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5162361 |
Method of treating diseases associated with elevated levels of interleukin 1
The present invention relates to a method of treating diseases associated with elevated levels of interleukin 1 (IL-1) including inflammatory diseases such as arthritis, skin hypersensitivity and...
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5134154 |
Phenoxy-heterocyclic compounds
The present invention is directed to a new class of phenoxy-heterocyclic compounds and to their use as anti-depressants and as anxiolytics.
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5128361 |
Imidazoline derivatives for systemic combating of ectoparasites in host animals
The present invention relates to agents for systemic combating of ectoperasites in host animals, containing a compound of the formul I ##STR1## in which R 1 denotes hydrogen, (C 1 -C 5 )-alkyl,...
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5120713 |
Treatment of obesity with an alpha-2-adrenergic agonist and a growth hormone releasing peptide
Obese patients may be effectively treated by cojointly administering an alpha-2-adrenergic agonist, such as clonidine, and a growth hormone releasing peptide, such as GHRH, to restore or...
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5110824 |
Method of treating disorders of cognitive function with substituted benzamides
The invention relates to the use of benzamide derivatives of the formula: ##STR1## in which: A is a diethylaminoethyl group or a group of the formula II: ##STR2## where R is a C 1 -C 3 alkyl,...
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5106845 |
Calcium antagonists
The present invention is directed to a new class of cyclic guanidines of the formula: ##STR1## in which Q is represented by a substituent selected from the group consisting of (CH 2 ) n in which n...
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5091404 |
Method for restoring functionality in muscle tissue
The use of cyclocreatine to preserve and/or restore the physiological functionality of muscle tissue subject to ischemia.
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5068240 |
Antitumor pharmaceutical compositions and process for preparing the same
A pharmaceutical composition and process for preparing the same is provided, wherein the active ingredient of the said composition is one or more compounds of the general formula /I/ ##STR1## In...
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5051441 |
Imidazoline derivative
Imidazoline derivative of the formula: ##STR1## wherein R is a halogenophenyl group or a pyridyl group and X 1 and X 2 are a hydrogen atom or a lower alkoxy group, or a pharmaceutically...
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5049315 |
Polycarboxylic acid imidazolines, process for the preparation thereof and cleaning agents containing them
The present invention provides polycarboxylic acid imidazolines of the general formula: ##STR1## wherein X is --Cl, --OH, --O--SO 3 H, --O--PO 3 H 2 , --O--CH 2 --CH 2 --COOH, --NH 2 , --NHalk...
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5025015 |
Thioformamidines, and use as medicaments
Formamidine compounds of general formula I ##STR1## in which: R 1 represents H or C 1 -4 alkyl, R 2 represents benzoyl, benzyl, or alphahydroxybenzyl, the aromatic ring being optionally...
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5013750 |
Glycocyamidine derivatives
The glycocyamidine derivatives of the present invention are represented by the following formula (I): ##STR1## wherein R 1 , R 2 and R 3 , which may be the same or different, is hydrogen or a...
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5006523 |
Antiarrhythmic agents: aryl cyanoguanidine potassium channel blockers
Novel compounds of the formula ##STR1## and tautomers thereof are disclosed. These compounds possess potassium channel blocking activity and, as such, are useful as antiarrhythmic agents.
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5001141 |
N-(2-(2-oxo-1-imidazolidinyl)ethyl)-3-phenyl-urea and analogs as agents for induction of antioxidant enzymes
N-[2-(2-oxo-1-imidazolidinyl)ethyl]-3-phenylurea and analogs are useful for protecting against oxygen-derived free radical damage in mammals, by inducing endogenous antioxidant enzymes, including...
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4980349 |
Sulphonamides derived from diarylmethanes, the processes for preparing them and pharmaceutical compositions containing them
The invention relates to new compounds corresponding to formula I: ##STR1## in which: W represents C=O, CH 2 or CHOH, Z represents ##STR2## R 1 and R 2 represent especially Cl or F, R, R' and...
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4973592 |
1,3-diazocycloalkenes as muscarinic receptor blocking agents
New pharmacologically active heterocyclic derivatives as muscarinic receptor blocking agents, useful for the treatment of gastrointestinal disorders, of the following formula ##STR1## wherein the...
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4940723 |
Use of bis-(5-amidino-2-benzimidazolyl) methane (BABIM) to treat arthritis
A method of treating arthritis, and/or bone marrow hyperplasia, osteitis and synovitis, and/or granulomatosis including of the liver and spleen, which comprises administering to a patient an...
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4910215 |
Pharmaceutical formulations designed to stimulate the release of somatotropic hormone
The use of 2,6-dichlorophenyl compounds as active principles in pharmaceutical formulations designed to stimulate the secretion or release of somatotropic hormone in man and animals is described.
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4897412 |
Imidazolines useful in lowering intraocular pressure
Antiglaucoma compounds having beta adrenoreceptor antagonist properties and alpha adrenoreceptor antagonist properties are described. The compounds comprise a beta blocker-derived moiety designed...
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4897411 |
Method of treatment of premenstrual syndrome
A method of using clonidine for the treatment of Premenstrual Syndrome (PMS) in selective subjects to reduce or alleviate subject's manifestation of psychiatric symptoms associated with PMS.
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4889868 |
Bis-imidazolinoamino derivatives as antiallergy compounds
This invention relates to chemical compounds which possess valuable therapeutic activity particularly as lipoxygenase and phospholipase C inhibitors and as platelet-activating factor receptor...
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4876266 |
1-aralkyl-2-mercaptoimidazolines as DBH inhibitors
Disclosed are novel substituted 3-aralkylimidazolines of the structure. ##STR1## processes for their preparation, intermediates useful in their preparation, pharmaceutical compositions containing...
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4871760 |
Use of 2-(N-2,6-dichlorophenyl-N-allylamino)-2-imidazoline as cytoprotective agent
The invention relates to the use of 2-[N-(2,6-dichlorophenyl)-N-allylamino]-2-imidazoline as a cytoprotective agent.
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4863947 |
N-aryl-3-aryl-4,5-dihydro-1H-pyrazole-1-carboxamides and methods of their production
This invention relates to novel N-aryl-3-aryl-4,5-dihydro-1H-pyrazole-1-carboxamide compounds which are useful as pesticides, compositions containing those compounds, methods of controlling pests...
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4800209 |
Method of alleviating withdrawal symptoms
The use of lofexidine and its pharmaceutically acceptable salts in alleviating the adverse symptoms of drug withdrawal, pre-menstrual tension and peri-menopausal flushing is disclosed.
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4789681 |
Cytoprotective guanidine derivatives useful in ischemic diseases
Compounds of the general formula I ##STR1## wherein R 1 is hydrogen or methyl; R 2 and R 3 , which are the same or different, represent hydrogen or methyl, or taken together, form the amidine...
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4788189 |
Method to treat smoking withdrawal symptoms by potentiated central noradrenergic blocking
Administering divided dose of oral Clonidine potentiated by an intramuscular tricyclic antidepressant alleviates the abstinence syndrome resulting from withdrawal of nicotine by smoking cessation....
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4785014 |
Use of clonidine in memory enhancement
Disclosed is a method of treating cognitive decline in a normal aged primate by administering thereto a therapeutically effective amount of 2-[(2,6-dichlorophenyl)-amino]-2-imidazoline or a...
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4783457 |
Pest controlling agents
The invention relates to an invertebrate pest controlling composition comprising an invertebrate pest-controlling amount of a non-formamidine octopamine against having substantial activity toward...
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4746660 |
Process for reducing reflex tachycardia in the treatment of hypertension employing a combination of a diazacyclopentene derivative and a pyridazinone derivative
The invention relates to a new process for the treatment of hypertension and thromboembolic diseases in humans by simultaneous administration of (±)- or...
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4728664 |
Uniquely non-mutagenic substituted nitroimidazole
There is disclosed a substituted nitroimidazole compound, 1-methyl-2-methylsulfonyl-4-nitroimidazole which is an antiprotozoal and bactericidal compound with the unique and surprising property of...
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4678775 |
Method of controlling pests
A method of controlling a pest which comprises bringing into contact with the pest a pest-controlling amount of an agent selected from the group consisting of (1) a non-formamidine -p-octopamine...
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4665095 |
Use of 2-[(3,5-dihalo-4-aminobenzyl)]imidazolines to stimulate alpha-1 adrenergic receptors and to treat nasal congestion
Disclosed herein are alpha adrenergic and nasal decongestant compounds of the formula ##STR1## wherein R 1 and R 2 , each being the same or different, are halogens, and the pharmaceutically...
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4663340 |
Alpha-adrenoreceptor agonistic 2-[(2-cyclopropyl-5-methyl- or 2-cyclopropyl-5-chlorophenoxy)methyl]-2-imidazolines
The present invention relates to imidazolines of general formula (I) ##STR1## and the addition salts formed therefrom with the pharmaceutically acceptable mineral or organic acids, possibly having...
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4659714 |
Anesthetic methods for mammals
Improved methods of anesthesia for mammals, especially humans, are provided wherein the prolonging effect upon local anesthesia which is exhibited by co-administration of vasoconstrictors,...
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4649150 |
Antiulcerogenic amidine derivatives of 2-substituted 4-phenylimidazole
Compounds of the formula ##STR1## wherein R represents substituents of various types; R 1 and R 2 are each independently hydrogen or lower alkyl; R 3 represents substituents of various...
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4647557 |
Novel heterocyclic derivatives bearing an amino radical, processes for their production and the pharmaceutical compositions containing them
This invention relates to novel heterocyclic derivatives bearing an amino group and to processes for making said compounds. More particularly this invention provides novel heterocyclic compounds...
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4634705 |
Adrenergic amidines
Disclosed herein are adrenergic compounds represented by the formula ##STR1## wherein m is 0, 1 or 2; R 1 , R 2 , R 3 and R 7 are taken from the group consisting of hydrogen, hydroxy, loweralkyl,...
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4624960 |
Sedative having analgesic and bradycardiac properties
The invention relates to the use of a substance as a sedative with an analgesic and bradycardiac effect in warm-blooded animals. The possible applications are, for example, in the field of...
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4610999 |
4-substituted Δ2-imidazolinyl-thioethers with prostaglandin-like activity
The present invention relates to 4-substituted Δ2-imidazolinyl-thioethers and to intermediates and processes for their preparation. The components according to the invention are distinguished in...
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4611000 |
5-substituted Δ2-imidazolinyl-thioethers with prostaglandin-like activity
The present invention relates to 5-substituted Δ2-imidazolinyl-thioethers and to intermediates and processes for their preparation. The components according to the invention are distinguished in...
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4598077 |
Amidine derivatives and cardiotonic compositions
Amidine derivatives of the formula ##STR1## wherein R 1 and R 2 , which may be the same or different, represent each a hydrogen atom or a lower alkyl group, or R 1 and R 2 together with an...
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4596818 |
Amidines
A compound of formula (I): ##STR1## or a salt thereof wherein R 1 is halogen, C 1 -4 alkyl or C 1 -4 alkoxy R 2 is hydrogen, halogen, C 1 -4 alkyl or C 1 -4 alkoxy R 3 and R 4 are the...
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4567181 |
Bicyclo (4.2.0) 1,3,5-octatriene compounds and use as α-adrenergics
Compounds of the formula: ##STR1## in which: R 1 and R 2 each represent, independently of one another, hydrogen, halogen, alkyl or alkoxy having from 1 to 4 carbon atoms, sulphonamide possibly...
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4559356 |
2-(Inden-2-yl)-imidazoline derivatives, process for their preparation and pharmaceutical compositions containing them
Compounds of the general formula (I) ##STR1## in which R 1 is a hydrogen atom or a (C 1 -C 4 )-alkyl, benzyl, phenethyl or methoxy group and R 2 is a hydrogen atom or a methyl group, and their...
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4558063 |
Treatment of diarrhoea with 2-aminoimidazoline derivatives
Compounds A--B--C wherein A is 2 imidazolinyl or N-alkyl derivative thereof, B is oxygen, sulphur, CR 1 R 2 wherein R 1 and R 2 are hydrogen or alkyl, or NR 3 wherein R 3 is hydrogen or...
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4540705 |
Antidepressant imidazolines and related compounds
2-(2-Naphthalenyl)alkyl-4,5-dihydro-1H-imidazoles and -tetrahydropyrimidines, the corresponding 3,4-dihydronaphthalenyl and 1,2,3,4-tetrahydronaphthalenyl compounds; and the corresponding indene...
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4532135 |
Renoprotective treatments employing vasodilator compounds
A treatment method and substances have been found to reduce the risk of incurring renal damage or failure. Vasodilators useful for the treatment of hypertension have been found to lower cholesterol...
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4520014 |
Treatment of diarrhoea
Vasoconstrictor α-adrenergic agonists of formula (I) A-B-C (I) wherein, A is a 2-imidazoline group or a guanidine group; B is a chemical bond...
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4478822 |
Drug delivery system utilizing thermosetting gels
This invention relates to a unique drug delivery system for delivering drugs to a body cavity. The drug delivery system comprises a medicament and a polymer such that the drug delivery system is a...
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