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7592338 |
Pyrazole-amine compounds useful as kinase inhibitors
The present invention provides pyrazole derived compounds of formula (I)
useful for treating p38 kinase-associated conditions, where W, X, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and m are as...
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7547719 |
3′-[(2z)-[1-(3,4-Dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4h-pyrazol-4-ylidene]hy-drazino]-2′-hydroxy-[1,1′-piphenyl]-acid bis-(monoethanolamine)
An improved thrombopoietin mimetic, the bis-(monoethanolamine) salt of...
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7517900 |
Pyrazole derivatives as cannabinoid receptor modulators
The present application describes compounds according to Formula I, wherein A, B, E, R 1 , R 2 , R 3 , R 4 , Y and Z are described herein. Additionally, the present application describes...
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7514461 |
Chroman derivatives
The invention relates to novel chroman derivatives, stereoisomers and pharmaceutically acceptable salts of Formula I
wherein the substituents are as defined in the specification. They are...
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7507833 |
Therapeutic N-aryl or N-heteroaryl pyrazolidine and pyrazolidinone derivatives
A compound having a structure
and therapeutic methods, compositions, and medicaments related thereto are disclosed herein.
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7452874 |
Thrombopoietin mimetics
Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating...
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7410991 |
Pyrazolidinone compounds as ligands of the prostaglandin EP2 and/or EP4 receptors
The invention provides substituted pyrazolidinone compounds, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention...
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7312239 |
Medicament for prevention and/or therapy of arterial wall disorder
An object of the present invention is to provide a medicament and method which is useful for prevention and/or therapy of arterial wall injury. According to the present invention, there is provided...
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7276516 |
CB1 antagonist compounds
Novel compounds of structural formula (I) are disclosed. As modulators of the Cannabinoid-1 (CB1) receptor, these compounds are useful in the treatment, prevention and suppression of diseases...
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7217729 |
Substituted indoles, process for the production thereof and use thereof for combatting pain
Substituted indoles of the formula I,
a process for the production of such compounds, pharmaceutical preparations containing these compounds and the use of these compounds for alleviating pain.
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7211600 |
Methods of modulating c-kit tyrosine protein kinase function with indolinone compounds
The present invention concerns compounds and their use to inhibit the activity of a receptor tyrosine kinase. The invention is preferably used to treat cell proliferative disorders such as cancers...
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7211596 |
Stable high-concentration injection containing pyrazolone derivative
An injection which contains as the active ingredient a pyrazolone derivative which typically is Edaravone, a physiologically acceptable salt thereof, or a hydrate or solvate of either in an amount...
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7034049 |
3(5)-amino-pyrazole derivatives, process for their preparation and their use as antitumor agents
Compounds which are 3-amino-pyrazole derivatives represented by formula (I) wherein R is C 3 –C 6 cycloalkyl group optionally substituted by a straight or branched C 1 –C 6 alkyl or arylalkyl...
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6979693 |
Pyrazole derivatives-p38 MAP kinase inhibitors
The present invention relates to certain pyrazole derivatives of Formula (I):
that are p-38 MAP kinase inhibitors, pharmaceutical compositions containing them, methods for their use, and...
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6946474 |
Nitrogen-containing compounds and their use as glycine transport inhibitors
The present invention provides trichloroethyl-sulfonylurea-containing compounds that inhibit glycing transporters, pharmaceutical compositions comprising such compounds, methods for using such...
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6939830 |
Method for fighting soil insects with phenyl-pyrazoles
The invention concerns insecticide compositions comprising:
(a) between 0.001 and 5%, preferably between 0.05 and 1% of a compound of the type 1-phenyl pyrazole, in particular 1-[2,6-Cl 2...
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6900234 |
Synergistic therapeutic compositions and methods
Compositions and methods for achieving a therapeutic effect such as lowering blood pressure and treating congestive heart failure in a mammal. More specifically, synergistic compositions comprising...
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6869914 |
Process for the preparation of solvent-free suspensions
A process for the preparation of a solvent-free suspension of a low-melting point water-insoluble solid agrochemical active ingredient, which comprises suspending 1-40% by weight of a silica-based...
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6867236 |
Method of preventing of delaying the onset and progression of Alzheimer's disease and related disorders
The present invention relates, in general, to a method of preventing or delaying the onset of Alzheimer's disease and related neurodegenerative disorders. The invention also relates to a method of...
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6852749 |
Pyrazolidinol compounds
The invention provides the use of an optionally hydroxy-protected 4-hydroxyo or hydroperoxy-3,5-dioxopyrazolidine or an equivalent wherein a pyrazolidine ring attached oxygen is replaced by a...
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6835743 |
Pesticidal pyrazoles and derivatives
Process for the protection of a building that has already been built or is going to be built, whereby an effective amount of an insecticidally active compound is spread around or under the said...
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6822001 |
Combination therapy using pentafluorobenzenesulfonamides and antineoplastic agents
Combination therapies are provided for the treatment of proliferative disorders which use a pentafluorobenzenesulfonamide of formula I and an antineoplastic agent such as gemcitabine or paclitaxel.
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6797724 |
Direct spot-on antiparasitic skin solution for domestic animals
A spot-on composition for the treatment or protection of a domestic animal against parasitic infestation comprising, (a) an insecticidal active substance of the formula (X): (b) an organic...
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6730329 |
Zinc containing compositions for anti-viral use
One aspect of the invention relates to anti-viral composition containing at least one zinc compound and at least one phenolic antioxidant (and optionally other ingredients such as at least one...
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6720345 |
Semicarbazone derivatives and their use as thrombopoietin mimetics
Compounds of formula (I), particularly a compound of formula (Ia), are non-peptide TPO mimetics, useful in the treatment of thrombocytopenia.
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6716875 |
Synergistic therapeutic compositions of ACE and renin inhibitors and methods
This invention relates to compositions and methods for achieving a therapeutic effect such as lowering blood pressure and treating congestive heart failure in a mammal. More specifically, this...
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6689805 |
Pyrazole-3-one derivative, method for preparing the same, and pharmaceutical composition containing the same
A pyrazole-3-one derivative of formula 1 or a non-toxic salt thereof, a preparation method thereof, and a pharmaceutical composition containing the derivative or the salt as an active ingredient...
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6660732 |
Compounds useful as anti-inflammatory agents
Disclosed are novel aromatic compounds which are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are...
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6656933 |
Compounds useful as anti-inflammatory agents
Disclosed are novel aromatic compounds which are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are...
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6638956 |
Pesticidal 1-arylpyrazoles
The invention relates to novel 1-arylpyrazole oxime derivatives, of general formula (I) or (I bis) These compounds are found to be generally safe systemic insecticides for control of arthropod,...
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6617342 |
Hypoglycemic sulfonyl pyrazolones and pyrazolines
This invention provides compounds and their pharmaceutically acceptable salts, pharmaceutical formulation of said compounds and methods for treating hyperglycemia associated with non-insulin...
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6593347 |
Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use
The present invention describes novel nitrosated and/or nitrosylated nonsteroidal antiinflammatory compounds, and novel compositions comprising at least one nitrosated and/or nitrosylated...
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6589973 |
Preparation of selective cyclooxygenase II inhibitors
A clear, stable novel pharmaceutical preparation of selective cyclooxygenase II inhibitors (COX 2) inhibitors in the parenteral form for the treatment of pain & inflammatory conditions arising...
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6576632 |
Biaryl compounds useful as anticancer agents
The present invention relates to compounds of formula I and to pharmaceutically acceptable salts, hydrates and prodrugs thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 10 , R 11 , b, m, n, p...
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6566388 |
Emulsifiable composition for the control of insects
An emulsifiable composition for the control of insects, especially of termites, comprising a 1-substituted phenyl-3-cyanopyrazole, a weakly polar solvent and an emulsifying agent, optionally...
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6559175 |
Method of insect control
A method of protecting a corn plant from destructive insects which comprises applying to the seed from which it grows or the soil from which the seed grows a composition comprising an insecticidal...
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6559173 |
3-(heteroarylamino)methylene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors
The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.
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6552063 |
Phenylbutazone carrier formulation
A formulation for delivery of phenylbutazone for the treatment of equine ailments is disbursed homogeneately in a powdered carrier agent having a flavoring agent and a coloring agent in an amount...
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6552051 |
Energetic nitramine-linked azoles and related compounds as oxidizers, initiators and gas generators
Novel compounds are provided having the structural formula R[—N(NO 2 )—L—R 1 ] n wherein R, L, R 1 and n are defined herein. The compounds are useful in a variety of contexts, but are...
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6538014 |
Process for the aggrochemical treatment of rangelands
A process for the treatment of grasslands against insects, comprising applying an effective quantity of...
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6531478 |
Amino pyrazole derivatives useful for the treatment of obesity and other disorders
Amino pyrazole derivatives of the formula: which are ligands for the neuropeptide Y, subtype 5 receptor and pharmaceutical compositions containing an amino pyrazole derivative as the active...
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6531449 |
Hexahydropyrazolo&lsqb 4,3,-c&rsqb pyridine metabolites
The invention provides metabolites of the compound...
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6521568 |
Plant disease controlling compositions and plant disease controlling method
The present invention relates to a plant diseases controlling composition containing as active ingredients: the pyrazolinone derivative represented by Chemical Formula: wherein R 1 represents...
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6518266 |
1- Aryl-3-thioalkyl pyrazoles, the synthesis thereof and the use thereof as insecticides
The present invention is directed to novel pyrazole derivatives and their use as pesticidal agents. The pyrazole derivatives have Formula I: or a salt thereof, where R 1 represents R 5 O, R 5...
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6492357 |
Compositions and methods for controlling insects which damage rice and other crops
Compositions and methods for controlling insect populations, in particular, insects which attack rice crops, are disclosed. The compositions include one or more compounds from the Formula 1A and...
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6472417 |
Synergistic pesticidal composition of pyrethroid and N-phenyl-pyrazole
The present invention provides an insecticidal composition comprising, as active ingredients, (a) at least one pyrethroid compound and (b) an N-arylpyrazole compound such as...
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6458823 |
Diaminopyrazoles
This invention concerns the treatment of smooth muscle spasticity or excess muscle contraction such as urge urinary incontinence with a compound of the formula wherein: R 1 and R 2 are...
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6444696 |
Pyrazole derivatives P38 MAP kinase inhibitors
The present invention relates to certain pyrazole derivatives of Formula (I): that are p-38 MAP kinase inhibitors, pharmaceutical compositions containing them, methods for their use, and methods...
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6436915 |
Pyrazole compounds
Pharmaceutical compositions and compounds are provided. The compounds of the invention have anti-proliferative activity, and may promote apoptosis in cells lacking normal regulation of cell cycle...
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6432997 |
Pyrazole pesticides
The invention relates to new 1-arylpyrazole hydroxylamines and hydrazines of the formula wherein the structural variables are as defined in the specification. The subject compounds are...
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