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7605129 |
Splice variant of human placental growth hormone
This invention relates to a protein, termed INSP105, herein identified as a splice variant of human placental growth hormone and to the use of this protein and nucleic acid sequences from the...
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7572921 |
Substituted benzylimidazoles useful for the treatment of inflammatory diseases
The invention comprises a class of derivatives of substituted benzylimidazoles of the formula (I) and methods for making the same. These compounds are useful for the treatment of inflammatory...
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7566734 |
Imidazolyl derivatives
The present invention is directed to imidazolyl derivatives of formula (I) where the substituents are defined in the specification, which are useful as agonists or antagonists of somatostatin...
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7563779 |
L-ergothioneine, milk thistle, and S-adenosylmethionine for the prevention, treatment and repair of liver damage
This invention provides therapeutic compositions and combinations for the protection, treatment and repair of liver tissue. The invention relates to novel compositions and combinations comprising...
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7560446 |
Use of angiotensin II receptor antagonists for treating acute myocardial infarction
The invention relates to the use of an angiotensin II receptor antagonist or a pharmaceutically acceptable salt thereof for the manufacture of a medicament for the treatment of acute MI and for the...
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7550497 |
Phosphoramide derivatives
New phosphoramide derivatives of formula (I) and the salts and solvates thereof, wherein the meanings of the various substituents are as disclosed in the description. Said compounds are useful as...
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7550496 |
Compositions and methods for treating cancer
Hypoxia-activated prodrugs can be used to treat cancer when administered alone or in combination with one or more anti-neoplastic agents.
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7514459 |
Gamma-secretase inhibitors
Compounds of formula I:
are potent inhibitors of gamma-secretase and hence find use in treatment or prevention of diseases associated with deposition of β-amyloid.
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7511034 |
Dialkylhydroxybenzoic acid derivatives containing metal chelating groups and their therapeutic uses
Novel dialkylhydroxybenzoic acid derivatives containing metal chelating groups are disclosed. The novel compounds are used as therapeutics for treating and/or preventing various medical...
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7507757 |
Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method
Compounds are provided which are useful as antidiabetic agents and antiobesity agents and have the structure
wherein m is 0, 1 or 2; n is 0, 1 or 2;
Q is C or N; A is (CH 2 ) x where x...
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7459476 |
Methods for treating Alzheimer's disease using hydroxyethylene compounds containing a heterocyclic amide bond isostere
Disclosed are methods for treating Alzheimer's disease, and other diseases, and/or inhibiting beta-secretase enzyme, and/or inhibiting deposition of A beta peptide in a mammal, by use of compounds...
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7456208 |
CCK-1 receptor modulators
Certain imidazole compounds are CCK1 modulators useful in the treatment of CCK1 mediated diseases.
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7429575 |
N-(phosphonoalkyl)-amino acids, derivatives thereof and compositions and methods of use
The present invention relates to an N-(phosphonoalkyl)-amino acid, a related compound or a derivative thereof, the N-(phosphonoalkyl)-amino acid, related compound or derivative thereof being in a...
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7365070 |
Modulators of melanocortin receptor
This invention provides compounds and methods for treating melanocortin receptor associated disorders, such as weight loss disorders including cachexia resulting from cancer and other chronic...
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7361678 |
Azole derivatives and fused bicyclic azole derivatives as therapeutic agents
This invention provides certain compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human or animal disorders. The compounds of...
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7326705 |
Heterocyclic sodium/proton exchange inhibitors and method
Heterocyclic are provided which are sodium/proton exchange (NHE) inhibitors which have the structure
wherein n is 1 to 5; X is N or C—R 5 wherein R 5 is H, halo, alkenyl, alkynyl, alkoxy,...
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7294644 |
CB 1 receptor inverse agonists
The present invention relates to compounds of formula (I)
wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , m and X are as defined in the description and claims, and pharmaceutically acceptable salts...
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7282503 |
Fungicidal mixtures based on imidazole derivatives
Disclosed are fungicidal mixtures containing a synergistically effective amount of A) a triazolopyrimidine of formula I, and B) imidazole derivatives of formula II, wherein X 1 and X 2 represent...
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7279478 |
Cathepsin cysteine protease inhibitors
This invention relates to class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating...
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7250412 |
PH sensitive prodrugs of 2,6-Diisopropylphenol
The present invention is directed to water-soluble derivatives of 2,6-diisopropylphenol (Propofol). The compounds act as prodrugs of 2,6-diisopropylphenol and metabolize rapidly to Propofol thereby...
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7232817 |
α- and β-amino acid hydroxyethlamino sulfonyl urea derivatives useful as retroviral protease inhibitors
α- and β-amino acid hydroxyethylamino sulfonyl urea derivative compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
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7220770 |
Heterocyclo-substituted imidazoles for the treatment of inflammation
A class of imidazolyl compounds is described for use in treating inflammation. Compounds of particular interest are defined by formula (V), wherein R 3 is a radical selected from hydrido, alkyl,...
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7217718 |
Induction of immune tolerance
Methods of inducing immune tolerance by administering an immunosuppressive agent and a compound represented by Formula (I) are disclosed:
Additionally methods of suppressing an immune response...
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RE39634 |
Bisarylimidazoly fatty acid amide hydrolase inhibitors
The present invention relates to bisarylimidazolyl derivatives and pharmaceutical compositions comprising said compounds inhibiting fatty acid amide hydrolase and useful for the treatment of pain,...
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7214698 |
Beta-agonists, processes for preparing them and their use as pharmaceutical compositions
The present invention relates to new beta-agonists of general formula 1:
wherein the groups R 1 to R 12 have the meanings given in the claims and specification, the isomers thereof, processes...
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7205328 |
Oxindoles with anti-HIV activity
The present invention relates to inhibition of viruses, e.g., HIV using oxindoles and compounds related to oxindoles. The invention further relates to methods for identifying and using agents,...
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7176198 |
1H-pyrazole and 1H-pyrrole-azabicyclic compounds for the treatment of disease
The invention provides compounds of Formula I:
wherein Azabicyclo is
where the variables have the definitions discussed herein. These compounds may be in the form of pharmaceutical salts or...
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7166590 |
Amino acid derivatives
A compound of the formula (I):
[wherein R 1 is (substituted) alkyl, alkoxy, phenyl, hetero ring etc.; A is bond, CO, SO 2 ; R 2 is H, (substituted) alkyl etc.; D is alkylene etc.; E is COO,...
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7157078 |
Devices and methods for eliminating termite colonies
This invention relates to devices, kits, and methods for eliminating termite colonies. The kits, devices, and methods employ a termiticidal bait matrix containing
a) a termiticide selected...
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7144909 |
Phenoxy substituted benzocondensed heteroaryl derivatives as thyroid receptor ligands
This invention relates to novel compounds which are thyroid receptor ligands, preferably antagonists, and to methods for using such compounds in the treatment of cardiac and metabolic disorders,...
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7132421 |
CIS-imidazoles
The present invention provides compounds according to formula I and pharmaceutically acceptable salts and esters thereof, having the designations provided herein and which inhibit the interaction...
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7115632 |
Sulfonyl aryl or heteroaryl hydroxamic acid compounds
A sulfonyl aromatic or heteroaromatic ring hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed as are a treatment process that comprises administering a...
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7064124 |
NF-κB inhibitor containing substituted benzoic acid derivative as active ingredient
A NF-κB inhibitor represented by the following formula (I) is provided:
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7053114 |
Prodrugs of a 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives
The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to...
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7048910 |
Use of ectoine or ectoine derivatives for oral care
The invention relates to the use of one or more compounds selected from compounds of formulae Ia and Ib, the physiologically compatible salts of compounds of formula Ia and Ib and the stereoisomer...
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7041303 |
Use of moxonidine for postmyocardial infarction treatment
A method of treating myocardial damage secondary to myocardial infarction using moxonidine or a physiologically compatible salt thereof. Pharmaceutical preparations containing moxonidine and its...
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7029706 |
Composition for the treatment of cutaneous mycosis
The inventions relates to the use of silica in the formulation of antifungal composition for the treatment of cutaneous mycoses, and method to manufacture an antifungal powder with boric acid and...
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7001918 |
7-pyrrolyl tetracycline compounds and methods of use thereof
A compound of Formula (I): wherein variables R, R 1 , R 2 , R 3 and A are as defined in the
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RE38962 |
Diphenyl-triazole derivatives and their use as anti-gestative immuno-suppressant and anti-tumoral agents
Compounds of formula (I), wherein X and Y are independently carbon or nitrogen but not both simultaneously carbon, R 1 is a group (II) and R 2 is a group (III), R 5 being a carbonate, carbamate...
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6989399 |
Antiamyloid phenylsulfonamides: N-alkanol derivatives
A series of N-alkanol-N-phenyl benzenesulfonamide and related derivatives of the Formula I are disclosed,
wherein R 1 , R 2 , R 3 , X, and Y are defined herein. The compounds are inhibitors of...
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6979696 |
Method for detecting a gram-negative bacterial autoinducer molecule
This invention relates to compounds which are alpha-1 receptor agonists, preferably alpha-1A/L receptor agonists, and which are represented by Formula I:
wherein m, A, X, Y, R 1 , R 2 , R 3 ,...
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6960600 |
Azole or triazole derivatives, method for preparing the same and use thereof as antifungal medicaments
The invention concerns novel azole or triazole derivatives of formula (I), wherein: X, Ar 1 , Ar 3 , A, R 1 , R 5 , R 6 , R 7 and B are such as defined in the description, their preparation method...
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6949578 |
Cycloalkyl alkanoic acids as integrin receptor antagonists
The present invention relates to a class of compounds represented by the Formula I
or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the...
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6943183 |
5-substituted tetralones as inhibitors of ras farnesyl transferase
The present invention provides novel 5-substituted tetralones of Formulas I, II, III, and IV and pharmaceutically acceptable salts, esters, amides, and prodrugs thereof, which are useful for...
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6927227 |
Heterocyclic containing biphenyl aP2 inhibitors and method
aP2 inhibiting compounds are provided having the formula
wherein R 1 , R 2 , R 3 , R 4 , X—Z and
are as described herein.
A method is also provided for treating diabetes and related...
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6916837 |
Amidino derivatives and anticoagulants and thrombosis therapeutic agents containing them
Amidino derivatives represented by the following general formula (I):
{where X is a group represented by R 1 SO 2 NR 2 — (wherein R 1 represents optionally substituted C 6-14 aryl, etc....
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6916813 |
(1-phenyl-2-heteoaryl)ethyl-guanidine compounds as inhibitors of mitochondrial F1F0 ATP hydrolase
Compounds having the formula (I), and pharmaceutically acceptable salts thereof,
are useful for modulating mitochondrial F 1 F 0 ATPase activity and treating ischemic conditions including...
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6884821 |
Carboxylic acid derivatives and drugs containing the same
Novel carboxylic acid derivatives of general formula (I), salts of the same, esters thereof, or hydrates of them, which are useful as insulin resistance improvers; and drugs containing the...
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6884809 |
Method and compositions for reducing cardiac dysfunctions with a selective histamine H3 receptor agonist
The invention provides a method for reducing cardiac dysfunctions in a human. The method comprises administration to the human of an effective amount of a selective histamine H 3 Receptor agonist....
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6884801 |
Imidazoline derivatives as alpha-1A adrenoceptor ligands
Compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof are disclosed. Such compounds are useful in the treatment of Alpha-1A mediated diseases or conditions such as...
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