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5854263 |
1- (1,4-benzodioxanyl)alkyl!-3-(heteroaryl) pyrrolidines and related compounds and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a...
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5854243 |
3-heteroaryl-1-pyrrolidinealkylthiols and derivatives thereof and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a...
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5854235 |
17-spiromethylene steroids
The invention relates to a steroid derivative which steroidal skeleton is bound at carbon atom 17 to a spiromethylene ring of the formula: ##STR1## wherein R a and R b are independently selected...
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5849778 |
N-pyrazolyl anilines as pesticides
The present invention relates to new N-pyrazolylanilines and N-pyrazolylaminopyridines of the formula (I) ##STR1## in which R 1 , R 2 , R 3 , R 4 , X, Y and Z have the meanings given in the...
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RE35985 |
Fungicidal compositions
The invention provides a fungicidal composition comprising at least one systemic, contact and/or soil fungicide and at least one acrylic acid morpholide derivative of the general formula ##STR1##...
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5843977 |
(3-heteroaryl-1-pyrrolidinyl) alkoxy!-3,4-dihydro-1(2H)-naphthalenones and related compounds and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a...
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5837706 |
Drug for neuroprotection
A drug containing a calmodulin inhibitor as an active ingredient is disclosed. This drug is useful in the suppression of neuronal cell death, in particular brain neuronal cell death, due to, for...
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5798311 |
N-aryl-3-aryl-4-substituted-4,5-dihydro-1H-pyrazole-1-carboxamides and methods of their production
This invention relates to novel N-aryl-3-aryl-4-substituted-4,5-dihydro-1H-pyrazole-1-carbox
amide compounds which are useful as pesticides, compositions containing those compounds, methods of...
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5783576 |
Benzoyl guanidine derivatives, the preparation thereof and their use in pharmaceutical compositions
New compounds of general formula (I) are provided: ##STR1## which are explained in the specification can be prepared by a variety of methods. The compounds may be used in pharmaceutical compositions.
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5776963 |
3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a...
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5760029 |
Spirocycle integrin inhibitors
This invention relates to novel heterocycles, including (S)-2-phenylsulfonylamino-3- 8-(2-pyridinylaminomethyl)-!-1-oxa-2-azaspi ro- 4,5!-dec-2-en-3-yl!carbonylamino! propionic acid, which are...
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5756532 |
Aminomethyl-2 3 8 9-tetrahydro-7H-1 4-dioxino 2 3-E!-indol-8-ones and derivatives
The compounds of formula I: ##STR1## wherein R 1 and R 2 are, independently, hydrogen, alkyl, phenyl or benzyl; or R 1 and R 2 , taken together, are benzylidene optionally substituted with R 3 ...
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5747518 |
Substituted thiophene derivative and agricultural and horticultural fungicide containing the same as active ingredient
The substituted thiophene derivative of the invention which is represented by the general formula (1) has a broad disease spectrum for a pathogenic fungus of various crops, exhibits an excellent...
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5741801 |
5-HT.sub.4 receptor antagonist
Compounds of formula (I) and pharmaceutically acceptable salts thereof, and the use of a compound of formula (I) or a pharmaceutically acceptable salt thereof: X--CO--CH 2 --Z ...
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5731335 |
(1-Heteroazolyl-1-heterocycane derivatives and their use as neuroprotective agents
This invention provides heterocyclic compounds of formula (I) that are potentially useful in the treatment of neuropsychiatric disorders associated with progressive processes leading to neuronal...
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5714491 |
Peptidyl derivatives as metalloproteinase inhibitors
Peptidyl derivatives are disclosed that are orally active metalloproteinase inhibitors. The peptidyl derivatives have a selective gelatinase action, have a long duration of action, and are useful...
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5707936 |
Methyl α-phenylbutenoates
Methyl α-phenylbutenoates of the formula I ##STR1## where -- is a single or double bond and the index and the substituents have the following meanings: n is 0, 1, 2, 3 or 4; R 1 is nitro,...
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5696143 |
Benz G! indazolyl derivatives for the treatment of inflammation
A class of benz g!indazolyl derivatives is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula I ##STR1## wherein...
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5693633 |
Angiotensin II antagonists
This invention provides novel heterocyclic derivatives, their pharmaceutical formulations, and their use for antagonizing angiotensin II receptors in mammals.
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5686486 |
4-hydroxy-benzopyran-2-ones and 4-hydroxy-cycloalkyl b!pyran-2-ones useful to treat retroviral infections
The present invention relates to compounds of formula I which are 4-hydroxy-benzopyran-2-ones and 4-hydroxy-cycloalkyl b!pyran-2-ones useful for inhibiting a retrovirus in a mammalian cell infected...
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5686480 |
Fused tricyclic heteroaromatic derivatives as dopamine receptor subtype ligands
A class of fused tricyclic heteroaromatic compounds of formula (I), or a salt thereof or a prodrug thereof containing a fused pyrazole ring are ligands for dopamine receptor subtypes within the...
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5679699 |
(Phenylalkylaminoalkyloxy) -heteroaryl-compounds, processes and intermediates for their production and pharmaceutical compositions containing them
3-(Phenylalkylaminoalkyloxy)-heteroaryl compounds having heart rate lowering and/or anti-ischemic effects, methods for their preparation and pharmaceutical compositions containing them are...
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5670532 |
Pyrazolyl derivatives for the treatment of inflammation
A class of benzopyranopyrazolyl derivatives is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula I ##STR1##...
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5670522 |
Dopamine receptor subtype ligands
Fused tricyclic heteroaromatic compounds of formula ##STR1## wherein one of X and Y represents nitrogen, and the other of X and Y represents oxygen, sulphur or N--R 2 ; Q represents a...
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5668136 |
Trisubstituted benzene derivatives, composition and methods of treatment
A benzene, pyridine or pyrimidine derivative having the below shown formula is novel and useful as an anti-arteriosclerotic agent. ##STR1## wherein R 1 stands for a lower alkyl group, an amino...
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5665757 |
Method for treating anxiety
A method of treating anxiety in a warm blooded animal by administering an anti-anxiety effective amount of a nitric oxide synthase inhibitor, and compositions containing the same.
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5665732 |
Indazole derivatives
A class of chemical compounds comprising a 1-H-indazole moiety and a substituted heterocyclic moiety, linked via the 3-position of the indazole moiety by a methylene group, are ligands for dopamine...
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5663053 |
Inhibition of inflammatory lipid mediators
Coenzyme A-independent transacylase is required for the release of free arachidonic acid, and the production of arachidonic acid metabolites and platelet activation factor. Blocking of this enzyme...
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5654319 |
N-[(4-heteroaryl-1-piperidinyl)alkyl]-2,3-naphthalimides and related compounds and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a...
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5652255 |
Potentiation of bioreductive agents
A human or animal subject having a solid tumour is treated by administering to the subject therapeutically effective amounts of a nitric oxide (NO) synthase inhibitor and a compound which is an...
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5643938 |
Pyrazolopyridine compounds for the treatment of anemia
The present invention relates to a pharmaceutical composition for the prevention and/or the treatment of anemia in a human being or an animal which comprises, as an active ingredient, a...
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5639764 |
2-[(4-heteroaryl)-1-piperidinyl)alkyl]-1,3-indandiones and related compound and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents, the compounds are especially useful for treating psychoses by administering to a mammal a...
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5633265 |
***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analgetics
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a...
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5629326 |
4-(heteroaryl)-1-[(2,3-dihydro-1H-indol-1-yl)alkyl]piperidines and related compounds and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a...
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5624931 |
Pyrazole derivatives
Pyrazole derivatives useful for inhibiting the production of Interleukin-1 (IL-1) and tumor necrosis factor (TNF) and the like, which can be represented by the following formula: ##STR1## and a...
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5624927 |
N-[4-(heteroaryl)-1-piperazinyl)alkyl]-1,2,3,4-tetrahydroisoquinolines and n-[4(heteroaryl)-1-piperazinyl)alkyl]-1,2,3,4-tetrahydroisoquinolines, related compounds and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a...
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5614543 |
1-(aryloxyalkyl)-3- (heteroaryl) pyrrolidines and related compounds useful as antipsychotics and analgesics
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a...
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5612343 |
N-[(4-heteroaryl-1-piperazinyl)alkyl]-2,3-naphthalimides and related compounds and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a...
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5612342 |
***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
[(4-heteroaryl-1-piperindyl)alkoxy]-3,4-dihydro-1(2H)-naphthalenones and related compounds and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a...
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5607956 |
1-heteroazolyl-1-heterocyclyl alkane derivatives and their use and their use as neuroprotective agents
The present invention relates to novel heterocyclic compounds having the general formula (1) ##STR1## geometric and optical isomers and racemates thereof where such isomers exist, as well as...
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5607945 |
N-[(4-(heteroaryl)-1-piperidinyl)alkyl]-1,2,3,4-tetrahydroisoquinolines and related compounds and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a...
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5605913 |
***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
1-(arylthioalkyl, arylaminoalkyl or arylmethylenealkyl)-4-(heteroaryl) piperidines and related compounds useful as antipsychotics and analgesics
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a...
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5605909 |
Substituted N-heteroaryl-1,2-diaminocyclobutene-3,4-dione compounds
The compounds of formula I are smooth muscle relaxants: ##STR1## wherein R 1 is hydrogen, alkyl, cycloalkyl, alkanoyl, alkylsulfonyl, aroyl, arylalkenoyl, arylsulfonyl, arylalkanoyl or...
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5604224 |
Substituted heterocyclylisoquinolinium salts and compositions and methods of use thereof
Substitutued heterocyclylisoquinolinium salts, pharmaceutical compositions containing them and methods for the treatment or prevention of neurodegenerative disorders or neurotoxic injuries...
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5604182 |
Milbemycin ether derivatives, their preparation and their therapeutic and agrochemical uses
Compounds of formula (I): ##STR1## and salts and esters thereof have valuable anthelmintic, acaricidal and insecticidal activities. Methods of preparing the compounds are also provided.
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5602165 |
Transdermal absorptive drug formulation
A transdermal absorptive drug formulation containing 3-isobutyryl-2-isopropylpyrazolo [1,5-a ]pyridine as active ingredient effective for bronchial asthma and cerebrovascular disorder is provided....
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5597842 |
3-heteroaryl-1-pyrrolidinealkanols and derivatives thereof and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a...
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5596013 |
Dihydro pyrazolopyrroles
The compounds of the formula ##STR1## and the pharmaceutically acceptable salts thereof; wherein X 1 , R 1 , R 2 , R 3 and R 4 are as defined herein, are inhibitors of PDE IV and the production...
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5593995 |
2-[(4-heteroaryl-1-piperazinyl)alkyl]-1,3-indandiones and related compounds and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a...
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5591764 |
N-acylated pyrazolines
N-sulfenylated and N-acylated pyrazoline arthropodicides, compositions containing them and methods for controlling arthropods by applying compounds of the invention to them or to their environment....
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