Matches 251 - 300 out of 408 < 1 2 3 4 5 6 7 8 9 >
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5591745 (4-heteroaryl)-1-[(2,3-dihydro-1H-isoindol-2-yl)alkyl] piperidines and related compounds and their therapeutic utility  
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a...
5589495 2-[(3-heteroaryl-1-pyrrolidinyl)alkyl]-1,3- indandiones and related compounds and their therapeutic utility  
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents, the compounds are especially useful for treating psychoses by administering to a mammal a...
5589494 2-[(3-heteroaryl-1-pyrrolidinyl)alkyl]-1,3-dioxanes and related compounds and their therapeutic utility  
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a...
5589488 N-[(4-heteroaryl-1-piperidinyl)alkyl]-2-benzoxazolinones and related compounds and their therapeutic utility  
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a...
5580891 N-[heteroaryl-1-pyrrolidinyl)alkyl]-2-benoxazolinones and related compounds and their therapeutic utility  
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a...
5580886 Cis-2-[(4-heteroaryl-1 -piperidinyl)alkyl]hexahydro-1H-isoindole-1,3(2H)-diones and related compounds and their therapeutic utility  
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a...
5580879 N-[(4-heteroaryl-1-pyrrolidinyl)alkyl]-1H-benz[DE]isoquinoline-1;3(2H)-di ones and related compounds and their therapeutic utility  
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a...
5580875 1-[(2-pyrimidinyloxy)alkyl]-3-(heteroaryl)pyrrolidines and related compounds and therapeutic utility  
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents the compounds are especially useful for treating psychoses by administering to a mammal a...
5578624 Heteroarylpyrrolidines and their use as antipsychotics and analgesics  
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a...
5578605 N-[(4-heteroaryl)-1-piperidinyl)alkyl]-1,2,3,4-tetrahydroquinolines and related compounds and their therapeutic utility  
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents, the compounds are especially useful for treating psychoses by administering to a mammal a...
5574032 N-[(4-(he teroaryl)-1-piperazinyl)alkyl]-10,11-dihydro-5H-dibenz[BFS]azepines and related compounds and their therapeutic utility  
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents, the compounds are especially useful for treating psychoses by administering to a mammal a...
5571828 N-[(3-heteroaryl-1-pyrrolidinyl)alkyl]-2,3-napthalimides and related compounds and their therapeutic utility  
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a...
5569667 Treatment of prostate cancer  
Prostate cancer is treated with 5-[(2-aminoethyl)amino]-2-[2-(diethylamino)ethyl]-2H-[1]benz othiopyrano-[4 ,3,2-cd]indazol-8-ol or a pharmaceutically acceptable salt thereof.
5569655 Substituted heterocyclylisoquinolinium salts and compositions and method of use thereof  
Substitutued heterocyclylisoquinolinium salts, pharmaceutical compositions containing them and methods for the treatment or prevention of neurodegenerative disorders or neurotoxic injuries...
5561128 N-[(4-(hete roaryl)-1-piperidinyl)alkyl]-10,11-dihydro-5H-dibenz[B,F]azepines and related compounds and their therapeutic utility  
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a...
5559126 1-[(1,4-benodioxanyl)alkyl]-4-(heteroaryl)piperidines and related compounds and their therapeutic utility  
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a...
5559117 N-[(4-heteroaryl-1-piperazinyl) alkyl]-2-Benoxazolinines and related compounds and their therapeutic utility  
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents the compounds are especially useful for treating psychoses by administering to a mammal a...
5559116 N-[(4-heteroaryl-1-piperazinyl) alkyl]-1H-benz[de]isoquinoline-1,3 (2H-)-diones and related compounds and their therapeutic utility  
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a...
5556858 Cis-2-[(4-heteroaryl-1-piperazinyl)alkyl] hexahydro-1H-isoindole-1,3 (2H)-diones and related compounds and their therapeutic utility  
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents the compounds are especially useful for treating psychoses by administering to a mammal a...
5552398 Azabicyclic compounds as 5-HT4 receptor antagonists  
Compounds of formula (I), ##STR1## wherein L is N or CR c , wherein R c is hydrogen, alkoxy, halo, alkyl or cyano; Q is NR 1 , CH 2 , O, or S; R a is hydrogen, halo, alkyl, amino, nitro or...
5550134 Methods for inhibiting bone loss  
The present invention provides methods of inhibiting bone loss in mammals via the administration to a mammal in need of such treatment an effective amount of a compound from a series of...
5550130 1-[(1,4-benzodioxanyl)alkyl]-4-(heteroaryl)piperidines and related compounds and their therapeutic utility  
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a...
5543433 Azine-substituted phenylacetic acid derivatives and fungicides containing these  
Compounds of the formula I ##STR1## where X is hydrogen, halogen, alkyl, alkoxy, trifluoromethyl, cyano or nitro, Y is an amino, methylamino or dimethylamino group, Z is a group CHCH 3 ,...
5525622 Substituted pyrazolines  
There are provided new substituted pyrazolines of the general formula (I) ##STR1## in which R 1 represents optionally substituted phenyl and either R 2 represents a radical of the formula...
5510361 Di-tert-butylphenol compounds with heterocyclic moiety, useful as anti-inflammatory agents  
The subject invention relates to compounds having the structure: ##STR1## wherein a) each R is independently alkyl having from 1 to about 7 carbon atoms; b) Z is O or N--X; c) X is selected...
5508300 Dihydro pyrazolopyrroles, compositions and use  
The compounds of the formula ##STR1## and the pharmaceutically acceptable salts thereof; wherein X 1 , R 1 , R 2 , R 3 and R 4 are as defined herein, are inhibitors of PDE IV and the production...
5506193 Herbicidally, acaricidally and insecticidally active pyrazolidine compounds  
The present invention relates to herbicidally, acaricidally and insecticidally active pyrazolidine-3,5-diones of the formula I ##STR1## in which R 1 is ##STR2## R 2 and R 3 independently of one...
5491162 N-acylated pyrazolines, compositions and use  
N-sulfenylated and N-acylated pyrazoline arthropodicides, compositions containing them and methods for controlling arthropods by applying compounds of the invention to them or to their environment....
5475017 Diaryl-substituted heterocyclic compounds, drugs and cosmetics obtained therefrom  
Compounds of formula I ##STR1## and compounds of formula Ia ##STR2## and their physiologically tolerated salts, processes for their preparation and drugs and cosmetics prepared therefrom.
5468766 1,5,6,7-tetrahydro-4H-indazol-4-ones  
Pharmaceutical compositions are described which contain 1,5,6,7-tetrahydro-4H-indazol-4-ones of the formula ##STR1## some of these substances themselves being new. The pharmaceutical compositions...
5459161 Process for the preparation of substituted benzofuran derivatives  
Substituted benzofuran derivatives of the formula (I): ##STR1## wherein one of R 1 and R 2 is hydrogen or halogen and the other is, independently, an amino group or a C 2 -C 4 alkanoyl amino...
5455247 Methods for the treatment of hyperlipidemia using azaspiranes  
Invented is a method of treatment of hyperlipidemia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective therefor amount of a substituted...
5447950 Anthra[1,9-c,d]pyrazol-6-(2H)-ones useful for treating anaerobic bacterial infections  
Compounds of formula (I) ##STR1## in which R 1 is A-N(O)R'R" and R 2 , R 3 and R 4 are each separately selected from hydrogen, X and NH-A-N(O)R'R" wherein X is hydroxy, halogeno, amino, C 1 -4...
5441953 4- amino derivatives of mycophenolic acid  
The disclosed derivatives of mycophenolic acid are therapeutic agents advantageous in the treatment of disease states indicated for mycophenolic acid and/or mycophenolate mofetil and other...
5439929 Bicyclic carbamates, pharmaceutical compositions and use  
The present invention relates to bicyclic carbamate compounds and, specifically, to compounds of the formula ##STR1## wherein X, Y, R 1 and R 2 are as defined in the specification. The compounds...
5438070 Carboxanilides, their preparation and compositions containing them for controlling harmful fungi  
Carboxanilides of the formula I where the substituents have the following meanings: R is substituted or unsubstituted alkyl, alkoxy, alkenyl, alkenyloxy, alkynyl, alkynyloxy, cycloalkyl,...
5426109 Phenylnaphthalene hydroxy acids  
Compounds having the formula I: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They...
5424308 Condensed pyrazole 3-oxo-propanenitrile derivatives  
Condensed pyrazole 3-oxo-propanenitrile derivatives of formula (I) ##STR1## wherein X represents a --CH(R 4 )-- group, an oxygen atom or a --S(O) n -- group where n is 0, 1 or 2; R 1 represents C...
5385928 Tetrahydrobenz [CD] indazoles, compositions and use  
A series of 1,3,4,5-tetrahydrobenz[c,d]indazoles having activities as regulators of serotonin functions, particularly in the brain.
5380744 Phenoxyalkylamine derivative and agricultural and horticultural chemical for controlling noxious organisms containing the same  
Disclosed are a phenoxyalkylamine compound represented by the formula (I): ##STR1## wherein R 1 is C 1 -8 alkyl group, C 3 -8 cycloalkyl group, a hydrogen atom, a phenyl group, or C 1 -4 haloalkyl...
5364866 Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analetics  
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a...
5340832 Prolinal derivatives useful for treating amnesia  
A novel prolinal derivative of the general formula: ##STR1## [wherein A represents alkylene or alkenylene group of from 1 to 8 carbon atom(s) or a saturated hydrocarbon ring of from 3 to 7 carbon...
5334607 Methods for treating mycoses  
Antimycotics containing a compound of the formula ##STR1## where Y is CH--OCH 3 , CH--CH 3 , CH--CH 2 --CH 3 , CH--SCH 3 or N--OCH 3 , and X is oxygen, or X may also be NH if Y...
5324741 Heterocyclic isoxazole compounds having nematicidal activity  
The compounds of formula (I): ##STR1## wherein R is (CH 3 ) 2 CHCH 2 -- or (CH 3 ) 3 CCH 2 --, or R is the group CH 3 --O--(R 1 )CH-- where R 1 is hydrogen or methyl, or R is a cycloalkyl...
5314886 N-substituted lactams useful as cholecystokinin antagonists  
This invention relates to novel N-substituted lactams having the following formula ##STR1## useful in the treatment and prevention of Cholecystokinin (CCK) related disorders of the...
5304557 Substituted oxoophthalazinyl acetic acids and analogs thereof  
A compound of the formula ##STR1## wherein A 1 and A 2 are independently N or CH; B is a covalent bond or C O; R 1 is hydrogen or C 1 -C 6 alkyl; R 2 is hydrogen, fluorine,...
5294630 Treatment of inflammatory bowel disease  
Inflammatory bowel disease is treated, and patients are protected from a relapse into active disease, by the administration of a compound chosen from a series of 3-phenyl-5-carboxypyrazoles and...
5278183 Method for the treatment of autoimmune diseases  
A pharmaceutical composition for the treatment of autoimmune diseases comprising an effective amount of a compound of formula A--CH 2 --O--CRR'--COOR"' (I) where ...
5276039 Substituted indazole arthropodicides  
Indazole arthropodicides, compositions containing them and a method for controlling arthropods employing these indazoles as the active ingredient. The indazoles have the following general formula...
5276037 Heterocyclic 5-lipoxygenase inhibitors  
The invention concerns an aryl derivative of the formula I, ##STR1## wherein Ar 1 is optionally substituted phenyl, naphthyl or a heterocyclic moiety, and X 1 is oxy, thio, sulphinyl, sulphonyl,...
Matches 251 - 300 out of 408 < 1 2 3 4 5 6 7 8 9 >