, n, R 1 and R 2 are defined herein. These compounds are highly selective agonists,...
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6730312 |
Pesticidal composition for seed treatment
The present invention provides an at least quaternary composition for controlling insects or representatives of the order Acarina and microorganisms, which composition comprises: (A) an...
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6727278 |
Pharmaceutically active agents that impede amyloid formation in vivo
Dense microspheres can be extracted and purified to substantial homogeneity from mammalian brain tissue, and used in the screening of therapies for potential effectiveness in impeding the formation...
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6720317 |
Inhibitors of factor Xa
Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating...
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6716841 |
Nitrogen containing heterobicycles as factor Xa inhibitors
This invention relates generally to nitrogen containing heterobicycles of formulas A and B: which are inhibitors of trypsin-like serine protease enzymes, especially factor Xa, pharmaceutical...
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6713463 |
Methods and compositions for treating and preventing mucositis
A method of reducing or inhibiting mucositis in a patient, which includes administering an inflammatory cytokine inhibitor or a mast cell inhibitor, or a combination thereof, is disclosed.
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6706743 |
β3 adrenergic receptor agonists and uses thereof
The instant invention provides β 3 adrenergic receptor agonists of structural Formula (I), the stereoisomers and prodrugs thereof, and the pharmaceutically acceptable salts of the compounds,...
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6699860 |
Di-substituted aminomethyl-chroman derivative beta-3 adrenoreceptor agonists
This invention is related to novel di-substituted aminomethyl chroman derivatives which are useful in the treatment of beta-3 receptor-mediated conditions.
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6677353 |
Substituted N-phenyl-N-heteroaralkyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity
The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer...
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6664277 |
Prenylation inhibitors containing dimethylcyclobutane and methods of their synthesis and use
The present invention is directed to compounds useful in the treatment of diseases associated with prenylation of proteins and pharmaceutically acceptable salts thereof, to pharmaceutical...
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6660732 |
Compounds useful as anti-inflammatory agents
Disclosed are novel aromatic compounds which are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are...
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6656933 |
Compounds useful as anti-inflammatory agents
Disclosed are novel aromatic compounds which are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are...
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6653309 |
Inhibitors of IMPDH enzyme technical field of the invention
The present invention relates to compounds which inhibit IMPDH. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions...
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6652860 |
Peptide, apoEp 1.B, compositions and uses thereof
A peptide derived from apolipoprotein E termed apoEp1.B which includes amino acids 239-252 of the apolipoprotein E is described. The apoEp1.B peptide is a potent immune modulator that acts on a...
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6649645 |
Combination therapy of radiation and a COX-2 inhibitor for treatment of neoplasia
The present invention provides methods to treat or prevent neoplasia disorders in a mammal using a combination of radiation therapy and a cyclooxygenase-2 inhibitor.
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6642234 |
Acrylonitrile compounds
The present invention relates to acrylonitrile compounds of formula (1): [wherein, R is a C 1 -C 6 alkyl, a C 3 -C 7 cycloalkyl optionally substituted by a C 1 -C 4 alkyl, a naphthyl, etc., R...
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6632830 |
ACE-2 inhibiting compounds and methods of use thereof
ACE-2 inhibiting compounds are disclosed. These compounds include compounds of formula (IV): wherein the variables are as described in the specification. Pharmaceutical compositions containing...
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6627643 |
Methods for preparing sodium-hydrogen exchanger type-1 inhibitors
This invention relates to methods of preparing sodium-hydrogen exchanger type 1 (NHE-1) inhibitors of formula I′ and methods of preparing pharmaceutical compositions comprising such NHE-1...
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6620834 |
Medicinal compositions for treating colorectal cancer
Medicinal compositions for colorectal cancer to be administered to the large intestine by taking advantage of preparations disintegrating in the large intestine, characterized by containing a...
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6617342 |
Hypoglycemic sulfonyl pyrazolones and pyrazolines
This invention provides compounds and their pharmaceutically acceptable salts, pharmaceutical formulation of said compounds and methods for treating hyperglycemia associated with non-insulin...
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6610726 |
Compositions and agents for modulating cellular proliferation and angiogenesis
The invention is directed to pharmaceutical compositions containing small organic molecules having the ability to mimic or agonize hepatocyte growth factor/scatter factor (HGF/SF) activity, useful...
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6596741 |
Biaryl ether derivatives useful as monoamine reuptake inhibitors
The present invention relates to compounds of formula I: and to their pharmaceutically acceptable salts. Compounds of formula I exhibit activity as serotonin, norepinephrine, and dopamine...
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6593357 |
Pyrazole compositions useful as inhibitors of ERK
Described herein are compounds that are useful as protein kinase inhibitors having the formula: where R 1-4 , Q, and T are described in the specification. The compounds are useful for treating...
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6593347 |
Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use
The present invention describes novel nitrosated and/or nitrosylated nonsteroidal antiinflammatory compounds, and novel compositions comprising at least one nitrosated and/or nitrosylated...
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6589973 |
Preparation of selective cyclooxygenase II inhibitors
A clear, stable novel pharmaceutical preparation of selective cyclooxygenase II inhibitors (COX 2) inhibitors in the parenteral form for the treatment of pain & inflammatory conditions arising...
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6589970 |
6-(aryl-amido or aryl-amidomethyl)-naphthalen-2-yloxy-acidic derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1)
This invention provides novel compounds, pharmaceutical compositions and methods of treating thrombotic disorders in mammals, the compounds having the formula: Wherein: Ar is phenyl, naphthyl,...
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6583182 |
Compounds with chelation affinity and selectivity for first transition series elements: use in medical therapy and diagnosis
This invention involves synthesis and use of a class of compounds with chelation affinity and selectivity for first transition series elements. Administration of the free or conjugated compound, or...
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6579896 |
Method for treating allergies using substituted pyrazoles
A method for the treatment of an allergic condition, including an an atopic allergic conditions, using substituted pyrazoles.
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6579895 |
Use of a celecoxib composition for fast pain relief
There is provided a method of rapidly relieving pain in a mammalian, preferably human, subject. The method comprises orally administering to the subject an effective pain-relieving amount of a...
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6573290 |
DFMO and celecoxib in combination for cancer chemoprevention and therapy
Celecoxib, a COX-2 specific non-steroidal anti-inflammatory agent, is provided in combination with DFMO for the prevention and/or treatment of cancers. Provided with the present invention are...
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6573287 |
2,1-oxazoline and 1,2-pyrazoline-based inhibitors of dipeptidyl peptidase IV and method
Dipeptidyl peptidase IV (DP 4) inhibiting compounds are provided having the formula where n is 0 or 1; X is H or CN; Y is N, NH or O; Z is CH 2 when Y is O or N—H, with Y—Z forming a single...
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6566388 |
Emulsifiable composition for the control of insects
An emulsifiable composition for the control of insects, especially of termites, comprising a 1-substituted phenyl-3-cyanopyrazole, a weakly polar solvent and an emulsifying agent, optionally...
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6559102 |
Substituted 3-aryl-pyrazoles
The invention relates to novel substituted 3-aryl-pyrazoles of the general formula (I) in which n, Q, R 1 , R 2 , R 3 , R 4 , R 5 and X are each as defined in the description, and also to...
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6559174 |
N-arylsulfonyl aryl aza-bicyclic derivatives as potent cell adhesion inhibitors
Compounds of Formula I are antagonists of VLA-4 and/or alpha4/beta7, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds...
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6552051 |
Energetic nitramine-linked azoles and related compounds as oxidizers, initiators and gas generators
Novel compounds are provided having the structural formula R[—N(NO 2 )—L—R 1 ] n wherein R, L, R 1 and n are defined herein. The compounds are useful in a variety of contexts, but are...
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6545033 |
Fused 1-(2,6-dichloro-4-trifluoromethylphenyl)-pyrazoles, the synthesis thereof and the use thereof as pesticides
The present invention is directed to novel pyrazole derivatives and their use as pesticidal agents. The pyrazole derivatives have Formula I: or a salt thereof, where R 1 is amino, hydrogen,...
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6545031 |
Endothelin receptor antagonists
Novel pyrroles, pyrazoles and triazoles, pharmaceutical compositions containing these compounds and their use as endothelin receptor antagonists as described.
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6544975 |
Substituted porphyrins
The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby...
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6541499 |
Antithrombotic agents
The invention relates to novel compounds of formula (I), and their pharmaceutically acceptable salts, as defined herein, processes and intermediates for their preparation, pharmaceutical...
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6537525 |
Medicated chewing-gum
The present invention is directed to chewing-gum preparations which are particularly useful for treating gastroesophageal reflux disease. Typically, the chewing-gum preparation comprises a...
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6521638 |
2,3-dihydro-1H-isoindole derivatives useful as modulators of dopamine D3 receptors (antipsychotic agents)
Compounds of formula (I) wherein R 1 , R 2 , A, q are as defined herein, and salts thereof, have affinity for dopamine receptors, in particular the D3 receptor, and thus have potential in the...
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6521656 |
Remedies for male sterility
Efficacious remedies for male sterility which are in the form of preparations containing as the active ingredient an adenosine A 1 antagonist.
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