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5340826 |
Pharmaceutical agents for treatment of urinary incontinence
The present invention relates to a method of treating or preventing urinary incontinence in mammals, including humans, using certain quinuclidine derivatives, piperidine derivatives, azanorbornane...
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5338744 |
Angiotensin II antagonists used to treat reproductive functions associated with AT.sub.2 receptors
The present invention relates to the use of 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acids and analogs thereof in antagonizing the binding of angiotensin II to AT 2 receptors.
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5334607 |
Methods for treating mycoses
Antimycotics containing a compound of the formula ##STR1## where Y is CH--OCH 3 , CH--CH 3 , CH--CH 2 --CH 3 , CH--SCH 3 or N--OCH 3 , and X is oxygen, or X may also be NH if Y...
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5331004 |
Aromatic mustards and aziridines and pharmaceutical uses thereof
The invention relates to novel polybenzamide mustards having anticancer and hypoxia-selective properties, to methods of preparing the novel compounds, and to the use of these compounds as...
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5330997 |
1H-indazole-3-acetic acids as aldose reductase inhibitors
Certain 1H-indazole-3-acetic acid derivatives, and their pharmaceutically-acceptable esters and salts, are inhibitors of the aldose reductase enzyme, and so are useful in the treatment of diabetic...
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5302613 |
Antiatheroscleroic and antithrombotic 2-amino-6-phenyl-4H-pyran-4-ones
This invention relates to compounds of Formula I ##STR1## which are useful as antiatherosclerotic agents and inhibitors of cell proliferation for the treatment of proliferative diseases. In...
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5300521 |
Pyrazoles, fungicidal compositions and use
The invention compounds of formula I ##STR1## wherein R is H, C 1 -4 alkyl; optionally substituted aryl or CF 3 ; Y is C 1 -4 alkyl or optionally substituted aryl; A is nitrogen or CH; and ...
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5298521 |
1,5-diphenyl-3-pyrazolylalkyl-N-hydroxydithiocaramates, compositions and use
1,5-Diphenyl-3-pyrazolylalkyl-N-hydroxydithiocarbamates of the general formula: ##STR1## are disclosed to have anti-inflammatory activity in mammals.
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5296499 |
Indole derivatives, their production and use
An agent for inhibiting bone resorption comprising an indole derivative of the formula (I): ##STR1## wherein each ring of A and B is optionally substituted, R is a hydrogen atom, a lower alkyl...
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5278184 |
Synthetic derivatives of pyrrole and pyrrolidine suitable for the therapy of infections caused by rhinoviruses
Antirhinoviral compounds having the formula ##STR1## wherein R is hetrocyclic, particularly pyrrole or pyrrolidine, X is H 2 or O, n IS 3 to 7, and R 1 is substituted phenyl are disclosed.
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5270043 |
Arthropodicidal composition comprising thiodicarb and a phenylpyrazole
The invention provides arthropodicidal compositions comprising an arthropodicidally effective amount of (A) 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-t
rifluoromethyl...
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5262412 |
Substituted pyrazoles, compositions and use
Substituted pyrazole compounds are angiotensin II antagonists and therefore useful in the treatment of hypertension, and related cardiovascular disorders and ocular hypertension. These compounds...
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5260328 |
Phenyl-indenopurazol 3-oxo-propanamide derivatives useful in the treatment of rheumatoid arthritis
Heteroaryl-3-oxo-propanenitrile derivatives of formula (I) ##STR1## wherein X represents an oxygen atom or a --CH(R 4 )--, --O--CH(R 4 )--, --S(O) n --CH(R 4 )--, --CH(R 4 )--O--, --CH(R 4 )--S(O)...
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5258401 |
Cholesterol lowering compounds
Disclosed herein are compounds of structural formula (I) ##STR1## which are useful as cholesterol lowering agents. These compounds are also useful as inhibitors of squalene synthase, inhibitors of...
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5256661 |
Substituted 2-aminotetralins and pharmaceutical use
Certain novel compounds having the structural formula ##STR1## where R 2 , R 3 and R 4 are each selected from the group consisting of H and OA; A is H or is selected from the group consisting of...
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5252593 |
Pyrazole containing benzofuran derivatives and pharmaceutical compositions
The invention provides compounds of formula (I): ##STR1## or a physiologically acceptable salt, solvate or metabolically labile ester thereof. The compounds may be used in the treatment or...
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5246949 |
Preparation for endermism containing dopamine derivatives
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5242940 |
Pharmacologically active N-1 and C-5 heterocyclic pyrazoles and method for synthesizing the same
N-1 and C-5 heterocyclic pyrazoles, a method of their preparation, compositions containing the same and methods of their use are disclosed. The pyrazoles are useful in alleviating inflammatory and...
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5234942 |
Heterocyclic amides and leucotriene antagonistic use thereof
The invention provides a series of novel heterocyclic amides of the formula I in which the group A; CRa can be --CRbCRa--, --CHRb--CHRa-- or --NCRa--, the amidic group Re.L can be Rd.X.CO.NH,...
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5234939 |
3,5-di-tertiary-butyl-4-hydroxyphenyl imidazolyl methanones and related compounds as antiinflammatory agents
The novel 3,5-di-tertiary-butyl 4-hydroxyphenylimidazolyl methanones and methanone oximes of the present invention are antiinflammatory agents having activity as inhibitors of 5-lipoxygenase,...
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5234946 |
Substituted alkylamine derivatives
The substituted alkylamine derivatives represented by formula (I) ##STR1## wherein R 1 represents (a) substituted or unsubstituted C 2 -6 alkenyl group, (b) substituted or unsubstituted C 3 -6...
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5232915 |
9α-hydroxy-19,11β-bridged steroids, their production and pharmaceutical preparations containing these steroids
9α-Hydroxy-19,11β-bridged steroids of general formula I ##STR1## are described. The more detailed meaning of A, B, R 1 , R 2 , G, Z, R 4 --Y and R 4 ' --Y' follows from the description. The...
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5227392 |
Alkoxycoumarins substituted by a heterocyclic radical, their preparation and therapeutic agents containing these compounds
An alkoxycoumarin substituted by a heterocyclic radical, or the formula ##STR1## R 1 and R 2 independently of one another are each hydrogen, C 1 -C 5 -alkyl, trifluoromethyl, phenyl or halogen,...
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5227394 |
Pyrazole derivatives, compositions and use
The invention relates to pyrazole derivative having formula I ##STR1## wherein R 1 is ##STR2## and R 2 is hydrogen, or R 1 is wherein n is 1 or 2 and R 2 is hydrogen or halogen; and R 3 is...
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5225432 |
Control of micro-organisms on plants with 1-hydroxymethylpyrazoles
A method of protecting plants and seeds thereof which are susceptible to attack by microorganisms. To the plant or seed is applied a compound having the formula ##STR1## wherein R and R' are...
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5223526 |
Pyrazole carboxanilide fungicides and use
Novel N-[2-(cyclic alkyl)phenyl]pyrazole-4-carboxamides useful as fungicides, methods of using said compounds, and fungicidal compositions containing them.
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5223517 |
Heterocyclically substituted cycloalkano[b]-indolesulphonamides
Heterocyclically substituted cycloalkano[b]-indolesulphonamides can be prepared by reaction of appropriate N-unsubstituted indoles with acrylonitrile, followed by hydrolysis, esterification or...
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5223521 |
Pyrazole and thiozole derivatives for treatment of gastrointestinal ulcer disease
The invention relates to a method of preventing or treating gastrointestinal ulcer disease and microvascular injury in a mammal comprising administering to said mammal a pyrazole derivative alone...
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5219855 |
Anxiolytic drug
Disclosed herein are anxiolytic drugs containing as an active ingredient a piperazine derivative represented by the following general formula (I): ##STR1## wherein m represents an integer from 2 to...
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5216009 |
Method for controlling Nilaparvata lugens
A method for controlling insect pests which belong to Homoptera which comprises applying an insect pesticidally effective amount of the conpound having the formula: ##STR1## wherein A is a phenyl...
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5208251 |
Styryl pyrazoles, isoxazoles and analogs thereof having activity as 5-lipoxygenase inhibitors, pharmaceutical compositions and methods of use therefor
The present invention is 3,5-substituted, isoxazoles, pyrazoles, isothiazoles, and analogs thereof having 5-lipoxygenase or cyclooxygenase inhibiting activity or as a sunscreen.
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5206242 |
Diaryl-substituted pyrazole compounds and drugs and cosmetics obtained therefrom
Compounds of formula I ##STR1## where R 1 and R 2 are each hydrogen or methyl, A is en ethylene or methylene radical which is unsubstituted or substituted by methyl, hydroxyl or oxo, L is a...
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5202345 |
Carbamoylpyrrolidone derivatives and drugs for senile dementia
A compound of the formula: ##STR1## wherein R 1 is hydrogen, or C 1 14 C 6 alkyl; n is an integer of from 2 to 3; Z 1 is phenyl, benzyl, or isoxazolyl and each is optionally substituted by a...
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5196546 |
Selective pyrazoline insecticides and fungicides
Certain pyrazolines have been found to be useful as aphicides and fungicides.
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5196454 |
Method of treating disorders of the dopaminergic systems using 2,5-diaminotetralines
The invention relates to novel 2,5-diaminotetralines of the formula: ##STR1## wherein R1, R2, R3 and R4 are defined herein, processes for preparing them and their use in pharmaceutical...
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5192800 |
Glutaramide diuretic agents
A series of novel spiro-substituted glutaramide derivatives have been prepared, including the pharmaceutically acceptable salts thereof and bioprecursors therefor, wherein the spiro-substituent...
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5192787 |
Pyrazole-containing juvenile hormone mimics for pest control
A compound having pesticidal activity and which has the following general formula: ##STR1## wherein: R 1 is selected from hydrogen, C 1 -6 alkyl, halogen, C 1 -6 alkoxy, C 2 -6 alkoxycarbonyl,...
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5185359 |
N-phenoxphenyloxymethyl substituted azoles and method for controlling pests therewith
N-substituted azoles of the formula I ##STR1## where R 1 , R 2 , R 3 are each hydrogen, halogen, C 1 -C 8 -alkyl, C 1 -C 8 -alkoxy, C 1 -C 4 -haloalkyl, C 1 -C 4 -haloalkoxy, C 3 -C 10 ...
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5166153 |
Bisacylethylamines
Novel N-acylated 2-[4-(halophenoxy)-phenoxy]-ethylcarbamic acid esters of formula I ##STR1## wherein R 1 is C 1 -C 8 alkyl or C 3 -C 5 alkenyl, R 2 is C 1 -C 8 alkyl, C 1 -C 8 alkoxy,...
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5166152 |
Tricyclic 3-oxo-propanenitrile derivatives
Compounds having the general formula (I) ##STR1## wherein X represents an oxygen atom or a --S(O) n --group, wherein n is zero, 1 or 2; R represents C 1 -C 6 alkyl, pyridyl or substituted or...
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5164381 |
Pharmacologically active 1,5-diaryl-3-substituted pyrazoles and method for synthesizing the same
1,5-Diaryl-3-substituted pyrazoles, a method of their preparation, compositions containing the same and methods of their use are disclosed. The pyrazoles are useful in alleviating inflammatory and...
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5155126 |
Treatment of central nervous system disorders with pyrazole, pyrrole and triazole angiotensin-II receptor antagonists
Substituted pyrazole, pyrrole and triazole angiotensin-II-1 receptor antagonists and pharmaceutically acceptable salts thereof are useful for treating central nervous system disorders, such as...
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5141951 |
5-phenyl-1H-pyrazol-4-propionic acid derivatives, compositions and use
Compounds of formula I ##STR1## wherein R 1 is alkyl, alkoxy, alkylthio, alkylamino, aryl, aryloxy, arylthio, arylamino, aralkyl, aralkoxy, aralkylthio or aralkylamino, R 2 and R 3 are each...
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5137907 |
1-(3-(4-(3,5-difluorophenoxy) phenoxy) propyl) - pyrazole, and its production and use
A pyrazole compound of the formula: ##STR1## which is useful as an insect pesticide.
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5134142 |
Pyrazole derivatives, and pharmaceutical composition comprising the same
The present invention concerns pyrazole derivatives of formula: ##STR1## used for the treatment of inflammation, pain, thrombosis and rheumatism.
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5128346 |
Derivatives of D-glutamic acid and D-aspartic acid
A compound of the formula: ##STR1## wherein R 1 and R 2 are substituents; R 6 is hydrogen, loweralkyl, cycloalkyl, loweralkenyl, arylalkyl, (substituted aryl)alkyl, or (heterocyclic)alkyl; B is...
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5128358 |
Aryl substituted nitrogen heterocyclic antidepressants
Antidepressant agents having the formula ##STR1## wherein R 1 is a polycycloalkyl group; R 2 is methyl or ethyl, X is O; and Y comprises a 5-membered heterocyclic ring having one or two nitrogens.
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5126362 |
Oxime derivative and fungicide for agricultural and horticultural use
An oxime derivative represented by the general formula [1]: ##STR1## wherein A, B, Y and W represent each a specified group, and an optically active isomer thereof and a fungicide for agricultural...
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5118685 |
Aminopropanol derivatives of substituted 2-hydroxy-propiophenones, and therapeutic agents containing these compounds
Aminopropanol derivatives of the formula: ##STR1## where R 1 and R 2 are identical or different and are each hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl or hydroxyalkyl, each of not more than 6...
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5118683 |
Esters of 4-hydroxy-1,3-benzenedimethanol and compositions and methods employing such compounds
Compounds of the formula I ##STR1## wherein R 5 represents C 1 to C 6 -alkyl or the group --(CH 2 ) n --Z--(CH 2 ) m --Ar; Z represents O, S or --CH 2 --; n represents an integer of 1...
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