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6878731 |
Imidazole alkaloids from Lepidium meyenii and methods of usage
The present invention relates to novel imidazole alkaloid compounds that have been isolated as a form of chloride salt from a root extract of Lepidium meyenii Walp, with the common name Maca, and...
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6875775 |
Triphenylalkene derivatives and their use as selective estrogen receptor modulators
The invention provides novel selective estrogen receptor modulator compounds of the general formula:
wherein R1 and R2, which are the same or different are
a) H, halogen, OCH 3 , OH; or...
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6867229 |
Antiparasitic composition for the treatment and protection of pets
Composition which is useful in particular for the treatment and protection of domestic animals which are infested with parasites or are likely to be infested with them, these compositions...
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6855727 |
Muscular fatigue-controlling composition and method for providing muscular fatigue-controlling effect
An antifatigue composition for reducing muscular fatigue or the like during or after exercise, which includes an imidazole compound obtained from extracts of fishes, shelifishes, fowl, flesh or the...
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6846833 |
Vitronectin receptor antagonist bicyclic compounds, preparation method and compositions containing same
Compounds of formula (1):
wherein:
G represents an optionally substituted phenyl or optionally substituted heterocycle, G 1 and G 2 being N or C, T 1 represents —CH 2 —CH 2 —,...
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6846837 |
Topical administration of basic antifungal compositions to treat fungal infections of the nails
Methods and topical pharmaceutical formulations are provided for the treatment of nail fungus (onychomycosis). The invention involves a pharmacologically active antifungal agent, plus a...
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6838475 |
Imidazolidinones as NS3-serine protease inhibitors of hepatitis C virus
The present invention discloses novel imidazolidinones which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses...
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6835726 |
Pyrimidine derivatives
Compounds and compositions are provided which are useful for the treatment of viral infections, particularly human Cytomegalovirus infection. The compounds include novel pyrimidine-based derivatives.
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6821997 |
Therapeutic and prophylactic treatment of aging and disorders of aging in humans
A method for the treatment and prophylaxis of conditions of aging in humans, such conditions of aging associated with a decreased presence of cell-specific carbonic anhydrase enzymes in the brain,...
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6815440 |
Cyclic and heterocyclic N-substituted α-iminohydroxamic and -carboxylic acids
Cyclic and heterocyclic N-substituted α-iminohydroxamic and -carboxylic acids Compounds of the formula I are suitable for preparing pharmaceuticals for the treatment of disorders in the course...
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6806291 |
Analgesic compounds, their synthesis and pharmaceutical compositions containing them
New analgesic compounds, which are prepared by the hydrolysis of N-acylated 4-hydroxyphenylamine derivatives, their synthesis and pharmaceutical compositions containing them are disclosed. These...
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6794405 |
Alicyclic imidazoles as H3 agents
Alicyclic imidazole compounds; pharmaceutically active compositions containing such compounds; and the use of such compounds in formulations for the control or prevention of disease states in which...
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6774116 |
Prodrugs via acylation with cinnamate
A prodrug composition containing a cinnamate moiety and a biologically active molecule moiety which can be released by hydrolysis or activated by light is disclosed. The cinnamate moiety can have...
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6770306 |
Drugs for reducing vaginal acidity and treatment of vaginitis, and the use thereof
The present invention relates to a pharmaceutical composition for reducing vaginal acidity, treating abnormal enhancement of vaginal acidity, and high acidity vaginitis associated with abnormal...
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6762198 |
Dihetero-substituted metalloprotease inhibitors
Disclosed are compounds which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the compounds have...
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6743816 |
Imidazole derivatives with anti-inflammatory activity
Novel imidazole derivatives of formula I and their salts, solvates and prodrugs, wherein the meanings of the different radicals are as shown in the description. Said compounds are useful as...
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6737418 |
Aryl substituted pyrazoles, imidazoles, oxazoles, thiazoles and pyrroles, and the use thereof
This invention relates to compounds having the Formula I: or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein Het and R 5 -R 13 are set in the specification. The...
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6716867 |
Use of dexmedetomidine for ICU sedation
The present invention relates to a method of sedating a patient while in the intensive care unit comprising administering dexmedetomidine of a pharmaceutically acceptable salt thereof to the...
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6713500 |
Agent for controlling animal diseases caused by parasites
The present invention provides an agent for controlling animal diseases caused by parasites, which contains, as an active ingredient, an imidazole compound represented by the formula (I): ...
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6699898 |
Substituted N,N-disubstituted non-fused heterocyclo amino compounds useful for inhibiting cholesteryl ester transfer protein activity
The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer...
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6673807 |
Immunosuppressive imidazole derivatives and their combination preparations with tacrolimus or cyclosporins
Methods for increasing graft survival time comprising administering the combination of a compound that inhibits the production of nitric oxide and a compound that is a tricyclic macrolide, such as...
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6667342 |
Benzenesulfonamide-derivatives and their use as medicaments
Compounds of formula (I), pharmaceutically acceptable salts or in vivo hydrolysable esters thereof, wherein: Ring X is phenyl or a six membered heteroaryl ring containing one or two ring nitrogens...
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6664283 |
Pharmaceuticals for neurogenic pain
This invention relates to pharmaceuticals for neuropathic pains comprising an mGluR1 receptor antagonist for systemic administration. Drugs efficacious in treating various neuropathic pain can be...
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6660761 |
Method of treatment for fungal infections with a synergistic formulation of antifungal agents
The present invention relates to a method of treatment of fungal infections consisting essentially of a synergistic combination of plant compounds that are useful for enhancing the activity of...
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6656928 |
Composition for the topical treatment of rashes, dermatoses and lesions
Composition for topical administration comprising (a) a corticosteroid, (b) a drying agent, and (c) a broad spectrum anti-fungal agent that treats both dermatophytes and yeast.
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6653335 |
Pharmaceutical composition for inhibiting the growth of viruses and cancers
This invention is a method of treating cancer, both carcinomas and sarcomas, and viral infections, in particular HIV through the administration of a pharmaceutical composition containing a...
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6635630 |
Selective neurokinin antagonists
Compound represented by the structural formula or a pharmaceutically acceptable salt thereof, wherein Ar 1 and Ar 2 are optionally substituted heteroaryl or optionally substituted phenyl; X 1 ...
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6613788 |
Elevation of circulating blood histamine levels
Methods for obtaining beneficial stable levels of circulating histamine are disclosed for use in methods for enhancing natural killer cell cytotoxicity and for elevating histamine levels in...
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6610746 |
Synergistic effect of a sulfonylurea and/or non-sulfonylurea K&plus ATP channel blocker, and a phosphodiesterase 3 type inhibitor
The present invention provides methods of treating non-insulin dependent diabetes mellitus, insulin resistance, Syndrome X, diabetic neuropathy, diabetic nephropathy, diabetic retinopathy, diabetic...
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6610682 |
Pharmaceutical compositions and methods for the treatment of arteriosclerosis
A pharmaceutical composition comprising as its active ingredients one or more drugs selected from the group consisting of angiotensin II receptor antagonists and angiotensin converting enzyme...
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6602896 |
p38MAPK inhibitor and uses thereof
The present invention demonstrates that p38 MAPK inhibitor induces low density lipoprotein receptor expression 6-8 fold, and further provides the application of such inhibitor in the treatment of...
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6599926 |
Heteroaryl-phenyl substituted factor Xa inhibitors
The present application describes heteroaryl-phenyl substituted compounds and derivatives thereof, or pharmaceutically acceptable salt or prodrug forms thereof, which are useful as inhibitors of...
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6582683 |
Dermal barrier composition
Disclosed is a dermal barrier composition which contains a hydrophilic polymer emulsion and a hydrophobic polymer emulsion. The dermal barrier composition is moisture activated, and remains inert...
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6576652 |
Use of an angiotensin II receptor antagonist for the preparation of drugs to increase the survival rate of renal transplant patients
The present invention relates to the use, for the preparation of drugs to increase the survival rate of transplant patients, including renal and heart transplant patients, of a therapeutically...
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6576645 |
Triphenylalkene derivatives and their use as selective estrogen receptor modulators
The invention provides novel selective estrogen receptor modulator compounds of the general formula: wherein R1 and R2, which are the same or different are a) H, halogen, OCH 3 , OH; or where...
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6566381 |
Hetero-substituted metalloprotease inhibitors
Heterocyclic substituted compounds having the general structure: which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these...
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6565894 |
Healthcare formulations comprising imidazole and hydrogen peroxide
An ophthalmic solution comprising: 0.01 to 5 weight percent imidazole: 0.01 to 30 weight percent hydrogen peroxide and the balance water which can further comprisie 0.01 to 2 weight percent of a...
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6559157 |
Dihydronaphthalene compounds
Dihydronaphthalene compounds have excellent 17α-hydroxylase/C 17-20 -lyase inhibiting activity, thromboxan A 2 synthesis inhibiting activity, and aromatase inhibiting activity and are thereby are...
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6551583 |
Antibiofouling method and apparatus for optical sensors
An antibiofouling material, a method for making said antibiofouling material, a sensor apparatus employing said antibiofouling material, and a method of making said sensor apparatus. The disclosed...
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6552060 |
Asymmetric disulfides and methods of using same
The present invention is directed to a composition or formulation which includes an asymmetric disulfide which alone or in combination inhibits or interferes with cellular redox function, as well...
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6545009 |
Retinoid-related receptor function regulating agent
1,3-Azole derivatives, pharmaceutical compositions thereof and methods for regulating the function of retinoid-related receptors with 1,3-azole derivatives are disclosed. Such regulation may be...
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6544550 |
Medicaments for gastrointestinal disorders
The invention relates to the co-administration in human or veterinary medicine of 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)me
thyl]-4H-carbazol-4-one or a physiologically...
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6541505 |
Substituted (aminoiminomethyl or aminomethyl) benzoheteroaryl compounds
This invention is directed to an (aminoiminomethyl or aminomethyl)benzoheteroaryl compound of formula I which is useful for inhibiting the activity of Factor Xa by combining said compound with a...
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6541421 |
Buffered phosphorus containing solution
This invention relates to a buffered phosphorus containing solution comprising at least one phosphorus compound selected from the group consisting of phosphorous acid, hypophosphorous acid,...
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6537970 |
Pharmaceutical composition
The invention relates to a novel pharmaceutical combination comprising clindamycin and clotrimazole for use for vaginal infections.
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6525082 |
Apoptosis inducer
A substance for inducing apoptosis represented by specific formulae. A pharmaceutical composition which can be used for an anticancer agent containing said substance.
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6518287 |
Substituted imidazoles as dual histamine H1 and H3 agonists or antagonists
The present invention discloses novel substituted imidazole compounds which have either or dual histamine-H 1 and H 3 receptor antagonist activity as well as methods for preparing such compounds....
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6514934 |
Imidazoline α-adrenergic receptor antagonist compounds in combination with nitric oxide donors, compositions and methods of use
The present invention is directed to nitrosated or nitrosylated α-adrenergic receptor antagonists, compositions comprising α-adrenergic receptor antagonists that are optionally substituted with...
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6515007 |
Methods for managing scalp conditions
This application relates to a pharmaceutical composition for the prevention, treatment, and management of scalp conditions, such as dandruff, seborrheic dermatitis, psoriasis, folliculitis, and...
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6514966 |
Compounds for the treatment of obesity
NPY antagonists, methods of using such NPY antagonists and pharmaceutical compositions containing such NPY antagonists. The NPY antagonists are useful for the treatment of NPY mediated...
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