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7622556 |
Modified cytokines for use in cancer therapy
Cytokine derivatives capable of homing the tumoral vessels and the antigen presenting cells and the use thereof as antitumoral agents.
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7605123 |
Fatty acid formulations for oral delivery of proteins and peptides, and uses thereof
Fatty acid compositions for administration of of pharmaceutical agents, such as proteins and peptides, protein and peptide conjugates, and/or cation-polypeptide conjugate complexes. In particular,...
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7601515 |
Process of high purity albumin production
A process is provided for the preparation of albumin from a yeast culture medium which has extremely low levels of or is essentially free of colorants, metal ions, human proteins, host proteins,...
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7547441 |
PAI-2 conjugates for the treatment and imaging of cancer
A method is described for detecting, visualizing, or treating cells, particularly cancerous cells, that express a uPA/uPAR complex. The method employs a PAI-2 conjugate molecule that comprises...
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7531500 |
Preventing airway mucus production by administration of EGF-R antagonists
Hypersecretion of mucus in the lungs is inhibited by the administration of an epidermal growth factor receptor (EGF-R) antagonist. The EGF-R antagonist may be in the form of a small organic...
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7476652 |
Acidic insulin preparations having improved stability
The invention relates to a pharmaceutical formulation comprising a polypeptide selected from the group consisting of insulin, an insulin metabolite, an insulin analog, an insulin derivative and...
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7452858 |
Treatment of gestational diabetes
Methods for treating gestational diabetes which comprise administration of an effective amount of an exendin or an exendin agonist, alone or in conjunction with other compounds or compositions that...
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7435380 |
Pseudo-plastic or thixotropic liquid deodorant product for ostomy pouches
A pseudo-plastic or thixotropic carrier having anti-malodorous components dissolved or suspended therein is sprayed on the internal surfaces of an ostomy bag or pouch. The viscoelastic properties...
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7429564 |
Oral insulin therapy
Pharmaceutical dosage forms for oral administration to a patient for the treatment of diabetes, comprising insulin and a delivery agent that facilitates insulin transport in a therapeutically...
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7419952 |
Use of exendins and agonists thereof to treat diabetes
Methods for treating conditions or disorders which can be alleviated by reducing food intake are disclosed which comprise administration of an effective amount of an exendin or an exendin agonist,...
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7417028 |
Human glucagon-like-peptide-1 modulators and their use in treatment of diabetes and related conditions
The present invention provides novel human glucagon-like peptide-1 (GLP-1)-receptor modulators that have biological activity similar or superior to native GLP-1 peptide and thus are useful for the...
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7414021 |
Method and composition for restoration of age related tissue loss in the face or selected areas of the body
A treatment method for restoring of age related tissue loss in the face or selected areas of the body is disclosed which includes injecting an injectable composition containing a growth factor and...
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7411042 |
Tumor associated nucleic acids and uses therefor
The invention describes SAGE (sdph3.10) and sdp3.5 tumor associated nucleic acids, including fragments and biologically functional variants thereof. Also included are polypeptides and fragments...
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7393865 |
Sleep inducing compounds and methods relating thereto
Compounds having the following structure (I):
including stereoisomers, prodrugs, and pharmaceutically acceptable salts, esters and solvates thereof, wherein R 1 , R 2 , R 3a , R 3b , L 1 , L 2 ...
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7387996 |
Formulations of insulin
Stable insulin formulations can be prepared by mixing a monomeric insulin and a soluble acylated insulin analog.
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7357936 |
Adjuvant systems and vaccines
The present invention provides vaccine and adjuvant formulation comprising an immunostimulant and a metal salt. The immunostimulant is adsorbed onto a particle of metal salt and the resulting...
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7326680 |
Uterine contraction inhibitors
A composition for inhibiting spontaneous myometrial contraction or bradykinin-induced contraction, comprising adrenomedullin. The composition of the present invention may be used to selectively...
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7312196 |
Formulations for amylin agonist peptides
The present invention is concerned with a pharmaceutical formulation comprising an amylin agonist and optionally a buffer, a tonicifier or stabilizer, and a preservative in a container, for...
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7304029 |
Neuroprotective effect of growth hormone
The invention relates to neuroprotection and to medicaments for use therein. Neuroprotection is induced by activation of neural growth hormone receptors, primarily using medicaments comprising...
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7291591 |
Alcohol-free transdermal insulin composition
The instant invention is directed toward a dermal delivery system composition comprising an aqueous base vehicle including Emu oil, at least one fatty acid alkyl ester, polyethylene glycol, and a...
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7279457 |
Rapid acting drug delivery compositions
Drug formulations for systemic drug delivery with improved stability and rapid onset of action are described herein. The formulations may be administered via buccal administration, sublingual...
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7276236 |
Methods of preparing immune globin and uses thereof
The present invention provides for methods of preparing purified immune globulins, immune globulin compositions, and methods of treating allergies and conditions by administering immune globulin...
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7268112 |
Use of insulin for the treatment of cartilaginous disorders
The present invention relates to methods for the treatment and repair of cartilage, including cartilage damaged by injury or cartilaginous disorders, including arthritis, comprising the...
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7259139 |
Means for maintenance and/or correction of glucose concentration in blood
The invention relates to preparations that are useful in maintaining mammalian blood glucose concentrations. These preparations contain insulin, and a polymeric matrix. The polymeric matrix has a...
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RE39789 |
Tumor therapy
Neoplasia is treated by administering to a mammalian host a composition comprising ligands for the NKG2D receptor. In addition, other NKG2D ligands, proteins specific for the neoplastic cells and...
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7244438 |
Uses for polycationic compounds
The invention relates to the use of a polycationic compound for the preparation of a medicament with retarded in vivo release.
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7223561 |
Process of high purity albumin production
A process is provided for the preparation of albumin which has extremely low levels of or is essentially free of colorants, metal ions, human proteins, host proteins, fragments of albumin, polymers...
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7192714 |
LDL receptor signaling assays
The invention provides methods and compositions for modeling and detecting LDL receptor transmembrane signaling by detecting proteolysis of an LDL receptor transmembrane domain. The method...
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7186686 |
Formulated composition
A composition is disclosed that comprises a mixture of polypeptides of opposite charge and an excipient selected from the group consisting of arginine, lysine, glutamic acid, sodium dodecyl...
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7150869 |
Modified cytokines for use in cancer therapy
Cytokine derivatives capable of homing the tumoral vessels and the antigen presenting cells and the use thereof as antitumoral agents.
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7122517 |
Crystallized structure of type IV collagen NC1 domain hexamer
The present invention provides a crystallized NC1 domain hexamer of Type IV collagen, and methods for making the crystal, wherein the NC1 domain hexamer is crystallized such that the three...
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7118753 |
Enhancing cell-based immunotherapy
An immunogenic composition containing antigen-presenting cells and a heat shock protein or a heat shock fusion protein. Also disclosed is a method of using such a composition for enhancing...
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7108867 |
Process for preparing particles
A process for preparing particles of a substance, such as a protein or polypeptide, comprising: (a) preparing a first liquid comprising water, the substance and a modulator, wherein the modulator...
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7091173 |
FAP48-interacting proteins and use thereof
Protein complexes are provided comprising FAP48 and one or more FAP48-interacting proteins. The protein complexes are useful in screening assays for identifying compounds effective in modulating...
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7060676 |
T. cruzi-derived neurotrophic agents and methods of use therefor
The invention relates to T. cruzi trans-sialidase (TS) and to the neurotrophic and IL-6 secretion-inducing activities of the protein. TS, neurotrophic variants and/or neurotrophic peptides based...
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7053041 |
Methods and compositions useful for inhibition of αvβ5mediated angiogenesis
The present invention describes methods for inhibiting angiogenesis in tissues using vitronectin α v β 5 antagonists. The α v β 5 -mediated angiogenesis is correlated with exposure to...
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7018980 |
Method for preparation of orally administrated insulin formulation
The invention relates to the method for preparation of orally administrated insulin oil formulation comprising: dissolving an amount of insulin in an acidic aqueous buffer(A); adding A to liquid...
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7014855 |
Prevention and treatment of amyloidogenic disease
The invention provides compositions and methods for treatment of amyloidogenic diseases. Such methods entail administering an agent that induces a beneficial immune response against an amyloid...
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RE38827 |
Adhesive sealant composition
This invention is related to an adhesive composition which may be used to bond or seal tissue in vivo. The adhesive composition is readily formed from a two component mixture which includes a first...
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6946132 |
Vaccine compositions and methods useful in inducing immune protection against arthritogenic peptides involved in the pathogenesis of rheumatoid arthritis
Vaccine compositions useful in inducing immune protection in a host against arthritogenic peptides involved in the pathogenesis of rheumatoid arthritis are disclosed. Each vaccine composition...
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6923964 |
Active immunization of AScr for prion disorders
Disclosed are pharmaceutical compositions and methods for preventing or treating a number of amyloid diseases, including Alzheimer's disease, prion diseases, familial amyloid neuropathies and the...
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6923956 |
Liquid interferon-β formulations
The present invention relates to liquid formulations of human interferon-β. The formulations are characterized in that they have a buffer with a pH in the weakly acidic to neutral range of between...
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6906028 |
Stable insulin formulations
The present invention provides a monomeric insulin analog formulation stabilized against aggregation in which the buffering agent is either TRIS or arginine. The stable formulations of the present...
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6906026 |
Methods for treating conditions associated with the accumulation of excess extracellular matrix
The present invention is methods and compositions for reducing and preventing the excess accumulation of extracellular matrix in a tissue and/or organ or at a wound site using a combination of...
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6902744 |
Exendin agonist formulations and methods of administration thereof
Novel exendin and exendin agonist compound formulations and dosages and methods of administration thereof are provided. These compositions and methods are useful in treating diabetes and conditions...
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6867184 |
Methods of treating diabetic cardiomyopathy using glycogen phosphorylase inhibitors
The present invention provides methods of treating diabetic cardiomyopathy, the methods comprising administering to a patient having or at risk of having diabetic cardiomyopathy a therapeutically...
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6852694 |
Stabilized insulin formulations
The present invention is directed to stabilized insulin composition comprising a mixture of insulin species such as insulin and an insulin analog. As disclosed herein, insulin compositions...
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6846801 |
Systemic administration of a therapeutic preparation
A method of treating a patient in need of insulin treatment, including the steps of introducing into the lower respiratory tract of the patient an effective amount of a therapeutic preparation in...
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6809076 |
Use of anticoagulant agents in the extracorporeal treatment of blood
The present invention relates to the use of anticoagulant agents for the treatment of individuals with extracorporeal circulation as anticoagulant during the extracorporeal circulation and for...
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6790827 |
Bioconjugates and delivery of bioactive agents
The present invention relates to bioconjugates and the delivery of bioactive agents which are preferably targeted for site-specific release in cells, tissues or organs. More particularly, this...
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