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7618969 |
Compounds which potentiate glutamate receptor and uses thereof in medicine
Compounds of formula (I) or a pharmaceutically acceptable salt, solvate or prodrug thereof, are disclosed:
wherein R 1 is C 1-6 alkyl, haloC 1-6 alkyl, C 2-6 alkenyl, amino, monoC 1-4...
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7608633 |
Heteroaryl-substituted acetone derivatives as inhibitors of phospholipase A2
The invention relates to novel heteroaryl substituted acetone derivatives which inhibit the enzyme phospholipase A 2 , pharmaceutical preparations containing these compounds and a method of...
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7598394 |
Process for the synthesis of imidazoles
The present invention provides a process for the preparation of imidazoles by reacting a cyano compound with a silylalkylisocyanide compound. Such imidazoles are useful pharmacologically-active...
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7592362 |
Substituted imidazoles
This invention relates to a range of alpha substituted 2-benzyl substituted imidazole compounds and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such...
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7579481 |
Method of making imidazole-2-ones and 2-thiones
A method of 4-substituted imidazole-2-ones and thiones which comprises reacting a methylene urea or methylene thiourea wherein said methylene is substituted with the 4-subsituent and a cyano or...
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7572790 |
Biphenyl carboxylic amide p38 kinase inhibitors
Compound of formula (I):
or pharmaceutically acceptable derivatives thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors.
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7560483 |
Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof
The present invention provides a method for synthesizing 1-(acyloxy)-alkyl derivatives from 1-acyl-alkyl derivatives, which typically proceeds stereospecifically, in high yield, does not require...
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7560475 |
Phenylacetic acid derivative, process for producing the same, and use
The present invention relates to the compound represented by formula (I)
(wherein R 1 and R 2 is hydrogen atom, C1-8 alkyl etc.; R 3 is C1-8 alkyl which may be substituted with 1 to 3...
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7550496 |
Compositions and methods for treating cancer
Hypoxia-activated prodrugs can be used to treat cancer when administered alone or in combination with one or more anti-neoplastic agents.
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7550491 |
Ionic liquids having [N(CF3)2]− anions
The present invention relates to salts comprising bis(trifluoromethyl)imide anions and saturated, partially or fully unsaturated, heterocyclic cations, to a process for the preparation thereof, and...
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7547718 |
Substituted imidazoles
This invention relates to a range of alpha substituted 2-benzyl substituted imidazole compounds and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such...
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7547701 |
Haloalkyl containing compounds as cysteine protease inhibitors
The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these...
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7534805 |
Imidazole derivatives, their preparation and their use as medicaments
Novel imidazole compounds of the formula
wherein the substituents are as defined in the application having antitumoral activity and use thereof.
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7524867 |
Tetrasubstituted imidazole derivatives as cannabinoid CB1 receptor modulators with a high CB1/CB2 receptor subtype selectivity
The present invention relates to 1,2,4,5-tetrasubstituted imidazole derivatives as selective cannabinoid CB 1 receptor modulators, in particular CB 1 receptor antagonists or inverse agonists...
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7524516 |
Corrosion inhibiting mildew remover kit
The corrosion inhibiting mildew remover kit includes a premeasured amount of sodium perborate, a premeasured amount of a liquid inhibitor and a premeasured amount of a liquid blend. The premeasured...
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7514459 |
Gamma-secretase inhibitors
Compounds of formula I:
are potent inhibitors of gamma-secretase and hence find use in treatment or prevention of diseases associated with deposition of β-amyloid.
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7507281 |
Antimicrobial cementitious composition, method and article
An antimicrobial cementitious composition for imparting antimicrobial characteristics to cement comprises a cement-based compound and an imazalil agent; combinations of agents also may be employed.
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7504426 |
Heterocyclic compounds
Certain thienopyrrolyl and furanopyrrolyl compounds are disclosed as useful to treat or prevent disorders and conditions mediated by the histamine H 4 receptor, including allergic rhinitis.
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7501445 |
Imidazolidinone compounds
This invention relates to compounds of the following formula:
in which R 1 , R 2 , A 1 , A 2 , X, Y, m, n, p, x and y are as defined herein, pharmaceutical compositions comprising the compounds...
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7498354 |
Pyrrolo[2,3-D]imidazoles for the treatment of hyperproliferative disorders
or a pharmaceutically acceptable salt or N-oxide thereof, are useful in the treatment of tumors and cancers.
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7494670 |
Composition and process for removing and preventing mildew and fungal growth
This invention comprises a composition and the process of using the composition for removing and preventing mold, mildew, and fungal growth. The composition comprises at least one alkali metal...
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7476763 |
Oxo-substituted cyclohexyl-1,4-diamine compounds
Novel cyclohexyl-1,4-diamine compounds corresponding to formula I:
methods for their production, pharmaceutical formulations containing these compounds, methods of producing such pharmaceutical...
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7470722 |
Multicyclic sulfonamide compounds as inhibitors of histone deacetylase for the treatment of disease
Disclosed herein are carbonyl compounds of Formula I as described herein.
Methods and compositions are disclosed for treating disease states including, but not limited to cancers, autoimmune...
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7459476 |
Methods for treating Alzheimer's disease using hydroxyethylene compounds containing a heterocyclic amide bond isostere
Disclosed are methods for treating Alzheimer's disease, and other diseases, and/or inhibiting beta-secretase enzyme, and/or inhibiting deposition of A beta peptide in a mammal, by use of compounds...
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7459473 |
N-linked sulfonamides of N-heterocyclic carboxylic acids or carboxylic acid isosteres
This invention relates to novel N-linked sulfonamides of N-heterocyclic carboxylic acid and carboxylic acid isosteres, their preparation, and use for treating neurological disorders including...
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7456207 |
Vaginal pharmaceutical compositions and methods for preparing them
Vaginal pharmaceutical compositions are described. These compositions contain (i) an active pharmaceutical ingredient selected from the group consisting of antimicrobial imidazoles and mixtures...
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7452899 |
Gamma-secretase inhibitors
Compounds of Formula (I): inhibit the processing of APP by gamma-secretase, and hence are useful for treatment or prevention of Alzheimer's disease.
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7449315 |
Bifunctional energy-reversible acyl-compositions
Energy-reversible acyl conjugates, intermediates, and related compositions are disclosed. In preferred aspects, examples of such compositions include:
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7449195 |
Fungicide mixtures
Fungicidal mixtures, comprising
A) imidazole derivatives of the formula I
in which R 1 and R 2 are halogen or phenyl, which may be substituted by halogen or alkyl, or R 1...
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RE40558 |
Therapeutic uses of di-aryl acid derivatives
The use of diaryl acid derivatives of formula (I)
or pharmaceutically acceptable salts, N-oxides, hydrates or solvates thereof, wherein the variables shown are defined in the disclosure, and...
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7432254 |
Method for treating glaucoma IC
Provided is a method of treating or ameliorating or preventing glaucoma, decreasing intraocular pressure or improving or amemliorting ocular accommodation in an animal, including a human comprising...
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7425638 |
Cis-imidazolines
The present invention provides compounds according to formula I
having the designations provided herein, and pharmaceutically acceptable salts and esters thereof. These compounds inhibit the...
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7423015 |
Antihelminthic drugs as a treatment for hyperproliferative diseases
The present invention is directed to the use of benzimidazole derivatives for the treatment of tumors and in combination with tumor suppressor gene therapy. In a particular embodiment, treatment of...
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7407989 |
Compounds useful for modulating abnormal cell proliferation
There is described compounds of Formula I, and salts, solvates and hydrates thereof:
wherein: R 1 , R 2 and R 3 are each independently selected from OH, C 1-6 alkyl, OC 1-6 alkyl, OC(O)C 1-6...
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7405222 |
Methods and compositions for treatment of erectile dysfunction
Disclosed are methods and compositions for treatment of male sexual dysfunction. A method of treating male sexual dysfunction includes administering a pharmaceutical composition effective to cause...
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7402602 |
Imidazole derivatives modulating the sodium channels
A method of treating cardiac rhythm disorders linked with neurodegenerating depression, bipolar disorders and irritable bowel disorders in warm-blooded animals in need thereof by administering a...
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7396848 |
Neurotrophin production/secretion promoting agent
A neurotrophin production/secretion promoting agent which comprises an azole derivative of the formula:
wherein R 1 represents a halogen atom, a heterocyclic group which may optionally be...
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7393857 |
Use of 5-HT3 receptor antagonists for treating musculoskeletal diseases
The present invention relates to a new use for compounds having 5-HT 3 (serotonin M) receptor antagonist activity, especially tropisetron, for the manufacture of a pharmaceutical composition for...
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7368467 |
Ion channel modulators
The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein...
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7351429 |
Oral solid preparation
The invention is to provide an oral solid pharmaceutical that is uniform in the content of KRP-197, having bladder-selective anticholinergic activity, being a therapeutic drug for pollakiuria and...
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7323485 |
4-(substituted cycloalkylmethyl) imidazole-2-thiones, 4-(substituted cycloalkenylmethyl) imidazole-2-thiones, 4-(substituted cycloalkylmethyl) imidazol-2-ones and 4-(substituted cycloalkenylmethyl) imidazol-2-ones and related compounds
Compounds of Formula 1
where X is S and the variables have the meaning defined in the specification are specific or selective to alpha 2B and/or alpha 2C adrenergic receptors in...
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7323433 |
R-(-)-1-[2-(7-chlorobenzo[b]thiopen-3-yl-methoxy)-2-(2,4-dichlorophenyl)-ethyl]-1H-imidazole
The invention relates to R-(−)-1-[2-(7-Chloro-benzo[b]thiophen-3-yl-methoxy)-2-(2,4
-dichloro-phenyl)-ethyl]-1H-imidazole and the salts thereof. The invention also relates to compositions thereof...
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7312219 |
Heteroaromatic inhibitors of fructose 1,6-bisphosphatase
Novel FBPase inhibitors of the formula I and X
are useful in the treatment of diabetes and other conditions associated with elevated blood glucose.
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7311766 |
Method and use of nanoparticles to bind biocides in paints
This invention relates to the use of a combination of selected substances in paint to prevent the settlement and growth of different biofouling organisms with a reduced negative effect on the...
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7297708 |
Heteroaromatic substituted cyclopropane as corticotropin releasing hormone ligands
Provided herein are novel heteroaromatic substituted cyclopropanes of the Formula (I):
as well as compositions, including pharmaceutical compositions, containing the same, and the use thereof...
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7294457 |
Direct binding assay for identifying inhibitors of HCV polymerase
A method for identifying compounds binding to HCV polymerase comprising the steps of: contacting said HCV polymerase or an analog thereof with a probe formula I:
wherein A is O, S, N, NR 1 , or...
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7282512 |
Cycloalkyl ketoamides derivatives useful as cathepsin K inhibitors
Cycloalkyl ketoamide derivatives, which are useful as cathepsin K inhibitors are described herein. The described invention also includes methods of making such cycloalkyl ketoamide derivatives as...
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7282503 |
Fungicidal mixtures based on imidazole derivatives
Disclosed are fungicidal mixtures containing a synergistically effective amount of A) a triazolopyrimidine of formula I, and B) imidazole derivatives of formula II, wherein X 1 and X 2 represent...
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7279497 |
Benzopyran derivatives substituted with secondary amines including imidazole, their preparation and pharmaceutical compositions containing them
The present invention relates to benzopyran derivatives substituted with secondary amines including imidazole, their preparation, and pharmaceutical compositions containing them. The present...
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7279496 |
Dihydroimidazo[4,5-e]indole and 7h-pyrrolo[3,2-f]quinoxaline derivatives as nicotinic acetylcholine receptor ligands and/or serotonergic ligands
Compounds of the formula (I) in which R 1 , R 2 , R 3 and R 4 are as defined in Claim 1 , are ligands of the nicotinic acetylcholine receptor and/or serotonergic ligands and are suitable for the...
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