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7250436 |
Indazole-aminoacetonitrile derivatives having special pesticidal activity
The invention relates to compounds of the general formula
wherein Ar 1 , Ar 2 , R 4 , R 5 , R 6 , R 7 , R 8 , W, X, a and b have the significances given in the specification, and optionally the...
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7250435 |
Acylsemicarbazides as cyclin dependent kinase inhibitors useful as anti-cancer and anti-proliferative agents
The present invention relates to the synthesis of a new class of indeno[1,2-c]pyrazol-4-ones of formula (I):
that are potent inhibitors of the class of enzymes known as cyclin dependent...
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7241791 |
Substituted 4-(indazol-3-yl)phenols
This invention provides compound of formulae I or II having the structure
wherein
R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , and R 10 are as defined in the specification or a...
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7226941 |
Compound for treating angiogenesis
The present invention provides methods and pharmaceutical compositions for inhibiting expressions of HIF and HIF regulated genes, inhibiting angiogenesis, inducing cell cycle arrest in tumor cells,...
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RE39681 |
1-(4-sulfamyaryl)-3-substituted-5-aryl-2-pyrazolines and inhibitors of cyclooxygenase-2
Compounds of the formula
wherein:
X is selected from the group consisting of trihalomethyl, C 1 -C 6 alkyl, and a group of formula II:
wherein:
R 3 and R 4 are...
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7220771 |
Methods of using indazole derivatives as JNK inhibitors
Compounds having activity as selective inhibitors of JNK are disclosed. The compounds of this invention are indazole derivatives having the following structure:
wherein R 1 , R 2 and A are as...
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7217706 |
Propanolamine derivatives
This invention relates to new propanolamine derivatives or salts thereof represented by the following formula [I]:
Wherein each symbol is as defined in the specification or salts thereof which...
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7214701 |
Active substance combinations having insecticidal and acaricdal properties
The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising
(a) compounds of the formula (I)
in which W, X, Y, Z, A, B, D and G...
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7214699 |
Indazole derivatives as CRF antagonists
This invention relates to compounds which are generally CRF-1 receptor antagonists and which are represented by Formula I or Formula II:
wherein R 3 is optionally substituted aryl or...
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7211594 |
Indazole compounds and compositions thereof as JNK inhibitors and for the treatment of diseases associated therewith
This invention is generally directed to Indazole Derivatives having the following structure:
or pharmaceutically acceptable salt thereof, wherein R 1 , R 2 and A are as defined herein. Such...
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7196111 |
Pyrazolo[1,5a]pyrimidine compounds as antiviral agents
The invention relates to the inhibition of hepatitis C virus (HCV) replication. In particular, embodiments of the invention provide compounds and methods for inhibiting HCV RNA-dependent RNA...
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7192953 |
Antibacterial agents
Compounds of formula (I) have antibacterial activity; wherein Q represents a radical of formula —N(OH)CH(═O) or formula —C(═O)NH(OH); Y represents —C(═O)—, —C(═S)—,...
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7186741 |
Neurotensin active 2,3,diaryl-pyrazolidine derivatives
The invention relates to a group of novel 2,3 diaryl-pyparazolidine derivatives having formula (1). The symbols used in formula (1) have the meanings given in the specification. The compounds have...
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7186738 |
Antibacterial oxalidinones
Compounds of the formula (I), or a pharmaceutically-acceptable salts, or in-vivo-hydrolysable esters thereo Formula (I): wherein N-HeT is for example triazolyl; Q is for example phenyl or pyridyl,...
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7183316 |
Treatment of HPV caused diseases
Human papillomavirus (HPV) protein expression is downregulated in patients infected with HPV by administration of PPARγ ligand, selective inhibitor of cyclooxygenase-2 (COX-2), diaryl heterocycle,...
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7157482 |
Antibacterial 1,3-oxazolidin-2-one derivatives
Compounds of the formula (I), or a pharmaceutically-acceptable salts, or in-vivo-hydrolysable esters thereof, wherein: N—HET is for example triazolyl substituted with R 1 ; R 1 is for example...
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7153881 |
Compounds acting as melanocortin receptor ligands
The present invention provides novel compounds and use of compounds of general formula (I) as ligands to the melanocortin receptors and/or for treatment of disorders in the melanocortin system:...
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7148240 |
Aminoalkoxybenzoyl-benzofuran or benzothiophene derivatives, method for preparing same and compositions containing same
The invention relates to benzofuran or benzothiophene derivatives of general formula:
These compounds are of use as medicinal products, in particular in the treatment of pathological syndromes...
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7144883 |
Bicyclic sulfonamide compounds
The present invention relates to substituted sulfonamide compounds of the general formula (I), wherein P is sulfonamide or amide-substituted sulfonic acid, which compounds are potentially useful...
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7144570 |
Sunscreen compositions and methods of use thereof
Disclosed herein are novel methods for reducing or preventing the harmful effects of solar radiation on skin. Also disclosed are novel sunscreen compositions comprising thaizolium, thiadiazolium or...
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7141587 |
Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use
Indazole compounds that modulate and/or inhibit the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating...
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7138418 |
Pentafluorobenzenesulfonamides and analogs
The invention provides methods and compositions relating to novel pentafluorophenylsulfonamide derivatives and analogs and their use as pharmacologically active agents. The compositions find...
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7129257 |
Pyrazolo[3,4- e]benzoxazoles for the treatment of glaucoma
Pyrazolo[3,4-e]benzoxazoles and analogues thereof for lowering intraocular pressure and treating glaucoma are disclosed.
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7119114 |
Pyrazoloanthrone and derivatives thereof as JNK inhibitors and compositions and methods related thereto
Compounds having activity as selective inhibitors of JNK are disclosed The compounds of this invention are pyrazoloanthrone and derivatives thereof having the following structure:
wherein R 1 ...
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7115624 |
Method of inhibiting protein tyrosine phosphatase 1B and/or T-cell protein tyrosine phosphatase 4 and/or other PTPases with an Asp residue at position 48
The present invention provides a method of inhibiting a member of a family of Protein Tyrosine Phosphatases (PTPases, PTPs) such as PTP1B, TC-PTP, CD45, SHP-1, SHP-2, PTPα, PTPε, PTPμ, PTPδ,...
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7101884 |
Tyrosine kinase inhibitors
The present invention relates to compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to...
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RE39265 |
Heteroarylpiperidines, and their use as antipsychotics and analgetics
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a...
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RE39198 |
Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analgesics
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a...
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7071182 |
Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor
The present invention relates to the antagonism of the effects of melanin-concentrating hormone (MCH) through the melanin concentrating hormone receptor which is useful for the prevention or...
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7049307 |
Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor
The present invention relates to the antagonism of the effects of melanin-concentrating hormone (MCH) through the melanin concentrating hormone receptor which is useful for the prevention or...
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7029706 |
Composition for the treatment of cutaneous mycosis
The inventions relates to the use of silica in the formulation of antifungal composition for the treatment of cutaneous mycoses, and method to manufacture an antifungal powder with boric acid and...
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7026301 |
Method of orally treating inflammatory skin conditions with prodrugs of 5-fluorouracil
The present invention relates to the treatment of inflammatory skin conditions, including psoriasis, with a prodrug of 5-fluorouracil. The invention relates to methods for treatment of psoriasis...
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7015233 |
Fused compounds that inhibit vanilloid subtype 1 (VR1) receptor
Compounds of formula (I)
are novel VR1 antagonists that are useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence, or bladder overactivity.
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7005443 |
5-Hydroxy indazole derivatives for treating glaucoma
3-(2-aminoethyl)-1H-indazol-5-ols useful for treating elevated intraocular pressure and glaucoma are disclosed.
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6989400 |
Treatment of benign prostatic hyperplasia
A method for treatment or prophylaxis of benign prostatic hyperplasia by administration of lonidamine or a lonidamine analog is provided. Also provided are unit dosage forms of lonidamine or an...
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6982274 |
1H-indazole compound
The present invention provides a novel 1H-indazole compound having an excellent JNK inhibitory action. More specifically, it provides a compound represented by the following formula, a salt thereof...
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6974810 |
4,5-Dihydro-1H-pyrazole derivatives having potent CB1-antagonistic activity
The present invention relates to a group of novel 4,5-dihydro-1H-pyrazole derivatives which are potent cannabinoid (CB 1 ) receptor antagonists with utility for the treatment of diseases connected...
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6949579 |
Aminoindazole derivatives and intermediates, preparation thereof, and pharmaceutical compositions thereof
The present invention relates to the novel indazole derivatives of general formula (I):
in which: R is either O, S or NH; R3 is an alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, aryl,...
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6949556 |
Acylated 1,2,3,4-tetrahydronaphthyl amines and their use as pharmaceutical agents
The present invention relates to compounds of general formula (I),
wherein R 1 -R 4 have the meanings given in the specification, A is CH2, CHOH or CH—(C 1 -C 3 -alkyl), B and C are...
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6939830 |
Method for fighting soil insects with phenyl-pyrazoles
The invention concerns insecticide compositions comprising:
(a) between 0.001 and 5%, preferably between 0.05 and 1% of a compound of the type 1-phenyl pyrazole, in particular 1-[2,6-Cl 2...
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6933310 |
Therapeutic agent for amyotrophic lateral sclerosis (ALS)
An object of the present invention is to provide a novel medicament with which motor neuron diseases can be treated. According to the present invention, there is provided a therapeutic agent for...
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6927233 |
5ht2 agonists for controlling IOP and treating glaucoma
Compositions and methods for controlling intraocular pressure and treating glaucoma using 1-(2-aminopropyl)-indazol-6-ol are disclosed.
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6916839 |
Pyrazolylarylalkines
The present invention relates to pyrazolylarylalkines and to their use, to a process for preparing pyrazolylarylalkines and also to intermediates.
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6897231 |
Indazole derivatives as JNK inhibitors and compositions and methods related thereto
Compounds having activity as selective inhibitors of JNK are disclosed. The compounds of this invention are indazole derivatives having the following structure:
wherein R 1 , R 2 and A are as...
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6881749 |
Pyranoindazoles and their use for the treatment of glaucoma
Pyranoindazoles are disclosed. Also disclosed are methods for the lowering and controlling of normal or elevated intraocular pressure as well as a method for the treatment of glaucoma using...
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6872736 |
Non-aqueous emulsifiable concentrate formulation
The invention relates to a non-aqueous, emulsifiable concentrate (EC) formulation for crop protection active compounds which comprises
(a1) 50 to 300 g/L of at least one azole derivative having a...
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6867229 |
Antiparasitic composition for the treatment and protection of pets
Composition which is useful in particular for the treatment and protection of domestic animals which are infested with parasites or are likely to be infested with them, these compositions...
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6867202 |
Treatment of insulin resistance
This invention is directed to methods of treating insulin resistance in a mammal which comprise administering an effective amount of a compound of formula I,
where the variables are defined in...
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6861431 |
Compounds capable of modulating the activity of multidrug transporters and therapeutic use of the same
Methods of modulating the activity of multidrug transporters are disclosed. The methods of modulating the activity of multidrug transporters use compounds that selectively increase or decrease the...
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6849620 |
N-(azabicyclo moieties)-substituted hetero-bicyclic aromatic compounds for the treatment of disease
The invention provides compounds of Formula I:
wherein Azabicyclo is
W 0 is a bicyclic moiety and is
These compounds may be in the form of pharmaceutical salts or...
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