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4517183 N-Substituted aziridine-2-carboxylic acid derivatives  
The present invention provides pharmaceutical compositions containing N-substituted aziridine-2-carboxylic acid derivatives of the general formula: ##STR1## wherein X is a carboxyl, a cyano, an...
4515803 Substituted derivatives of octahydroindole-2-carboxylic acids  
Compounds of the formula I ##STR1## in which n denotes 0-3, R 1 and R 1 ' are the same or different and denote hydrogen, alkyl or alkenyl, phenyl or benzyl, each substituted as desired; R 2...
4503059 1,3-Dioxacyclopentanes, their pesticidal use and compositions for pesticidal use  
Substituted aminoketals of the formula ##STR1## in which R 1 to R 4 are various organic radicals and R 2 may also be hydrogen, are fungicidally active. Some of the compounds are new.
4500536 Derivatives of N,N'-substituted azolecarboxamide and agricultural and horticultural fungicidal or nematicidal composition containing same as active ingredients  
Disclosed herein are novel derivatives of N,N-substituted azolecarboxamide represented by the formula (I): ##STR1## wherein R 1 represents a hydrogen atom, methyl group, ethyl group or propyl...
4496571 Histamine H2-antagonists  
The invention relates to carbonyl derivatives which are histamine H-2 antagonists and which inhibit gastric acid secretion. According to the invention where is provided a guanidine derivative of...
4495195 Xanthine oxidase inhibiting 3(5)-phenyl-substituted-5(3)-pyrazole-carboxylic acid derivatives, compositions, and methods of use  
Aryl pyrazole carboxylic acids and derivatives thereof, are xanthine oxidase inhibitors in vivo.
4486439 Treatment of coccidiosis  
A method for the preventive and curative treatment of coccidial infections in humans and other animals comprising the administration thereto of an amidinourea of amidinothiourea.
4479962 Indazoloxypropanolamine derivatives and use in combating, and for the prophylaxis of, cardiac and circulatory diseases  
The present invention provides heteroaryloxypropanolamines and pharmaceutical compositions containing them, for combating, and for the prophylaxis of, cardiac and circulatory diseases. The...
4465685 Antiinflammatory pyrazole thioureas  
Compounds of formula (I) ##STR1## inhibit both the cyclo-oxygenase and lipoxygenase pathways of arachidonic acid oxygenation and are useful in medicine as, e.g., anti-inflammatory and...
4463001 6-Substituted 6H-dibenzo[b,d]pyran derivatives and process for their preparation  
The present invention relates to new 6-substituted 6H-dibenzo [b,d]pyran derivatives, to a process for their preparation and pharmaceutical and veterinary compositions containing them.
4456613 6-Keto- and 6-hydroxy-8-azaprostanoids and anti-ulcer use thereof  
Biologically active 6-keto- and 6-hydroxy-8-azaprostanoids having the formula: ##STR1## wherein A is O or ##STR2## R is CO 2 R 4 or CH 2 OH; R 1 is H, CH 3 , or C 2 H 5 ; R 2 is H, CH 3 ,...
4448773 Microbicidal N-alkoxycarbonyl-alkyl-N-substituted acetyl-anilines and -naphthylamines  
Compounds of the formula ##STR1## in which Ar is 2-alkyl-, -alkoxy- or -halo-methyl-phenyl or α-naphthyl, each of which is further substituted, R 1 is 2-furyl, 2-tetrahydrofuryl, alkenyl,...
4442117 Homoserine derivatives and their use as microbicides  
There are described novel homoserine derivatives of the formula (I) ##STR1## which possess valuable microbicidal properties. In the formula: Ar is substituted phenyl or naphthyl; R 1 is C 2 -C 6 ...
4438128 Cardioactive aryloxypropanolamines  
The present invention provides aryloxypropanolamines of the general formula: ##STR1## wherein R 1 , R 2 , R 3 and R 4 , which may be the same or different, are hydrogen or halogen atoms or lower...
4421927 New cinnamoyl-cinnamic acid derivative, and its use as pharmaceutical  
The present invention relates to a new cinnamoyl-cinnamic acid derivative selected from the group constituted by: (i) the m-cinnamoyl-cinnamic acid derivatives of formula ##STR1## in which: X o...
4419363 Alkanolamine derivatives  
Novel 1-aryloxy-3-amidoamidoalkylamino-2-propanol derivatives, processes for their manufacture, pharmaceutical compositions containing them and methods of using them in the treatment of heart...
4416889 Combating fungi with N-allenyl-acetanilides  
N-allenyl-acetanilides of the formula ##STR1## in which R 1 represents hydrogen, alkyl or halogen, R 2 represents hydrogen or alkyl, R 3 represents hydrogen or alkyl, R 4 represents...
4415569 Pyrazoloindazole derivatives and pharmaceutical composition containing the same  
Pyrazoloindazole derivatives of the formula: ##STR1## [wherein R 1 is a cyano group, carboxy group, a lower alkoxycarbonyl group or a group ##STR2## (wherein R 2 and R 3 are each a hydrogen...
4409231 Substituted aryloxyamino propanols, and process for their use  
Substituted aryloxyamino propanols and pharmaceutically acceptable acid addition salts thereof according to the following formula ##STR1## wherein X is selected from oxygen and NH, R 1 is selected...
4407797 1,2-Dithiol-3-ylideneammonium derivatives, compositions and use  
New compounds of the formula: ##STR1## wherein X .crclbar . is an anion, R is (C 1 -7) alkyl [unsubstituted or substituted by hydroxy, carboxy, alkoxycarbonyl, cyano, dialkylamino, alkylcarbonyl,...
4397851 2,3-Dihalo-2,3-(disubstituted) propanoate antimicrobial compounds  
Antimicrobial compounds of the formula: ##STR1## wherein Hal is bromine or chlorine; R is C 1 -4 alkyl, straight or branched chain; and one of R 1 and R 2 is hydrogen and the other is selected...
4391814 Derivatives of antiphlogistically effective carboxylic acids, their preparation and medicinal use  
Compounds of Formula I ##STR1## wherein R 1 is the residue of an antiphlogistically effective carboxylic acid of the formula R 1 COOH, n is an integer 1, 2, or 3, and X is oxygen, sulfur,...
4388319 N-Heterocyclic alkyl-N'-thiadiazolyl, thiazolyl and isothiazolyl alkylthioureas, ureas and guanidines  
The compounds are N,N'-substituted thioureas, ureas and guanidines which are H-2 histamine receptor inhibitors. A compound of this invention is...
4368202 Combating fungi with pyrazole-substituted oximino-cyano-acetamide derivatives  
Pyrazole-substituted oximino-cyano-acetamide derivatives of the formula ##STR1## in which R 1 and R 2 each independently is hydrogen or alkyl with up to 3 carbon atoms, R 3 is hydrogen, alkyl...
4363804 Phosphonodithioylacetylamino phenyl pyrazoles  
Compounds having the formula ##STR1## wherein R is lower alkoxy or alkyl having from 1 to 6 carbon atoms, and preferably 1 to 3 carbon atoms and most preferably 1 carbon atom, R 1 is lower alkoxy...
4359469 Combating pests with N-sulphenylated oxime-carbamates  
N-Sulphenylated oxime-carbamates of the formula ##STR1## in which R is alkyl or optionally substituted cycloalkyl, aryl or aralkyl, R 1 is an optionally substituted N-containing heterocyclic...
4359474 1-Phenyl-pyrazole derivatives as glucagon inhibitors  
The invention discloses certain 1-phenyl-pyrazole derivatives having pharmacological activity in animals and useful as glucagon inhibiting agents. Nearly all of the compounds of this invention are...
4353915 Combating pests with 2-(azol-1-yl)-aldoxime-carbamates  
2-(Azol-1-yl)-aldoxime-carbamates of the formula ##STR1## wherein R 1 and R 2 each independently is alkyl or together form an alkylene bridge, R 3 is hydrogen or alkyl, R 4 is hydrogen,...
4349558 Anti-inflammatory 8H-phenanthro-[2,3-c]pyrazole derivatives  
The compounds of the formulas ##STR1## where R and R' are lower-alkyl possess glucocorticoid activity, and are prepared by reacting the compound of the formula ##STR2## with the appropriate...
4349559 Anti-inflammatory spiro-2H-indene-[2,3']-3H-pyrazolo[4",5":7',6']naphtho[2,1-b]pyran-1,3-d ione derivatives  
The compounds of formula ##STR1## where R is hydrogen or fluorine possess glucocorticoid activity, and are prepared by reacting a compound of the formula ##STR2## with 1,2,3-indantrione.
4342769 2-[(Methylsulfinyl)acetyl]-3-heterocyclicindoles and derivatives thereof as immunosuppressants  
This invention relates to compositions of matter classified in the art of chemistry as substituted 2-[(methylsulfinyl)acetyl]-3-heterocyclicindoles, various derivatives thereof, and to the...
4338328 Sulphoxides of heterocyclicthioalkylthioureas, ureas and guanidines  
The compounds are sulphoxides of heterocyclicthioalkylthioureas, ureas and guanidines which are useful to produce inhibition of histamine H-2 receptors.
4337268 Combating fungi with N-oximinoalkyl-anilides  
N-Oximinoalkyl-anilides of the formula ##STR1## in which R 1 represents hydrogen, alkyl or halogen, R 2 represents hydrogen or alkyl, R 3 represents hydrogen or alkyl, R 4 represents...
4331678 Carbamoyl pyrazole compounds and their pesticidal application  
Carbamoyl pyrazoles of formula ##STR1## and their salts, wherein R 1 represents alkyl or cycloalkyl; R 2 represents a hydrogen atom or alkyl of 1-6 carbon atoms; R 3 represents alkyl or...
4325962 Pharmaceutical compositions comprising a pyrazole derivative and method of use  
Pyrazol-4-acetic acid compounds, such as substituted pyrazol-4-acetic acid, its esters, amides, nitriles and their pharmaceutically acceptable salts and method for the preparation of these...
4323576 Derivatives of pyrazole for use in therapy  
Derivatives of pyrazole represented by the general formula: ##STR1## wherein R 1 represents an alkyl group of 7 to 11 carbon atoms and R 2 represents a hydrogen atom or a lower alkyl group, have...
4322442 Combating fungi with 1-halo-1-propyn-3-ols  
1-Halo-1-propyn-3-ols of the formula ##STR1## in which R is optionally substituted phenyl, pyridyl, furyl, thienyl or pyrazolyl, R' is optionally substituted phenyl, and X is halogen, which...
4322430 Amino-substituted 4,5,6,7-tetrahydro-1H (or 2H)-indazoles  
Amino-substituted-4,5,6,7-tetrahydro-1H (or 2H)-indazoles, useful as prolactin inhibitors and in treatment of Parkinson's Syndrome.
4307112 9-Deoxy-9A-methylene isosteres of PGI.sub.2 and process for their preparation  
9-deoxy-9A-methylene-isosteres of PGI 2 , including processes for their preparation and pharmaceutical and veterinary compositions containing same, are disclosed. The compounds are useful as...
4296118 Fungicidal 3-[N-(pyrazol-1-yl-acetyl)-N-(substituted phenyl)]-amino-tetrahydro-2-furanones  
N-Acylated N-phenyl-aminotetrahydro-2-furanones of tthe formula ##STR1## wherein R represents C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy or halogen, R 1 represents C 1 -C 3 -alkyl, C 1 -C 4 ...
4282237 Method with substituted 1-benzyl-1H-indazole-3-carboxylic acids for interrupting pregnancy in mammals  
This invention relates to the use of substituted 1-benzyl-1H-indazole-3-carboxylic acids to interrupt pregnancy. These compounds are described in the U.S. Pat. No. 3,895,026 assigned to the same...
4281019 4-[(Unsaturated or cyclopropylated alkyl)amino]phenyl compounds useful as hypolipidemic and antiatherosclerotic agents  
This disclosure describes 4-[(unsaturated or cyclopropylated alkyl)amino]phenyl compounds and derivatives useful as hypolipidemic and antiatherosclerotic agents.
4276300 Amino-substituted-4,5,6,7-tetrahydro-1H (or 2H)-indazoles  
Amino-substituted-4,5,6,7-tetrahydro-1H (or 2H)-indazoles, useful as prolactin inhibitors and in treatment of Parkinson's Syndrome. Intermediate 6-keto(or 6-alkoxy or...
4275073 Fungicidal compounds  
Pentathiepinopyrazoles and pyrazolotrithiocarbonates, such as 7-methyl-7H-1,2,3,4,5-pentathiepino[6,7-c]pyrazole, useful for the control of fungi.
4209526 Antiviral arylenedioxyalkyl substituted pyrazoles  
4-(Aryloxyalkyl)pyrazoles of the formula ##STR1## useful as antiviral agents, are prepared by reacting the corresponding diketones of the formula Ar-O-Alk-CH(COR')COR" with hydrazine or a...
4207326 Antimicrobial quaternary pyrazole derivatives  
Quaternary N-alkyl pyrazole derivatives and their method of preparation are described. The pyrazole derivatives are useful as antimicrobial agents.
4173634 Basically-substituted tricyclic pyrazoles useful as antiinflammatory agents  
Compounds of the structure ##STR1## are provided, wherein n is 1, 2 or 3, m is 2, 3 or 4, X and Y may be the same or different and are hydrogen, halogen, lower alkyl, lower alkoxy, lower alkylthio...
4171365 Antiviral aryloxyalkylpyrazoles  
4-(Aryloxyalkyl)pyrazoles of the formula ##STR1## useful as antiviral agents, are prepared by reacting the corresponding diketones of the formula Ar--O--Alk--CH(COR')COR" with hydrazine or a...
4167577 Anaphylactic inhibitors  
Compounds for use as orally active anaphylactic inhibitors are disclosed. The compounds are trans-2,3b,4,5,7,8b,9,10-octahydronaphto [1,2-c:5,6-c'] dipyrazoles which may be substituted in both of...
4153712 Pyrazolylacetanilide compounds and fungicidal compositions  
Amino aceto anilides of the formula I shown hereinafter are effective microbicides. They may be used to control fungi on plants or parts of plants or to protect them from fungi attack.
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