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6075023 |
Method for combatting fish mycoses and one-celled ectoparasites
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6071935 |
Derivatives of 2-(2-oxo-ethylidene)-imidazolidin-4-one and their use as farnesyl protein transferase inhibitors
The present invention relates to compounds of the formula ##STR1## wherein R 1 , R 2 , R 3 and R 4 are as defined herein. The invention also relates to pharmaceutical compositions containing the...
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6057322 |
Basically-substituted benzoylguanidines, a process for preparing them, their use as a medicament or diagnostic agent, and a medicament containing them
Compounds of the formula I ##STR1## and the pharmaceutically tolerated salts thereof, are described. A process for their preparation and their use as medicaments in cardiovascular diseases are also...
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6057319 |
3,4-Diaryl-2-hydroxy-2,5-dihydrofurans as prodrugs to cox-2 inhibitors
The invention encompasses the novel compound of formula (I) useful in the treatment of cyclooxygenase-2 mediated diseases. The invention also encompasses certain pharmaceutical compositions for...
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6057346 |
Inhibition of retroviral LTR promoters by calcium response modifiers
A class of calcium-response modification compounds is disclosed which inhibits the activation of retroviral LTR promoters, including the HIV-LTR. This class of compounds are used to delay or...
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6040328 |
Aromatic diselenides and selenosulfides, their preparation and their uses, more particularly their therapeutical use
The objects of the present invention are: novel organoselenium compounds: aromatic diselenides and selenosulphides; the use of said novel compounds as antioxidant agents; pharmaceutical...
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6034114 |
Medicament
The present invention relates to the use of an angiotensin II receptor antagonist in the manufacture of a medicament for the treatment of left ventricular hypertrophy regression.
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6034110 |
Method for preventing onset of restenosis after angioplasty employing an RXR-specific retinoid and a PPARγ ligand
A method is provided for preventing or reducing the risk of restenosis following angioplasty by administering a retinoid, such as an RXR-selective retinoid, e.g. the compound of the formula:...
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6015828 |
Chemical modification of chloride channels as a treatment for cystic fibrosis and other diseases
This invention relates generally to medical treatment methods. Specifically, the invention relates to methodology for the correction of defective chloride transport by activation of chloride...
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6007865 |
Reversing the formation of advanced glycosylation endproducts
The present invention relates to compositions and methods for inhibiting and reversing nonenzymatic cross-linking (protein aging). Accordingly, compositions are disclosed which comprise an agent...
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5998447 |
Heterocycles as inhibitors of leucocyte adhesion and as VLA-4 antagonists
Compounds of the formula I ##STR1## in which B, D, E, R, W, Y, Z, b, c, d, e, f, g and have the meanings indicated in the claims, are inhibitors of the adhesion and migration of leucocytes and/or...
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5985319 |
Multi-phase compositions for an initial and delayed release of a vaginal medicament
The present invention relates to multi-phase compositions for treating vaginal infections, for example, infections caused by Trichomonas vaginitis. The compositions, which are preferably formulated...
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5981492 |
Substituted 5-membered ring heterocycles, their preparation and their use
The present invention pertains to 5-ring heterocycles of general formula (I), wherein W, Y, Z, B, D, E and R as well as b, c, d, e, f, g, and h are as indicated in the description; to methods for...
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5981556 |
1,3-diazolino and 1,3-diazolidino heterocycles as useful nitric oxide synthase inhibitors
1,3-diazolino and 1,3-diazolidino heterocycle derivatives useful as nitric oxide synthase inhibitors.
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5977155 |
Imidazole-5-carboxamides
Products of formula (1), wherein R 1 is particularly ##STR1## alkyl, alkylthio or alkoxy; R 2 is particularly halogen, --S--R, --O--R or --C(OH)(R)--COOH, where R is alkyl or alkenyl; R 3 is...
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5965621 |
Methods and compositions for reducing or maintaining body weight in a mammal
A method for reducing or maintaining the level of adipose tissue formation in a mammal includes the step of administering a pantethine composition to the mammal in an amount and for a period of...
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5958958 |
1,2,4-oxa diazolino and 1,24-oxa diazolidion heterocycles as useful nitric oxide synthase inhibitors
1,2,4-oxa-diazolino and 1,2,4-oxa-diazolidino heterocycle derivatives useful as nitric oxide synthase inhibitors.
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5952354 |
Tris carbamic acid esters: inhibitors of cholesterol absorption
Inhibition of the enzymes cholesterol ester hydrolase (CEH) and/or acyl coenzyme A: cholesterol acyltransferase (ACAT) results in the inhibition of the esterification of cholesterol and are...
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5945413 |
Aspartyl protease inhibitors
This invention relates to a novel class of compounds that are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of aspartyl protease inhibitors characterized...
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5945425 |
Method of using (H.sup.+ /K.sup.+)ATPase inhibitors as antiviral agents
A class of compounds which are (H + /K + )ATPase inhibitors can be used for the treatment of viral infections. Compounds of particular interest are defined by Formula III: ##STR1## wherein D is N...
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5922744 |
Ethane-1-2-diamine derivatives and tachykinin antagonists
The present invention provides a compound of formula: ##STR1## wherein R, R 1 , R 2 , R 3 , R 4 , R 5 , R 6a and R 6b are defined herein or a pharmaceutically acceptable salt thereof, a process...
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5914343 |
Compounds and methods for inhibiting hyper-proliferative cell growth
The present invention features compounds and methods for inhibiting hyper-proliferative cell growth. The compounds and method are preferably used to treat patients having a hyperproliferative cell...
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5910507 |
Methods for control and mitigation of molluscs
A method is provided for controlling the proliferation of molluscs in target habitat by applying to the habitat a compound or mixture of compounds which are amines, ethoxylated amines, quaternary...
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5906961 |
Alkanolamide spreader-sticker surfactant combination
An adjuvant composition containing at least an alkanolamide surfactant and optionally other surfactants or pesticides or formulation aids. The surfactant preferably is reacted with a fatty acid....
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5891881 |
Aminoheterocycle-substituted glycerols
Aminoheterocycle-substituted glycerols of Formula I are disclosed: ##STR1## wherein one of A, B or C is --X--R, wherein X is --O-- or --S--, and R is a substituted or unsubstituted C 12 -24 alkyl...
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5889038 |
Methods and products for treating diarrhea and scours: use of clotrimazole and related aromatic compounds
A method and product for treating and preventing diarrhea and scours is provided. The method involves treating a subject who has diarrhea, or scours, or is at risk of getting diarrhea or scours...
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5869509 |
Diphenyl oxadiazolones as potassium channel modulators
Novel compounds of Formula 1 are useful to treat disorders responsive to openers of the large conductance calcium-activated potassium channels: ##STR1## wherein "Het" is one of a select group of...
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5869515 |
1,3-dihydro-2H-imidazol-2-one compounds
The present invention concerns the compounds of formula ##STR1## the N-oxide forms, the pharmaceutically acceptable acid or base addition salts and the stereochemically isomeric forms thereof,...
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5854268 |
Azetidine, pyrrolidine and piperidine derivatives
A class of substituted azetidine, pyrrolidine and piperidine derivatives are selective agonists of 5-HT 1 -like receptors, being potent agonists of the human 5-HT 1D α receptor subtype whilst...
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5852007 |
Cysteine and serine protease inhibitors containing D-amino acid at the P2 position, methods of making same, and methods of using same
The present invention is directed to (D)-amino acid containing inhibitors of cysteine or serine proteases. Methods for the use of the protease inhibitors are also described.
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5849776 |
Medicaments based on metronidazole or on a synergic mixture of metronidazole and clindamycin
The invention relates to the use of metronidazole, or preferably of a combination of metronidazole and clindamycin, as active principle for the manufacture of pharmaceutical compositions, more...
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5840744 |
Intravaginal treatment of vaginal infections with buffered metronidazole compositions
A non-flowing composition and method for treatment of bacterial vaginosis are disclosed. An afflicted vagina is treated with a therapeutically effective but relatively low dose of metronidazole in...
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5837718 |
Imidazole-derivatives having agonistic or antagonistic activity on the histamine H3-receptor
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5827543 |
Methods and compositions for the prevention and treatment of urogenital disorders
The subject invention encompasses methods for prevention and treatment of a human or lower animal subject having a urogenital disorder caused or mediated by one or more parasitic protozoa...
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5811444 |
Compositions for reducing abnormal stimulation of endothelin receptors and novel compounds
The invention relates to the new use and the new products of formula (I): ##STR1## in which: R 1 =represents hydroxyl, alkyl, alkenyl, alkynyl, alkoxy, alkylthio, formyl, cycloalkyl, optionally...
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5811445 |
Method of preventing abnormal stimulation of AT.sub.1 and AT.sub.2 receptors
Products of formula (1), wherein R 1 is particularly ##STR1## alkyl, alkylthio or alkoxy; R 2 is particularly halogen, --S--R, --O--R or --C(OH)(R)--COOH, where R is alkyl or alkenyl; R 3 is...
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5807875 |
Amino acid derivatives, pharmaceutical compositions containing these compounds and processes for preparing them
Amino acid derivatives, suitable for the treatment of obesity. The following compound is exemplary of the class: (R,S)-N 2 -(diphenylacetyl)-N- (4-hydroxyphenyl)methyl!-N 5 ...
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5763364 |
Thixotropic aqueous plant protection agent suspensions
The invention relates to thixotropic aqueous suspension concentrates of plant protection agents. The invention furthermore relates to the use of these agents in plant protection and the use of...
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5756527 |
Imidazole derivatives useful as modulators of multi drug resistances
The present invention relates to imidazole derivatives having formula 1 ##STR1## wherein: R 1 is selected from the group consisting of: mono-,di-,and tri-substituted phenyl or thienyl, the...
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5750547 |
Certain carbanate anti-cancer agents
The present invention is concerned with novel anticancer agents having potent antineoplastic activity without systemic toxicity and mutagenicity. The novel anticancer agents of the present...
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5747516 |
Dihydroazole compounds and their use for controlling fungal plant diseases
Dihydroisoxazoles, dihydroisothiazoles, dihydropyrazoles, dihydrothiazoles and dihydroimidazoles of Formula I ##STR1## wherein: A is O; S; N; NR 5 ; or CR 14 ; G is C or N; provided that when...
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5741794 |
Heterocyclic sulfonamide derivatives as antagonists of PAF and angiotensin II
Compounds of formula (I), wherein: A represents: a) a --VR 6 group wherein v is --C(O), --C(O)O--, --CH 2 O--, --CH 2 OC(O)--, --C(S)--, --CH 2 OC(O)NH--, --C(S)O--, --CH 2 ...
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5739148 |
6-(2-Imidazolinylamino) quinoline compounds useful as alpha-2 adrenoceptor agonists
The subject invention relates to compounds having the structure: ##STR1## wherein: (a) R is unsubstituted C 1 -C 3 alkanyl or alkenyl; (b) R' is selected from unsubstituted C 1 14 C 3 ...
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5739142 |
4-aminobenzoylguanidine derivatives
4-Aminobenzoylguanidines of the formula I ##STR1## in which A, R 1 , R 2 and R 3 have the meanings given, and the physiologically unobjectionable salts thereof exhibit antiarrhythmic properties...
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5733882 |
Retroviral protease inhibitors
The present invention provides compounds, more particularly dipeptide analogs, which bind to retroviral proteases. These compounds are inhibitors of retroviral proteases and are useful for treating...
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5721265 |
Fluorinated 2-nitroimidazole analogs for detecting hypoxic tumor cells
Agents useful for detecting hypoxic tumor cells are provided. The compounds have the structural formula (I) ##STR1## Methods of using the compounds to detect hypoxic tumor cells are also provided,...
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5721266 |
Substituted imidazolinyl-imidazolines as antagonists of SH-2 binding and therapeutic uses thereof
Methods of treating proliferative diseases or viral, inflammatory, allergic and cardiovascular diseases, and restenosis are disclosed. The present invention demonstrates the use of...
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5705514 |
Signal transduction inhibitor compounds
A method of inhibiting the invasion and metastasis of malignant solid tumors in mammals, said method comprising administering to said mammal an anti-proliferative, anti-invasive and anti-metastasis...
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5703065 |
Heteroarylamino and heteroarylsulfonamido substituted 3-benyzlaminomethyl piperidines and related compounds
The invention relates to compounds of the formula ##STR1## and to pharmaceutically acceptable salts thereof, wherein A, W, P, R 3 , Q and R 1 are as defined herein. The compounds of formula I, and...
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5700826 |
1,2,4,5-tetra substituted imidazoles as modulators of multi-drug resistance
This invention relates to compounds of Formula 1 which are pharmacologically useful for the treatment of cancer through sensitization of multi-drug resistant cancer cells to chemotherapeutic...
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