Patents in Class 514/401

Matches 1 - 50 out of 232

1 2 3 4 5 >

Match	Document	Document Title
1	7579481	Method of making imidazole-2-ones and 2-thiones A method of 4-substituted imidazole-2-ones and thiones which comprises reacting a methylene urea or methylene thiourea wherein said methylene is substituted with the 4-subsituent and a cyano or...
2	7575757	Stabilized formulations of alpha adrenergic receptor antagonists and the uses thereof The present invention provides compositions and stable liquid formulations comprising alpha adrenergic receptor antagonists and use thereof for increasing blood flow. In one embodiment, the stable...
3	7553862	4-amino-1,5-substituted-1,5-dihydro-imidazol-2-ones The present invention relates to compounds of formula I wherein R 1 , R 2 , R 3 , and R 4 are as defined herein and to pharmaceutically acceptable acid addition salts thereof. Compounds of...
4	7528161	NF-kappaB inhibitors and uses thereof A new class of imidazolines as 4-position esters with very potent anti-inflammatory as well as antimicrobial activity is described. The synthesis of these imidazolines includes a multicomponent...
5	7495108	Imidazoline derivatives having CB₁-antagonistic activity The present invention relates to 1,2,4-tri-substituted imidazoline derivatives, to methods for the preparation of these compounds, to novel intermediates useful for the synthesis of said...
6	7459473	N-linked sulfonamides of N-heterocyclic carboxylic acids or carboxylic acid isosteres This invention relates to novel N-linked sulfonamides of N-heterocyclic carboxylic acid and carboxylic acid isosteres, their preparation, and use for treating neurological disorders including...
7	7439241	Compounds, formulations, and methods for treating or preventing rosacea In methods, compounds, and topical formulations for treatment of rosacea incorporating compounds represented by the formulas below: wherein each of R 1 , R 2 , and R 3 is independently...
8	7407980	Imidazolinylmethyl aralkylsulfonamides Compounds of the Formula: where R 1 -R 6 are those defined herein and methods for producing the same. Also provided are pharmaceutical compositions comprising a Compound of Formula I and...
9	7375125	Melanocortin-4 receptor binding compounds and methods of use thereof Provided are MC4-R binding compounds of the formula XVII: wherein L 2 is a linker group, and P 1 , P 2 , P 3 , P 4 , Z 1 , Z 2 , Z 3 , Z 4 , Z 5 , t, s, and R are as described in the...
10	7345078	NF-κB inhibitors and uses thereof A new class of imidazolines as 4-position acids or esters with very potent anti-inflammatory as well as antimicrobial activity is described. The synthesis of these imidazolines includes a...
11	7309706	Method for the treatment of diseases requiring inhibition or a reduction in the activity of pH value-regulating bicarbonate transporter proteins The use of selective imidazoline receptor agonists, such as moxonidine, rilmenidine, LNP-509, S-23515, PMS-812, PMS-847 and BU-98008, and their physiologically compatible acid addition salts in...
12	7304037	Cytostatic conjugates with integrin ligands The present invention relates to cytostatics which have a tumor-specific action as a result of linkage to α v β 3 integrin antagonists via preferred linking units which can be selectively...
13	7291642	Bradykinin-B1 antagonists, process for their preparation and their use as medicaments The present invention provides bradykinin-B1 antagonists of the formula in which A, Ar, G, Q, R 1 and R 4 are as defined in claim 1, their enantiomers, their diastereomers, their mixtures and...
14	7262223	Amidine derivatives for treating amyloidosis The present invention relates to the use of amidine compounds in the treatment of amyloid-related diseases. In particular, the invention relates to a method of treating or preventing an...
15	7029706	Composition for the treatment of cutaneous mycosis The inventions relates to the use of silica in the formulation of antifungal composition for the treatment of cutaneous mycoses, and method to manufacture an antifungal powder with boric acid and...
16	6878735	Multi-substituted imidazolines and method of use thereof A new class of imidazolines as 4-position acids or esters with very potent anti-inflammatory as well as antimicrobial activity is described. The synthesis of these imidazolines includes a...
17	6838475	Imidazolidinones as NS3-serine protease inhibitors of hepatitis C virus The present invention discloses novel imidazolidinones which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses...
18	6777426	Imidazole and imidazoline derivatives and uses thereof This invention is directed to novel imidazole and imidazoline derivatives which are selective agonists for cloned human α 2 adrenergic receptors. This invention is also related to the use of...
19	6756395	Imidazolinyimethyl aralklsulfonamides Compounds of the Formula: where R 1 -R 6 are those defined herein and methods for producing the same. Also provided are pharmaceutical compositions comprising a Compound of Formula I and...
20	6677341	(R)-Chiral halogenated substituted heteroaryl benzyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity The invention relates to substituted aryl and heteroaryl (R)-Chiral Halogenated 1-Substitutedamino-(n+1)-Alkanol compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma...
21	6649637	Inhibition of intracellular replication by pyridinylimidazoles Substituted pyridinylimidazoles SB203580 and SB202190 strongly inhibit replication and cause stage conversion from active tachyzoites to relatively dormant bradyzoites of the medically important,...
22	6596752	Inhibitors of α4β1 mediated cell adhesion The present invention relates to small molecules according to the formula [I]: which are potent inhibitors of α 4 β 1 mediated adhesion to either VCAM or CS-1 and which can be used for...
23	6589972	β-phenylalanine derivatives as integrin antagonists The present invention relates to compounds of the general formula (1) wherein R 4 is —SO 2 R 4′ , —COOR 4″ , —COR 4′ , —CONR 4′ 2 or —CSNR 4′ 2 ; R 4′ is hydrogen, a...
24	6586478	Methods and compositions for improving sleep Methods and compositions for improving sleep in individuals with sleep disorders or other conditions which interfere with normal sleep via administration of a NO-mimetic are provided.
25	6569862	Methods for treatment of disorders of cardiac contractility The present invention relates to methods for modulating calcium sensitivity of cardiac muscle. In preferred aspects, the invention provides methods for enhancing myocardial contractility and...
26	6552061	Amino acid derivatives and anti-inflammatory agents Provided are an anti-inflammatory agent containing, as an active ingredient, at least one selected from amino acid derivatives represented by formula (I) wherein Ar represents an optionally...
27	6541478	Smoking cessation treatments using naltrexone and related compounds Nicotine dependency is treated by administration of an opioid antagonist. In some embodiments, rapid or ultra rapid detoxification techniques include using a combination of an effective amount of...
28	6503950	Triple drug therapy for the treatment of narcotic and alcohol withdrawal symptoms A triple drug, pharmaceutical kit, composition, and method of treatment containing a combination of effective amounts of at least one anxiolytic agent, at least one centrally acting alpha...
29	6458822	2-oxo-imidazolidine-4-carboxylic acid hydroxamide compounds that inhibit matrix metalloproteinases The present invention relates to a compound of the formula wherein R 1 , R 2 , R 3 and R 4 are as defined above, and pharmaceutically acceptable salts and solvates thereof, that are useful,...
30	6432996	Pharmaceutical composition To provide a pharmaceutical composition which performs a remarkable effect with a relatively decreased dosage, and, with less side effects, a pharmaceutical composition formulated by combination of...
31	6417186	Substituted-phenyl ketone derivatives as IP antagonists This invention relates to compounds which are generally IP receptor modulators, particularly IP receptor antagonists, and which are represented by Formula I: wherein A, R 1 and R 2 are as...
32	6417184	Triple drug therapy for the treatment and prevention of acute or chronic pain A triple drug therapy, pharmaceutical kit, composition, and method of treatment regimen utilized as a combination of effective amounts of an anxiolytic agent, centrally acting alpha antiadrenergic...
33	6410562	Hypoglycemic imidazoline compounds This invention relates to certain novel imidazoline compounds and analogues thereof, to their use for the treatment of diabetes, diabetic complications, metabolic disorders, or related diseases...
34	6380237	Diphenylimidazolines The invention relates to novel diphenylimidazolines of the formula (I) in which Ar 1 , Ar 2 and R are each as defined in the description, and a plurality of processes for their preparation and...
35	6348464	Pyrrolecarbonylimino derivatives as naaladase inhibitors The present invention relates to pharmaceutical compositions and methods of using pyrrolecarbonylimino derivatives to inhibit N-Acetylated α-Linked Acidic Dipeptidase (NAALADase) enzyme activity,...
36	6329369	Methods of treating pain and other conditions Methods of treating glaucoma or elevated pressure and other diseases with reduced side effects by treating a mammal in need thereof an agonist of the alpha 2B or alpha 2B/2C adrenergic receptor(s)....
37	6316483	Oxymetazoline HCI and/or chlorpheniramine maleate nasal spray compositions Aqueous nasal spray compositions comprising a medicament and an aqueous carrier comprising water soluble polymers selected from the group consisting of polyvinylpyrrolidone and mixtures thereof.
38	6294566	Imidazoline derivatives and uses thereof This invention is directed to novel imidazole and imidazoline derivatives which are selective agonists for cloned human α 2 adrenergic receptors. This invention is also related to the use of...
39	6255331	Stable biocidal compositions Disclosed are biocidal compositions comprising mixtures of formaldehyde-releasing imidazolidines, such as 1,3-dimethylol-5,3-dimethylhydantoin, and 3-isothiazolones stabilized with low levels of...
40	6251940	Inflammatory cell inhibitors Compounds of general formula (I) ##STR1## wherein R 4 is an ester or thioester group and R, R 1 , R 2 , and R 3 are as specified in the description, inhibit monocyte and/or macrophage and/or...
41	6162818	2-imidazolinylaminoindole compounds useful as alpha-2 adrenoceptor agonists This invention involves compounds having the following structure: ##STR1## wherein: a) R 1 is hydrogen; or alkyl; bond (a) is a single or a double bond; b) R 2 and R 3 are each independently...
42	6153638	Use of efaroxan for producing medicine for treating huntington 's disease The invention concerns the use of efaroxan or therapeutically-acceptable salts, in its racemic form or in the form of an optically-active isomer, for treating Huntington's disease.
43	6136818	Combination of phentolamine and apomorphine for the treatment of human sexual function and dysfunction A method of treating sexual dysfunction comprising administering a therapeutically effective amount of a combination of phentolamine and apomorphine, as well as pharmaceutical compositions and kits...
44	6133278	Use of quinone and hydroquinone derivatives for the treatment of cachexia A pharmaceutical composition for treating cachexia which containing a compound (I) ##STR1## wherein R 1 , R 2 is H, alkyl, alkoxy, may form --CHCH--CHCH--; R 3 is H, alkyl; R 4 is...
45	6043268	Agent for treatment of viral infections A method for treatment of viral infections which comprises administering to the patients being suffering from said viral infections an effective amount of one or more substances selected from the...
46	6042877	Method for the manufacture of anti-microbial articles A method for making an anti-microbial article is described, the method comprising: providing a substrate; forming a solution comprising a chelating polymer and a metal ion; depositing the solution...
47	6040317	Sulfonamide fibrinogen receptor antagonists A series of non-peptide derivatives that are antagonists of the fibrinogen IIb/IIIa receptor and thus are platelet anti-aggregation compounds useful in the prevention and treatment of diseases...
48	6013660	Externally targeted prophylactic and chemotherapeutic method and agents Methods and associated compositions are provided for the effective treatment of mammalian disease conditions associated with infection by pathogenic organisms through the identification of...
49	5972964	Aminomethylindans, -benzofurans and -benzothiophenes Compounds of formula I ##STR1## wherein R1(cyclo)alk(en)yl, aralkyl, alkyl(oxy)carbonyl, CONH2, etc.; R2H, (cyclo)alk(en)yl, aralkyl, etc.; R3-R5H, halo, alkyl, alkoxy, etc.; R6,R7H,...
50	5965621	Methods and compositions for reducing or maintaining body weight in a mammal A method for reducing or maintaining the level of adipose tissue formation in a mammal includes the step of administering a pantethine composition to the mammal in an amount and for a period of...

Matches 1 - 50 out of 232

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