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6916481 |
Active-substance vector multiparticulate system, production and use thereof
The invention relates to an active substance vector multiparticulate system and to the production and use thereof. The object of the invention is an active-substance vector multiparticulate system...
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6916837 |
Amidino derivatives and anticoagulants and thrombosis therapeutic agents containing them
Amidino derivatives represented by the following general formula (I):
{where X is a group represented by R 1 SO 2 NR 2 — (wherein R 1 represents optionally substituted C 6-14 aryl, etc....
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6897229 |
Synergistic combination comprising roflumilast and a PDE-3 inhibitor
The PDE 4 inhibitor N-(3,5-dichloropyrid-4-yl)-3-cyclopropylmethoxy-4-difluorome
thoxy benzamide, a pharmacologically tolerable salt or N-oxide thereof, in combination with a PDE 3 inhibitor is...
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6894069 |
Method for treating perinatal asphyxia in a human or animal neonate
A selective inhibitor of neuronal nitric oxide synthase (nNOS) and of inducible nitric oxide synthase (iNOS), which does not substantially inhibit endothelial nitric oxide synthase (eNOS), can be...
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6890942 |
Acyl sulfonamides as inhibitors of HIV integrase
The present invention relates a series of compounds of Formula I
wherein R 1 , R 2 , R 3 , and B are as defined in the specification. The compounds are useful for the inhibition of HIV...
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6881748 |
Drug targeting
A bioreductive conjugate comprises a bioreductive moiety with at least one therapeutic agent linked thereto and physiologically acceptable derivatives thereof. The bioreductive moiety incorporates...
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6869945 |
Pyrrolyl-and imidazolyl-acid amide derivatives useful as inhibitors of PDE4 isozymes
This application is directed to compounds useful as inhibitors of PDE4 in the treatment of diseases regulated by the activation and degranulation of eosinophils, especially asthma, chronic...
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6849634 |
Potassium channel inhibitors
Compounds useful as potassium channel inhibitors and especially useful for the treatment of cardiac arrhythmias and cell proliferative disorders are described.
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6846833 |
Vitronectin receptor antagonist bicyclic compounds, preparation method and compositions containing same
Compounds of formula (1):
wherein:
G represents an optionally substituted phenyl or optionally substituted heterocycle, G 1 and G 2 being N or C, T 1 represents —CH 2 —CH 2 —,...
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6846838 |
Ureido-substituted aniline compounds useful as serine protease inhibitors
Compounds having the formula (I),
or pharmaceutically-acceptable salts, hydrates or prodrugs thereof, are effective as inhibitors of Factor VIIa.
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6838475 |
Imidazolidinones as NS3-serine protease inhibitors of hepatitis C virus
The present invention discloses novel imidazolidinones which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses...
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6831092 |
Pesticidal composition and method for controlling pests
A pesticidal composition comprising at least one specific imidazole and at least one fungicide selected from the group consisting of...
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6828342 |
Nitric esters and nitrate salts of specific drugs
The present invention relates to nitric acid salts with medicines active in the respiratory system pathology treatment.
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6828331 |
Growth hormone secretagogues
What is disclosed are growth hormone secretagogues, and their uses, of the formula wherein R1 is C 6 H 5 CH 2 OCH 2 —, C 6 H 5 (CH 2 )3— or indol-3-ylmethyl; Y is pyrrolidin-1-yl, 4-C 1 -C...
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6821997 |
Therapeutic and prophylactic treatment of aging and disorders of aging in humans
A method for the treatment and prophylaxis of conditions of aging in humans, such conditions of aging associated with a decreased presence of cell-specific carbonic anhydrase enzymes in the brain,...
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6787552 |
PPAR delta activators
Compounds of the general formula (I) or salts thereof and activators of PPARδ (peroxisome proliferator activated receptor δ) containing the compounds or the salts as the active ingredient:...
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6777403 |
Method and structure for inhibiting activity of serine elastases
Therefore, it is critical that the roles these enzymes play in biological processes outside of extracellular matrix degradation or remodeling be understood in order to assess their potential as...
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6762173 |
Fungicidal composition comprising a 2-imidazolin-5-one
Fungicidal compositions comprising a compound of formula I and iprovalicarb and optionally fosetyl-Al.
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6737433 |
1-N-phenylamino-1H-imidazole derivatives as aromatase inhibitors and pharmaceutical compositions containing them
Imidazole derivatives of the formula: in which R 1 and R 2 are each independently hydrogen, (C 1 -C 6 )alkyl or (C 3 -C 8 )cycloalkyl; n is 0, 1 or 2; R 3 , R 4 , R 5 and R 6 are each...
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6730685 |
Formulation of substituted benzimidazoles
The present invention relates to stable liquid formulations that comprise a water free or almost water free, polyethylene glycol solution of sodium or potassium salt of a H + , K + -ATPase...
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6710033 |
Methods and treatment of multiple sclerosis
The invention features methods and reagents for the diagnosis, monitoring, and treatment of multiple sclerosis. The invention is based in part on the discovery that Chlamydia is present in patients...
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6696456 |
Beta disubstituted metalloprotease inhibitors
Disclosed are compounds which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the compounds have...
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6689787 |
Method of using an integrin antagonist and radiation therapy as combination therapy in the treatment of neoplasia
The present invention provides methods to treat neoplasia disorders in a mammal using a combination of radiation and an integrin antagonist.
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6683078 |
Use of sulfonyl aryl or heteroaryl hydroxamic acids and derivatives thereof as aggrecanase inhibitors
This invention is directed to a process for inhibiting aggrecanase activity. The process comprises administering a therapeutically effective amount of a sulfonyl aromatic or heteroaromatic...
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6677360 |
Biphenyl and biphenyl-analogous compounds as integrin antagonists
The present invention relates to biphenyl and biphenyl-analogous compounds, their preparation and use as pharmaceutical compositions, as integrin antagonists and in particular for the production of...
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6677353 |
Substituted N-phenyl-N-heteroaralkyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity
The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer...
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6660732 |
Compounds useful as anti-inflammatory agents
Disclosed are novel aromatic compounds which are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are...
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6656933 |
Compounds useful as anti-inflammatory agents
Disclosed are novel aromatic compounds which are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are...
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6656954 |
Sulfonyl divalent aryl or heteroaryl hydroxamic acid compounds
A sulfonyl divalent aromatic or heteroaromatic ring hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed as are a treatment process that comprises...
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6653335 |
Pharmaceutical composition for inhibiting the growth of viruses and cancers
This invention is a method of treating cancer, both carcinomas and sarcomas, and viral infections, in particular HIV through the administration of a pharmaceutical composition containing a...
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6649613 |
Diacylhydrazine derivatives
Diacylhydrazine derivatives of general formula (I) wherein X, Y, Z, R 1 , 2 and R 3 are as defined herein, and their physiologically acceptable salts or solvates thereof, are integrin...
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6645991 |
αvβ3 integrin inhibitors
The invention describes novel compounds of the formula I which are biologically active as ligands of integrin α v β 3 X—Y—Z—R 1 —CH 2 —R 2 (R 4 )—CH 2 —CO—R 5 in which X, Y, Z,...
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6638961 |
Fungicidal composition comprising a 2-imidazolin-5-one
A fungicidal composition comprising a compound A having the formula: wherein M is an oxygen or sulphur atom, n is 0 or 1, and Y is a fluorine or chlorine atom or a methyl radical; and at least...
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6635630 |
Selective neurokinin antagonists
Compound represented by the structural formula or a pharmaceutically acceptable salt thereof, wherein Ar 1 and Ar 2 are optionally substituted heteroaryl or optionally substituted phenyl; X 1 ...
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6630489 |
Quinoline derivatives as tyrosine kinase inhibitors
The invention concerns quinoline derivatives of formula (I) wherein n is 0-3 and each R 4 , which may be the same or different, is a substituent such as halogeno, hydroxy, amino, nitro,...
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6605619 |
Nitroxides as protectors against oxidatives stress
The instant invention is directed to the use of a biologically compatible composition, containing an effective amount of a metal-independent nitroxide compound which is preferably represented by...
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6605447 |
Methods and means of detecting nitric oxide synthase
Methods for identifying and monitoring increased or decreased levels of inducible nitric oxide synthase in biological samples are provided. A collection device for detecting inducible nitric oxide...
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6602514 |
Use of ectoine or ectoine derivatives in cosmetic formulations
The use of one or more compounds chosen from the compounds of the formulae Ia and Ib the physiologically compatible salts of the compounds of the formulae Ia and Ib and the stereoisomeric forms...
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6596739 |
N-(1-phenylethyl)-5-phenyl-imidazole-2-amine compounds, their compositions and uses
The subject invention involves compounds having structure (I): wherein each R1 is independently alkyl, aryl, or heterocycle; each R2, R4, R7, and R8 is independently hydrogen or other substituent;...
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RE38132 |
Phenylpyrrolidines, phenylimidazolidines,3-phenyl-1,3-oxizolidines and 3-phenyl-1,3-thiazolidines and their use in the treatment of inflammatory disease
A method treating or preventing inflammatory and immune cell-mediated diseases by the administration of certain novel and known small molecules. Exemplary of the novel compounds are those of the...
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6573288 |
Substituted sulphonyl cyanamides, method for producing same and their use as medicament
The invention relates to compounds of formula (I) in which the symbols have the meanings given in the claims. Said compounds are inhibitors of the sodium-dependent bicarbonate/chloride ion...
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6555141 |
L-ergothioneine, Milk thistle, and S-adenosylmethionine for the prevention, treatment and repair of liver damage
This invention provides therapeutic compositions for the protection, treatment and repair of liver tissue. The invention relates to novel compositions comprising two or more compounds selected from...
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6552060 |
Asymmetric disulfides and methods of using same
The present invention is directed to a composition or formulation which includes an asymmetric disulfide which alone or in combination inhibits or interferes with cellular redox function, as well...
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6552047 |
H2 receptor antagonist compounds in combination with nitric oxide donors, compositions and methods of use
The present invention describes novel nitrosated and/or nitrosylated H 2 receptor antagonist compounds, and novel compositions comprising at least one H 2 receptor antagonist compound that is...
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6541478 |
Smoking cessation treatments using naltrexone and related compounds
Nicotine dependency is treated by administration of an opioid antagonist. In some embodiments, rapid or ultra rapid detoxification techniques include using a combination of an effective amount of...
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6528535 |
Bicyclic inhibitors of protein farnesyl transferase
The present invention provide compounds of Formula I The present invention also provides a method of treating cancer and treating or preventing restenosis or atherosclerosis. Also provided by...
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6528528 |
Thiourea and benzamide compounds, compositions and methods of treating or preventing inflammatory diseases and atherosclerosis
The present invention provides compounds of Formula I shown below. The present invention also provides methods of treating or preventing 3 inflammation or atherosclerosis, and a pharmaceutical...
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6514952 |
Hydantoin derivatives as inhibitors of leucocyte adhesion and as VLA-4 antagonists
Compounds of the formula I in which B, D, E, R, W, Y, Z, b, c, d, e, f, g and have the meanings indicated in the claims, are inhibitors of the adhesion and migration of leucocytes and/or...
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6508954 |
1,3-dibromo-5,5-dimethylhydantoin of enhanced properties
Among the enhanced properties of the 1,3-dibromo-5,5-dimethylhydantoins described are their larger average particle sizes, their compactibility even though devoid of a binder, their excellent...
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6509363 |
Heterocyclic inhibitors of p38
The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods...
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