Matches 101 - 150 out of 524 < 1 2 3 4 5 6 7 8 9 10 11 >
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6498172 Prostaglandin agonists and their use to treat bone disorders  
This invention relates to prostaglandin agonists, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits containing such...
6492356 Acylguanidine derivatives as inhibitors of bone resorption and as vitronectin receptor antagonists  
The present invention relates to acylguanidine derivatives of formula (I) in which R 1 , R 2 , R 4 , R 5 , R 6 , A, m and n have the meanings indicated in the patent claims, their physiologically...
6486189 Five-membered heterocycles having biphenylsulfonyl substitution, process for their preparation, their use as a medicament or diagnostic, and medicament comprising them  
Five-membered heterocycles having biphenylsulfonyl substitution, process for their preparation, their use as a medicament or diagnostic, and medicament comprising them. Compounds of the formula I ...
6479533 Methods and compositions for the protection of mitochondria  
Protection of mitochondria from oxidative damage due to natural or disease processes as well as by the effects of exogenous factors such as incident sunlight, exposure via inhalation to oxidative...
6479531 Gastrin and cholecystokinin receptor ligands  
Compounds of formula (I) and their pharmaceutically acceptable salts are ligands at gastrin and/or cholecystokinin receptors. X and Y are independently ═N—, —N(R 5 )—═CH—, —S— or...
6472415 Androgen receptor suppressors in the therapy and diagnosis of prostate cancer, alopecia and other hyper-androgenic syndromes  
Substituted phenylalanines are provided comprising an hydantoin, urea or 2-hydroxyl, 2-methylpropionyl group, dimers thereof and alkyl, polyfluoroamido and haloarylamino derivatives thereof, as...
6465473 Method for treatment of reactive arthritis or bursitis  
An improved method for treatment of conditions in human beings associated with either or both reactive arthritis or bursitis comprising administration of a combination of L-lysine, minocycline...
6462066 Method and composition for treatment of ischemic neuronal reperfusion injury  
Methods and compositions for treatment of, or protection from, neuropathy resulting from reperfusion injury upon reversal of an ischemic condition, comprising treatment or prophylactic treatment of...
6444695 Inhibition of thrombin-induced platelet aggregation by creatine kinase inhibitors  
Methods of using creatine compounds such as creatine kinase inhibitors, and more particularly, cyclocreatine and homocyclocreatine, to inhibit thrombin-induced cytoskeletal reorganization, platelet...
6440949 Method for promoting the growth of gram-positive bacilli and increasing the acidity in vagina  
The present invention relates to a pharmaceutical formulation for stimulating the growth of gram-positive bacilli and increasing the acidity in vagina in which comprises sugar(s), to the use of...
6426360 4,5-substituted imidazolyl compounds for the treatment of inflammation  
A class of compounds is described for treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula wherein R 1 is selected from lower alkyl,...
6423712 2,4-Substituted imidazolidine derivatives, their preparation, their use and pharmaceutical preparations comprising them  
The present invention relates to imidazolidine compounds of the formula I, The compounds of the formula I are valuable pharmaceutical active compounds, which are suitable, for example, for the...
6423707 Nitroimidazole ester analogues and therapeutic applications  
Novel nitroimidazole compounds are provided that have a substituent linked via an ester linkage. The ester linkage may be obtained by derivation of the hydroxyl group of metronidazole. These...
6413962 Guanidino compounds effective as anesthetics  
The compositions are aromatic, gaunidino group containing compounds used for inducing anesthesia and reducing core temperatures in mammals.
6410542 Aminotetrazole derivatives useful as nitric oxide synthase inhibitors  
The current invention discloses aminotetrazole derivatives useful as nitric oxide synthase inhibitors.
6410574 Fungicidal composition and method for using the same  
The present invention relates to a fungicidal composition obtained by mixing a 1,2,3-thiadiazole derivative of general formula (I) useful as a plant disease controller with at least one fungicide...
6403112 Ectoin and ectoin derivatives as moisturizers in cosmetics  
The present invention relates to a compound of the tantomeric formula Ia or Ib and/or of a physiologically acceptable salt of the compound of the formula Ia or Ib and/or of a sterio-isomeric...
6399643 Spiroimidazolidine derivatives, their preparation, their use and pharmaceutical preparations formed therefrom  
The present invention relates to spiroimidazolidine derivatives of the formula I in which E, V, W, X, R 1 and R 2 have the meanings indicated in the claims. The compounds of the formula I are...
6395764 2-imidazolinylaminoindole compounds useful as alpha-2 adrenoceptor agnonists  
This invention involves compounds having the following structure: wherein: a) R 1 is hydrogen; or alkyl; bond (a) is a single or a double bond; b) R 2 and R 3 are each independently selected...
6387906 2,4,4-trisubstituted-1,3-dioxolane antifungals  
The present invention concerns novel compounds of formula a N-oxide form, a pharmaceutically acceptable acid addition salt or a stereochemically isomeric form thereof, wherein n is zero, 1, 2 or...
6380165 Immunological advanced glycation endproduct crosslink  
There is disclosed a means for standardizing a kit that provides a means for measuring the formation of advanced glycosylation endproducts (AGEs). The present invention further provides a novel...
6380182 Methods and compositions controlling biofouling using sulfamic acids  
The invention relates to a method to inhibit bacteria from adhering to a submergible surface. The method contacts the submergible surface with an effective amount of at least one sulfamic acid or...
6372772 Inhibitors of redox signaling and methods of using same  
The present invention is directed to a composition or formulation which inhibits or interferes with cellular redox function, and method of using same to restore normal cellular function. More...
6365616 Methimazole derivatives and tautomeric cyclic thiones to treat autoimmune diseases  
The present invention provides methods for treating autoimmune diseases in mammals and for preventing or treating transplantation rejection in a transplant recipient. These methods utilize...
6362207 Methods of treating viral infections with benzimidazoles  
This invention is a method of treating cancer, both carcinomas and sarcomas, and viral infections, in particular HIV through the administration of a pharmaceutical composition containing a...
6358928 Peptidyl sulfonyl imidazolides as selective inhibitors of serine proteases  
Novel α-amino and peptidyl sulfonyl imidazolides, a method for their synthesis, and a method for inhibiting serine proteases therewith are disclosed. Pharmaceutical compositions containing...
6355664 Phenylpyrrolidines, phenylimidazolidines, 3-phenyl-1,3-oxizolidines and 3-phenyl-1,3-thiazolidines and their use in the treatment of inflammatory disease  
A method treating or preventing inflammatory and immune cell-mediated diseases by the administration of certain novel and known small molecules. Exemplary of the novel compounds are those of the...
6348482 Catechols as antimicrobial agents  
Compounds, pharmaceutically acceptable salts, and compositions thereof of the general formula: wherein Ar is aryl and heteroaryl; R 1 , R 2 , R 3 , and R 4 are hydrido, alkyl, cyano,...
6339082 Tricyclic compounds, preparation method and said method intermediates, application as medicines and pharmaceutical compositions containing same  
A compound selected from the group consisting of a compound of the formula wherein the substituents are defined as set forth in the specification and its salts with non-toxic pharmaceutically...
6300356 Method for decreasing QT dispersion or inhibiting the progression of QT dispersion with an angiotensin II receptor antagonist  
Angiotensin II receptor antagonists are useful for decreasing QT dispersion or inhibiting the progression of QT prolongation in patients. Also disclosed is a method for monitoring the reduction in...
6268389 Treatment of urinary incontinence by administration of α1L-adrenoceptor agonists  
The present invention relates to the use of α lL -agonists for treating urinary incontinence.
RE37303 Imidazole compounds and their therapeutic applications  
A compound selected from the group consisting of a compound of the formula ##STR1## wherein the substituents are defined as in the specification having antagonist properties to histamine H 3 ...
6265428 Substituted phenyl compounds and derivatives thereof that modulate the activity of endothelin  
Methods, compositions, and compounds for modulating the activity of an endothelin peptide are provided. The methods use compositions that contain compounds of formula (1): ##STR1## where X and Y...
6262093 Methods of treating cancer with benzimidazoles  
This invention is a method of treating cancer, both carcinomas and sarcomas, and viral infections, in particular HIV through the administration of a pharmaceutical composition containing a...
6255331 Stable biocidal compositions  
Disclosed are biocidal compositions comprising mixtures of formaldehyde-releasing imidazolidines, such as 1,3-dimethylol-5,3-dimethylhydantoin, and 3-isothiazolones stabilized with low levels of...
6251930 Activating C1- secretion  
Diazoimidazole compounds for activating Cl-secretion are disclosed that can be used for treating cystic fibrosis.
6218368 Antibiotic treatment of age-related macular degeneration  
A method is provided for the treatment of age-related macular degeneration by administering various antibiotics, such as tetracycline and its derivatives, rifamycin and its derivatives, macrolides,...
6218417 Ace-inhibitor nitric salts  
Compounds having platelet anti-aggregating activity and antihypertension activity having reduced branchial side effects.
6201002 Method for reducing mortality with an angiotensin II antagonist  
Angiotensin II receptor antagonists are useful in reducing and preventing mortality and sudden cardiac death in symptomatic heart failure patients. Losartan potassium has been shown to reduce...
6174910 AT1 receptor antagonist for the stimulation of apoptosis  
6162792 Use of spiramycin for treating gastrointestinal disorders caused by H. pylori  
Gastrointestinal disorders involving Helicobacter pylorid are treated by administering spiramycin or spiramycin/metronidazole combinations. In addition, administration of anti-ulcer agents may be...
6162818 2-imidazolinylaminoindole compounds useful as alpha-2 adrenoceptor agonists  
This invention involves compounds having the following structure: ##STR1## wherein: a) R 1 is hydrogen; or alkyl; bond (a) is a single or a double bond; b) R 2 and R 3 are each independently...
6156800 4-fluoroalkyl-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament containing them  
There are described benzoylguanidines of the formula I ##STR1## where R(1) is R(4)--SO m , R(5)R(6)N--SO 2 --; O p --(CH 2 ) q --(CF 2 ) r --CF 3 ; --SR(10), --OR(10) or --CR(10)R(11)R(12);...
6147097 Imidazole derivatives as anti-HIV agents  
An imidazole derivative represented by general formula (I) or a salt thereof, having the effect of specifically inhibiting the growth of HIV as a pathogenic virus and being reduced in toxicity. In...
6129782 Inhibition of bacterial growth  
The invention provides a means of inhibiting bacterial growth particularly on a coated substrate. It comprises a method of forming a substantially dry powder coating containing a biocide, applying...
6121260 Method of treating conditions susceptible to modulation of NPY receptors with diarylimidazole derivatives  
Certain diaryl imidazoles act as partial agonists or antagonists for NPY receptors, in particular NPY 5 receptors. They are of use, for example in treating loss of appetite. Such compounds bear...
6112900 Care kit for contact lens wearers  
A care kit for reducing irritation and other ocular problems associated with wearing contact lenses is disclosed. The care kit includes at least one solution for the care of contact lenses; at...
6107322 Pesticidal 1-polyarylimidazoles  
A compound of formula (I): ##STR1## compositions containing them and methods of use to control pests.
6103749 Aryl imidazole compounds having phosphodiesterase IV inhibitory activity  
Novel compounds which are effective PDE IV inhibitors are disclosed. These compounds have the general structure of: ##STR1## where R 1 , R 2 , R 3 , R 4 , X 1 , X 2 and Z are described herein. The...
6083958 Anti-HIV composition containing imidazole derivative  
An anti-HIV composition comprising 2-carbamoyloxymethyl-5-(3,5-dichlorophenylthio)-4-isopropyl- 1-(pyridin-4-y l)methyl-1H-imidazole or the pharmaceutical acceptable salt thereof and other one or...
Matches 101 - 150 out of 524 < 1 2 3 4 5 6 7 8 9 10 11 >