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5280034 |
Bis-heterocyclic prostaglandin analogs
Thromboxane receptor antagonist activity is exhibited by compounds of the formula ##STR1## wherein: W is --(CH 2 ) m -- or ##STR2## but if R 3 and R 4 complete an aromatic ring, then W cannot be...
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5276048 |
4-(1H-pyrrol-1-yl)imidazoles with angiotensin II antagonist activity
Novel substituted 4-(1-H-pyrrol-1-yl)imidazoles are disclosed as well as methods of preparing them, pharmaceutical compositions containing them, and methods of using them. Novel intermediates...
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5276050 |
Medicaments
The invention relates to the use of compounds of the general formula (I) ##STR1## and physiologically acceptable salts and solvates thereof, in which Im represents an imidazolyl group of formula:...
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5273991 |
Imidazole-containing compositions and methods of use thereof analogs of distamycin
The present invention relates to oligopeptide derivatives that are conjugated to DNA alkylating agents, having the formula ##STR1## wherein m is 0 to 4; n is 2 to 4; each R 1 is the same or...
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5266585 |
Arylphenyl ether derivatives, compositions containing these compounds and use thereof
Arylphenyl ether derivatives of the formula ##STR1## wherein Az is 1H-(1,2,4-triazolyl) or is 1-imidazolyl optionally substituted by alkyl, each of R a and R b is hydrogen, halogen, alkyl,...
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5264441 |
Disubstituted ureas and thioureas derivatives
The invention provides new ureas and thioureas derivatives of general formula (I) ##STR1## and pharmaceutically acceptable salts thereof, which are useful as therapeutic agents such as for the...
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5264206 |
Nail lacquer with antimycotic activity, and a process for the preparation thereof
A nail lacquer containing at least one film-former which is insoluble in water and at least one substance which has antimycotic activity and is from the group comprising tioconazole, econazole,...
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5262431 |
Prolinal derivatives and pharmaceutical compositions thereof
A novel prolinal derivative of general formula: ##STR1## [wherein A represents a group of the general formula: ##STR2## (wherein one of R 1 and R 2 represents hydrogen atom and the other...
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5260322 |
Angiotension II antagonists in the treatment of hyperuricemia
A pharmaceutical composition comprising a non-peptide type angiotension II receptor antagonist is useful for the treatment of hyperuricemia.
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5258401 |
Cholesterol lowering compounds
Disclosed herein are compounds of structural formula (I) ##STR1## which are useful as cholesterol lowering agents. These compounds are also useful as inhibitors of squalene synthase, inhibitors of...
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5258381 |
2-substituted-2-imidazolines
The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging) which contain novel 2-substituted-2-imidazolines. Accordingly, a composition is...
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5256657 |
Succinamide derivative matrix-metalloprotease inhibitors
Compounds having the structural formula ##STR1## wherein X is HONH or HO and especially wherein the carbon atom bearing CH 2 R 1 has the R-configuration, the carbon atom bearing CH 2 R 2 has...
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5254546 |
Fused aryl substituted imidazole angiotensin II receptor inhibitors
Substituted imidazoles such as ##STR1## which are useful as angiotensin II receptor inhibitors. These compounds have activity in treating hypertension and congestive heart failure.
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5252598 |
Labdane derivatives, a process for their preparation, and their use as medicaments
The present invention relates to labdane-derivatives of the formula ##STR1## a process for their preparation and the use of these substances as medicaments, preferably as medicaments having a...
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5248689 |
Substituted N-(imidazolyl)alkyl alanine derivatives
Angiotensin II receptor antagonists having the formula: ##STR1## which are useful in regulating hypertension and in the treatment of congestive heart failure, renal failure, and glaucoma,...
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5246956 |
N-imidazolyl derivatives of substituted alkoxyimino tetrahydronaphthalenes and chromans having antithromboxane A.sub.2 activity
The invention provides new imidazole containing alkoxyimino derivatives of tetrahydronaphthalene and chroman of general formula (I) ##STR1## wherein Z is --CH 2 --or--O--; m is an integer of 1...
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5246957 |
N-imidazolyl derivatives of substituted indole
The invention provides N-imidazolyl derivatives of substituted indole of general formula (I) ##STR1## wherein p is an integer of 1 to 4; A is a straight or branched C 1 -C 4 alkylene chain; ...
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5242939 |
Anilide derivatives with angiotensin II antagonist properties
This invention relates to anilide derivatives of Formula I ##STR1## which antagonize the binding of angiotensin II to its receptors. The compounds are useful in the treatment of hypertension, heart...
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5238953 |
N-imidazolyl derivatives of substituted tetrahydrocarbazole and cyclohept (B) indole
The invention provides new N-imidazolyl derivatives of substituted tetrahydrocarbazoles and cyclopent[b]indoles of general formula (I) ##STR1## wherein n is 1 or 2; p is an integer of 1 to 4; ...
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5236944 |
Compounds, compositions and anti-neoplastic methods
Method of treating neoplasms hosting in mammals by administering a C 1 -4 alkyl [4-[2-(4-C 1 -4 alkylphenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-ylmet
hyl-thio]pheny l]carbamate....
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5236943 |
Method for the treatment of cardiac and of vascular hypertrophy and hyperplasia
The invention relates to a method for the treatment of cardiac and of vascular hypertrophy and/or hyperplasia by administration of angiotensin II receptor blockers, preferably of the imidazole,...
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5234946 |
Substituted alkylamine derivatives
The substituted alkylamine derivatives represented by formula (I) ##STR1## wherein R 1 represents (a) substituted or unsubstituted C 2 -6 alkenyl group, (b) substituted or unsubstituted C 3 -6...
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5234917 |
Substituted 5-(alkyl)carboxamide imidazoles
Angiotensin II receptor antagonists having the formula: ##STR1## which are useful in regulating hypertension and in the treatment of congestive heart failure, renal failure, and glaucoma...
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5231106 |
Azacyclic carboxylic acid derivatives and their preparation and use
Novel O-alkylated oximes of the general formula I ##STR1## or ##STR2## wherein R 1 and R 2 are optionally substituted aromatic or heteroaromatic rings, R 3 is hydrogen or lower alkyl, R 4 is a...
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5231111 |
Imidazolyl/imidazolylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy β-amino acid derivatives
Non-peptidyl compounds characterized generally as imidazolyl/imidazolylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy β-amino acid derivatives are useful as renin inhibitors for treatment...
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5229407 |
Medicaments
The invention relates to the use of compounds of formula (I) ##STR1## wherein Im represents an imidazolyl group of formula: ##STR2## and R 1 represents a hydrogen atom or a group selected from C 1...
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5223517 |
Heterocyclically substituted cycloalkano[b]-indolesulphonamides
Heterocyclically substituted cycloalkano[b]-indolesulphonamides can be prepared by reaction of appropriate N-unsubstituted indoles with acrylonitrile, followed by hydrolysis, esterification or...
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5219855 |
Anxiolytic drug
Disclosed herein are anxiolytic drugs containing as an active ingredient a piperazine derivative represented by the following general formula (I): ##STR1## wherein m represents an integer from 2 to...
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5215989 |
Nitrogen-containing heterocyclic compounds as class III antiarrhythmic agents
Compounds of structural formula: ##STR1## wherein Ar is an aromatic ring, B is a cyclic moiety fused to Ar of 5-7 members, X and Y are bridging groups, Q is a nitrogen containing heterocycle, R 2 ...
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5214046 |
Substituted aminoalkoxybenzene anti-fungicidal compositions and use
The compound of the formula ##STR1## wherein each of R 1 and R 2 individually is hydrogen, lower alkyl or lower alkenyl or together signify straight-chain alkylene with 2 to 4 carbon atoms, R 3 ...
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5212198 |
Alkoxy-substituted dihydrobenzopyran-2-carboxylic acids and derivatives thereof
This invention relates to compounds of Formula I and the stereoisomers and pharmaceutically acceptable salts thereof ##STR1## wherein R is alkyl, alkenyl, alkynyl, or (CH 2 ) m R 3 where R 3 ...
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5211736 |
Azole derivatives of spiroheterocycles
A compound having the structural formula ##STR1## where R is C 2 -C 8 alkylene having 2 to 4 carbon atoms linking X and Y; R 1 is C 1 -C 8 linear or branched alkylene, C 1 -C 6 ...
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5212197 |
Fungicidally active pyrazole compounds
The invention relates to new, fungicidally active pyrazole compounds of the general formula ##STR1## wherein Ar is an unsubstituted phenyl group or a phenyl group, substituted with 1 or 2...
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5208235 |
Indole- and benzimidazole-substituted imidazole derivatives
Novel compounds having the formula ##STR1## where X R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as defined herein. These compounds inhibit the action of angiotensin II and are useful, therefore for...
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5208234 |
Substituted imidazole phosphonic and phosphinic acid derivatives
Novel compounds having the formula ##STR1## wherein R 1 , R 2 , R 3 , R 4 and R 5 are as defined herein. These compounds inhibit the action of angiotensin II and are useful, therefore, for...
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5204364 |
N-imidazolyl- and N-imidazolylmethyl-derivatives of substituted bicyclic compounds
The present invention relates to new N-imidazolyl and N-imidazolylmethyl derivatives of bicyclic compounds having the general formula (I) ##STR1## Wherein A is a ≥CR 3 or >CHR 3 group, in...
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5202345 |
Carbamoylpyrrolidone derivatives and drugs for senile dementia
A compound of the formula: ##STR1## wherein R 1 is hydrogen, or C 1 14 C 6 alkyl; n is an integer of from 2 to 3; Z 1 is phenyl, benzyl, or isoxazolyl and each is optionally substituted by a...
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5202343 |
Tricyclic ketones useful as HT.sub.3 -receptor antagonists
The invention relates to compounds of the general formula (I): ##STR1## wherein Im represents an imidazolyl group of the formula: ##STR2## R 1 represents a hydrogen atom or a group selected from C...
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5198458 |
Pyrrolidineamide derivatives of acylamino acid and pharmaceutical composition containing the same
A compound of the general formula: ##STR1## wherein m is an integer of 1 to 7, n is 0 or an integer of 1 to 5, R 1 is the phenyl, a substituted phenyl, the phenoxy, a substituted phenoxy or...
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5196546 |
Selective pyrazoline insecticides and fungicides
Certain pyrazolines have been found to be useful as aphicides and fungicides.
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5190942 |
Benzoxazole and related heterocyclic substituted imidazole and benzimidazole derivatives
Novel compounds are disclosed having the formula ##STR1## wherein X, Y, R 1 , R 2 , R 3 , R 4 , and R 5 are as defined herein. These compounds inhibit the action of angiotensin II and are useful,...
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5189053 |
Imidazol(in)e substituted haloarylpyrazole pesticides
Compounds of formula I ##STR1## and salts thereof, in which Ar, W, Z, A, R 1 -7, Y, m, p and n have the meanings given in the description, have pesticidal activity especially against insects,...
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5183810 |
Imidazole angiotensin II antagonists incorporating a substituted benzyl element
Substituted imidazoles attached through a methylene bridge to novel substituted phenyl derivatives of the Formula I, are useful as angiotensin II antagonists. ##STR1##
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5179111 |
Imidazole derivatives
Imidazole derivatives of general Formula I ##STR1## wherein R 1 means hydrogen, an optionally substituted C 1 -10 hydrocarbon or hetaryl residue, or a cyclic ether residue, R 2 means hydrogen,...
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5175182 |
Acryloyl substituted pyrrole derivatives
The invention relates to acryloyl substituted pyrrole derivatives of formula (I) ##STR1## wherein n is an integer of 1 to 5; each of R 1 and R 2 , which may be the same or different, is...
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5173502 |
Substituted trifluoropropan-1-yl-imidazole alpha 2-receptor anagonists
A compound selected from those of formula (I): ##STR1## in which R represents straight-chain or branched lower (C 1 -C 6 ) alkyl, (C 3 -C 8 ) cycloalkyl, optionally substituted phenyl, pyridyl or...
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5173487 |
Mevinic acid derivatives
Antihypercholesterolemic activity, due to competitive inhibition of HMG CoA reductase, is exhibited by a compound of the formula ##STR1## m is 0 to 3; R is selected from: (1) alkyl; (2)...
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5173503 |
Imidazole fungicides
Compounds of formula I ##STR1## in which X and R 1 -4 have the meanings given in the description, have activity against phytopathogenic fungi.
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5173494 |
Specific inhibition of angiotensin-II binding to angiotensin-II receptor subtype-2
4,5,6,7-Tetrahydro-1H-imidazo[4,5-c]pyridine derivatives such as 1-(4-amino-3-methylphenyl) methyl-5-diphenylacetyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]
pyridine-6-car boxylic acid are useful for...
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5166212 |
Certain n-substituted butyramide derivatives
Disclosed are compound of the formula ##STR1## wherein X and Y independently represent hydroxymethyl; cyano; carboxy; functionally modified carboxy selected from esterified carboxy, carbamoyl, and...
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