Matches 201 - 250 out of 1123 < 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >
Match Document Document Title
6498172 Prostaglandin agonists and their use to treat bone disorders  
This invention relates to prostaglandin agonists, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits containing such...
6492332 Irrigation solution and methods for inhibition of tumor cell adhesion, pain and inflammation  
This invention relates to a method of inhibiting tumor cell adhesion, pain, and inflammation at a wound during a surgical procedure by delivering an irrigation solution containing a tumor cell...
6486185 3-heteroarylidene-2-indolinone protein kinase inhibitors  
The present invention relates to novel 3-heteroarylidene-2-indolinone compounds and physiologically acceptable salts thereof which modulate the activity of protein kinases and therefore are...
6479532 Antifungal compositions  
This invention relates to an antimycotic composition comprising pyrrolnitrin and at least one member selected from the group consisting of lanoconazole, butenafine or a salt thereof, and an...
6479531 Gastrin and cholecystokinin receptor ligands  
Compounds of formula (I) and their pharmaceutically acceptable salts are ligands at gastrin and/or cholecystokinin receptors. X and Y are independently ═N—, —N(R 5 )—═CH—, —S— or...
6472416 Sulfonylphenylpyrazole compounds useful as COX-2 inhibitors  
The present invention encompasses novel sulfonylphenylpyrazole compounds useful in the treatment of cyclooxygenase-2 mediated diseases.
6472406 Sulfonamidomethyl phosphonate inhibitors of beta-lactamase  
The intention relates to bacterial antibiotic resistance and, in particular, to compositions and methods for overcoming bacterial antibiotic resistance. The invention provides novel β-lactamase...
6469032 3-(4′-bromobenzylindenyl)-2-indolinone and analogues thereof for the treatment of disease  
The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.
6469036 Peptidyl heterocyclic ketones useful as tryptase inhibitors  
The present invention relates to a series of peptidyl heterocyclic ketones which are inflammatory cell serine protease inhibitors and their compositions and methods for the prevention and treatment...
6465506 Instillation techniques for ophthalmic agents to enhance treatment effect  
The present invention provides methods for instilling an ophthalmic agent. One embodiment of a method according to the invention includes causing a patient to refrain from blinking for at least a...
6462065 Use of 5-HT3 receptor antagonists for treating musculoeskeletal diseases  
The present invention relates to a new use for compounds having 5-HT 3 (serotonin M) receptor antagonist activity, especially tropisetron, for the manufacture of a pharmaceutical composition for...
6458830 Tetrahydropyran derivatives and their use as therapeutic agents  
The present invention relates to compounds of the formula (I): wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 and n are defined herein. The compounds are of particular use...
6455537 Methods for treating opiate intolerance  
Provided are compositions comprising an opiate analgesic and an active compound containing the R isomer of N-methylnalorphine in a pharmaceutically acceptable carrier. Also provided are methods of...
6451833 N-substituted (α-imidazolyl-toluyl)pyrrole compounds for treatment of circulatory disorders  
A class of N-substituted (α-imidazolyl-toluyl)pyrrole compounds described for use in treatment of circulatory disorders. Compounds of particular interest are angiotensin II antagonists of the...
6436999 Diacyl-substituted guanidines, a process for their preparation, their use as medicine or diagnostic aid, and medicine containing them  
Diacyl-substituted guanidines of the formula I are described where X( 1 ) and X( 2 ) are as defined herein. The compounds are suitable for use as antiarrhythmic pharmaceuticals possessing a...
6429222 1-(p-thienylbenzyl)imidazoles as agonists of angiotensin (1-7) receptors, processes for their preparation, their use, and pharmaceutical preparations comprising them  
The invention relates to novel 1-(p-thienylbenzy)imidazoles of formula (I) where the radicals R(1) to R(6), X, and Y have the meaning indicated in the description, which are potent agonists of...
6426356 Imidazoethyl thiophenes  
Certain imidazoethyl thiophenes/thiazoles and benzothiophenes of the formula: where Z is CH or N; and X is independently selected from the group consisting of hydrogen, C 1-4 alkyl, bromine,...
6423712 2,4-Substituted imidazolidine derivatives, their preparation, their use and pharmaceutical preparations comprising them  
The present invention relates to imidazolidine compounds of the formula I, The compounds of the formula I are valuable pharmaceutical active compounds, which are suitable, for example, for the...
6423707 Nitroimidazole ester analogues and therapeutic applications  
Novel nitroimidazole compounds are provided that have a substituent linked via an ester linkage. The ester linkage may be obtained by derivation of the hydroxyl group of metronidazole. These...
6420412 Eprosartan dihydate and a process for its production and formulation  
The invention relates to (E)-α-[2-n-butyl-1-[(4-carboxyphenyl)methyl]-1-H-imidazol-5 -yl]methylene-2-thiopheneproprionic acid monomethanesulfonate dihydrate, a process for its production,...
6420395 Azacyclooctane and heptane derivatives, their preparation and use in therapy  
The present invention discloses compounds of formula (1) or (2), any of its enantiomers or any mixture thereof, or a pharmaceutically acceptable salt thereof; wherein n is 0, or 1; R is hydrogen,...
6420375 Fused ring compounds, process for producing the same and use thereof  
To provide a novel compound of the formula: [wherein A 1 ix a 5 or 6-membered ring which may be substituted by a group not containing a cyclic group, A 2 is an aromatic ring which may be...
6417219 Hetero-substituted cyclic amine metalloprotease inhibitors  
The invention provides compounds which are useful as inhibitors of metalloproteases, and which are effective in treating conditions characterized by excess activity of these enzymes. In particular,...
6410539 Imidazole derivatives and their use as farnesyl protein transferase inhibitors  
The present invention relates to a compound of Formula (1) wherein Ar 1 represent (A) or (B) or (C); R 1 is hydrogen, C 1-4 alkyl or C 1-4 alkanoyl; R 12 and R 13 are independently hydrogen or...
6410582 Thienylazolylalcoxyethanamines, their preparation and their application as medicaments  
The thienylazolylalkoxyethanamines (I) where R1 is a hydrogen atom, a halogen atom or a lower alkyl radical; R2, R3 and R4 represent, independently, a hydrogen atom or a lower alkyl radical; and Az...
6410576 Thiazolidine derivatives  
An object of the present invention is to provide novel thiazolidine derivatives which are useful as drugs. The thiazolidine derivatives according to the present invention are compounds represented...
6403581 Method of inhibition of farnesyl-protein transferase using substituted benz (cd) indol-2-imine and-amine derivatives  
The invention is a method of treating, inhibiting or controlling a ras-associated disease by inhibiting farnesyl-protein transferase(FPTase) enzyme, treating ras oncogene-dependent tumors, which...
6399643 Spiroimidazolidine derivatives, their preparation, their use and pharmaceutical preparations formed therefrom  
The present invention relates to spiroimidazolidine derivatives of the formula I in which E, V, W, X, R 1 and R 2 have the meanings indicated in the claims. The compounds of the formula I are...
6395764 2-imidazolinylaminoindole compounds useful as alpha-2 adrenoceptor agnonists  
This invention involves compounds having the following structure: wherein: a) R 1 is hydrogen; or alkyl; bond (a) is a single or a double bond; b) R 2 and R 3 are each independently selected...
6391901 Thrombin inhibitors  
This application relates to novel compounds of formula I (and their pharmaceutically acceptable salts), as defined herein, processes and intermediates for their preparation, pharmaceutical...
6391327 Pesticidal composition  
A pesticidal composition comprising prallethrin and a neonicotinoid compound given in the following formula (1), (2) or (3), as an active ingredient wherein, A represents a 6-chloro-3-pyridyl,...
6391879 Therapeutic anti-fungal nail preparation  
A therapeutic solution and application procedure for curing and preventing nail fungus and athlete's foot infections or Onychomycosis comprising a combination of an anti-fungal agent with DMSO in a...
6387906 2,4,4-trisubstituted-1,3-dioxolane antifungals  
The present invention concerns novel compounds of formula a N-oxide form, a pharmaceutically acceptable acid addition salt or a stereochemically isomeric form thereof, wherein n is zero, 1, 2 or...
6384042 Systemic use of 5-HT3 receptor antagonists against rheumatic inflammatory processes  
The present invention relates to a new use for compounds having 5-HT 3 (serotonin M) receptor antagonist activity, especially tropisetron, for the manufacture of a pharmaceutical composition for...
6376497 Antifungal azole derivatives having a fluorinated vinyl group and process for preparing same  
An antifungal compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein: X is CH or N; Y is O, R 1 and R 2 are each independently F or Cl; R 3 is a thiophenyl, naphthyl,...
6376509 Melanocortin receptor agonists  
Certain novel compounds and derivatives thereof are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are...
6372772 Inhibitors of redox signaling and methods of using same  
The present invention is directed to a composition or formulation which inhibits or interferes with cellular redox function, and method of using same to restore normal cellular function. More...
6369076 5-benzyl-octahydroindole and 6-benzyl-decahydroquinoline NMDA/NR2B antagonists  
Novel 5-benzyl-octahydroindoles and 6-benzyl-decahydroquinolines substituted in the 1-position are effective as NMDA NR2B antagonists useful for relieving pain.
6365615 Small molecules useful in the treatment of inflammatory disease  
Novel compounds of the formula I which are useful for treating or preventing inflammatory and immune cell-mediated diseases. Exemplary compounds are:...
6362212 Oxime derivative and bactericide containing the same as active ingredient  
A compound represented by general formula (I) or a salt thereof, a process for producing the same, an intermediate for the production thereof, and a bactericide (fungicide) containing the same as...
6362207 Methods of treating viral infections with benzimidazoles  
This invention is a method of treating cancer, both carcinomas and sarcomas, and viral infections, in particular HIV through the administration of a pharmaceutical composition containing a...
6358993 Pharmaceutically active nitrogen ring compounds and methods of use thereof  
The present invention relates to pharmaceutically acceptable compounds, including certain substituted indolinyl and derivatives thereof, 1,2,3,4-tetrahydroquinolinyl and derivatives thereof,...
6355672 Benzothiepin derivatives, process for the preparation of the same and uses thereof  
The invention provides compounds of the formula: wherein the ring A is an optionally substituted benzene ring; R 1 is an optionally substituted non-aromatic heterocyclic group; R 2 and R 3 ...
6346518 Itraconazole and saperconazole stereoisomers  
The present invention is concerned with the stereoisomeric forms of itraconazole (X=Cl) and saperconazole (X=F), which may be represented by the formula and the pharmaceutically acceptable acid...
6342516 Phenylazole compounds, process for producing the same and drugs for hyperlipemia  
Phenylazole compounds represented by general formula (1) or pharmaceutically acceptable salts thereof and drugs for hyperlipemia which contain these compounds as the active ingredient, wherein A...
6329369 Methods of treating pain and other conditions  
Methods of treating glaucoma or elevated pressure and other diseases with reduced side effects by treating a mammal in need thereof an agonist of the alpha 2B or alpha 2B/2C adrenergic receptor(s)....
6329148 Combined therapy of diterpenoid triepoxides and death domain receptor ligands for synergistic killing of tumor cells  
A synergistic combination of ligands that interact with death domain receptors, and diterpenoid triepoxides is used to increase tumor cell killing by induction of apoptosis. Ligands useful in the...
6323228 3-substituted indole angiogenesis inhibitors  
3-Substituted indole carbohydrazides having the formula ##STR1## are useful for inhibiting angiogenesis. Also disclosed are angiogenesis-inhibiting compositions and methods of inhibiting...
6313164 Dithiolin derivatives, their preparation and their therapeutic effect  
Compounds of the formula (I): ##STR1## wherein one of m and n is 0, and the other is 0, 1 or 2; k is 0 or 1 to 12; R 1 is hydrogen, a substituent which is an aryl or a heterocyclic, or an...
6310067 Urocanic acid derivatives  
Urocanic acid derivatives useful as antiallergic agents represented by the following formula (I) or a pharmacologically acceptable salt thereof: ##STR1## wherein R 2 denotes hydrogen or lower...
Matches 201 - 250 out of 1123 < 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >