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7553863 Ultrapure 4-methylpyrazole  
Disclosed is an ultrapure 4-methylpyrazole containing less than 0.1% pyrazole and containing less than 10 ppm each of hydrazine and nitrobenzaldehyde. The ultrapure 4-methylpyrazole is prepared by...
7544707 Bicyclic derivatives as PPAR modulators  
The present invention is directed to compounds represented by the following structural formula, Formula (I), and stereoisomers, pharmaceutically acceptable salts, solvates and hydrates thereof,...
7538134 Substituted arylpyrazoles  
This invention relates to a range of 1-aryl-4-cyclopropylpyrazoles in which the cyclopropyl ring is substituted at the angular position, and pharmaceutically acceptable salts and solvates thereof,...
7531560 Anti-cytokine heterocyclic compounds  
Disclosed are compounds of formula (I) which inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving...
7528162 4,5-dihydro-1H-pyrazole derivatives having CB1-antagonistic activity  
The present invention relates to a group of novel 4,5-dihydro-1H-pyrazole derivatives which are potent cannabinoid (CB 1 ) receptor antagonists with utility for the treatment of diseases connected...
7524957 Compounds effecting glucokinase  
The invention relates to the use of a compound of Formula (I) or a salt, solvate or prodrug thereof, wherein R 1 , R 2 , R 3 , n and m are as described in the specification, in the preparation of a...
7524844 Dipeptidyl peptidase IV inhibitors, process for their preparation and compositions containing them  
The present invention relates to novel compounds useful as dipeptidyl peptidase IV (DPP-IV) inhibitors of the formula: wherein X, Y, a, R 1 , and R 2 are as defined herein.
7521471 4-cyanopyrazole-3-carboxamide derivatives, preparation and application thereof  
The invention relates to 4-cyanopyrazole-3-carboxamide derivatives of formula (I): in which R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 are as described herein. Also disclosed and claimed...
7511069 Indazole compounds as β3 andrenoceptor agonist  
Compounds of the general formula (I): or a salt thereof, wherein R 1 is a hydrogen atom or the like; R 2 is NHSO 2 R 3 or the like; R 3 is a (C 1 -C 6 )alkyl group or the like; R 5 is a...
7507833 Therapeutic N-aryl or N-heteroaryl pyrazolidine and pyrazolidinone derivatives  
A compound having a structure and therapeutic methods, compositions, and medicaments related thereto are disclosed herein.
7507755 Inhibitors of cathepsin s  
The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at...
7504519 Derivatives of pyrazoline, procedure for obtaining them and use thereof as therapeutic agents  
The invention relates to derivatives of general formula (I), and to their pharmaceutically acceptable salts, their stereoisomeric forms, preferably their pure enantiomeric or diastereomeric forms...
7501449 2H -or 3H-benzo[e]indazol-1-yl carbamate derivatives, the preparation and therapeutic use thereof  
Compounds corresponding to the formula (I) as defined in the disclosure as well as methods for making such compounds, intermediates employed in such methods, pharmaceutical compositions...
7491741 Diaminopropionic acid derivatives  
A compound of formula 1a which is useful for treating reperfusion injury, and salts, prodrugs, and related compounds.
7485730 Pharmaceutical compounds  
Tricyclic pyrazole derivatives of the following formula (I) having affinity for the cannabinoidergic CB1 and/or CB2 receptors: wherein: A represents a group selected from one of the...
7485659 Anticancer compositions, and methods of making and using the same  
Compositions, containing a ruthenium(III) complex and a heterocycle, methods for their manufacture, medicament containing these compositions and a kit. The invention relates to a composition (A),...
7485657 Anti-cytokine heterocyclic compounds  
Disclosed are compounds of formula (I) The compounds inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions...
7482470 Cannabinoid receptor antagonists/inverse agonists useful for treating metabolic disorders, including obesity and diabetes  
The present invention provides novel pyrazoles that are useful as cannabinoid receptor antagonists and pharmaceutical compositions thereof and methods of using the same for treating obesity,...
7482375 Compounds useful in therapy  
Compounds of formula (I), or pharmaceutically acceptable derivatives thereof, wherein: R 1 represents H, C 1-6 -alkyl, C 1-6 alkyloxy, C 3-8 cycloalkyl, or halo; R 2 represents H, C...
7470717 Indazole derivatives  
The present invention provides a compound represented by Formula (I): [wherein R 1 represents CONR 1a R 1b (wherein R 1a and R 1b may be the same or different and each represents a hydrogen...
7468371 Tricyclic pyrazole kinase inhibitors  
Compounds of the present invention are useful for inhibiting protein tyrosine kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of...
7465805 Isoxazoline derivatives and their use as herbicides  
Compounds of formula: (I) wherein the substituents are as defined in claim 1 , are suitable for use as herbicides. Also claimed are processes for the preparation of the claimed compounds, a...
7465718 Ansamycins having improved pharmacological and biological properties  
Ansamycins and methods of preparing and using the same are described. At least some of these ansamycins exhibit one or more of improved aqueous formulation ability, chemical stability, and...
7459564 Substituted biaryl compounds as factor XIa inhibitors  
The present invention provides compounds of Formula (I): or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, L, Z, R 3 , and ring B...
7449488 Pyrazolopyrimidines as protein kinase inhibitors  
In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of protein and/or checkpoint kinases, methods of preparing such compounds,...
7446121 Pyrazole-based HMG CoA reductase inhibitors  
Novel compounds and pharmaceutical compositions useful as hypocholesterolemic and hypolipidemic agents are described. More specifically, potent inhibitors of the enzyme...
7432271 Pyrazolyl inhibitors of 15-lipoxygenase  
The present invention provides pyrazolyl inhibitors of 15-LO, pharmaceutical compositions containing such inhibitors and methods for treating diseases related to the 15-LO cascade using such...
7425572 Use of dioxindoindazoles and dioxoloindazoles for treating glaucoma  
Novel dioxinoindazole compounds and dioxoloindazole compounds are disclosed. Also disclosed are methods for the lowering and controlling of normal or elevated intraocular pressure as well as a...
7417030 Indazole peptidomimetics as thrombin receptor antagonists  
The invention is directed to novel indazole peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis,...
7410992 Ophthalmic compositions for treating ocular hypertension  
This invention relates to potent potassium channel blocker compounds of Formula (I) or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraoccular...
7407981 Aminoindazole derivatives as medicaments and pharmaceutical compositions including them  
The present invention relates to the use of novel derivatives of general formula (I) in which R3 is a (1-6C)alkyl, aryl, aryl(1-6C)alkyl, heteroaryl, heteroaryl(1-6C)alkyl, aryl or heteroaryl...
7399778 Heterocyclic sulfonamide inhibitors of beta amyloid production containing an azole  
Compounds useful for lowering beta amyloid levels are provided. The compounds have the structure of formula Ia: wherein, R 1 is lower alkyl, substituted lower alkyl, phenyl, substituted...
7396850 Pyrazole derivative as PPAR modulator  
The present invention is directed to a compound, {2-Methyl-4-[3-methyl-1-(4-trifluoromethyl-phenyl)-1H-pyrazo l-4-ylmethylsulfanyl]-phenoxy}-acetic acid and pharmaceutical uses thereof.
7393868 AMPA receptor potentiators  
The present invention relates to AMPA receptor potentiators of Formula I: formulations comprising them, methods for their use, and intermediates useful for their preparation.
7375126 Fused compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor  
The present invention discloses novel compounds of general formula (I) or a pharmaceutically acceptable salt or prodrug thereof (in which X 1 -X 5 , R 5 -R 8b , Z 1 -Z 2 and Ar 1 are defined...
7358214 Pyrazolyl carboxanilides for controlling unwanted microorganisms  
This invention relates to novel pyrazolylcarboxanilides of the formula (I) in which R 1 , G and n are as defined in the disclosure, to a plurality of processes for preparing these...
7320996 Indolinone protein kinase inhibitors and cyclooxygenase inhibitors for use in combination therapy for the treatment of cancer  
The present invention relates to methods for treatment or prevention of neoplasia disorders using protein tyrosine kinase inhibitors of the formula I: wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6...
7312199 Process for the production of (−)-epigallocatechin gallate  
A process is provided for making (−)-epigallocatechin gallate (EGCG) by subjecting a green tea extract to chromatography on a macroporous polar resin, eluting EGCG from the resin with a polar...
7307097 Chemical compounds  
Pyrazole derivatives are described herein. The described invention also includes methods of making such pyrazole derivatives as well as methods of using the same in the treatment of diseases.
7297710 Derivatives of N-[(1,5-diphenyl-1H-pyrazol-3-yl)methyl]sulfonamide, their preparation and their application in therapeutics  
The present invention relates to compounds corresponding to the formula (I): In which R 1 , R 2 , R 3 , R 4 and R 5 are as described herein. The invention also relates to the method of...
7294645 Derivatives of N′-(1,5-diphenyl-1H-pyrazol-3-yl) sulfonamide with CB1 receptor affinity  
The invention relates to compounds of formula (I): Wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 are as defined herein. The invention also relates to the preparation method...
7291647 Guanylhydrazone compounds, compositions, methods of making and using  
The present invention relates to compounds having the formula: salts thereof; compositions comprising one or more of the compounds and/or salts thereof; methods of using; and methods of...
7282512 Cycloalkyl ketoamides derivatives useful as cathepsin K inhibitors  
Cycloalkyl ketoamide derivatives, which are useful as cathepsin K inhibitors are described herein. The described invention also includes methods of making such cycloalkyl ketoamide derivatives as...
7271190 Indazole compounds as β3 adrenoceptor agonist  
A compound represented by the general formula I: I wherein R1 represents hydrogen, etc. R 2 represents NHSO 2 R 3 , etc., provided that R 3 represents C 1-6 alkyl, etc. R 5 represents hydrogen,...
7265130 NPY Y5 antagonist  
The present invention provides a pharmaceutical composition for use as an NPY Y5 receptor antagonist comprising a compound of the formula (I): wherein R 1 is lower alkyl, cycloalkyl or the...
7253201 Small molecule inhibitors of necrosis  
The invention features methods for decreasing necrosis. The invention also features methods for treating a subject with a condition in which necrosis occurs. The invention further features chemical...
7250436 Indazole-aminoacetonitrile derivatives having special pesticidal activity  
The invention relates to compounds of the general formula wherein Ar 1 , Ar 2 , R 4 , R 5 , R 6 , R 7 , R 8 , W, X, a and b have the significances given in the specification, and optionally the...
7250435 Acylsemicarbazides as cyclin dependent kinase inhibitors useful as anti-cancer and anti-proliferative agents  
The present invention relates to the synthesis of a new class of indeno[1,2-c]pyrazol-4-ones of formula (I): that are potent inhibitors of the class of enzymes known as cyclin dependent...
7241791 Substituted 4-(indazol-3-yl)phenols  
This invention provides compound of formulae I or II having the structure wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , and R 10 are as defined in the specification or a...
7226941 Compound for treating angiogenesis  
The present invention provides methods and pharmaceutical compositions for inhibiting expressions of HIF and HIF regulated genes, inhibiting angiogenesis, inducing cell cycle arrest in tumor cells,...
Matches 1 - 50 out of 499 1 2 3 4 5 6 7 8 9 10 >