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7608725 |
Processes for nitration of N-substituted imidazoles
The present invention relates to a process for making 2-nitroimidazoles that involves the selective nitration of N-substituted imidazoles.
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7569702 |
Method for producing 4-nitroimidazole compound
The present invention provides a method for producing a 4-nitroimidazole compound represented by general formula (1) at high yield and at high purity by a safe method causing few dangers such as...
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7563779 |
L-ergothioneine, milk thistle, and S-adenosylmethionine for the prevention, treatment and repair of liver damage
This invention provides therapeutic compositions and combinations for the protection, treatment and repair of liver tissue. The invention relates to novel compositions and combinations comprising...
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7560483 |
Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof
The present invention provides a method for synthesizing 1-(acyloxy)-alkyl derivatives from 1-acyl-alkyl derivatives, which typically proceeds stereospecifically, in high yield, does not require...
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7560446 |
Use of angiotensin II receptor antagonists for treating acute myocardial infarction
The invention relates to the use of an angiotensin II receptor antagonist or a pharmaceutically acceptable salt thereof for the manufacture of a medicament for the treatment of acute MI and for the...
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7553862 |
4-amino-1,5-substituted-1,5-dihydro-imidazol-2-ones
The present invention relates to compounds of formula I
wherein
R 1 , R 2 , R 3 , and R 4 are as defined herein
and to pharmaceutically acceptable acid addition salts thereof. Compounds of...
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7544812 |
Peroxisome proliferator activated receptor agonists
The present invention is directed to compounds represented by the following structural Formula (I), (a) R1 is selected from the group consisting of hydrogen, substituted or unsubstituted group...
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7491743 |
Inhibitors of cellular necrosis
The present invention relates to compounds and pharmaceutical preparations and their use in therapy for preventing or treating trauma, ischemia, stroke and degenerative diseases associated with...
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7456207 |
Vaginal pharmaceutical compositions and methods for preparing them
Vaginal pharmaceutical compositions are described. These compositions contain (i) an active pharmaceutical ingredient selected from the group consisting of antimicrobial imidazoles and mixtures...
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7442717 |
Substituted 2-aminoimidazoles, process for their preparation, their use as medicament or diagnostic aid
Novel substituted 2-aminoimidazoles of formula I, process for their preparation, their use as medicament or diagnostic aid, and medicament containing them. The compounds of this type are useful in...
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7439242 |
PPARγ modulators
Modulators of PPARγ activity are provided which are useful in pharmaceutical compositions and methods for the treatment of conditions such as type II diabetes and obesity.
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7405229 |
Cathepsin cysteine protease inhibitors
This invention relates to a class of compounds having the general formula (I) which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These...
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7361654 |
Substituted heteroaryl amide modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
The present invention relates to new class of non-steroidal compounds which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity...
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7348333 |
Cycloalkyl derivatives as inhibitors of bone resorption and vitronectin receptor antagonists
There are described cycloalkyl derivatives of the formula (I)
R 1 —Y-A-B-D-E-F-G (I)
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7348317 |
Aqueous compositions containing metronidazole
An aqueous solution of metronidazole in which the concentration of metronidazole is higher than 0.75%. The solution contains a combination of solubility-enhancing agents, one of which is a...
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7326728 |
Modulators of glucocorticoid receptor, AP-1, and/or NF-κβ activity and use thereof
Novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes,...
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7309721 |
Aminoalkylphosphonates and related compounds as Edg receptor agonists
The present invention encompasses compounds or Formula (I): as well as the pharmaceutically acceptable salts and hydrates thereof. The compounds are useful for treating immune mediated diseases and...
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7294641 |
Heterocyclic compound for stimulating or inducing the growth of the hair or eyelashes and/or slowing down their loss, composition comprising it and its uses
Heterocyclic compounds useful for stimulating/inducing the growth of keratinous fibers, notably human hair/eyelashes, and/or slowing the loss of same, have the following structural formula (I) or...
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7285565 |
Benzamides and related inhibitors of factor Xa
Novel benzamide compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or...
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7282503 |
Fungicidal mixtures based on imidazole derivatives
Disclosed are fungicidal mixtures containing a synergistically effective amount of A) a triazolopyrimidine of formula I, and B) imidazole derivatives of formula II, wherein X 1 and X 2 represent...
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7265135 |
2-oxy, 2-amino, and 2-thio-imidazole compounds
The invention relates to novel 2-Oxy, 2-Amino, and 2-Thio-imidazole compounds of formula (I):
wherein all variables are as herein defined, pharmaceutical compositions containing the...
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7256208 |
Monocyclic N-Aryl hydantoin modulators of androgen receptor function
The present invention relates to novel compounds useful in the treatment of androgen receptor associated conditions, such as age-related diseases, pharmaceutical compositions containing at least...
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7253191 |
2-thio-substituted imidazole derivatives and the use thereof in the pharmaceutical industry
The invention relates to 2-thio-substituted imidazole derivatives of the formula I
in which the radicals R 1 , R 2 , R 3 and R 4 are as defined in the description. The compounds according to...
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7223781 |
2-mercapto-4,5-diarylimidazole derivatives and the use thereof as cyclooxygenase inhibitors
The invention relates to the 2-mercapto-4,5-diarylimidazole derivatives of formula (I), wherein R 1 , R 2 , R 3 and R 4 are defined as in the description. The inventive compounds have an...
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7175851 |
Fungicidal composition comprising in particular an oil of plant origin with high siccative power
The subject of the present invention is a fungicidal composition useful for the treatment of fungal diseases of crops and which comprises in particular at least one vegetable oil with high...
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7166630 |
MAG expression promoters
A method for promoting myelination of an axon comprising administering 4-[α-hydroxy-5-(1-imidazolyl)-2-methylbenzyl]-3,5-dimethylb
enzoic acid is disclosed.
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7166593 |
Glucocorticoid receptor modulators
The present invention provides non-steroidal compounds of formula I which are selective modulators (i.e., agonist and antagonists) of a steroid receptor, specifically, the glucocorticoid receptor....
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7153826 |
Treatment of rosacea
Cyclic peptide antibiotics including the loloatins are effective in the treatment of rosacea, particularly when administered in conjunction with an antibiotic such as metronidazole that is...
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7115632 |
Sulfonyl aryl or heteroaryl hydroxamic acid compounds
A sulfonyl aromatic or heteroaromatic ring hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed as are a treatment process that comprises administering a...
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7115605 |
Peptide deformylase inhibitors
PDF inhibitors and novel methods for their use are provided.
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7109227 |
Imidazolamino compounds
The invention relates to novel imidazolamino compounds. Also disclosed are methods of treating cancer by using one of these compounds and pharmaceutical compositions containing one of these compounds.
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7094431 |
Method of healing skin wounds in mammals and a composition therefor
This invention pertains to therapeutic antibacterial/antifungal-wound healing compositions comprising a therapeutically effective amount of antibacterial agents and/or antifungal agents and/or...
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7087633 |
Method for treating perinatal asphyxia in a human or animal neonate
A method for treating perinatal asphyxia is disclosed comprising administering 2-iminobiotin or a salt or ester thereof.
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7078401 |
Thiophenylaminoimidazolines as IP antagonists
Methods for treatment of IP antagonist mediated diseases or conditions by administration to a subject in need thereof a compound of formula (I)
wherein R 1 , R 2 , A and X are as defined...
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7074834 |
Long acting, reversible veterinary sedative and analgesic and method of use
A veterinary composition comprising a guanidine derivative, e.g., guanabenz or guanabenz acetate is provided which produces a rapid acting and long lasting sedative and analgesic effect in a...
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7053073 |
Treatment for reactive arthritis or bursitis
A treatment for conditions in human beings associated with either or both reactive arthritis or bursitis comprising a combination of valacyclovir hydrochloride, minocycline hydrochloride, and...
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7048910 |
Use of ectoine or ectoine derivatives for oral care
The invention relates to the use of one or more compounds selected from compounds of formulae Ia and Ib, the physiologically compatible salts of compounds of formula Ia and Ib and the stereoisomer...
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7041303 |
Use of moxonidine for postmyocardial infarction treatment
A method of treating myocardial damage secondary to myocardial infarction using moxonidine or a physiologically compatible salt thereof. Pharmaceutical preparations containing moxonidine and its...
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7030149 |
Combination of brimonidine timolol for topical ophthalmic use
Disclosed are pharmaceutical compositions comprising brimondine and timolol for topical ophthalmic delivery and a method of treatment comprising administering said composition when indicated for...
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7029706 |
Composition for the treatment of cutaneous mycosis
The inventions relates to the use of silica in the formulation of antifungal composition for the treatment of cutaneous mycoses, and method to manufacture an antifungal powder with boric acid and...
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7001605 |
Composition for controlling harmful bio-organisms and method for controlling harmful bio-organisms using the same
A composition for controlling harmful bio-organisms comprising (a) at least one imidazole compound represented by formula (I):
wherein R represents a lower alkyl group or a lower alkoxy group;...
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6995181 |
Modulators of the glucocorticoid receptor and method
Novel non-steroidal compounds are provided which are glucocorticoid receptor modulators which are useful in treating diseases requiring glucocorticoid receptor agonist or antagonist therapy such as...
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6992097 |
Growth hormone secretagogues
This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the...
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6982097 |
Biocidal compositions and methods of using same
This invention relates to biocidal compositions and methods of using same. Also provided is a process for the manufacturing of a biocidal composition in the form of a tablet and a method of using...
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6979696 |
Method for detecting a gram-negative bacterial autoinducer molecule
This invention relates to compounds which are alpha-1 receptor agonists, preferably alpha-1A/L receptor agonists, and which are represented by Formula I:
wherein m, A, X, Y, R 1 , R 2 , R 3 ,...
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6974826 |
Imidazolidinedione derivatives for the treatment of diabetes and other diseases
The present invention relates to certain substituted heterocycles of Formula (I) which are useful in the treatment of diseases related to lipid and carbohydrate metabolism, such as type 2 diabetes,...
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6962937 |
Imidazolidine derivatives, their preparation and their use
The present invention relates to novel imidazolidine derivatives of the formula I,
in which B, E, W, Y, R, R 2 , R 3 , R 30 , e and h have the meanings given herein. The compounds of the...
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6958357 |
Substituted benzimidazoles, processes for their preparation, their use as medicaments, and medicaments comprising them
The invention relates to the use of compounds of formula I for the production of a medicament for the treatment of illnesses which can be influenced by inhibition of the Na+/H+ exchanger, and to a...
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6949578 |
Cycloalkyl alkanoic acids as integrin receptor antagonists
The present invention relates to a class of compounds represented by the Formula I
or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the...
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6949536 |
Sulfonylbenzene compounds as anti-inflammatory/analgesic agents
This invention provides a compound of the formula:
or its pharmaceutically acceptable salt thereof, wherein A is partially unsaturated or unsaturated five membered heterocyclic, or partially...
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