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8093292 |
Methods for the treatment of HIV-1 related fat maldistribution, fasting hyperlipidemia and modification of adipocyte physiology
Methods for treating or preventing metabolic dysregulation of adipocytes resulting from HIV-1 infection or chronic inflammation are disclosed. The compositions contain a conjugated fatty acid, a...
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8067394 |
Synthesis and biological activities of new tricyclic-bis-enones (TBEs)
This invention describes novel tricyclic-bis-enone derivatives (TBEs), such as TBE-31, TBE-34, TBE-45 and water-soluble TBEs. The methods of preparing these compounds are also disclosed. The...
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8067381 |
Methods and compositions for increasing the anaerobic working capacity in tissues
Provided are compositions comprising beta-alanylhistidine peptides and/or beta-alanines, and methods for administering these peptides and amino acids. In one aspect, the compositions and methods...
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8053439 |
Benzophenone derivatives useful for inhibiting formation of microtubule
Disclosed herein are novel benzophenone derivatives represented by formula I, a pharmaceutically acceptable salt thereof, a hydrate thereof or a solvate thereof, a pharmacological composition...
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8053427 |
Brimonidine gel composition
Improved topical gel compositions, such as those containing brimonidine, for the treatment of skin disorders are described. The gel compositions contain carbomer and methylparaben, and are...
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8034836 |
Amino acid compounds
An Amino Acid Compound is described. The Amino Acid Compound may comprise an Amino Acid and one of a Nitrate and a Nitrite. The Amino Acid may be one of Aspartic Acid, Cysteine, Glycine, Lysine,...
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8030339 |
Imidazole derivatives for the treatment of anxiety and related diseases
This invention relates to novel imidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds of the invention are useful in the...
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8026268 |
Method for scavenging radicals with urocanic acid, derivatives and analogues
The invention relates to antioxidants or radical scavengers and their reaction products. The invention provides compounds and compositions for use in methods for scavenging radicals or for...
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8017159 |
Phospholipid gel compositions for delivery of aptamers and methods of treating conditions using same
The present invention relates to pharmaceutical compositions in the form of a gel for controlled- or sustained-release of an aptamer and to methods for treating or preventing a condition in an...
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8017642 |
Functionally selective ALPHA2C adrenoreceptor agonists
In its many embodiments, the present invention provides a novel class of naphthene- and indane-type as inhibitors of α2C adrenergic receptor agonists, methods of preparing such compounds, ...
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7994206 |
Crystals and process of making 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1H-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid
The present invention relates to a novel crystals of 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-
[1-(4-phenyl-1h-imidazol-2-yl)-ethyl]-amino}-methyl)-2-metho
xy-benzoic acid and...
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7973068 |
Arthroscopic irrigation solution and method for peripheral vasoconstriction and inhibition of pain and inflammation
A method and solution for perioperatively inhibiting a variety of pain and inflammation processes during arthroscopic procedures. The solution preferably includes a vasoconstrictor that exhibits...
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7968124 |
Compositions for the reversal and detoxification of anesthetics and other compounds and methods of their use
Methods of attenuating the toxic or medically undesirable effects of drugs and toxins in a human by administering to a human an injectable formulation comprised of a dispersion of particles...
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7960350 |
Composition and method for the treatment of eye disease
Embodiments of the invention disclosed herein relate to methods of preventing and/or ameliorating one or more symptoms associated with an eye disease such as dry eye syndrome, cataracts of the eye...
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7939556 |
Imidazole derivatives and their use for modulating the GABAA receptor complex
This invention relates to novel imidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds of the invention are useful in the...
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7935359 |
Use of L 2-thiohistidine or one of its derivatives as a depigmenting agent in cosmetics
The invention relates to the use of L-2-thiohistidine, or a cosmetically acceptable salt or ester of its acid group, as a depigmenting agent in a cosmetic composition or for the preparation of a...
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7932282 |
Imidazolidine carboxamide derivatives as P2X7 modulators
The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof: The compounds or salts modulate P2X7 receptor function and are capable of antagonizing the...
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7928133 |
Compounds and compositions as hedgehog signaling pathway modulators
The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from...
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7928094 |
Treatment of diabetes with copper binding compounds
Novel methods of treating a patient for diseases, disorders, and conditions including diabetes mellitus, comprising administering, for example, copper binding compounds.
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7879896 |
Dual-acting imidazole antihypertensive agents
The invention is directed to compounds having the formula: wherein: Ar, r, R2-3, X, and R5-7 are as defined in the specification, and pharmaceutically acceptable salts thereof. These compounds have...
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7875645 |
Method for the treatment of CNS disorders with substituted 2-imidazoles or imidazole derivatives
The present invention relates a method for treating depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder, stress-related disorders, psychotic disorders such as...
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7842709 |
Method for treating inflammatory diseases of the digestive tract
A method for treating an inflammatory disease of the digestive tract, for example inflammatory bowel disease, in a subject comprises administering to the subject a therapeutically effective amount...
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7842708 |
Arylpropionamide, arylacrylamide, arylpropynamide, or arylmethylurea analogs as factor XIa inhibitors
The present invention provides compounds of Formula (I): or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, L1, M and R11 are as defined...
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7838513 |
Anti-cancer therapy comprising an H2-blocker, at least one antiinflammatory agent and a cytotoxic agent
The present invention relates to the treatment of a mammal with a pharmaceutical composition comprising an H2-blocker, at least one anti-inflammatory agent, a cytotoxic agent and, optionally,...
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7825084 |
Methods and compositions for increasing the anaerobic working capacity in tissues
Provided are compositions comprising beta-alanylhistidine peptides and beta-alanines, and methods for administering these peptides and amino acids. In one aspect, the compositions and methods cause...
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7825150 |
Compositions and methods for treating immunological and inflammatory diseases and disorders
Methods and compositions for treating immunological and inflammatory diseases and disorders are disclosed. Particular methods and compositions comprise the administration of an agent that inhibits...
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7812048 |
Glucokinase activators and methods of using same
Compounds are provided which are activators of the enzyme glucokinase and thus are useful in treating diabetes and related diseases, which compounds have the structure where Q is and R1, R2, R3,...
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7803776 |
Combined use of enzyme inhibitors and of pharmaceutical compositions thereof
Provided are combinations of inhibitors of dipeptidyl peptidase IV (DP IV) and of enzymes having the same substrate specificity (DP IV-analogous enzymatic activity) and inhibitors of alanyl...
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7795239 |
Saccharide compositions and method of use
Saccharide compositions and methods of their use to (a) treat functional bowel disorders, (b) gastroesophageal reflux disease and (c) syndromes of nausea, vomiting and diarrhea in man and animals....
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7790724 |
c-fms kinase inhibitors
The invention is directed to compounds of Formula II: wherein A, R1, R2, R3, R4, X, Y and W are set forth in the specification, as well as solvates, hydrates, tautomers or pharmaceutically...
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7781435 |
Imidazole compounds for the treatment of neurological disorders
The present invention relates to compounds of Formula I wherein R1, R2, R3, R4, R6, R7 and A are as defined. Compounds of Formula I have activity inhibiting production of Aβ-peptide. The invention ...
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7767667 |
Pesticidal heterocycles
It has now been found that certain novel heterocyclic derivitives have provided unexpected insecticidal activity. These compounds are represented by formula (I): R Preferred are those compounds of...
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7767704 |
Antiviral 4-aminocarbonylamino-substituted imidazole compounds
The invention relates to the substituted imidazoles of formula (I) and to methods for producing the same, to their use in the treatment and/or prophylaxis of diseases and to their use for producing...
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7754679 |
Pharmaceutical compositions for the administration of aptamers
Pharmaceutical compositions comprising an aptamer and an amino acid ester or amide or an aptamer; a divalent metal cation; and a carboxylic acid, a phospholipid, a phosphatidyl choline, or a...
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7750032 |
Compounds and compositions as PPAR modulators
The invention provides trisubstituted pyrazoles and imidazoles of Formula I: wherein L2, q, R13, R14, R15, R16, Z1 and Z2 are as described in the Summary of the Invention; and methods of using such...
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7741323 |
Indene derivatives and process for the preparation thereof
An indene derivative for selectively modulating the activities of peroxisome proliferator activated receptors (PPARs) having the following formula (I): wherein, R1 is C1-6 alkyl, C1-6 alkenyl, or...
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7741347 |
Hepatitis C virus inhibitors
The present disclosure relates to compounds, compositions and methods for the treatment of Hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such...
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7687473 |
5-amino-4-imidazolecarboxamide riboside and its nucleobase as potentiators of antifolate transport and metabolism
The present invention provides a method for increasing the efficacy of antifolates which act via inhibition of dihydrofolate reductase (DHFR). The method comprises the steps of administration of...
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7649005 |
Substituted benzylaminoalkylene heterocycles
This invention is related to compounds of general formula (I) wherein X is oxygen or sulphur or a NR7 group; R1 is C3-C8 alkyl, or C1-C8 alkyl substituted by phenoxy or phenyl, both phenoxy or...
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7638546 |
Imidazolyl derivatives
The present invention is directed to imidazolyl derivatives of formula (I) where the substituents are defined in the specification, which are useful as agonist or antagonists of somatostatin...
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7579369 |
CB 1 receptor inverse agonists
The present invention relates to compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, m and X are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The...
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7560446 |
Use of angiotensin II receptor antagonists for treating acute myocardial infarction
The invention relates to the use of an angiotensin II receptor antagonist or a pharmaceutically acceptable salt thereof for the manufacture of a medicament for the treatment of acute MI and for the...
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7560477 |
Compounds active in sphingosine 1-phosphate signaling
The present invention relates to S1P analogs that have activity as S1P receptor modulating agents and the use of such compounds to treat diseases associated with inappropriate S1P receptor...
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7560483 |
Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof
The present invention provides a method for synthesizing 1-(acyloxy)-alkyl derivatives from 1-acyl-alkyl derivatives, which typically proceeds stereospecifically, in high yield, does not require...
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7550466 |
Alpha and/or β-adrenergic antagonists and agonists to treat pain
The present disclosure provides for improved methods for treating pain, including pain associated with chronic inflammatory diseases, neuropathic pain and cancer by using α-adrenergic antagonists ...
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7504376 |
Methods and compositions for increasing the anaerobic working capacity in tissues
The invention provides compositions comprising beta-alanylhistidine peptides and beta-alanines, and methods for administering these peptides and amino acids. In one aspect, the compositions and...
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7498348 |
1 H-imidazole derivatives as cannabinoid receptor modulators
The invention relates to a group of 1H-imidazole derivatives which are modulators of cannabinoid receptors, to methods for the preparation of these compounds, to novel intermediates useful for the...
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7462618 |
Treatment of inflammatory autoimmune diseases with alpha-adrenergic antagonists and beta-adrenergic agonists
The present invention discloses a novel compound and method for the treatment of inflammatory autoimmune diseases, for example, rheumatoid arthritis, using α-adrenergic antagonists and ...
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7459476 |
Methods for treating Alzheimer's disease using hydroxyethylene compounds containing a heterocyclic amide bond isostere
Disclosed are methods for treating Alzheimer's disease, and other diseases, and/or inhibiting beta-secretase enzyme, and/or inhibiting deposition of A beta peptide in a mammal, by use of compounds...
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7459446 |
Treatment of diabetes with copper binding compounds
Novel methods of treating a patient for diseases, disorders, and conditions including diabetes mellitus, comprising administering, for example, copper binding compounds.
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