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8183340 |
GLP-1 pegylated compounds
The invention provides GLP-1 compounds coupled to two polyethylene glycol molecule or derivative thereof, resulting in a biologically active peptide with an extended half-life and a slower...
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8178492 |
Methods and compositions for modulating adipocyte function
Methods and compositions for treating obesity and related disorders. The methods include the use of BMP-2, -4, -6 and -7.
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8143062 |
Method and composition for enhancing weight loss
Compositions for enhancing satiety and weight loss in an individual, assays for assessing a tastant for enhancing satiety and weight loss, and methods of using the composition to suppress appetite...
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8143215 |
Method of promoting weight loss
Compositions for enhancing satiety and weight loss in an individual, assays for assessing a tastant for enhancing satiety and weight loss, and methods of using the composition to suppress appetite...
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8143216 |
Modified human growth hormone
Modified growth hormone polypeptide and uses thereof are provided.
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8088730 |
Ghrelin variant protein
The present invention concerns thirteen novel variants of alternative splicing of the obesity and/or diabetes related genes.
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8076282 |
Composition for improving membrane composition and functioning of cells
It has now been found that after administration to a diseased person or person that is at risk for developing such disease of a neutraceutical or pharmaceutical composition that comprises a/ a...
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8076281 |
Use of a ghrelin agonist to improve the catabolic effects of glucocorticoid treatment
A method and pharmaceutical composition for inhibiting the effect of glucocorticoids, particularly dexamethasone, which suppress growth hormone secretion, by administering ghrelin or a ghrelin...
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8063017 |
Process for preparing peptide products for promoting cholecystokinin secretion and use of the peptide products
A process for producing a peptide product having cholecystokinin secretion promoting effect, said process comprising hydrolyzing soybean residues with one or more proteases so that the peptide...
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8026210 |
Exendins and exendin agonist analogs to regulate gastrointestinal motility
Methods for reducing gastric motility and delaying gastric emptying for therapeutic and diagnostic purposes are disclosed which comprise administration of an effective amount of an exendin or an...
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7994119 |
Compounds for control of appetite
This invention relates generally to peptides including tripeptides and to methods for pharmaceutical treatment of mammals using such tripeptides and analogs thereof. More specifically, the...
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7981860 |
Use of ghrelin splice variant for treating cachexia and/or anorexia and/or anorexia-cachexia and/or malnutrition and/or lipodystrophy and/or muscle wasting and/or appetite-stimulation
The present disclosure relates, in one aspect, to use of ghrelin splice variant or an analogue thereof for the preparation of a medicament for one or more of: treatment and/or prevention of loss of...
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7910548 |
Methods for treating obesity
Methods for treating obesity are disclosed which comprise administration of a therapeutically effective amount of an amylin or an amylin agonist alone or in conjunction with another obesity relief...
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7906482 |
Anti-obesity agents
The present invention relates to a compound comprising a PYY peptide or a functional derivative thereof, which is coupled to a reactive group. Such a reactive group is capable of reacting on a...
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7875587 |
Peptide analogues of GIP for treatment of diabetes, insulin resistance and obesity
The present invention provides peptide analogues which are antagonists of gastric inhibitory peptide (GIP). The peptides, based on GIP 1-42 include substitutions and/or modifications which have...
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7851441 |
Water-soluble elastin, process for producing same, and food and medicine containing same
A low-molecular-weight water-soluble elastin having a molecular weight of about 10,000 to 30,000 and a high-molecular-weight water-soluble elastin having a molecular weight of about 30,000 to...
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7842663 |
Variants derived from ActRIIB and uses therefor
In certain aspects, the present invention provides compositions and methods for modulating (promoting or inhibiting) growth of a tissue, such as bone, cartilage, muscle, fat, and/or neuronal...
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7833972 |
Proteins and use thereof
A method of suppressing the differentiation of an adipocite and/or lipid accumulation in an adipocyte, which comprises contacting the adipocyte with a protein comprising the amino acid sequence of...
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7807622 |
Composition and use of phyto-percolate for treatment of disease
This invention relates generally to a method of preparation of a phyto-percolate that is derived from fresh water mixture including algae. The phyto-percolate is believed to contain an enzyme...
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7803764 |
Amphipathic glycopeptides
Amphipathic glycopeptides, the amino acid sequence of which comprises an N-terminal opioid message sequence, a C-terminal helical address sequence, and a linker sequence between the message...
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7737116 |
Modified and stabilized GDF propeptides and uses thereof
Modified and stabilized propeptides of Growth Differentiation Factor proteins, such as GDF-8 and Bone Morphogenetic Protein-11, are disclosed. Also disclosed are methods for making and using the...
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7638490 |
Methods of affecting feeding and weight in mammals by administration of relaxin-3
Relaxin-3 is found to have feeding-stimulating activity, body weight increasing activity, and fat weight increasing activity when intracerebroventricularly administered to rats through observation...
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7601691 |
Anti-obesity agents
The present invention relates to a compound comprising a PYY peptide or a functional derivative thereof, which is coupled to a reactive group. Such a reactive group is capable of reacting on a...
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7582610 |
Melanocortin receptor templates, peptides and use thereof
The present invention relates to novel chimeric peptides and templates containing a combination of antagonist and agonist endogenous ligand residues. In particular, the present invention relates to...
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7572599 |
Metalloprotease activation of myostatin, and methods of modulating myostatin activity
It has been determined that metalloprotease cleavage of a myostatin pro peptide results in activation of a latent inactive myostatin to an active form. Accordingly, methods of identifying agents...
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7407939 |
Protein kinase inhibitors comprising ATP mimetics conjugated to peptides or peptidomimetics
The present invention provides small molecules having high affinity to the ATP binding site of protein kinases, which are conjugated to apeptide or peptidomimetic moiety which mimics the substrate...
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7399744 |
Methods for affecting body composition
Methods for affecting body composition include the use of amylin or amylin agonist(s). Total body weight may be reduced, maintained or even increased; however, the body fat is reduced or body fat...
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7375074 |
Body weight gain inhibitor
The present invention intends to provide a body weight gain inhibitor and the like. The ligand of the present invention is useful as a superior body weight gain inhibitor and the like, or for a...
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7371726 |
Neutralizing GDF8 epitope-based growth enhancing vaccine
The invention provides new, specific antigenic peptides from the protein GDF8. The invention also provides fusion proteins comprising the new peptides, immunogens and vaccines based on the new...
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7326678 |
GMG-3 GMG-4 and GMG-6 polynucleotides and polypeptides and uses thereof
The present invention relates to the field of metabolic research. Metabolic disorders, such as obesity, are a public health problem that is serious and widespread. GMG-3, GMG-4, Cluster 1, GMG-6A,...
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7316998 |
Cerberus/Coco derivatives and uses thereof
The invention relates to Cerberus/Dan/Gremlin polypeptides or variants thereof for use in treating a variety of disorders associated with myostatin, nodal and GDF-11. Preferred polypeptides are...
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7314865 |
Compositions and methods for promoting lipid mobilization in humans
The invention provides methods of using polypeptide compounds based on the structures of insect peptides of the adipokinetic hormone family to mobilize lipids in humans. The compositions and...
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7312197 |
Method of modifying glucose activity using polypeptides selectively expressed in fat tissue
Isolated omentin polypeptides that selectively express in omental fat tissue and methods for the use of the polypeptides. The polypeptides can be used in a method for modifying insulin action...
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7300917 |
Remedy for chronic disease
A remedy and/or a preventive for a chronic disease which contains an EDG-2 antagonist. Because of binding to a subtype EDG-2 of LPA receptor, an EDG-2 antagonist is useful in treating and/or...
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7279282 |
Methods for identifying a candidate for treatment of obesity
Methods of identifying human subjects for treatment of obesity or an obesity-related condition with ciliary neurotrophic factor (CNTF) or a CNTF-related molecule, such as Axokine®, based on the ...
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7238671 |
Human glucagon-like-peptide-1 mimics and their use in the treatment of diabetes and related conditions
The present invention provides novel human glucagon-like peptide-1 (GLP-1) peptide mimics that mimic the biological activity of the native GLP-1 peptide and thus are useful for the treatment or...
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7229965 |
Use of growth hormone in low dose
The invention relates to treatment of patients in need of increasing insulin sensitivity by administration of growth hormone or analogues thereof, preferably human growth hormone, in a low dose and...
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7229966 |
Compositions and methods for enhanced mucosal delivery of Y2 receptor-binding peptides and methods for treating and preventing obesity
Pharmaceutical compositions and methods are described comprising at least one Y2 receptor-binding peptide, such as peptide YY(PYY), Neuropeptide Y (NPY) or Pancreatic Peptide (PP) and one or more...
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7226625 |
Identification of compositions, compositions, and methods of treatment of obesity and overweight conditions
A method for the identification of a composition useful in the treatment of an overweight or obese person to reduce the person's body mass index is provided which comprises obtaining an extract of...
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7223735 |
Abuse resistant lysine amphetamine compounds
The present invention describes compounds, compositions and methods of using the same comprising lysine covalently attached to amphetamine. These compounds and compositions are useful for reducing...
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7223727 |
GSSP4 polynucleotides and polypeptides and uses thereof
The present invention relates to the field of metabolic research. Metabolic disorders, such as obesity, are a public health problem that is serious and widespread. GSSP4 polypeptides have been...
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7217692 |
Complex of a human FOXC2 protein and a FOXC2-interacting protein
The present invention relates to complexes of the FOXC2 protein with other proteins, in particular complexes of FOXC2 with proteins designated p621, NOLP, HSC71, FTP3, CLH1, and Kinase A Anchor...
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7211557 |
Use of GLP-1 analogs and derivatives administered peripherally in regulation of obesity
This invention relates the use of glucagon-like peptides such as GLP-1, a GLP-1 analog, or a GLP-1 derivative in methods and compositions for reducing body weight.
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7192917 |
Antagonists of HMG1 for treating inflammatory conditions
There is disclosed a pharmaceutical composition and method for treating sepsis, including, septic shock and ARDS (acute respiratory distress syndrome), comprising administering an effective amount...
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7183266 |
Dual induced viscosity fiber system and uses thereof
The present invention relates generally to a method of blunting the postprandial glycemic response to a meal by feeding a dual induced viscosity fiber system. The first component of the induced...
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7144865 |
Compositions and methods for treating obesity
The present invention relates to dietary supplementing methods useful for controlling obesity. More particularly, the invention relates to methods of administration of compositions containing...
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7144863 |
GLP-1 formulations with protracted time action
The present invention encompasses compositions wherein a GLP-1 compound is complexed with a basic polypeptide. The compositions provide a prolonged duration of action and can be administered by the...
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7141548 |
Prevention of hyperinsulinemia in subjects undergoing growth hormone (GH) treatment
The present invention provides methods and compositions for preventing hyperinsulinemia that can result from therapeutic administration of growth hormone. The methods are carried out by imposing a...
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7138372 |
Agent for preventing and/or treating cachexia
The present invention provides an agent for preventing and/or treating cachexia comprising TCF-II as an effective ingredient. An agent for preventing and treating cachexia caused by cancer,...
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7122520 |
Methods of modulating appetite using agouti-related transcript polypeptides
Disclosed is a novel gene termed ART which is expressed primarily in selected regions of the brain, as well as adrenal and lung tissues. Polypeptides encoded by ART are also disclosed, as are...
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