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9040573 Anti-fungal agent  
An antifungal agent against a fungus of the genus Scytalidium (Scytalidium—dimidiatum, Scytalidium—hyalinum etc.), preferably an antifungal agent for superficial mycosis caused by a fungus of the...
9029402 Pyrrole inhibitors of S-nitrosoglutathione reductase  
The present invention is directed to inhibitors of S-nitrosoglutathione reductase (GSNOR), pharmaceutical compositions comprising such GSNOR inhibitors, and methods of making and using the same.
9029408 Compounds for treatment of cancer  
The present invention relates to a compound of formula XXII and a compound of formula 17ya, which are defined as anywhere in the specification, to a composition comprising the same, and to a...
9023850 Nematocidal sulfonamides  
Disclosed are compounds of Formula 1, N-oxides, and salts thereof, wherein Z is O or S;A1, A2, A3 and A4 are independently N or CR1, provided that only one of A1, A2, A3 and A4 is N; andR1, R2, R3...
9012484 Crystal and pharmaceutical preparation containing the same crystal  
An object is to provide means for improving the solubility of luliconazole. Disclosed is a crystal consisting of luliconazole and short chain alcohol having a number of carbon atom or atoms of 1 to 4.
9005643 Inhibition of bacterial biofilms with imidazole-phenyl derivatives  
Disclosure is provided for imidazole-phenyl derivative compounds that prevent, remove and/or inhibit the formation of biofilms, compositions comprising these compounds, devices comprising these...
8993609 Compounds for treating papilloma virus infection  
The present invention relates to polyamide compositions and therapies for treating cells and subjects infected with papilloma virus.
8992891 Therapeutic approaches for treating CMT and related disorders  
The present invention relates to compositions and methods for the treatment of the Charcot-Marie-Tooth disease and related disorders. More particularly, the invention relates to combined therapies...
8980931 Method of evaluating pharmaceutical preparation containing luliconazole and index substance  
Disclosed is a method of evaluating stability of a pharmaceutical preparation containing luliconazole. The method includes measuring an amount of production of an SE form of luliconazole...
8980920 Antiviral compounds of three linked aryl moieties to treat diseases such as hepatitis C  
The present invention relates to novel Linked Tricyclic Aryl Compounds, compositions comprising at least one Linked Tricyclic Compound, and methods of using Linked Tricyclic Aryl Compounds for...
8980321 Pharmaceutical compositions providing enhanced drug concentrations  
A drug in a solubility-improved form is combined with a concentration-enhancing polymer in a sufficient amount so that the combination provides substantially enhanced drug concentration in a use...
8975290 Methods and compositions for enhancing an immune response, blocking monocyte migration, amplifying vaccine immunity and inhibiting tumor growth and metastasis  
Provided are methods of enhancing an immune response and methods for reducing the recruitment of monocytes to a lymph node by administering to an individual an angiotensin II receptor blocker or a...
8969372 Aryl imidazoles and their use as anti-cancer agents  
Therapeutically effective 2,4,5-trisubstituted imidazole compounds are provided. Also provided are methods of preparing the compounds and pharmaceutical compositions comprising the compounds alone...
8969398 Methods of treating hepatic encephalopathy  
The application describes treatment of hepatic encephalopathy using gastrointestinal specific antibiotics. One example of a gastrointestinal specific antibiotic is rifaximin.
8969341 Pyrazolopyrrolidine compounds  
The invention relates to compounds of formula (I) as described herein, pharmaceutical preparations comprising such compounds, uses and methods of use for such compounds in the treatment of a...
8969395 Triterpenoid derivatives useful as antiproliferative agents  
Formula (I) and (II). The present invention relates to the use of a new lupane derivative of general formula (I) or (II), or a pharmaceutically acceptable salt, crystal form, complex, hydrate, or...
8962670 Anti-cancer agents  
Described herein are compounds that may be selectively activated to produce active anti-cancer agents in tumor cells. Also disclosed are pharmaceutical compositions comprising the compounds, and...
8962669 Antimycotic pharmaceutical composition  
An object is to provide a medicament preparation which is excellent in the solubilization stability in relation to a compound represented by the general formula (1) during the storage in a low...
8952044 Antimycotic pharmaceutical composition  
A pharmaceutical composition which comprises 1) a compound represented by the following general formula (1) and/or a salt thereof; and 2) a ketone such as methyl ethyl ketone. Preferably, the...
8946153 Fast dissolving pharmaceutical composition  
The subject invention is directed to a pharmaceutical composition comprising an open matrix network carrying a pharmaceutically active ingredient, wherein the open matrix network comprises levan.
8940774 Tris-Quaternary Ammonium Salts and Methods for Modulating Neuronal Nicotinic Acetylcholine Receptors  
Provided are tris-quaternary ammonium compounds which are modulators of nicotinic acetylcholine receptors. Also provided are methods of using the compounds for modulating the function of a...
8940763 Combinations of solifenacin and salivary stimulants for the treatment of overactive bladder  
Disclosed herein are pharmaceutical compositions comprising a therapeutically effective amount of extended release solifenacin, or a pharmaceutically acceptable salt thereof, and a therapeutically...
8927588 Imidazole carbonyl compound  
To develop an antibiotic having a novel mechanism of action, the present inventors have searched for a compound that has weak cytotoxicity, the physical property of high solubility in water, the...
8921404 Azole derivatives in the form of lipase and phospholipase inhibitors  
The invention relates to azole derivatives of the general formula I as defined in the present application as well as to their uses in treatment of conditions that would benefit from their...
8916194 Controlled release pharmaceutical compositions of milnacipran  
A controlled release pharmaceutical compositions comprising Milnacipran or pharmaceutically acceptable salts thereof is provided. The pharmaceutical composition comprises an immediate release core...
8912199 Modulators of ATP-binding cassette transporters  
Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including...
8900566 Hepatitis C virus inhibitors  
The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such...
8901119 Peptide deformylase inhibitors  
The present invention relates to a compound of Formula (I): or a pharmaceutically acceptable salt thereof, corresponding pharmaceutical compositions, compound preparation and treatment methods...
8895599 Lipoprotein lipase-activating compositions comprising benzene derivates  
The present invention provides pharmaceutical compositions containing benzene compound(s) represented by General Formula (1) below and, particularly, LPL-activating compositions for use in...
8895584 Inhibitors of c-fms kinase  
The invention is directed to compounds of Formula I: wherein Z, X, J, R2 and W are set forth in the specification, as well as solvates, hydrates, tautomers and pharmaceutically acceptable salts...
8889725 Sugar-based bait  
An ant bait which contains an active substance having insecticidal activity and a sugar syrup is described.
8889726 Chemica compounds  
Disclosed are compounds of Formula I, Formula II, and Formula III. Also disclosed are salts of the compounds, pharmaceutical composition comprising the compounds or salts, and methods for treating...
8871210 Chemokine receptor antagonists and use thereof  
The present invention relates to a compound represented by formula (I): wherein all symbols are as defined here, a salt thereof, a solvate thereof, or a prodrug thereof. The compound of the...
8865756 Inhibitors of HCV NS5A  
Provided herein are compounds, pharmaceutical compositions and combination therapies for inhibition of hepatitis C.
8859595 Potent and selective inhibitors of hepatitis C virus  
The present invention is directed to compounds, compositions and methods for treating or preventing hepatitis C virus (HCV) infection in human subjects or other animal hosts. The compounds are as...
8859602 Inhibitors of c-fms kinase  
The invention is directed to compounds of Formula I: wherein Z, X, J, R2 and W are set forth in the specification, as well as solvates, hydrates, tautomers and pharmaceutically acceptable salts...
8859611 Thiophene inhibitors of S-nitrosoglutathione reductase  
The present invention is directed to novel thiophene inhibitors of S-nitrosoglutathione reductase (GSNOR), pharmaceutical compositions comprising such GSNOR inhibitors, and methods of making and...
8853196 Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, pharmaceutical compositions containing them, and their use in therapy  
The present invention relates to aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives of the formula (I) or a physiologically tolerated salt thereof. The invention...
8846023 Hepatitis C virus inhibitors  
The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such...
8846741 N-substituted aminobenzocycloheptene, aminotetraline, aminoindane and phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy  
The present invention relates to N-substituted aminobenzocycloheptene, aminotetraline, aminoindane and phenalkylamine derivatives of the formula (I), (II), (III) or (IV) or a physiologically...
8841278 Antiviral compounds  
The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and...
8835479 Agent for fungal dermatitis  
The invention provides a method for the treatment of fungal dermatitis. The treatment method involves administering an effective amount of luliconazole or a pharmaceutically acceptable salt...
8829037 Optical correction  
The present disclosure describes compositions which improve visual acuity and to methods for their use.
8822430 Antiviral compounds  
The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and...
8822444 Hepatitis C virus inhibitors  
This disclosure concerns novel compounds of Formula (I) as defined in the specification and compositions comprising such novel compounds. These compounds are useful antiviral agents, especially in...
8822520 Substituted bicyclic HCV inhibitors  
Provided herein are compounds, pharmaceutical compositions and combination therapies for treatment of hepatitis C.
8822449 Substituted aminoindanes and analogs thereof, and the pharmaceutical use thereof  
The invention relates to substituted aminoindanes and analogs thereof of formula (I) and the pharmaceutical use thereof. Medicaments which comprise compounds of this type are suitable for the...
8822513 Compounds for treatment of cancer  
The present invention relates to novel compounds having anti-cancer activity, methods of making these compounds, and their use for treating cancer and drug-resistant tumors, e.g. melanoma,...
8815924 Heterocyclic carbonyl compounds  
Novel heterocyclic compounds of the formula (I), in which R1, D, W, T and T′ have the meanings indicated in Claim 1, are SGK inhibitors and can be used for the treatment of SGK-induced diseases...
8815928 Hepatitis C virus inhibitors  
The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit RNA-containing virus, particularly the hepatitis C virus...