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6498172 |
Prostaglandin agonists and their use to treat bone disorders
This invention relates to prostaglandin agonists, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits containing such...
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6495522 |
Substituted alpha-hydroxy acid caspase inhibitors and the use thereof
The present invention is directed to novel substituted α-hydroxy acid thereof, represented by the general Formula I: where R 1 -R 5 , X and Z are defined herein. The present invention also...
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6495584 |
Use of 3-(1H-imidazol-4-ylmethyl)-indan-5-ol in the manufacture of a medicament for intraspinal, intrathecal or epidural administration
The present invention relates to a method for obtaining analgesia by administering 3-(1H-imidazol-4-ylmethyl)-indan-5-ol, its enetiomer or pharmaceutically acceptable ester or salt thereof to a...
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6492410 |
Combinations of protein farnesyltransferase and HMG CoA reductase inhibitors and their use to treat cancer
Novel combinations of inhibitors of protein farnesyltransferase enzymes and HMG CoA reductases enzymes are described, as well as methods for the preparation and pharmaceutical compositions of the...
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6492356 |
Acylguanidine derivatives as inhibitors of bone resorption and as vitronectin receptor antagonists
The present invention relates to acylguanidine derivatives of formula (I) in which R 1 , R 2 , R 4 , R 5 , R 6 , A, m and n have the meanings indicated in the patent claims, their physiologically...
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6486189 |
Five-membered heterocycles having biphenylsulfonyl substitution, process for their preparation, their use as a medicament or diagnostic, and medicament comprising them
Five-membered heterocycles having biphenylsulfonyl substitution, process for their preparation, their use as a medicament or diagnostic, and medicament comprising them. Compounds of the formula I ...
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6486191 |
Nitrophenyl-sulphonyl-imidazoles and use thereof for controlling vegetable and animal pests
Novel nitrophenyl-sulphonyl-imidazole of the formula (I) wherein X, R 1 , R 2 and R 3 have the meanings stated in the description, a process for the preparation of the novel substances and...
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6482844 |
1-benzylimidazole derivatives
Provided are compounds (and pharmaceutically acceptable non-toxic salt of such compounds) of the formula: in which A and B are C 1 -C 3 alkylene; R 1 is C 1 -C 6 alkyl; R 2 and R 3 are...
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6479531 |
Gastrin and cholecystokinin receptor ligands
Compounds of formula (I) and their pharmaceutically acceptable salts are ligands at gastrin and/or cholecystokinin receptors. X and Y are independently ═N—, —N(R 5 )—═CH—, —S— or...
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6469040 |
Method of using cyclooxygenase-2 inhibitors in the treatment and prevention of neoplasia
This invention relates to the use of cyclooxygenase-2 inhibitors or derivatives thereof in preventing and treating neoplasia. In particular, the invention describes the method of preventing and...
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6436999 |
Diacyl-substituted guanidines, a process for their preparation, their use as medicine or diagnostic aid, and medicine containing them
Diacyl-substituted guanidines of the formula I are described where X( 1 ) and X( 2 ) are as defined herein. The compounds are suitable for use as antiarrhythmic pharmaceuticals possessing a...
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6432993 |
Substituted fused heterocyclic compound
Substituted fused heterocyclic compounds of the formula (I) and pharmacologically acceptable salts thereof: wherein R 1 is a group of the formula (II) or (III): R 4 is a substituted phenyl or...
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6426341 |
Treatment for diabetic complications
This invention is directed to methods, pharmaceutical compositions and kits comprising an aldose reductase inhibitor (ARI), a prodrug thereof or a pharmaceutically acceptable salt of said ARI or...
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6423712 |
2,4-Substituted imidazolidine derivatives, their preparation, their use and pharmaceutical preparations comprising them
The present invention relates to imidazolidine compounds of the formula I, The compounds of the formula I are valuable pharmaceutical active compounds, which are suitable, for example, for the...
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6423737 |
Benzamidoxime prodrugs as antipneumocystic agents
A method of treating Pneumocystis carinii pneumonia in a subject in need of such treatment is disclosed. The method comprises orally administering to the subject a bis-benzamidoxime, or a...
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6420384 |
Proton pump inhibitors
Compounds and methods of treating or preventing bone disorders including osteoporosis, rheumatoid arthritis, and metastatic bone disease are provided. The inventive compounds comprise a bone...
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6420427 |
Aminobutyric acid derivatives
An aminobutyric acid derivative of the formula (I): (wherein all symbols are as defined in the specification) and salt thereof. salt thereof. The compounds of the formula (I) possess an...
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6417218 |
Substituted imidazoles, their preparation and use
A class of substituted imidazole compounds of formula I methods for their preparation, pharmaceutical compositions comprising them and use thereof in the treatment of disorders related to the...
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6403630 |
Treating cancers associated with overexpression of HER-2/neu
Cancers associated with overexpression of HER-2/neu are treated with a selective inhibitor of cyclooxygenase-2 as the sole treating agent or said inhibitor in combination regimen with HERCEPTIN®...
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6403112 |
Ectoin and ectoin derivatives as moisturizers in cosmetics
The present invention relates to a compound of the tantomeric formula Ia or Ib and/or of a physiologically acceptable salt of the compound of the formula Ia or Ib and/or of a sterio-isomeric...
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6395724 |
Multibinding inhibitors of cyclooxygenase-2
Disclosed are multibinding compounds which inhibit cyclooxygenase-2 (COX-2), an enzyme which catalyzes the first committed step in the biosynthesis of prostaglandins. The multibinding compounds of...
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6387906 |
2,4,4-trisubstituted-1,3-dioxolane antifungals
The present invention concerns novel compounds of formula a N-oxide form, a pharmaceutically acceptable acid addition salt or a stereochemically isomeric form thereof, wherein n is zero, 1, 2 or...
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6384068 |
Imidazole containing compounds having relatively low hydrogen content and relatively high nitrogen content and polymers and copolymers formed therefrom
In one embodiment, the invention provides a polymer comprising imidazole ring units having nitrogen at the 1 and 3 positions of the ring; a carbon at each of the 2, 4 and 5 positions of the ring;...
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6380236 |
Method of treating onychomycosis
A method of treating onychomycosis is described which includes administration to an infected area around a nail of a patient a tissue softening composition containing urea and an antifungal...
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6380254 |
Method and composition for treating and preventing pathogenic effects caused by intracellular calcium overload
The present invention provides a method and composition for treating or preventing pathogenic effects in a mammal caused by intracellular calcium overload, comprising administering to a mammal a...
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6376509 |
Melanocortin receptor agonists
Certain novel compounds and derivatives thereof are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are...
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6372772 |
Inhibitors of redox signaling and methods of using same
The present invention is directed to a composition or formulation which inhibits or interferes with cellular redox function, and method of using same to restore normal cellular function. More...
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6362211 |
Polycyclic indanylimidazoles with alpha2 adrenergic activity
A compound of formula I wherein R 1 to R 3 , —A—, m and t are as defined in claim 1 , or a pharmaceutically acceptable salt or ester thereof, useful as an alpha2 adrenergic agent.
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6348482 |
Catechols as antimicrobial agents
Compounds, pharmaceutically acceptable salts, and compositions thereof of the general formula: wherein Ar is aryl and heteroaryl; R 1 , R 2 , R 3 , and R 4 are hydrido, alkyl, cyano,...
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6346518 |
Itraconazole and saperconazole stereoisomers
The present invention is concerned with the stereoisomeric forms of itraconazole (X=Cl) and saperconazole (X=F), which may be represented by the formula and the pharmaceutically acceptable acid...
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6333343 |
Diphenyl-triazole derivatives and their use as anti-gestative, immuno-suppressant and anti-tumoral agents
Compounds of formula (I), wherein X and Y are independently carbon or nitrogen but not both simultaneously carbon, R 1 is a group (II) and R 2 is a group (III), R 5 being a carbonate, carbamate...
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6333345 |
Methods of using and compositions comprising N-desmethylzolpidem
The invention is directed to compositions comprising, and methods of using, N-desmethylzolpidem in the treatment and prevention of diseases and conditions in mammals. Examples of such diseases and...
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6329403 |
Pharmaceutical composition for the treatment of diabetes
A pharmaceutical composition which comprises an insulin sensitizer in combination with an anorectic, which is useful as an agent for preventing or treating diabetes.
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6319949 |
Pesticidal sprays
A method for preventing fungal diseases in crops which comprises the steps of: (a) applying to a crop an aqueous or a non-aqueous spray composition which includes a pesticide and a spray adjuvant...
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6313102 |
Method for stabilization of biological substances during drying and subsequent storage and compositions thereof
The present invention encompasses methods of increasing stability of biological substances during drying and the dried compositions derived therefrom. The compositions have improved storage stability.
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6310067 |
Urocanic acid derivatives
Urocanic acid derivatives useful as antiallergic agents represented by the following formula (I) or a pharmacologically acceptable salt thereof: ##STR1## wherein R 2 denotes hydrogen or lower...
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6300356 |
Method for decreasing QT dispersion or inhibiting the progression of QT dispersion with an angiotensin II receptor antagonist
Angiotensin II receptor antagonists are useful for decreasing QT dispersion or inhibiting the progression of QT prolongation in patients. Also disclosed is a method for monitoring the reduction in...
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6297268 |
Imidazoles as cholesterol lowering agents
In one embodiment, the present invention discloses a method and pharmaceutical composition for lowering serum cholesterol in a patient. The method comprises administering to the patient a...
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6288101 |
Imidazoles with serotonin receptor binding activity
This invention relates compounds having serotonin receptor binding activity, to pharmaceutical compositions containing them and to their medical use, particularly in the treatment of CNS...
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6274582 |
Preparation for the treatment of metabolic syndrome containing human growth hormone in combination with a cortisol synthesis inhibitor
Human growth hormone is used in combination with a cortisol synthesis inhibitor, in particular ketoconazole, for prevention or treatment of conditions related to Metabolis Syndrome (Neuroendocrine...
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6271249 |
Diphenyl imidazoles as potassium channel modulators
Novel compounds of Formula 1 are useful to treat disorders responsive to openers of the large conductance calcium-activated potassium channels: ##STR1## wherein "Het" is one of a select group of...
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RE37303 |
Imidazole compounds and their therapeutic applications
A compound selected from the group consisting of a compound of the formula ##STR1## wherein the substituents are defined as in the specification having antagonist properties to histamine H 3 ...
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6265428 |
Substituted phenyl compounds and derivatives thereof that modulate the activity of endothelin
Methods, compositions, and compounds for modulating the activity of an endothelin peptide are provided. The methods use compositions that contain compounds of formula (1): ##STR1## where X and Y...
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6265391 |
Method for preventing peripheral nerve damage
A vitamin B 12 supplement composition comprising vitamin B 12 with and/or without added folic acid that is essentially free of antioxidants, such as vitamin C, as well as iron is disclosed. Also...
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6262093 |
Methods of treating cancer with benzimidazoles
This invention is a method of treating cancer, both carcinomas and sarcomas, and viral infections, in particular HIV through the administration of a pharmaceutical composition containing a...
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6258834 |
Method for prophylaxis and treatment of diabetic complications with 4[α-hydroxy-2-methyl-5-(1-imidazolyl)benzyl]-3,5-dimethylbenzoic acid and derivatives
The present invention relates to an agent for the prophylaxis and treatment of diabetic complications comprising, as an active ingredient,...
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6255331 |
Stable biocidal compositions
Disclosed are biocidal compositions comprising mixtures of formaldehyde-releasing imidazolidines, such as 1,3-dimethylol-5,3-dimethylhydantoin, and 3-isothiazolones stabilized with low levels of...
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6245792 |
Fungicidal mixture
A composition comprising effective amounts of a) a carbamate (I) ##STR1## wherein T is CH or N, n is 0, 1 or 2, and R is halogen, C 1 -C 4 -al-kyl or C 1 -C 4 -haloalkyl, where the...
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6245795 |
Melanogenesis inhibitor, skin cosmetic composition and bath preparation
An object of the present invention is to provide a melanogenesis inhibitor and a skin cosmetic composition, which are superior in the effect of preventing pigmentation due to inflammation by...
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6242474 |
Aromatic ring derivatives
Novel aromatic ring derivatives represented by formula (I) or their pharmaceutical acceptable salts are provided. ##STR1## wherein Nu represents a 5- or 6-membered aromatic ring; ch 1 and ch 2 ...
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