Patents in Class 514/403

Matches 1 - 50 out of 485

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Match	Document	Document Title
1	8183241	2-oxo-1-pyrrolidine derivatives The present invention concerns 2-oxo-1-pyrrolidine derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.
2	8168566	4-biphenyl-substituted pyrazolidin-3,5-dione derivatives The present invention relates to novel 4-biphenyl-substituted pyrazolidine-3,5-dione derivatives of the formula (I) in which A, D, G, W, X, Y and Z are as defined above, to a plurality of processes...
3	8138119	Alkoxyalkyl spirocyclic tetramic acids and tetronic acids The invention relates to novel alkoxyalkyl spirocyclic tetramic and tetronic acids of the formula (I), in whichA, B, D, Q1, Q2, Q3, Q4, G, W, X, Y and Z are as defined above,to a plurality of...
4	8138216	Cannabinoid receptor antagonists/inverse agonists useful for treating metabolic disorders, including obesity and diabetes The present invention provides novel pyrazoles that are useful as cannabinoid receptor antagonists and pharmaceutical compositions thereof and methods of using the same for treating obesity,...
5	8119566	4-biphenyl-substituted pyrazolidin-3,5-dione derivatives The present invention relates to novel 4-biphenyl-substituted pyrazolidine-3,5-dione derivatives of the formula (I) in which A, D, G, W, X, Y and Z are as defined above, to a plurality of processes...
6	8110572	Inhibitors of protein kinases Compounds that inhibit Aurora-kinases, compositions containing the compounds and methods of treating diseases using the compounds are disclosed.
7	8106085	Indoline-substituted pyrazoline derivatives, their preparation and use as medicaments The present invention relates to indoline-substituted pyrazoline compounds of formula (I), methods for their preparation, medicaments comprising these compounds as well as their use for the...
8	8093281	Indazoles as glucocorticoid receptor ligands A compound of formula (I): wherein A1 represents 2,3-dihydro-1-benzofuran-7-yl, 5-fluoro-2-methoxy-phenyl or 5-fluoro-2-hydroxy-phenyl;X represents —C(R3)— or nitrogen;when X represents —C(...
9	8088810	Phenoxypyrazole composition and process for the solvent extraction of metals A metal extractant comprising Formula (1) wherein R5, R6, R7 and R8 each independently are hydrogen, an optionally substituted hydrocarbyl group, an electron withdrawing group, an electron donating...
10	8088809	Cannabinoid receptor antagonists/inverse agonists useful for treating metabolic disorders, including obesity and diabetes The present invention provides novel pyrazoles that are useful as cannabinoid receptor antagonists and pharmaceutical compositions thereof and methods of using the same for treating obesity,...
11	8088811	Heterocycle derivatives useful as selective androgen receptor modulators (SARMs) The present invention is directed to novel heterocycle derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen...
12	8084486	Substituted arylpyrazoles This invention relates to a combination product comprising a compound of formula I wherein X, R1, R2, R3, R4, R5, R6, R7 and R9 are as described herein, and one or more further biologically active...
13	8080574	PDK-1/Akt signaling inhibitors Use of a new class of phosphoinositide-dependent kinase-1 (PDK-1) inhibitors of formula I for inducing apoptosis in unwanted rapidly proliferating cells, for treating, inhibiting, or delaying the...
14	8030323	Pyrazole carboxamide derivatives, pharmaceutical compositions and its preparation A compound of formula (I) or pharmaceutically acceptable salts and/or solvates or hydrates thereof. A process for preparing the compound, a pharmaceutical composition comprising the compound and an...
15	8030340	Indazolyl sulphonamide derivatives useful as glucocorticoid modulators Compounds of formula (I): or a pharmaceutically acceptable salt thereof, compositions comprising them, processes for preparing them and their use in medical therapy (for example modulating the...
16	8030304	Thiazole pyrazolopyrimidines CRF1 receptor antagonists The present invention relates to compounds of Formula (I), pharmaceutical compositions thereof, and use thereof as corticotropin releasing factor 1 (CRF1) receptor antagonists in the treatment of...
17	8017558	Carboxamides for controlling micro-organisms in plant and material protection Novel carboxamides of the formula (I) The present application is further directed toward a plurality of processes for preparing these compounds and their use for controlling unwanted...
18	8017635	Phenylalkyl substituted heteroaryl derivatives Certain novel phenylalkyl substituted azole derivatives have unexpected insecticidal activity. These compounds are represented by formula I: where A, B, D, E, G, a, b, c, d, and R through R11,...
19	8012499	Anthranilamides for controlling invertebrate pests Disclosed are compounds of Formula (1), including all geometric and stereoisomers, N-oxides, and salts thereof, wherein R3 is —C(═B)C(═O)L or —C(R11R12)C(═O)L; R4 is, inter alia, H, C1-C4 alkyl or ...
20	8008327	Indazole compounds as CCR1 receptor antagonists Disclosed indazoles compounds that are useful as antagonists of CCR1 activity and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the...
21	8008290	Compounds A first aspect of the invention relates to a compound of formula (I), or a pharmaceutically acceptable salt, hydrate, complex or pro-drug thereof, wherein:R3 is selected from cyclopentyl and...
22	7998996	Substituted pyrazoline compounds for reducing triglycerides in blood The present invention relates to substituted pyrazoline compounds, methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for...
23	7994207	Process for preparing fluoromethyl-substituted heterocyclic compounds The present invention relates to a process for preparing fluoromethyl-substituted heterocyclic compounds of the general formula (I) in which R1 is H or F; R2 is an -[A-O]m—R3 group in which A is C...
24	7994200	Cycloalkane-substituted pyrazoline derivatives, their preparation and use as medicaments The present invention relates to Cycloalkane-substituted substituted pyrazoline compounds of formula (I), methods for their preparation, medicaments comprising these compounds as well as their use...
25	7989475	Substituted pyrazoles, compositions containing such compounds and methods of use The present invention relates to substituted pyrazoles, compositions containing such compounds and methods of treatment The compounds are glucagon receptor antagonists and thus are useful for...
26	7977366	Treating an inflammatory disorder or inhibiting respiratory burst in adherent neutrophils with chemical inhibitors of neutrophil activation The present invention relates to a method of treating an inflammatory disorder in a subject with an effective amount of compound having the general formula (I) as described in the present...
27	7977364	Indazoles, benzisoxazoles and benzisothiazoles and their use as estrogenic agents The present invention relates to compounds of formula (I): in which R1, R2, R3, X, Y and A are as defined in the specification. The compounds are modulators of the estrogen receptors.
28	7973061	Anaplastic lymphoma kinase modulators and methods of use The present invention relates to compounds of the Formula I, wherein L, X, Y, Z, R1, R2, R3 and R4 are defined herein. The invention also provides methods of using the compounds for inhibition of...
29	7968582	5(S)-substituted pyrazoline compounds, their preparation and use as medicaments The present invention relates to substituted pyrazoline compounds, methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for...
30	7968584	Substituted arylpyrazoles This invention relates to a range of 1-aryl-4-cyclopropylpyrazoles in which the cyclopropyl ring is substituted at the angular position, and pharmaceutically acceptable salts and solvates thereof,...
31	7968579	Antifungal triazole derivatives Disclosed herein are antifungal triazole derivatives or pharmaceutically acceptable salts thereof, a preparation method thereof, and a pharmaceutical composition comprising the same. The triazole...
32	7960426	Substituted arylpyrazoles This invention relates to a combination product comprising a compound of formula I wherein X, R1, R2, R3, R4, R5, R6, R7 and R9 are as described herein, and one or more further biologically active...
33	7956060	Pyrimidine derivative compound The present invention provides an antitumor agent and the like, which comprises as an active ingredient, a pyrimidine derivative represented by Formula (I): [wherein —X—Y—Z— represents —O—CR3═...
34	7951830	Compounds effecting glucokinase The invention relates to the use of a compound of Formula (I) or a salt, solvate or prodrug thereof, wherein R1, R2, R3, n and m are as described in the specification, in the preparation of a...
35	7943652	Hydroxamate-based inhibitors of deacetylases B The present teachings relate to compounds of Formula I: and pharmaceutically acceptable salts, hydrates, esters, and prodrugs thereof, wherein R1, R2, R3, Y, Z, and are as defined herein. The...
36	7943653	Substituted 5-vinylphenyl-1-phenyl-pyrazole cannabinoid modulators This invention is directed to a cannabinoid modulator compound of formula (I): or a form thereof, and methods for use in treating, ameliorating or preventing a cannabinoid receptor mediated...
37	7943651	Compounds The present invention provides compounds of formula (I): pharmaceutical compositions comprising the compounds and the use of the compounds for the manufacture of a medicament, particularly for the...
38	7939520	Aminoazacyclyl-3-sulfonylindazoles as 5-hydroxytryptamine-6 ligands The present invention provides a compound of formula I and the use thereof in the therapeutic treatment of disorders related to or affected by the 5-HT6 receptor.
39	7935720	Crystal of substituted phenylalkanoic acid ester and process for producing the same In the case of using 3-[3-amino-4-(indan-2-yloxy)-5-(1-methyl-1H-indazol-5-yl)phe nyl]propionic acid, methyl 3-[4-(indan-2-yloxy)-3-(1-methyl-1H-indazol-5-yl)-5-nitrophe nyl]propionate, or methyl...
40	7928134	5-aryl-4,5-dihydro-(1H)-pyrazolines as cannabinoid CB1 receptor agonists The invention is directed to 5-(hetero)aryl-4,5-dihydro-(1H)-pyrazole (pyrazoline) derivatives as cannabinoid CB1 receptor agonists, to pharmaceutical compositions comprising these compounds, to...
41	7928135	Benzene, pyridine, and pyridazine derivatives Disclosed are compounds and pharmaceutically acceptable salts of Formula I wherein R1, R2, R3, R4, R5, R6, R7, n, Q1, Q2, Q3, Y, and X1-X4 are as defined herein. Compounds of Formula I are useful...
42	7927613	Pharmaceutical co-crystal compositions A pharmaceutical composition comprising a co-crystal of an API and a co-crystal former; wherein the API has at least one functional group selected from ether, thioether, alcohol, thiol, aldehyde,...
43	7923465	Cannabinoid receptor ligands, pharmaceutical compositions containing them, and process for their preparation The present invention relates to novel cannabinoid receptor modulators, in particular cannabinoid 1 (CB1) or cannabinoid 2 (CB2) receptor modulators, and uses thereof for treating diseases,...
44	7919517	Indazole derivatives The present invention provides a compound represented by Formula (I): [wherein R1 represents CONR1aR1b (wherein R1a and R1b may be the same or different and each represents a hydrogen atom,...
45	7915250	Azetidines as MEK inhibitors for the treatment of proliferative diseases Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof. Such compounds are MEK inhibitors and are useful in the treatment of proliferative diseases, such...
46	7902248	Oxime glucokinase activators Disclosed herein are pyrazole glucokinase activators of the formula (I): that are useful for the treatment of metabolic diseases and disorders.
47	7901701	Methods for producing dried pesticide compositions Disclosed are compositions and methods related to powder and granular emulsifiable concentrate pesticide formulations. As disclosed, emulsions from non-aqueous based liquid or solvent soluble...
48	7897619	Heterocyclic modulators of PKB The invention relates to heterocyclic compounds of Formula I and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions...
49	7875646	Derivatives of N-[(1,5-diphenyl-1H-pyrazol-3-yl)methyl] sulfonamide, their preparation and their application in therapeutics The present invention relates to compounds corresponding to the formula (I): In which R1, R2, R3, R4 and R5 are as described herein. The invention also relates to the method of preparation of said...
50	7875647	Heteroaryl-pyrazole derivatives as cannabinoid CB1 receptor antagonists A heteroaryl-pyrazole compound of formula (I) or a pharmaceutically acceptable salt thereof is effective as a cannabinoid CB1 receptor inverse agonist or antagonist, which is useful for preventing...

Matches 1 - 50 out of 485

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