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5583136 |
Retinoid containing skin care compositions containing imidazoles
Skin care compositions comprising a water-in-oil emulsion base containing retinoids and at least one imidazole in a free base form and possessing good physical and chemical stability.
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5583128 |
Contraception in female primates without affecting the menstrual cycle
The invention relates to the use of aromatase inhibitors for contraception in female primates and to a method for contraception in female primates using such substances and to the use of those...
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5576316 |
Method for inhibiting tumor growth rate using creatine or creatine analogs
A method for inhibiting tumor growth rate using creatine or creatine analogs is described. The creatine or creatine analogs are administered to subjects such that tumor growth rate is inhibited....
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5575993 |
Ionene polymers containing biologically-active anions
Ionene polymers having biologically-active organic and/or inorganic anions are described. Methods to prepare the ionene polymers, compositions containing them and their methods of use are also...
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5573765 |
Composition and method for treatment of vaginal yeast infections
A composition for the treatment of vaginal yeast which promotes normal vaginal bacterial growth during treatment, comprising a yeast-inhibitory agent selected from one or more of the group...
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5565466 |
Methods for modulating the human sexual response
The invention is directed to improved methods for modulating the human sexual response by administering a vasodilator to the circulation by a route of administration that avoids the "first-pass"...
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5565460 |
Therapeutic purine agents for parkinson's disease
The present invention relates to a therapeutic agent for Parkinson's disease containing as an active ingredient a polycyclic compound or a pharmaceutically acceptable salt thereof, the compound...
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5559141 |
Selective aromatase inhibiting 4(5)-imidazoles
New 4(5)-imidazole derivatives of formula (Ia) and (Ib) wherein one of R 1 and R 2 is CN and the other one is H, CH 3 , OCH 3 , NO 2 , NH 2 , CN, CF 3 , CHF 2 , CH 2 F or halogen; R' is H or...
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5559128 |
3-substituted piperidines promote release of growth hormone
The present invention is directed to certain novel compounds identified as 3-substituted piperidines of the general structural formula: ##STR1## wherein R 1 , R 1a , R 2a , R 4 , R 5 , A, X, and Y...
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5556871 |
Method for treating epithelial precancerous lesions with topical inidazoles
A method of treating epithelial precancerous lesions is provided. The method involves the administration of certain imidazoles to an epithelial precancerous lesion. The preferred imidazoles are...
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5554641 |
Nonpeptides as tachykinin antagonists
The small nonpeptides of the instant invention are tachykinin antagonists. The compounds are highly selective and functional NK 3 antagonists expected to be useful in the treatment of pain,...
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5550145 |
Potentiation of antimicrobial effects
An antimicrobial composition comprising an antimicrobially effective amount of a combination of: A) a monoglyceride of lauric acid, a monoglyceride of monomyristic acid or a mixture of these...
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5541163 |
Renin inhibiting N-(2-amino-2-oxoethyl)butanediamide derivatives
Disclosed herein are compounds of the formula: A--N(R 1 )C(O)CH 2 CHR 2 C(O)--B wherein A is R 3 R 4 NC(O)CH 2 wherein, for example, R 3 is hydrogen or alkyl and R 4 is hydrogen, alkyl or...
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5541211 |
Administration of atipamezole to elicit a yohimbine-like alpha-adrenoreceptor antagonistic noradrenergic transmission
The present invention is in the art of eliciting a yohimbine-like alpha-adrenoreceptor antagonistic noradrenergic neurotransmission male sexual activity response in penile erection. The improvement...
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5527548 |
Food products containing benzimidazole
A method for promoting digestibility of a food product having an acid character which, when ingested, causes stimulation and hypersecretion of gastric and/or duodenum mucosae. The method comprises...
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5523312 |
Antipicornaviral agents
Disclosed herein are compounds and pharmaceutical compositions useful for combating picornaviruses and preventing or treating picornaviral infections. The compounds have the formula: ##STR1##...
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5521203 |
Nitro-substituted aromatic or hetero-aromatic compounds for use in cancer treatment
A compound for treating a patient having a solid tumor in which it is known or suspected that hypoxic cells are present, which is a compound of formula (A): ##STR1## wherein X represents a...
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5514698 |
Antifungal vaginal cream composition
A long-lasting antifungal vaginal cream composition having stable viscosity at human body temperature is disclosed.
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5506242 |
Arylsufonamido-substituted hydroxamic acids
The invention relates to a method of inhibiting metalloellastase activity, of inhibiting the degradation of elastin, or of treating macrophage metalloelastase dependent conditions in mammals which...
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5498623 |
4(5) substituted imidazoles and their preparation and use
The invention provides compounds of the formula ##STR1## wherein Y is --CH 2 -- or --CO--; R 1 is F, Cl or OH; R 2 is H, F or Cl; and R 3 is H, CH 3 or CH 2 CH 3 , excluding...
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5494919 |
2-substituted piperidines, pyrrolidines and hexahydro-1H-azepines promote release of growth hormone
The present invention is directed to certain piperidine, pyrrolidine, and hexahydro-1H-azepine compounds of the general structural formula: ##STR1## wherein R 1 , R 3 , R 4 , R 5 , A, W, X, Y, and...
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5476846 |
Substituted sulfonamides, process of preparation and medicines containing same
The present invention concerns new substituted sulfonamides, and the physiologically acceptable salts, complexes, esters and amides thereof, represented by the formula ##STR1## which is defined...
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5464628 |
Pharmaceutical compositions containing 4-substituted imidazoles to be administered transdermally
This invention relates to a transdermal preparation comprising a therapeutically active compound of the formula: ##STR1## where R 1 , R 2 , and R 3 , which can be the same or different are H, CH 3...
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5459148 |
Biphenyl derivatives and their use for the treatment of hypertension and cardiac disease
Compounds of formula (I): ##STR1## [wherein: A represents a group (IIa), (IIb) or (IIc): ##STR2## R 1 is alkyl, alkenyl, cycloalkyl or a group of formula R 4 --Y--R 5 --, where: R 4 is...
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5447918 |
Gastrointestinal anti-irritant composition comprising sucralfate and methods of use
A composition comprising sucralfate and one or more anti-acid epigastralgic relieving agents in a weight ratio of between 0.5:1.0 to 1.3 sucralfate to anti-acid epigastralgic relieving agent and a...
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5444069 |
Imidazo-pyridine angiotensin II antagonists used to treat memory loss
The present invention relates to the use of 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acids and analogs thereof in antagonizing the binding of angiotensin II to AT 2 receptors to...
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5439928 |
Aromatase inhibiting 4(5)-imidazoles
Novel 4(5)-imidazole derivatives of specified formula and their non-toxic salts possess selective aromatase inhibiting properties, which are valuable in the treatment of estrogen dependent diseases...
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5438067 |
Medetomidine preparations for transdermal administration
Salts of medetomidine and optically active enantiomers, thereof, particularly the d-enantiomer are disclosed. These salts may be used to regulate the rate of the transdermal administration of...
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5433947 |
Antifungal synergistic combination of enzyme fungicide and non-enzymatic fungicide and use thereof
Antifungal composition comprising synergistic combination of fungal cell wall degrading enzyme selected from the , group consisting of chitinolytic enzymes, glucanolytic enzymes and cellulases and...
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5434177 |
Imidazoles for the treatment of age-related cognitive disorders and alzheimer
This invention relates to the use of a compound of formula ##STR1## wherein X is --CH 2 -- or ##STR2## R 1 is H, C 1 -5 -alkyl or benzyl, which can be substituted of unsubstituted; R 2 is H, C 1...
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5424309 |
N-substituted acylamino acid compounds, process for their production and their use
The present invention provides an N-substituted acylamino acid compound of the formula: ##STR1## a process for their production and pharmaceutical uses, and intermediates useful for their production.
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5422361 |
Stable cream and lotion bases for lipophilic drug compositions
A cosmetically elegant, physically and chemically stable base in the form of an oil-in-water emulsion for use in cream and lotion lipophilic drug containing- pharmaceutical compositions containing...
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5399581 |
Method and compositions for treatment of sexual impotence
A method and compositions is described for treating sexual impotence with an oral drug regimen amenable to once a day therapy. The method combines the administration of a non-selective alpha 1 ...
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5389664 |
Alleviating stomach ulcers in swine
Alleviation of stomach ulcers in swine which are being administered exogenous somatotropin, by administering to the swine a benzimidazole compound selected from heterocyclylalkyl(sulfinyl or...
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5387600 |
Treating arteriosclerosis using benzimidazole compositions
Disclosed are an antihyperlipidemia or antiarteriosclerosis agent comprising a certain benzimidazole or 2,2'-methylenebisphenol derivative such as 5-dodecanoylamino-2-mercaptobenzimidazole or...
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5382590 |
N-phenyl-N-acetamidoglycinamides, their preparation and medicaments containing them
Compounds of formula: ##STR1## in which R 1 represents a hydrogen atom or an alkyl, alkoxycarbonyl or an unsubstituted or substituted phenyl radical, R 2 represents a hydrogen atom or an...
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5373017 |
Imidazolyl/benzimidazolyl-terminated alkylamino ethynyl alanine amino diol compounds for treatment of hypertension
Compounds characterized generally as imidazolyl/benzimidazolyl-terminated alkylamino ethynyl alanine amino diol derivatives are useful as renin inhibitors for the treatment of hypertension....
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5369128 |
Method of synchronizing farrowing in swine
The invention provides a method of synchronizing farrowing in swine comprising the steps of administering an effective amount of a prostaglandin and then administering to the sows an effective...
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5366984 |
Methyl α-arylacrylates substituted by a heterocyclic radical and their use
Methyl α-arylacrylates substituted by a heterocyclic radical and having the general formula ##STR1## where R is alkyl, alkenyl, haloalkyl, cycloalkyl, alkoxy, alkylcarbonyl, alkoxycarbonyl,...
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5358959 |
Methods for treating arteriosclerosis
The applicant has identified a particular class of imidazoles that inhibit endothelial cell, vascular smooth muscle cell and fibroblast proliferation. These imidazoles can be used to beneficially...
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5354770 |
Using imidazolyl tetrahydronaphthalene carboxylic acids to inhibit restenosis
A restenosis inhibiting agent for the treatment or prevention of restenosis after percutaneous transluminal coronary angioplasty which comprises a pharmaceutically effective amount of a compound of...
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5354779 |
Substituted oxime ether amides
New oxime ether amides of the formula (I) ##STR1## in which R has the meaning given in the description, and a plurality of processes for their preparation were described. The new oxime ether amides...
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5344840 |
4-substituted imidazole derivatives useful in perioperative care
4-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole, known as medetomidine, and in particular its d-enantiomer and salts thereof are useful in perioperative care, in particular in reducing the amount of...
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5340823 |
Organosilane derivatives, pharmaceutical compositions containing them and process for preparing same
A method of treating a mammalian subject for Parkinson's disease or to provide a central muscle relaxant effect, which comprises the step of administering to the mammalian subject in need of the...
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5338749 |
Diaryl-substituted heterocyclic compounds, their preparation and drigs and cosmetics obtained therefrom
Compounds of formula I ##STR1## and compounds of formula Ia ##STR2## where the substituents are as defined in the specification.
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5338744 |
Angiotensin II antagonists used to treat reproductive functions associated with AT.sub.2 receptors
The present invention relates to the use of 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acids and analogs thereof in antagonizing the binding of angiotensin II to AT 2 receptors.
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5332427 |
Wood preservatives
A wood preservative comprising a styryl triazole derivative of the formula [I] ##STR1## wherein X represents chlorine or hydrogen as an active ingredient. The present wood preservative has a...
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5324731 |
Method of inhibiting transformation of cells in which purine metabolic enzyme activity is elevated
A method of inhibiting growth, transformation and/or metastasis of mammalian cells, particularly epithelial cells, in which activity of at least one enzyme, which participates in purine metabolism...
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5321030 |
Creatine analogs having antiviral activity
The present invention relates to the use of analogs of creatine, such as cyclocreatine, as antiviral agents. Analogs of creatine can be used as antiviral agents against a variety of viruses,...
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5304569 |
Compositions and their use in lowering intraocular pressure
Compounds of formula: ##STR1## where X is --CH 2 --, --CH(CH 3 )--, --CHR 3 --CH 2 -- or --CR 3 CH-- and R 1 , R 2 and R 3 , which can be the same or different, are each H or CH 3 or a...
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