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7589214 |
Thiazoles, imidazoles, and pyrazoles useful as inhibitors of protein kinases
The present invention relates to compounds useful as inhibitors of protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds, to methods of...
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7579369 |
CB 1 receptor inverse agonists
The present invention relates to compounds of formula (I)
wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , m and X are as defined in the description and claims, and pharmaceutically acceptable salts...
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7576221 |
Substituted imidazole derivatives
The present invention relates to new substituted imidazole compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with...
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7566734 |
Imidazolyl derivatives
The present invention is directed to imidazolyl derivatives of formula (I) where the substituents are defined in the specification, which are useful as agonists or antagonists of somatostatin...
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7560483 |
Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof
The present invention provides a method for synthesizing 1-(acyloxy)-alkyl derivatives from 1-acyl-alkyl derivatives, which typically proceeds stereospecifically, in high yield, does not require...
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7560477 |
Compounds active in sphingosine 1-phosphate signaling
The present invention relates to S1P analogs that have activity as S1P receptor modulating agents and the use of such compounds to treat diseases associated with inappropriate S1P receptor...
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7560446 |
Use of angiotensin II receptor antagonists for treating acute myocardial infarction
The invention relates to the use of an angiotensin II receptor antagonist or a pharmaceutically acceptable salt thereof for the manufacture of a medicament for the treatment of acute MI and for the...
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7550466 |
Alpha and/or β-adrenergic antagonists and agonists to treat pain
The present disclosure provides for improved methods for treating pain, including pain associated with chronic inflammatory diseases, neuropathic pain and cancer by using α-adrenergic antagonists...
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7504376 |
Methods and compositions for increasing the anaerobic working capacity in tissues
The invention provides compositions comprising beta-alanylhistidine peptides and beta-alanines, and methods for administering these peptides and amino acids. In one aspect, the compositions and...
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7498348 |
1 H-imidazole derivatives as cannabinoid receptor modulators
The invention relates to a group of 1H-imidazole derivatives which are modulators of cannabinoid receptors, to methods for the preparation of these compounds, to novel intermediates useful for the...
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7462618 |
Treatment of inflammatory autoimmune diseases with alpha-adrenergic antagonists and beta-adrenergic agonists
The present invention discloses a novel compound and method for the treatment of inflammatory autoimmune diseases, for example, rheumatoid arthritis, using α-adrenergic antagonists and...
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7459476 |
Methods for treating Alzheimer's disease using hydroxyethylene compounds containing a heterocyclic amide bond isostere
Disclosed are methods for treating Alzheimer's disease, and other diseases, and/or inhibiting beta-secretase enzyme, and/or inhibiting deposition of A beta peptide in a mammal, by use of compounds...
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7459446 |
Treatment of diabetes with copper binding compounds
Novel methods of treating a patient for diseases, disorders, and conditions including diabetes mellitus, comprising administering, for example, copper binding compounds.
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7456179 |
Methods of treating ischemic related conditions
The present invention relates to methods of treating ischemia-related conditions by administering to a patient in need of such methods certain thiosemicarbazone compounds. Preferred embodiments of...
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7432295 |
Preparation of compounds useful for the detection of hypoxia
Novel 18 F-fluorine compounds useful for non-invasive imaging techniques such as PET, for detecting tissue hypoxia and methods for preparing them are disclosed. Novel intermediate compounds and...
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7427619 |
Formulation of amino acids and riboflavin useful to reduce toxic effects of cytotoxic chemotherapy
Pharmaceutical compositions effective in alleviating or reducing the effects of fatigue and weakness associated with cancer and cancer chemotherapy are disclosed. The pharmaceutical compositions of...
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7419998 |
Therapeutic methods and compositions involving isoflavones
Therapeutic methods of treatment, compositions and foodstuffs are described which contain isoflavone compounds described by general formula (I), in which Z is H, R 1 is H, or R A CO where R A is...
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7402600 |
Nitroderivatives of cardiovascular agents
Compounds or their salts having general formulas (I) and (II) wherein: s=is an integer equal to 1 or 2, preferably s=2; b0=0 or 1; A is the radical of a drug and is such as to meet the...
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7351429 |
Oral solid preparation
The invention is to provide an oral solid pharmaceutical that is uniform in the content of KRP-197, having bladder-selective anticholinergic activity, being a therapeutic drug for pollakiuria and...
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7341717 |
Therapeutic targets for treatment of HCV infections, methods of treating HCV infections and compounds useful therefor
The present invention relates to the human cellular protein glutathione peroxidase-gastrointestinal as a target for medical intervention against Hepatitis C virus (HCV) infections. Furthermore, the...
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7291641 |
Derivatives of heterocycles with 5 members, their preparation and their use as medicaments
Thiaxozle, oxazole, imidazole, isoxazole and isoxazoline compounds of the formula
wherein Het is thiazole, oxazole, imidazole, isoxazole or isoxazoline, n is an integer from 0 to 6, A is...
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7291599 |
Use of inhibitors of enzymes having activities of amino peptidase N and/or dipeptidyl peptidase IV and of pharmaceutical preparations thereof for a therapy and prevention of chronical neurodegenerative diseases
The invention relates to a process for the treatment of neurodegenerative diseases wherein mis-folded proteins accumulate in characteristic lesions and contribute substantially to a pathogenesis...
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7282503 |
Fungicidal mixtures based on imidazole derivatives
Disclosed are fungicidal mixtures containing a synergistically effective amount of A) a triazolopyrimidine of formula I, and B) imidazole derivatives of formula II, wherein X 1 and X 2 represent...
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7279498 |
Substituted aryl amides as IP antagonists
Compounds effective as IP receptor modulators, particularly IP receptor antagonists, that are of the formula I:
wherein A, R 1 , R 2 , R 3 and R 4 are as defined in the specification; and...
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7271189 |
1H-imidazole derivatives as cannabinoid receptor modulators
The invention relates to a group of 1H-imidazole derivatives which are modulators of cannabinoid receptors, to methods for the preparation of these compounds, to novel intermediates useful for the...
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7265135 |
2-oxy, 2-amino, and 2-thio-imidazole compounds
The invention relates to novel 2-Oxy, 2-Amino, and 2-Thio-imidazole compounds of formula (I):
wherein all variables are as herein defined, pharmaceutical compositions containing the...
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7262217 |
Compositions with anisic acid and glycerides
This invention relates to formulations containing a combination of anisic acid, or a salt thereof, or an ester thereof, and a C 6-14 fatty acid monoglyceride and to the use of such combinations as...
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7247628 |
Cannabinoid receptor ligands and uses thereof
Compounds of Formula (I) that act as cannabinoid receptor ligands and their uses in the treatment diseases, conditions and/or disorders herein.
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7241790 |
Compounds active in spinigosine 1-phosphate signaling
The present invention relates to S1P analogs that have activity as S1P receptor modulating agents and the use of such compounds to treat diseases associated with inappropriate S1P receptor...
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7229969 |
Combinations of enzyme inhibitors and the use thereof
Combination of inhibitors of dipeptidyl peptidase IV (DP IV) and enzymes having the same substrate specificity (DP IV-analogous enzymatic activity) and inhibitors of alanyl aminopeptidase...
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7205327 |
Imidazole and benzimidazole caspase inhibitors and uses thereof
This invention provides caspase inhibitors having the formula:
wherein R 1 is CO 2 H, CH 2 CO 2 H, or esters, amides or isosteres thereof; R 2 and R 3 are each independently selected from...
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7189748 |
Compounds and methods for treating insulin resistance and cardiomyopathy
Novel compounds, compositions comprising compounds, and methods for methods for preparing and using compounds are described herein. Methods of treating or ameliorating various conditions, including...
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7186734 |
Aryl imidazoles and related compounds as C5a receptor modulators
The invention provides Aryl substituted imidazoles, pyrazoles, pyridizines and related compounds of the Formula
where the variables are defined herein.
Such compounds are ligands of C5a...
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7179825 |
Retinoic acid mimetic anilides
The present invention is concerned with compounds of formula
the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein X represents...
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7179817 |
Carboxylic acid derivatives and drugs containing the same as the active ingredient
Compounds represented by formula (I), prodrugs thereof and salts thereof, and pharmaceutical compositions comprising the same as an active ingredient (wherein each symbol has the meaning as defined...
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7157078 |
Devices and methods for eliminating termite colonies
This invention relates to devices, kits, and methods for eliminating termite colonies. The kits, devices, and methods employ a termiticidal bait matrix containing
a) a termiticide selected...
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7148208 |
Pharmaceutical compositions for headache, migraine, nausea and emesis
S-alkylsiothiouronium derivatives such as S-ethylisothiouronium diethylphosphate are used for the treatment of headaches, in particular, migraines, as well as for the prevention or treatment of...
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7122547 |
Anthranilic acid amides and the use thereof as medicaments
The invention relates to anthranilic acid amides and the use thereof as medicaments for the treatment of diseases that are triggered by persistent angiogenesis, in addition to intermediate products...
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7094797 |
Organ fibrosis inhibitor
An organ fibrosis inhibitor, in particular, a liver fibrosis inhibitor is provided, which contains histidine, preferable together with cysteine and/or cystine as active ingredients. Owing to the...
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7060721 |
Imidazole compounds and medicinal use thereof
Imidazole compounds represented by general formula (I):
wherein each symbol is as defined in the specification, and salts thereof, and a pharmaceutical composition containing same are provided....
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7056938 |
Method for scavenging radicals with urocanic acid, derivatives and analogues
Upon exposure to UVB, the epidermal component trans-urocanic acid is not only photoisomerized into cis-urocanic acid, but will also, at least in part, be photooxidized into urocanic acid oxidation...
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7048918 |
Insect bait
Disclosed are insect baits for attracting insects such as ants, flies and cockroaches. The baits include amino acids and a sugar. The baits can be combined with an insect toxicant to effectively...
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7045532 |
ACE-2 modulating compounds and methods of use thereof
ACE-2 inhibitors for the treatment of body weight and related disorders are disclosed. ACE-2 inhibitors include peptides and small molecules. Examples of small molecule ACE-2 inhibitors include...
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7041692 |
Methods of treating factor VIIa-associated conditions with compounds having an amine nucleus
Methods of treating Factor VIIa-associated conditions in a mammal are described, comprising administering to the mammal in need of treatment thereof an effective amount of at least one compound...
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7029706 |
Composition for the treatment of cutaneous mycosis
The inventions relates to the use of silica in the formulation of antifungal composition for the treatment of cutaneous mycoses, and method to manufacture an antifungal powder with boric acid and...
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7026345 |
Resolution of 3-amino alkylnitriles
The present invention relates to chiral N-acetyl-alpha-amino acid salts of optically active β-amino alkylnitriles, and also to a process for preparing optically active β-amino alkylnitriles by...
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6998414 |
Substituted arylamides as IP antagonists
Compounds effective as IP receptor modulators, particularly IP receptor antagonists, that are of the formula I:
wherein A, R 1 , R 2 , R 3 and R 4 are as defined in the specification; and...
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6987112 |
Organic compound having cyano group and insecticides/miticides
The present invention is directed to compounds represented by Formula (1);
wherein A, R, X, Y and n are as defined in the description, the salts thereof, and insecticide/acaricide compositions...
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6984645 |
Dual inhibitors of adipocyte fatty acid binding protein and keratinocyte fatty acid binding protein
Compounds that are dual aP2/k-FABP inhibitors are provided having the formula
wherein A, B, X, Y, R 1 , R 2 and R 3 are as described herein. A method is also provided for treating diabetes...
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6979696 |
Method for detecting a gram-negative bacterial autoinducer molecule
This invention relates to compounds which are alpha-1 receptor agonists, preferably alpha-1A/L receptor agonists, and which are represented by Formula I:
wherein m, A, X, Y, R 1 , R 2 , R 3 ,...
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