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7030139 |
Compounds
Compounds of general formula (I), are disclosed and claimed in the present application, as well as salts and pharmaceutical compositions comprising the novel compounds and their use in therapy, in...
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7029706 |
Composition for the treatment of cutaneous mycosis
The inventions relates to the use of silica in the formulation of antifungal composition for the treatment of cutaneous mycoses, and method to manufacture an antifungal powder with boric acid and...
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7030149 |
Combination of brimonidine timolol for topical ophthalmic use
Disclosed are pharmaceutical compositions comprising brimondine and timolol for topical ophthalmic delivery and a method of treatment comprising administering said composition when indicated for...
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7030144 |
Substituted imidazole derivatives: GABAA receptor ligands
Substituted imidazole derivatives that bind to GABA A receptors are provided. Such compounds may be used to modulate ligand binding to GABA A receptors in vivo or in vitro, and are particularly...
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7026316 |
Dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
The present invention is directed to compounds which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in...
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7011700 |
Antibacterial colorant and ink composition comprising the same
The present invention relates to an antibacterial colorant and a composition that includes the antibacterial colorant. The antibacterial colorant has at least one functional group and at least one...
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6984651 |
Piperidine amides as modulators of chemokine receptor activity
The present application describes modulators of CCR3 of formula (I):
or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases.
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6982264 |
Substituted alcohols useful in treatment of Alzheimer's disease
The invention relates to substituted alcohol compounds of the formula (I):
wherein X, R 1 , R 2 , R 3 , R N , R 20 and R C are defined herein. The compounds are useful in the treatment or...
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6962942 |
Azacycloalkanone serine protease inhibitors
The present invention is directed to non-peptidic factor Xa inhibitors which are useful for the treatment of arterial and venous thrombotic occlusive disorders, inflammation, cancer, and...
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6960586 |
Imidazole derivatives, process for their preparation and their use
The present invention provides a compound having a steroid C 17,20 -lyase inhibitory activity, which is useful as a prophylactic or therapeutic agent of prostatism and tumor such as breast cancer...
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6951874 |
Compounds
The invention provides compounds of general formula (I) wherein Q, R, R 2 , R 4 , R 5 , R 6 , R 7 and R 8 are as defined in the specification, processes for their preparation, pharmaceutical...
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6951881 |
(1-substituted-indol-3-yl) alkylidenehydrazinecarboximidamide derivatives as 5-hydroxytryptamine-6 ligands
The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of a disorder relating to or affected by the 5-HT6 receptor.
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6949564 |
NPY-5 antagonists
The present invention provides NPY-5 receptor antagonists having a Formula (IA)
Methods and pharmaceutical compositions useful for treating diseases, conditions and/or disorders modulated by...
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6949550 |
Substituted amino methyl factor Xa inhibitors
The present application describes substituted-aminomethyl substituted compounds and derivatives thereof, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of factor Xa.
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6949578 |
Cycloalkyl alkanoic acids as integrin receptor antagonists
The present invention relates to a class of compounds represented by the Formula I
or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the...
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6949241 |
Use of lacrophyl preparation in eye drops containing therapeutically active compounds
The invention refers to the use of a lacrophyl preparation containing lysozyme, tris(hydroxymethyl)aminomethane, if desired other lacrophyl components, preferably ascorbic acid and/or citric acid...
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6943183 |
5-substituted tetralones as inhibitors of ras farnesyl transferase
The present invention provides novel 5-substituted tetralones of Formulas I, II, III, and IV and pharmaceutically acceptable salts, esters, amides, and prodrugs thereof, which are useful for...
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6927211 |
Method for reducing toxicity of combined chemotherapies
Compositions and methods are provided for use in the treatment of cancer.
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6924291 |
Process for making spiro isobenzofuranone compounds
This invention relates to a process for making spiro isobenzofuranone compounds by coupling of an aminopyrazine fragment with a spirolactone piece.
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6919331 |
Substituted 2-methyl-benzimidazole respiratory syncytial virus antiviral agents
The present invention concerns antiviral compounds, their methods of preparation and their compositions, and use in the treatment of viral infections. More particularly, the invention provides...
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6916813 |
(1-phenyl-2-heteoaryl)ethyl-guanidine compounds as inhibitors of mitochondrial F1F0 ATP hydrolase
Compounds having the formula (I), and pharmaceutically acceptable salts thereof,
are useful for modulating mitochondrial F 1 F 0 ATPase activity and treating ischemic conditions including...
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6916481 |
Active-substance vector multiparticulate system, production and use thereof
The invention relates to an active substance vector multiparticulate system and to the production and use thereof. The object of the invention is an active-substance vector multiparticulate system...
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6903117 |
Indole derivatives for the treatment of osteoporosis
A compound of formula (I):
or a salt thereof, or a solvate thereof, wherein Ra represents a group R 5 which is hydrogen, alkyl or optionally substituted aryl and Rb represents a moiety of...
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6903104 |
Indol-3-YL-2-oxoacetamide compounds and methods of use thereof
The invention is based on the discovery that certain 3-oxoacetamideindolyl compounds have potent anticancer and anti-angiogenic activity. The 3-oxoacetamideindolyl compounds are of the following...
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6900197 |
Cobalt-porphyrin complexes and use thereof as an anti-obesity agent
Cobalt-porphyrin (Co-P) complexes for use as anti-obesity agents, and compositions and methods related thereto. The Co-P complexes exhibit reduced redox activity compared to cobalt mesoporphyrin...
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6887865 |
N-heterocyclic derivatives as NOS inhibitors
N-Heterocyclic derivatives of the formula (I):
are described herein, as well as other N-heterocycles, as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these...
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6884809 |
Method and compositions for reducing cardiac dysfunctions with a selective histamine H3 receptor agonist
The invention provides a method for reducing cardiac dysfunctions in a human. The method comprises administration to the human of an effective amount of a selective histamine H 3 Receptor agonist....
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6878734 |
Gastrin and cholecystokinin receptor ligands(II)
Ligands for the gastrin and cholecystokinin (CCK) receptors are provided, together with methods for preparing such ligands, and compounds which are useful intermediates in such methods....
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6878733 |
Formulations for pharmaceutical agents ionizable as free acids or free bases
The present invention features formulations of indolinones which compounds are ionizable as free acids or free bases. The formulation is suitable for parenteral or oral administration, wherein the...
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6875788 |
Imidazoline compounds
Compounds of formula (I):
wherein:
R 1 represents an optionally substituted heteroaryl group, R 2 represents an optionally substituted cycloalkyl group, R 3 represents a hydrogen...
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6869945 |
Pyrrolyl-and imidazolyl-acid amide derivatives useful as inhibitors of PDE4 isozymes
This application is directed to compounds useful as inhibitors of PDE4 in the treatment of diseases regulated by the activation and degranulation of eosinophils, especially asthma, chronic...
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6867229 |
Antiparasitic composition for the treatment and protection of pets
Composition which is useful in particular for the treatment and protection of domestic animals which are infested with parasites or are likely to be infested with them, these compositions...
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6867230 |
Hygromycin A derivatives
This invention relates to compounds of the formula
and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R 1 , R 2 , R 3 and R 10 are as defined herein. The...
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6864270 |
Iron binding agents
Composition, article of manufacture for and method of treating malaria in a human having an infestation of Plasmodium protozoans are described. The method comprises administering a...
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6858611 |
Potassium channel inhibitors
Compounds which are useful as potassium channel inhibitors and which because of their slow off-rates are especially useful for the treatment of cardiac arrhythmias are described.
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6846839 |
Methods for treating diseases and disorders related to unregulated angiogenesis and/or vasculogenesis
The present invention relates to methods for treating diseases and disorders related to unregulated angiogenesis and/or vasculogenesis. More specifically, this invention relates to methods for...
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6835743 |
Pesticidal pyrazoles and derivatives
Process for the protection of a building that has already been built or is going to be built, whereby an effective amount of an insecticidally active compound is spread around or under the said...
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6833381 |
TNF-α inhibitors
TNF-α inhibitors containing a heterocyclic compound having angiotensin II antagonistic activity which are useful as preventives/remedies for inflammatory diseases, etc.
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6828331 |
Growth hormone secretagogues
What is disclosed are growth hormone secretagogues, and their uses, of the formula wherein R1 is C 6 H 5 CH 2 OCH 2 —, C 6 H 5 (CH 2 )3— or indol-3-ylmethyl; Y is pyrrolidin-1-yl, 4-C 1 -C...
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6821997 |
Therapeutic and prophylactic treatment of aging and disorders of aging in humans
A method for the treatment and prophylaxis of conditions of aging in humans, such conditions of aging associated with a decreased presence of cell-specific carbonic anhydrase enzymes in the brain,...
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6809098 |
Compounds
The present invention relates to compounds of formula I which are antagonists of gonadotropin releasing hormone (GnRH) activity. The invention also relates to pharmaceutical formulations, the use...
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6803370 |
Alpha amino acid derivatives—inhibitors of leukocyte adhesion mediated by VLA-4
Disclosed are certain alpha amino acid compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such...
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6784173 |
Aromatic dicarboxylic acid derivatives
Compounds of formula I wherein A, R 1 and R 2 are defined in the specification. These compounds are useful as HDAC inhibitors. Also disclosed are methods of making and using said compounds.
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6777403 |
Method and structure for inhibiting activity of serine elastases
Therefore, it is critical that the roles these enzymes play in biological processes outside of extracellular matrix degradation or remodeling be understood in order to assess their potential as...
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6770262 |
Nasal administration of agents for the treatment of gastroparesis
The present invention is directed to a method for the treatment of gastroparesis by the use of metoclopramide nasal formulation.
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6770667 |
Amide compounds
The present invention is a compound and pharmaceutical composition comprising a compound of formula (I): wherein R 1 is a 4-(lower) alkyl-imidazol-1-yl or a 4,5-di(lower) alkyl-imidazol-1-yl...
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6759428 |
Indole nitriles
Compounds of the formula (I) wherein m, n, R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as described herein, together with methods for making the compounds and using the compounds for treatment of...
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6759424 |
Imidazolidine derivatives, their preparation, their use, and pharmaceutical preparations comprising them
The present invention relates to novel imidazolidine derivatives of the formula I, in which B, E, W, Z, R, R 0 , R 2 , R 3 , e and h have the meanings indicated in the application. The compounds...
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6756391 |
Antiviral compounds
The present invention is drawn to novel antiviral compounds, pharmaceutical compositions and their use. More specifically this invention is drawn to derivatives of monocyclic polyamines which have...
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6753316 |
Acryloyl derivatives analogous to distamycin, process for preparing them, and their use as antitumor agents
Compounds which are acryloyl substituted distamycin derivatives of formula (I) wherein: n is 2, 3 or 4; m is 1 or 2; X and Y are the same or different and are selected, independently for each...
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