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7625876 |
Methods of optimizing drug therapeutic efficacy for treatment of immune-mediated gastrointestinal disorders
The present invention provides a method of optimizing therapeutic efficacy and reducing toxicity associated with 6-mercaptopurine drug treatment of an immune-mediated gastrointestinal disorder such...
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7601745 |
Heterocyclic NF-kB inhibitors
The present invention relates to compounds of the general formula (III) or pharmaceutically acceptable salts thereof with an acid or a base, or pharmaceutically acceptable prodrugs or a...
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7560483 |
Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof
The present invention provides a method for synthesizing 1-(acyloxy)-alkyl derivatives from 1-acyl-alkyl derivatives, which typically proceeds stereospecifically, in high yield, does not require...
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7524851 |
Diagnostic methods for therapeutic compounds and methods for monitoring azathioprine therapy
The present invention provides diagnostic methods for predicting therapeutic efficacy in an individual being treated for an autoimmune or an inflammatory disease. In addition, the present invention...
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7514457 |
Substituted aryloxymethyl bicyclicmethyl acetamide compounds
Compounds of the general formula (I):
pharmaceutical compositions comprising a compound of general formula (I); and methods of treating disease conditions caused by overactivation of the VR1...
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7488746 |
Substituted thiophenes: compositions, processes of making, and uses in disease treatment and diagnosis
Substituted thiophenes, processes for their preparation, their use as medicament or diagnostic agent. The substituted thiophene derivatives have the following backbone structure:
Medicaments...
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7456183 |
Guanidino compounds
Compounds having the general structure I are provided. X and Y are independently selected from the group consisting of CH 2 , N, NR 9 , C═O, C═S, S═O, SO 2 , S, O, (CR 6 R 7 ) n ,...
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7452912 |
Fused ring heteroaryl and heterocyclic compounds which inhibit leukocyte adhesion mediated by VLA-4
Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the...
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7429608 |
Benzo[d]imidazol analogs as vanilloid receptor ligands and their use in treatments
Substituted benzimidazoles and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular...
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7425546 |
Methods of optimizing drug therapeutic efficacy for treatment of immune-mediated gastrointestinal disorders
The present invention provides a method of optimizing therapeutic efficacy and reducing toxicity associated with 6-mercaptopurine drug treatment of an immune-mediated gastrointestinal disorder such...
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7414138 |
Benzoxazole and benzodiazole UV-A sunscreens
The present invention relates to 1,3-benzoxazole or benzodiazole UV-A sunscreens and to compositions, in particular topical compositions, containing the above UV-A sunscreens.
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7410990 |
Heterocyclic compounds
This invention features a compound of formula (I):
R 1 is aryl or heteroaryl; each of R 2 and R 4 , independently, is H, halogen, CN, alkyl, OR a , or NR a R b ; R 3 is H, halogen, CN,...
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7399772 |
Substituted benzimidazole dosage forms and method of using same
The present invention relates to pharmaceutical preparations comprising substituted benzimidazole proton pump inhibitors. There is provided a liquid or solid pharmaceutical composition consisting...
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RE40245 |
Gyrase inhibitors and uses thereof
The present invention relates to compounds of the formula I:
or a pharmaceutically acceptable derivative or prodrug thereof. The compounds are useful as inhibitors of bacterial gyrase...
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7348333 |
Cycloalkyl derivatives as inhibitors of bone resorption and vitronectin receptor antagonists
There are described cycloalkyl derivatives of the formula (I)
R 1 —Y-A-B-D-E-F-G (I)
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7332505 |
Nitrosated and nitrosylated proton pump inhibitors, compositions and methods of use
The present invention describes novel nitrosated and/or nitrosylated proton pump inhibitor compounds, and novel compositions comprising at least one proton pump inhibitor compound that is...
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7300947 |
N-dihydroxyalkyl-substituted 2-oxo-imidazole derivatives
The invention provides the compounds represented by the formula (I)
in which, R stands for a dihydroxy-substituted C 1 -C 6 alkyl group, and Cy stands for an optionally substituted C 6 -C...
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7285569 |
Tricycles, their manufacture and use as pharmaceutical agents
The present invention relates to compounds of formula I
their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned...
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7282503 |
Fungicidal mixtures based on imidazole derivatives
Disclosed are fungicidal mixtures containing a synergistically effective amount of A) a triazolopyrimidine of formula I, and B) imidazole derivatives of formula II, wherein X 1 and X 2 represent...
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7241789 |
Substituted indoles and their use as integrin antagonists
The present invention relates to novel substituted indole compounds that are antagonists of alpha V (αv) integrins, for example α v β 3 and α v β 5 integrins, their pharmaceutically...
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7176163 |
Pharmacological effect potentiators for pesticides
By applying a compound selected from jasmonic acid represented by the following general formula (I) or 2-substituted form of jasmonic acid or derivatives thereof or salts thereof, the...
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7169793 |
Process for preparation of optically pure or optically enriched sulfoxide compounds, including amorphous esomeprazole and salts thereof
A process of preparation of optically pure or optically enriched isomers of omeprazole and structurally related sulfoxides is provided. Also provided are an amorphous form of esomeprazole, as well...
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7160915 |
N-methyl-substituted benzamidazoles
The present invention relates to N-methyl-substituted benzamidazole derivatives of formula (I):
as defined in the specification; pharmaceutical compositions and methods of use thereof.
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7157078 |
Devices and methods for eliminating termite colonies
This invention relates to devices, kits, and methods for eliminating termite colonies. The kits, devices, and methods employ a termiticidal bait matrix containing
a) a termiticide selected...
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7141599 |
Immunosuppressive effects of administration of a cyclooxygenase-2 inhibitor, a leukotriene B4 receptor inhibitor and a cyclosporin
Treatment with a cyclooxygenase-2 inhibitor and a leukotriene B 4 receptor antagonist is described as being useful in reducing recipient rejection of transplanted organs and for treatment of...
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7125863 |
Inhibitors of dipeptidyl peptidase IV
Compounds according to formula (1), wherein R 1 is H or CN, X 1 is S, O, SO 2 or CH 2 , X 2 is CO, CH 2 or a covalent bond, Het is a nitrogen-containing heterocycle and n is 1–5 are new. The...
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7105497 |
Methods of optimizing drug therapeutic efficacy for treatment of immune-mediated gastrointestinal disorders
The present invention provides a method of optimizing therapeutic efficacy and reducing toxicity associated with 6-mercaptopurine drug treatment of an immune-mediated gastrointestinal disorder such...
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RE39197 |
Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds
The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions comprising these compounds, and to methods...
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7049333 |
Substituted thiophenes: compositions, processes of making, and uses in disease treatment and diagnosis
Substituted thiophenes, processes for their preparation, their use as medicament or diagnostic agent. The substituted thiophene derivatives have the following backbone structure:
Medicaments...
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7045507 |
Substituted tetracycline compounds as synergistic antifungal agents
Methods and compositions for treating for the synergistic treatment of fungal associated disorders are discussed.
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7045542 |
Low-temperature-stable preservatives
A liquid, cold-temperature-stabilized preservative is based on carbendazim or a salt thereof, which includes, as low-temperature stabilizer, at least one aromatic alcohol and/or at least one...
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7041694 |
Cyclooxygenase-2 inhibition
Selective inhibitors of cyclooxygenase-2 are used to treat liver disease and in combination with anti-viral drugs to treat virus-caused liver disorders. Selective inhibitors of cyclooxygenase-2...
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RE39088 |
Amide compounds and use of the same
An amide compound of the formula (I):
wherein R is amino and the like, A is alkylene and the like, X is O, S and the like, M is arylene and the like, R 1 , R 2 , R 3 and R 4 are H,...
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7022728 |
Benzimidazoles that are useful in treating male sexual dysfunction
The present invention relates to the use of compounds of formula (I)
for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual...
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7001887 |
Peptide derivatives
A compound of Formula (1):
wherein
R 1 represents an amidinophenyl group, etc.; R 2 represents a hydrogen atom, etc.; R 3 represents a carbamoylalkyl group, etc.; R 4 represents a...
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RE38984 |
Antifungal combination therapy
There is described antifungal combination therapy comprising the use of known antifungal agents such as the azoles or polyenes in combination with a pneumocandin derivative antifungal agent. More...
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6969712 |
Benzimidazole derivatives
This invention relates to the compounds represented by a general formula [I]:
[in which A 1 and A 2 represent optionally fluorine-substituted methine or the like; B represents halogen,...
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6900235 |
Benzimidazole compounds, and pharmaceutical compositions and unit dosages thereof
Benzimidazole derivatives and salts and prodrugs thereof are disclosed, together with methods for the treatment of cancers or viral infections in warm blooded animals by administration of these...
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6884811 |
Antifungal composition
An antifungal composition comprising 3-iodo-2-propynyl butylcarbamate, 4,5-dichloro-2-octyl-isothiazolin-3-one and methyl 2-benzimidazolylcarbamate is useful as industrial antifungal composition,...
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6878700 |
Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds
The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immunune diseases, to pharmaceutical compositions containing these compounds, and to methods...
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6867203 |
Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds
The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immune diseases and cerebral vasospasm, to pharmaceutical compositions containing these...
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6864275 |
Compounds and methods for use thereof in the treatment of cancer
Benzimidazole derivatives and salts and prodrugs thereof are disclosed, together with methods for the treatment of cancers or viral infections in warm blooded animals by administration of these...
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6852743 |
Preventives for the recurrence of cerebrovascular failure and agents for ameliorating troubles following cerebrovascular failure and inhibiting progress thereof
There is provided an agent for preventing the recurrence of cerebrovascular disorder and an agent for ameliorating troubles following cerebrovascular disorder and inhibiting the progress thereof...
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6749864 |
Stabilized pharmaceutical composition
The pharmaceutical composition of the invention, which comprises a benzimidazole compound of the formula wherein R 1 is hydrogen, alkyl, halogen, cyano, carboxy, carboalkoxy, carboalkoxyalkyl,...
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6699860 |
Di-substituted aminomethyl-chroman derivative beta-3 adrenoreceptor agonists
This invention is related to novel di-substituted aminomethyl chroman derivatives which are useful in the treatment of beta-3 receptor-mediated conditions.
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6699885 |
Substituted benzimidazole dosage forms and methods of using same
Disclosed herein are methods, kits, combinations, and compositions for treating gastric acid disorders employing pharmaceutical compositions comprising a proton pump inhibiting agent (PPI) and a...
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6689787 |
Method of using an integrin antagonist and radiation therapy as combination therapy in the treatment of neoplasia
The present invention provides methods to treat neoplasia disorders in a mammal using a combination of radiation and an integrin antagonist.
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6653335 |
Pharmaceutical composition for inhibiting the growth of viruses and cancers
This invention is a method of treating cancer, both carcinomas and sarcomas, and viral infections, in particular HIV through the administration of a pharmaceutical composition containing a...
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6638960 |
Halogenobenzimidazoles and their use as microbicides
New halogenobenzimidazoles of the formula in which A, R 1 , R 2 , R 3 , R 4 and X have the meanings given in the description, and their acid addition salts and metal salt complexes, a process...
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6576636 |
Method of treating a liver disorder with fatty acid-antiviral agent conjugates
The invention provides conjugates of fatty acids and antiviral agents useful in treating liver disorders.
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