Matches 401 - 450 out of 713 < 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >


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5348739 Combined anti-tumor therapy with interleukin-2 and histamine, analogs thereof or H2 -receptor agonists  
A method of inhibiting the development of malignant tumors and the formation of metastases of malignant tumor cells in a subject carrying the comprises administering to the subject IL-2 and an...
5346887 Glaucoma treatment  
A method and a composition for treating or reducing and/or controlling intraocular pressure comprising administering an effective amount of a renin inhibiting compound of the formula: ##STR1##...
5338740 Angiotensin II receptor antagonists  
The present invention relates to novel heterocyclic derivatives of the formula Ar--W--Hetwherein Ar, W and Het are as defined below, and related compounds, pharmaceutical compositions comprising...
5338749 Diaryl-substituted heterocyclic compounds, their preparation and drigs and cosmetics obtained therefrom  
Compounds of formula I ##STR1## and compounds of formula Ia ##STR2## where the substituents are as defined in the specification.
5326762 Inhibitors of acyl-coenzyme A: cholesterol acyl transferase  
Amides of the formula ##STR1## wherein R1 and R2 are independently heteroaryl, X-substituted heteroaryl, X-substituted phenyl, N-substituted triazinyl or N-substituted imidazolyl; and in addition,...
5324728 Naphthoic acid derivative  
A naphthoic acid derivative represented by the following general formula or a salt thereof: ##STR1## wherein R1, R2 and R3 are each independently a hydrogen atom, a halogen atom, a hydroxyl group,...
5321039 Method of inducing a histamine agonist action on H2 receptors  
The invention claims as drugs which are active as agonists of the histamine H3 receptor, the O-[2-(4(5-imidazolyl)-ethyl] isothiourea, 4-(4(5)-imidazolyl) butyramidine and...
5312828 Substituted imidazoles having angiotensin II receptor blocking activity  
Angiotensin II receptor antagonists having the formula: ##STR1## which are useful in regulating hypertension and in the treatment of congestive heart failure, renal failure, and glaucoma,...
5302610 Renal-selective biphenylmethyl imidazole angiotensin II antagonists for treatment of hypertension  
Renal-selective compounds are described which, in one embodiment, are prodrugs preferentially converted in the kidney to compounds capable of blocking angiotensin II (AII) receptors. These prodrugs...
5296493 1-substituted-2-(N-pheny l-N-(phenylmethyl)methanamine)-4,5-dihydro-imidazoles and related compounds and their use in treating calcium overload in brain cells  
The present patent application discloses compounds of the formula ##STR1## wherein R1 is C1-10 saturated or unsaturated alkyl; or ##STR2## wherein R'" is H or ##STR3## R2 is phenyl which is...
5294440 Composition for treatment of cold sores  
A pharmaceutical composition of water, water soluble vinyl polymer gel, amine alcohol dispersant and 1H-imidazole-4-ethanamine, phosphate (IEP) is used topically to treat herpes labialis lesions.
5294634 Osteogenesis promoter  
The present invention relates to an orally-administrable osteogenesis promoter, which comprises, as an active ingredient, a zinc salt or complex of L-carnosine, has excellent...
5292887 Substituted imidazole derivatives and their preparation and use  
Compounds of the formula: ##STR1## wherein X is --CH2 -- or ##STR2## R1 is H, C1-5 -alkyl or benzyl, which can be substituted or unsubstituted R2 is H, C1-4 -alkyl, OH or C1-3 -alkoxy R3 is H, CH3,...
5292755 USPA benzolyguanidines  
Benzoylguanidines of the formula I ##STR1## where R(1) or R(2) is equal to R(6)--S(O)n -- or R(7)R(8)N--O2 S-- and the other substituent R(1) or R(2) is in each case equal to H, F, Cl, Br, I,...
5286739 Parenteral formulations for the inhibition of systemic hypotension associated with nitric oxide production or endothelial derived relaxing factor  
An anti-hypotensive formulation comprising an essentially arginine-free or low arginine (less than about 0.1%, most preferably, about 0.01%) containing mixture of amino acids is provided. The...
5284645 Fluorocarbon emulsions containing amino acid based anti-inflamatory agents and buffer systems  
Disclosed are fluorocarbon emulsions comprising amino acids and substances related to amino acids, such as substituted amino acids or amphoteric groups of amino acid side chains, for example, the...
5284876 Method of treating tardive dyskinesia using dopaminergic agents of prodrugs of therapeutic agents  
This invention pertains to a method for treating a subject for Tardive Dyskinesia by administering a dopaminergic agent to the subject such that the dopaminergic agent enters the brain or by...
5280034 Bis-heterocyclic prostaglandin analogs  
Thromboxane receptor antagonist activity is exhibited by compounds of the formula ##STR1## wherein: W is --(CH2)m -- or ##STR2## but if R3 and R4 complete an aromatic ring, then W cannot be...
5278148 Amino acid derivatives useful for treating high blood pressure  
Compounds of the formula ##STR1## wherein R1 is hydrogen or methyl, R2 is ethyl, propyl, isopropyl, imidazol-2-yl, imidazol-4-yl, pyrazol-3-yl, thiazol-4-yl, thien-2-yl, ethoxycarbonyl,...
5276018 Composition comprising amino acids and methods for decreasing muscle breakdown  
The present invention provides compositions and methods for decreasing tissue breakdown in mammals. Specifically, tissue breakdown in a mammal can be decreased by the administration of composition,...
5273984 Salts formed between basic histamine H2 -receptor antagonists and bismuth complexes  
The invention relates to salts formed between basic H2 -receptor antagonists and a complex of bismuth with a carboxylic acid, and solvates of such salts, excluding salts in which the basic H2...
5273993 Compounds having one or more aminosulfonyloxy radicals useful as pharmaceuticals  
Methods of treating chronic arthritis and osteoporosis which utilize both known and novel compounds which would fall under the general formula: (HO)p--A--[--OS(O)2 NR1 R2 ]zwherein A encompasses a...
5273991 Imidazole-containing compositions and methods of use thereof analogs of distamycin  
The present invention relates to oligopeptide derivatives that are conjugated to DNA alkylating agents, having the formula ##STR1## wherein m is 0 to 4; n is 2 to 4; each R1 is the same or...
5272176 Advanced glycation inhibitors containing amino-benzoic acids and derivatives, and methods of use  
The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises an agent capable of...
5266585 Arylphenyl ether derivatives, compositions containing these compounds and use thereof  
Arylphenyl ether derivatives of the formula ##STR1## wherein Az is 1H-(1,2,4-triazolyl) or is 1-imidazolyl optionally substituted by alkyl, each of Ra and Rb is hydrogen, halogen, alkyl, alkoxy or...
5266318 Skin therapeutic mixture containing cold-processsed aloe vera extract, with yellow sap and aloin removed  
According to present invention, a non-ionic skin therapeutic mixture useful for treatment of irradiated skin, open sores, wounds and abrasions is comprised of an extract of cold-processed aloe vera...
5264441 Disubstituted ureas and thioureas derivatives  
The invention provides new ureas and thioureas derivatives of general formula (I) ##STR1## and pharmaceutically acceptable salts thereof, which are useful as therapeutic agents such as for the...
5260048 Tissue fixative solution and method  
A tissue fixative solution and method is disclosed which comprises a histological fixing composition of diazolidinyl urea, 2-bromo-2-nitropropane-1,3-diol and a water-soluble zinc salt such as zinc...
5258398 Antithrombotic diaminoalkanoic acid derivatives  
This invention relates to novel diaminoalkanoic acid derivatives that inhibit platelet aggregation and thrombus formation in mammalian blood thereby being useful in the prevention and treatment of...
5256657 Succinamide derivative matrix-metalloprotease inhibitors  
Compounds having the structural formula ##STR1## wherein X is HONH or HO and especially wherein the carbon atom bearing CH2 R1 has the R-configuration, the carbon atom bearing CH2 R2 has the...
5248689 Substituted N-(imidazolyl)alkyl alanine derivatives  
Angiotensin II receptor antagonists having the formula: ##STR1## which are useful in regulating hypertension and in the treatment of congestive heart failure, renal failure, and glaucoma,...
5246959 Poly(aminoalkyl)aminocarbonyl aminoacyl aminodiol amino acid derivatives as anti-hypertensive agents  
Non-peptidyl compounds characterized generally as poly(aminoalkyl)aminocarbonyl aminoacyl aminodiol derivatives of amino acids are useful as renin inhibitors for the treatment of hypertension....
5240940 Quinoline and cinnoline fungicide compositions  
Fungicidal compositions comprise a combination of two fungicides, one of which is a quinoline or cinnoline compound of the formula (1) ##STR1## the substituents being as described in the...
5238931 Inflammatory bowel disease preventive and curative agent containing zinc L-carnosine salt as active ingredient  
An agent for the prevention and treatment of inflammatory bowel disease (IBD) containing at least one of zinc L-carnosine salts and complexes as an active ingredient. A use of the zinc L-carnosine...
5236928 Imidazole derivatives bearing acidic functional groups at the 5-position, their compositions and methods of use as angiotensin II antagonists  
There are disclosed substituted imidazole derivatives of Formula I bearing acidic functional groups which are useful as angiotensin II antagonists. ##STR1##
5234917 Substituted 5-(alkyl)carboxamide imidazoles  
Angiotensin II receptor antagonists having the formula: ##STR1## which are useful in regulating hypertension and in the treatment of congestive heart failure, renal failure, and glaucoma...
5234939 3,5-di-tertiary-butyl-4-hydroxyphenyl imidazolyl methanones and related compounds as antiinflammatory agents  
The novel 3,5-di-tertiary-butyl 4-hydroxyphenylimidazolyl methanones and methanone oximes of the present invention are antiinflammatory agents having activity as inhibitors of 5-lipoxygenase,...
5229369 Aminoalkylaminocarbonyl aminodiol amino acid derivatives as anti-hypertensive agents  
Non-peptidyl compounds characterized generally as aminoalkylaminocarbonyl aminodiol derivatives of amino acids are useful as renin inhibitors for the treatment of hypertension. Compounds of...
5229137 Methods and pharmaceutical compositions for treating episodic heartburn  
Pharmaceutical medications and methods are disclosed for providing instant and sustained relief from pain or symptoms associated with episodic heartburn in humans. The medications consist...
5223525 Pesticidal 1-arylimidazoles  
The invention describes novel 1-arylimidazoles of formula (I) ##STR1## wherein typically preferred substituents are: X is S(O)n R1, in which R1 is an alkyl group, preferably a methyl group, which...
5221688 Imidazole derivatives  
The invention relates to salts formed between basic H2 -receptor antagonists and a complex of zinc with a carboxylic acid selected from tartaric acid, citric acid and alkyl citric acids, and to...
5219870 Omeprazole compositions designed for administration in rectum  
This invention relates to omeprazole compositions designed for administration in the rectum, wherein said compositions comprise omeprazole, an active ingredient, a mixture of polyethylene glycols...
5217986 Anti-allergy agent  
The compound of the formula ##STR1## is described. This compound is active in an H3 receptor assay and is an H3 antagonist. Accordingly, the compound of formula I is useful in the treatment of...
5216003 Diacid-containing benzimidazole compounds for treatment of neurotoxic injury  
A class of diacid-containing benzimidazole compounds is described for treatment to reduce neurotoxic injury associated with anoxia or ischemia which typically follows stroke, cardiac arrest or...
5214063 4-aminobutyric acid compounds, compositions and methods of use for treating disorders related to a dysfunction of GABAB receptors  
A compound of formula (I): ##STR1## in which R, R1 and R2 are as defined in the description. Medicinal product, which is useful in treating disorders related to a dysfunction of GABAB receptors.
5214064 Phenoxyphenylmethyl substituted azoles and pesticidal composition thereof  
N-substituted azoles of the formula I ##STR1## where R1, R2, R3 are each hydrogen, halogen, C1 -C8 -alkyl, C1 -C8 -alkoxy, C1 -C4 -haloalkyl, C1 -C4 -haloalkoxy, C3 -C10 -cycloalkyl, nitro or...
5208234 Substituted imidazole phosphonic and phosphinic acid derivatives  
Novel compounds having the formula ##STR1## wherein R1, R2, R3, R4 and R5 are as defined herein. These compounds inhibit the action of angiotensin II and are useful, therefore, for example, as...
5206257 Pesticidal method using 2-phenylimidazole derivatives  
The invention provides a method for the control of arthropod, plant nematode, helminth or protozoan pests using a 2-phenylimidazole derivative of the formula: ##STR1## wherein R1 represents...
5204352 Compounds exhibiting anti-parasitic activity and a method for their use  
Novel compounds are provided which exhibit high levels of anti-parasitic activity, specifically against parasites of the genus Trypanosoma. The compounds are comprised of aryl-substituted...
5196454 Method of treating disorders of the dopaminergic systems using 2,5-diaminotetralines  
The invention relates to novel 2,5-diaminotetralines of the formula: ##STR1## wherein R1, R2, R3 and R4 are defined herein, processes for preparing them and their use in pharmaceutical...
Matches 401 - 450 out of 713 < 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >