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7589214 Thiazoles, imidazoles, and pyrazoles useful as inhibitors of protein kinases  
The present invention relates to compounds useful as inhibitors of protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds, to methods of...
7579369 CB 1 receptor inverse agonists  
The present invention relates to compounds of formula (I) wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , m and X are as defined in the description and claims, and pharmaceutically acceptable salts...
7576221 Substituted imidazole derivatives  
The present invention relates to new substituted imidazole compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with...
7566734 Imidazolyl derivatives  
The present invention is directed to imidazolyl derivatives of formula (I) where the substituents are defined in the specification, which are useful as agonists or antagonists of somatostatin...
7560483 Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof  
The present invention provides a method for synthesizing 1-(acyloxy)-alkyl derivatives from 1-acyl-alkyl derivatives, which typically proceeds stereospecifically, in high yield, does not require...
7560477 Compounds active in sphingosine 1-phosphate signaling  
The present invention relates to S1P analogs that have activity as S1P receptor modulating agents and the use of such compounds to treat diseases associated with inappropriate S1P receptor...
7560446 Use of angiotensin II receptor antagonists for treating acute myocardial infarction  
The invention relates to the use of an angiotensin II receptor antagonist or a pharmaceutically acceptable salt thereof for the manufacture of a medicament for the treatment of acute MI and for the...
7550466 Alpha and/or β-adrenergic antagonists and agonists to treat pain  
The present disclosure provides for improved methods for treating pain, including pain associated with chronic inflammatory diseases, neuropathic pain and cancer by using α-adrenergic antagonists...
7504376 Methods and compositions for increasing the anaerobic working capacity in tissues  
The invention provides compositions comprising beta-alanylhistidine peptides and beta-alanines, and methods for administering these peptides and amino acids. In one aspect, the compositions and...
7498348 1 H-imidazole derivatives as cannabinoid receptor modulators  
The invention relates to a group of 1H-imidazole derivatives which are modulators of cannabinoid receptors, to methods for the preparation of these compounds, to novel intermediates useful for the...
7462618 Treatment of inflammatory autoimmune diseases with alpha-adrenergic antagonists and beta-adrenergic agonists  
The present invention discloses a novel compound and method for the treatment of inflammatory autoimmune diseases, for example, rheumatoid arthritis, using α-adrenergic antagonists and...
7459476 Methods for treating Alzheimer's disease using hydroxyethylene compounds containing a heterocyclic amide bond isostere  
Disclosed are methods for treating Alzheimer's disease, and other diseases, and/or inhibiting beta-secretase enzyme, and/or inhibiting deposition of A beta peptide in a mammal, by use of compounds...
7459446 Treatment of diabetes with copper binding compounds  
Novel methods of treating a patient for diseases, disorders, and conditions including diabetes mellitus, comprising administering, for example, copper binding compounds.
7456179 Methods of treating ischemic related conditions  
The present invention relates to methods of treating ischemia-related conditions by administering to a patient in need of such methods certain thiosemicarbazone compounds. Preferred embodiments of...
7432295 Preparation of compounds useful for the detection of hypoxia  
Novel 18 F-fluorine compounds useful for non-invasive imaging techniques such as PET, for detecting tissue hypoxia and methods for preparing them are disclosed. Novel intermediate compounds and...
7427619 Formulation of amino acids and riboflavin useful to reduce toxic effects of cytotoxic chemotherapy  
Pharmaceutical compositions effective in alleviating or reducing the effects of fatigue and weakness associated with cancer and cancer chemotherapy are disclosed. The pharmaceutical compositions of...
7419998 Therapeutic methods and compositions involving isoflavones  
Therapeutic methods of treatment, compositions and foodstuffs are described which contain isoflavone compounds described by general formula (I), in which Z is H, R 1 is H, or R A CO where R A is...
7402600 Nitroderivatives of cardiovascular agents  
Compounds or their salts having general formulas (I) and (II) wherein: s=is an integer equal to 1 or 2, preferably s=2; b0=0 or 1; A is the radical of a drug and is such as to meet the...
7351429 Oral solid preparation  
The invention is to provide an oral solid pharmaceutical that is uniform in the content of KRP-197, having bladder-selective anticholinergic activity, being a therapeutic drug for pollakiuria and...
7341717 Therapeutic targets for treatment of HCV infections, methods of treating HCV infections and compounds useful therefor  
The present invention relates to the human cellular protein glutathione peroxidase-gastrointestinal as a target for medical intervention against Hepatitis C virus (HCV) infections. Furthermore, the...
7291641 Derivatives of heterocycles with 5 members, their preparation and their use as medicaments  
Thiaxozle, oxazole, imidazole, isoxazole and isoxazoline compounds of the formula wherein Het is thiazole, oxazole, imidazole, isoxazole or isoxazoline, n is an integer from 0 to 6, A is...
7291599 Use of inhibitors of enzymes having activities of amino peptidase N and/or dipeptidyl peptidase IV and of pharmaceutical preparations thereof for a therapy and prevention of chronical neurodegenerative diseases  
The invention relates to a process for the treatment of neurodegenerative diseases wherein mis-folded proteins accumulate in characteristic lesions and contribute substantially to a pathogenesis...
7282503 Fungicidal mixtures based on imidazole derivatives  
Disclosed are fungicidal mixtures containing a synergistically effective amount of A) a triazolopyrimidine of formula I, and B) imidazole derivatives of formula II, wherein X 1 and X 2 represent...
7279498 Substituted aryl amides as IP antagonists  
Compounds effective as IP receptor modulators, particularly IP receptor antagonists, that are of the formula I: wherein A, R 1 , R 2 , R 3 and R 4 are as defined in the specification; and...
7271189 1H-imidazole derivatives as cannabinoid receptor modulators  
The invention relates to a group of 1H-imidazole derivatives which are modulators of cannabinoid receptors, to methods for the preparation of these compounds, to novel intermediates useful for the...
7265135 2-oxy, 2-amino, and 2-thio-imidazole compounds  
The invention relates to novel 2-Oxy, 2-Amino, and 2-Thio-imidazole compounds of formula (I): wherein all variables are as herein defined, pharmaceutical compositions containing the...
7262217 Compositions with anisic acid and glycerides  
This invention relates to formulations containing a combination of anisic acid, or a salt thereof, or an ester thereof, and a C 6-14 fatty acid monoglyceride and to the use of such combinations as...
7247628 Cannabinoid receptor ligands and uses thereof  
Compounds of Formula (I) that act as cannabinoid receptor ligands and their uses in the treatment diseases, conditions and/or disorders herein.
7241790 Compounds active in spinigosine 1-phosphate signaling  
The present invention relates to S1P analogs that have activity as S1P receptor modulating agents and the use of such compounds to treat diseases associated with inappropriate S1P receptor...
7229969 Combinations of enzyme inhibitors and the use thereof  
Combination of inhibitors of dipeptidyl peptidase IV (DP IV) and enzymes having the same substrate specificity (DP IV-analogous enzymatic activity) and inhibitors of alanyl aminopeptidase...
7205327 Imidazole and benzimidazole caspase inhibitors and uses thereof  
This invention provides caspase inhibitors having the formula: wherein R 1 is CO 2 H, CH 2 CO 2 H, or esters, amides or isosteres thereof; R 2 and R 3 are each independently selected from...
7189748 Compounds and methods for treating insulin resistance and cardiomyopathy  
Novel compounds, compositions comprising compounds, and methods for methods for preparing and using compounds are described herein. Methods of treating or ameliorating various conditions, including...
7186734 Aryl imidazoles and related compounds as C5a receptor modulators  
The invention provides Aryl substituted imidazoles, pyrazoles, pyridizines and related compounds of the Formula where the variables are defined herein. Such compounds are ligands of C5a...
7179825 Retinoic acid mimetic anilides  
The present invention is concerned with compounds of formula the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein X represents...
7179817 Carboxylic acid derivatives and drugs containing the same as the active ingredient  
Compounds represented by formula (I), prodrugs thereof and salts thereof, and pharmaceutical compositions comprising the same as an active ingredient (wherein each symbol has the meaning as defined...
7157078 Devices and methods for eliminating termite colonies  
This invention relates to devices, kits, and methods for eliminating termite colonies. The kits, devices, and methods employ a termiticidal bait matrix containing a) a termiticide selected...
7148208 Pharmaceutical compositions for headache, migraine, nausea and emesis  
S-alkylsiothiouronium derivatives such as S-ethylisothiouronium diethylphosphate are used for the treatment of headaches, in particular, migraines, as well as for the prevention or treatment of...
7122547 Anthranilic acid amides and the use thereof as medicaments  
The invention relates to anthranilic acid amides and the use thereof as medicaments for the treatment of diseases that are triggered by persistent angiogenesis, in addition to intermediate products...
7094797 Organ fibrosis inhibitor  
An organ fibrosis inhibitor, in particular, a liver fibrosis inhibitor is provided, which contains histidine, preferable together with cysteine and/or cystine as active ingredients. Owing to the...
7060721 Imidazole compounds and medicinal use thereof  
Imidazole compounds represented by general formula (I): wherein each symbol is as defined in the specification, and salts thereof, and a pharmaceutical composition containing same are provided....
7056938 Method for scavenging radicals with urocanic acid, derivatives and analogues  
Upon exposure to UVB, the epidermal component trans-urocanic acid is not only photoisomerized into cis-urocanic acid, but will also, at least in part, be photooxidized into urocanic acid oxidation...
7048918 Insect bait  
Disclosed are insect baits for attracting insects such as ants, flies and cockroaches. The baits include amino acids and a sugar. The baits can be combined with an insect toxicant to effectively...
7045532 ACE-2 modulating compounds and methods of use thereof  
ACE-2 inhibitors for the treatment of body weight and related disorders are disclosed. ACE-2 inhibitors include peptides and small molecules. Examples of small molecule ACE-2 inhibitors include...
7041692 Methods of treating factor VIIa-associated conditions with compounds having an amine nucleus  
Methods of treating Factor VIIa-associated conditions in a mammal are described, comprising administering to the mammal in need of treatment thereof an effective amount of at least one compound...
7029706 Composition for the treatment of cutaneous mycosis  
The inventions relates to the use of silica in the formulation of antifungal composition for the treatment of cutaneous mycoses, and method to manufacture an antifungal powder with boric acid and...
7026345 Resolution of 3-amino alkylnitriles  
The present invention relates to chiral N-acetyl-alpha-amino acid salts of optically active β-amino alkylnitriles, and also to a process for preparing optically active β-amino alkylnitriles by...
6998414 Substituted arylamides as IP antagonists  
Compounds effective as IP receptor modulators, particularly IP receptor antagonists, that are of the formula I: wherein A, R 1 , R 2 , R 3 and R 4 are as defined in the specification; and...
6987112 Organic compound having cyano group and insecticides/miticides  
The present invention is directed to compounds represented by Formula (1); wherein A, R, X, Y and n are as defined in the description, the salts thereof, and insecticide/acaricide compositions...
6984645 Dual inhibitors of adipocyte fatty acid binding protein and keratinocyte fatty acid binding protein  
Compounds that are dual aP2/k-FABP inhibitors are provided having the formula wherein A, B, X, Y, R 1 , R 2 and R 3 are as described herein. A method is also provided for treating diabetes...
6979696 Method for detecting a gram-negative bacterial autoinducer molecule  
This invention relates to compounds which are alpha-1 receptor agonists, preferably alpha-1A/L receptor agonists, and which are represented by Formula I: wherein m, A, X, Y, R 1 , R 2 , R 3 ,...