Matches 201 - 250 out of 524 < 1 2 3 4 5 6 7 8 9 10 11 >
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5686455 Imidazole derivatives and their use as cytokine inhibitors  
As cytokine inhibitors 2,4,5-triarylimidazole compounds and compositions for use as cytokine inhibitors.
5684028 Sulphorous derivatives of imidazole, their preparation process, the new intermediates obtained, their use as medicaments and the pharmaceutical compositions  
Novel compounds of the formula ##STR1## wherein the, substituents are defined as in the specification and their non-toxic, pharmaceutically acceptable salts which inhibit the effects of angiotensin...
5681838 Substituted amino compounds, their preparation and their use as inhibitors of thrombocyte-aggregation  
The present invention relates to novel substituted amino compounds of the formula I: R 1 -(A) a -(B) b -(D) c -(CH 2 ) m -N(R 2 )-(CH 2 ) n -R 3 as defined in the present application, and...
5681843 Parabanic acid derivatives  
Parabanic acid derivatives, pharmaceutically acceptable salts thereof, and therapeutic agents containing said compounds as an effective component are useful pharmaceuticals for the treatment of...
5674858 Medicaments for treating gastrointestinal disorders  
The use is described of both (i) ranitidine bismuth citrate and (ii) one or more Helicobacter pylori-inhibiting antibiotics in treating or preventing gastrointestinal disorders. Pharmaceutical...
5668130 Medicament for treating gastrointestinal disorders  
The use is described of both (i) ranitidine bismuth citrate and (ii) one or more Helicobacter pylori-inhibiting antibiotics in treating or preventing gastrointestinal disorders. Pharmaceutical...
5663053 Inhibition of inflammatory lipid mediators  
Coenzyme A-independent transacylase is required for the release of free arachidonic acid, and the production of arachidonic acid metabolites and platelet activation factor. Blocking of this enzyme...
5656651 Androgenic directed compositions  
Substituted phenylthiohydantoins are provided for use in detecting the presence of tumor cells having androgenic receptors and providing for cytostatic and cytotoxic activity toward such cells. The...
5652255 Potentiation of bioreductive agents  
A human or animal subject having a solid tumour is treated by administering to the subject therapeutically effective amounts of a nitric oxide (NO) synthase inhibitor and a compound which is an...
5650428 Arylsulfonamide derivative and pharmaceutical compositions and use thereof  
An arylsulfonamide derivative of the formula (I): ##STR1## wherein R 1 is unsubstituted phenyl or naphthyl, or phenyl substituted by 1 to 3 same or different substituents selected from the group...
5648373 CoA-IT and PAF inhibitors  
Coenzyme A-independent transacylase is required for the release of free arachidonic acid, and the production of arachidonic acid metabolites and platelet activation factor. Blocking of this enzyme...
5635522 Immunosuppressive agents  
A suppression of the human immune system is accomplished by administering to the person an effective amount of a non-toxic thioheterocycle compound having the formula ##STR1## wherein R1 is a...
5633237 Imidazo[1,2-a]pyridinylalkyl phosphonic acid compounds for treatment of neurotoxic injury  
A class of imidazo[1,2-a]pyridinylalkyl phosphonic acid compounds is described for treatment to reduce neurotoxic injury associated with anoxia or ischemia which typically follows stroke, cardiac...
5627200 β.sub.3 -Adrenoceptor agonists and antagonists for the treatment of intestinal motility disorders, depression, prostate disease and dyslipidemia  
This invention relates to methods for treating intestinal motility disorders, intestinal ulcerations, including inflammatory bowel disease, ulcerative colitis, Crohn's disease and proctitis, and...
5624947 Phenyl derivatives useful as tachykinin antagonists  
Compounds of formula (I), or a salt or prodrug thereof are tachykinin antagonists.
5620999 Benzenesulfonamide subtituted imidazolyl compounds for the treatment of inflammation  
A class of imidazolyl compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula II ##STR1## wherein R 1 is...
5618564 Composition for the treatment of helicobacter pylori infection  
The present invention is directed to a method for the treatment of Helicobacter pylori infection wherein a composition containing protease and an antibacterial agent as active ingredients, which...
5616600 Griseolic acid compounds and their use as a phosphodiesterase inhibitor  
A compound of the formula (I) is provided ##STR1## wherein A represents a group of the formula: ##STR2## R 1 and R 2 are independently hydrogen, halogen or a group of the formula --OR 9 ; R 9 ...
5616601 1,2-aryl and heteroaryl substituted imidazolyl compounds for the treatment of inflammation  
A class of imidazolyl compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula I: ##STR1## wherein R 1 -R...
5614519 (1-(2,3 or 4-N-morpholinoalkyl)-imidazol-4-yl)-benizimidazol-1-yl-methyl]-biphenyls useful as angiotensin-II antagonists  
Angiotensin-II antagonists of the formula ##STR1## wherein R 1 is, other than hydrogen and, inter alia, halogen, lower alkyl or cycloalkyl; R 2 is, inter alia, optionally substituted...
5614545 Topical composition for treatment of blepharitis  
A pharmaceutical composition for treating blepharitis or blepharoconjunctivitis is disclosed for topical administration comprising a nitroimidazole, as metronidazole, in a suitable ophthalmic...
5612365 Angiotensin II receptor antagonists for the treatment and prophylaxis of coronary heart disease  
Angiotensin II receptor antagonists for the treatment and prophylaxis of coronary heart disease. Antagonists for angiotensin II receptors of the AT 1 subtype can be employed for the prophylaxis...
5607953 Butenoic or propenoic acid derivative  
A butenoic or propenoic acid derivative having the following formula in which G is an aryl or a heterocyclic ring, R11 and R12 are hydroben or an alkyl, X is sulfur or oxygen, R2 and R3 are...
5604246 2-aminoalkyl-5-aminoalkylamino substituted-isoquinoindazole-6(2H)-ones  
This invention is directed to 2-aminoalkyl-5-aminoalkylamino substituted isoquino[8,7,6-cd]indazole-6-(2H)-ones and to 2-aminoalkyl-5-aminoalkylamino...
5602127 (Alkanesultam-1-yl)-benzimidazol-1-yl)-1yl)-methyl-biphenyls useful as angiotensin-II antagonists  
Angiotensin-II antagonists of the formula ##STR1## wherein R 1 is, other than hydrogen and, inter alia, halogen, lower alkyl or cycloalkyl; R 2 is, inter alia, optionally substituted...
5602156 Method for inhibiting metalloproteinase expression  
Calcium homeostasis is an important regulator of MMP-2 transcription, activation and activity. Disclosed herein are compounds which inhibit the expression of matrix metalloproteinases in cells....
5599795 Method for treatment of idiopathic inflammatory bowel disease (IIBD)  
A new method for the prevention and treatment of Idiopathic inflammatory Bowel Disease (IIBD), including Crohn's Disease and Ulcerative Colitis, in human patients is provided. The key steps include...
5599830 Sulphorous derivatives of imidazole and their use as medicaments  
The invention relates to the products: ##STR1## in which: R 1 =alkyl, alkenyl, alkynyl, alkylthio, R 2B , R 3B representing: hydrogen, mercapto, formyl, acyl, carboxy nitro, cyano, --PO...
5594003 Tetrahydroimidazo[1,2-a]pyridin-2-yl-(benzimidazol-1-yl)-methyl-biph enyls useful as angiotensin-II antagonists  
Angiotensin-II antagonists of the formula ##STR1## wherein R 1 is, other than hydrogen and, inter alia, halogen, lower alkyl or cycloalkyl; R 2 is, inter alia, optionally substituted...
5591762 Benzimidazoles useful as angiotensin-11 antagonists  
Disclosed herein are angiotensin-II antagonists of the formula ##STR1## wherein R 1 is, other than hydrogen and, inter alia, halogen, lower alkyl or cycloalkyl; R 2 is, inter alia, optionally...
5565480 Substituted histidines  
Angiotensin II receptor antagonists having the formula: ##STR1## which are useful in regulating hypertension and in the treatment of congestive heart failure, renal failure, and glaucoma,...
5563159 Dithiocarbonimide derivatives useful as acaricidal, fungicidal, and insecticidal agents  
There is disclosed a dithiocarbonimide derivative of the formula: ##STR1## wherein B is a C 1 -C 6 alkyl group; X is an NH group or an oxygen atom and Y is a nitrogen atom or a CH group, A is a...
5552427 Glutaminase inhibitory compounds, compositions, and methods of use  
There is disclosed a pharmaceutical composition for inhibiting glutaminase which comprises a imidazole derivative or a salt thereof. This compound selectively inhibits the proliferation of tumor...
5550145 Potentiation of antimicrobial effects  
An antimicrobial composition comprising an antimicrobially effective amount of a combination of: A) a monoglyceride of lauric acid, a monoglyceride of monomyristic acid or a mixture of these...
5545651 Imidazole 5-position substituted angiotensin II antagonists  
Novel substituted imidazoles of Formula (I), which are useful as angiotensin II antagonists, are disclosed: ##STR1##
5538988 Benzocycloalkylazolethione derivatives  
The present invention relates to novel benzocycloalkylazolethione compounds which are dopamine β-hydroxylase inhibitors in which the benzocycloalkyl portion of the compound is selected from...
5536749 Method for attenuation of sympathetic nervous system activity or onset of migraine by selectively metabolized beta-blocking agents  
Disclosed is a method for attenuating sympathetic nervous system hyperactivity or onset of migraine in a patient in need of such treatment, by the sublingual, buccal or intranasal administration to...
5523317 Method of reducing blood pressure  
Disclosed is a method of reducing blood pressure which comprises administering to a patient an imidazole derivative of the formula: ##STR1## wherein: each of R 1 and R 2 is hydrogen, substituted...
5514698 Antifungal vaginal cream composition  
A long-lasting antifungal vaginal cream composition having stable viscosity at human body temperature is disclosed.
5510344 Acrylate fungicides  
Compounds of formula I ##STR1## wherein X is oxygen or sulphur, W is CH or N, m is 0 or 1, and either a) n is 1 and Q is a non-aromatic heterocyclic ring of 3 to 10 ring atoms, containing one to...
5506263 Benzyl derivatives and pesticides containing them  
Benzyl derivatives of the formula I ##STR1## where A is CH 2 , CHCl, CH-alkyl, CH-alkoxy, CH-alkylthio or N-alkoxy, B is OH, alkylthio, alkoxy or alkylamino, U, V, W are hydrogen, halogen,...
5506243 Sulfonamide derivatives  
Since sulfonamide derivatives of the present invention show strong inhibitory activity against cysteine protease such as calpain papain, cathepsin B, cathepsin H, cathepsin L, they can be used as...
5494934 Guanidine compounds  
A compound of formula (I): ##STR1## in which: R 1 represents substituted or unsubstituted phenyl or (C 3 -C 7 ) cycloalkyl, R 2 represents trifluoromethyl or (C 3 -C 4 ) cycloalkyl, A...
5482954 Signal transduction inhibitor triazole and diazole compounds  
A discovery underlying this invention is the concordance between particular cellular signaling mechanisms and cancer cell growth and metastasis. It has now been discovered that certain compounds...
5482957 Azole derivatives, process for their preparation and their use  
Azole derivatives, process for their preparation, and their use Azole derivatives of the formula (I) ##STR1## in which A, L, O, R 1 , X, Y, Z and q have the meanings given, process for their...
5476669 Method for treatment of gastro intestinal disorders  
A method is disclosed for preventing the recurrence of duodenal ulcer associated with Campylobacter pylori (Helicobacter pylori) infection in a patient suffering from duodenal ulcer disease...
5472956 Phosphoramidates useful as antitumor agents  
Cyclophosphamide analogs are provided of the general formula: ##STR1## wherein R 1 and R 2 are each (C 2 -C 6 )alkyl, substituted with a leaving group such as halo or alkylsulfonyl, R 3 and R 4...
5464857 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide derivatives and their use as therapeutic agents for maintaining blood pressure  
(1) The imidazoline derivative represented by the following general formula (1) ##STR1## where R 1 is a substituent endowed with water solubility or fat solubility, particularly carboxyl group or...
5462946 Nitroxides as protectors against oxidative stress  
The instant invention is directed to the use of a biologically compatible composition, containing an effective amount of a metal independent nitroxide compound which is preferably represented by...
5446065 Sulfonamides of phenylalkylamines or phenoxyalkylamines processes for their preparation and medicaments containing these compounds  
Compounds of the formula I ##STR1## in which R 1 signifies an aryl, aralkyl or an aralkenyl group, the aryl radical of which can, in each case, be substituted one or more times by halogen, cyano,...
Matches 201 - 250 out of 524 < 1 2 3 4 5 6 7 8 9 10 11 >