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7618993 |
Compounds
The present invention relates to new compounds
or salts, solvates or solvated salts thereof, processes for their preparation and to new intermediates used in the preparation thereof,...
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7615642 |
Therapeutic compounds
Compounds of formula I or pharmaceutically acceptable salts thereof:
wherein R 1 , R 2 , R 3 and R 4 are as defined in the specification as well as salts and pharmaceutical compositions...
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7615563 |
Compositions useful as inhibitors of voltage-gated sodium channels
The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of...
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7615555 |
Piperidine derivatives as modulators of chemokine receptor CCR5
Compounds of formula (I): compositions comprising them, processes for preparing them and their use in medical therapy (for example modulating CCR5 receptor activity in a warm blooded animal).
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7612211 |
Benzimidazole TRPV1 inhibitors
The invention is directed to compounds of Formula (I):
to pharmaceutical compositions containing such compounds and to methods of treatment using them.
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7608723 |
Indole and benzimidazole derivatives
The present invention relates to new indole and benzimidazole compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with...
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7598393 |
Sulfonyl benzimidazole derivatives
This invention relates to compounds of the formula (I):
or a pharmaceutically acceptable salt thereof, wherein A, B, R 1 , R 2 and R 3 are each as described herein, and compositions...
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7595406 |
Substituted 1H-benzimidazole-4-carboxamides are potent PARP inhibitors
Compounds of Formula (I)
inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of...
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7595343 |
Inhibitors of histone deacetylase
The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides...
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7595330 |
Benzimidazole thiophene compounds
The present invention provides benzimidazole thiophene compounds pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.
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7582770 |
Viral polymerase inhibitors
An enantiomer, diastereoisomer or tautomer of a compound, represented by formula I:
wherein A, B, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , and R 10 are as defined herein, or a...
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7576114 |
N3 alkylated benzimidazole derivatives as MEK inhibitors
Disclosed are compounds of the Formula I
and pharmaceutically acceptable salts and prodrugs thereof, wherein W, R 1 , R 2 , R 7 , R 8 , R 9 and R 10 are as defined in the specification. Such...
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7576098 |
Heterocyclic compounds as inhibitors of factor VIIa
The present invention relates generally to compounds that inhibit serine proteases. In particular it is directed to novel heterocyclic compounds, or a stereoisomer or pharmaceutically acceptable...
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7569700 |
Substituted, bicyclic 8-pyrrolidinobenzimidazoles, methods for their production and their use as medicaments
The present invention relates to carboxamide derivative compounds of formula I
in which R1-R6 and R12 are hereinafter defined and together comprise carboximide derivatives for the therapeutic...
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7569688 |
Propane-1, 3-dione derivative
Provided is a pharmaceutical composition containing a propane-1,3-dione derivative as the active ingredient, particularly a GnRH receptor antagonist. Also, provided is a propane-1,3-dione...
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7566789 |
Benzimidazole derivatives
Novel compounds of the formula I
in which
D, X, X′, W, Y, T and R 1 are as defined in Patent claim 1 , are inhibitors of coagulation factor Xa and can be employed for the prophylaxis...
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7566788 |
Crystalline forms
A salt of the compound N-{2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzim
idazol-5-yl}ethanesulfonamide, which is an ethanesulphonic acid salt, a sulphuric acid salt, an ethane...
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7566733 |
Benzimidazole derivatives useful as selective androgen receptor modulators (sarms)
The present invention is directed to novel benzimidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the...
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7563815 |
Benzamidazoles, compositions containing such compounds and methods of use
The present invention relates to substituted benzimidazoles, compositions containing such compounds and methods of treatment The compounds are glucagon receptor antagonists and thus are useful for...
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7557221 |
Substituted hydantoins
This invention relates to compounds of formula I:
or pharmaceutically acceptable salts thereof,
wherein R1, R2, R3, R4, R5, and R6 are described in this application. These compounds inhibit...
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7557114 |
Heterocyclic-substituted phenyl methanones
The present invention relates to compounds of formula I
wherein R 1 and R 2 are defined in the specification and to pharmaceutically acceptable acid addition salts thereof. Compounds of the...
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7553848 |
Vanilloid receptor ligands and their use in treatments
bis-Bicyclic amides and derivatives thereof and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster...
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7550495 |
Compounds, compositions containing them, preparation thereof and uses thereof I
Compounds of Formula I, or pharmaceutically acceptable salts thereof:
wherein R 1 , R 2 , R 3 , R 4 , R 5 , and G are as defined in the specification as well as salts and pharmaceutical...
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7547716 |
Sulfonamide derivatives
A medicament for enhancing an effect of a cancer therapy based on a mode of action of DNA injury, which comprises as an active ingredient a compound represented by the general formula (I) or a...
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7544698 |
Indoles and benzoimidazoles as modulators of the histamine H4 receptor
Benzoimidazole and indole compounds are described, which are useful as H 4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease...
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7524516 |
Corrosion inhibiting mildew remover kit
The corrosion inhibiting mildew remover kit includes a premeasured amount of sodium perborate, a premeasured amount of a liquid inhibitor and a premeasured amount of a liquid blend. The premeasured...
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7517899 |
Phenylaminopropanol derivatives and methods of their use
The present invention is directed to phenylaminopropanol derivatives of formula I:
or a pharmaceutically acceptable salt thereof, compositions containing these derivatives, and methods of their...
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7501448 |
Process for preparing telmisartan
Provided are processes for preparing telmisartan alkyl ester and telmisartan using environmentally friendly organic solvents that are easily removed from the reaction mixture, wherein a telmisartan...
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7501447 |
Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
Compounds of formula (I) or pharmaceutically acceptable salts thereof: wherein R1, R2, R3, R4 and Z are as defined in the specification as well as salts and pharmaceutical compositions including...
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7494670 |
Composition and process for removing and preventing mildew and fungal growth
This invention comprises a composition and the process of using the composition for removing and preventing mold, mildew, and fungal growth. The composition comprises at least one alkali metal...
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7491733 |
Bicyclic guanidine derivatives and therapeutic uses thereof
The invention relates to compounds of general formula (I), in which A, X, Y and R1 are defined in Claim 1 . These compounds may be used in the treatment of pathologies associated with insulin...
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7485658 |
N-substituted pyrazolyl-amidyl-benzimidazolyl c-Kit inhibitors
Compounds represented by Formula (I):
or a pharmaceutically acceptable salt or N-oxide thereof, are useful in the treatment of cancer.
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7482469 |
2-(benzimidazol-1-yl)-acetamide bisaryl derivatives
The invention relates to 2-(benzimidazol-1-yl)-acetamide bisaryl derivative having the general Formula I
wherein n is 0 or 1; Ar 1 represents a diradical derived from a 5- or-6-membered...
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7482373 |
Bis-benzimidazoles and related compounds as potassium channel modulators
The present invention provides a genus of bis-benzimidazole compounds, methods and pharmaceutical compositions that are useful as modulators of potassium ion channels. The compounds of the...
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7479564 |
Aryl or heteroaryl fused imidazole compounds as anti-inflammatory and analgesic agents
This invention provides a compound of the formula (I):
or the pharmaceutically acceptable salts thereof, wherein Y 1 , Y 2 , Y 3 and Y 4 are independently selected from N, CH, etc.; R 1 is...
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7479502 |
2-(2-hydroxybiphenyl-3-yl)-1H-benzoimidazole-5-carboxamidine derivatives as factor VIIA inhibitors
The present invention relates to novel inhibitors of Factors VIIa, IXa, Xa, XIa, in particular Factor VIIa, pharmaceutical compositions comprising these inhibitors, and methods for using these...
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7476763 |
Oxo-substituted cyclohexyl-1,4-diamine compounds
Novel cyclohexyl-1,4-diamine compounds corresponding to formula I:
methods for their production, pharmaceutical formulations containing these compounds, methods of producing such pharmaceutical...
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7462724 |
Substituted 1H-benzimidazole-4-carboxamides are potent PARP inhibitors
Compounds of Formula (I)
inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of...
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7462639 |
Aminopyrazole derivatives
The present invention relates to the compounds of formula I:
their pharmaceutically acceptable salts or esters, enantiomeric forms, diastereoisomers and racemates, the preparation of the...
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7462638 |
Use of IκB-kinase inhibitors in pain therapy
The present invention relates to the use of IκB-kinase Inhibitors and methods for the prophylaxis and therapy for treating pain comprising administering such compounds.
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7456293 |
Substituted carboxylic acid derivatives for the treatment of diabetes and lipid disorders, their preparation and use
The present invention is concerned with racemic or enantiomerically enriched substituted carboxylic acids and derivatives thereof represented by Formula 1;
or pharmaceutically acceptable salts...
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7456183 |
Guanidino compounds
Compounds having the general structure I are provided. X and Y are independently selected from the group consisting of CH 2 , N, NR 9 , C═O, C═S, S═O, SO 2 , S, O, (CR 6 R 7 ) n ,...
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7439258 |
Viral polymerase inhibitors
A compound of the formula I:
wherein: X is CH or N; Y is O or S; Z is OH, NH 2 , NMeR 3 , NHR 3 ; OR 3 or 5- or 6-membered heterocycle, having 1 to 4 heteroatoms selected from O, N and S, said...
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7425637 |
N3 alkylated benzimidazole derivatives as MEK inhibitors
Disclosed are compounds of the Formula I
and pharmaceutically acceptable salts and prodrugs thereof, wherein W, R 1 , R 2 , R 7 , R 8 , R 9 and R 10 are as defined in the specification. Such...
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7419995 |
N-substituted benzimidazoyl c-Kit inhibitors and combinatorial benzimidazole library
Compounds represented by Formula (I):
or a pharmaceutically acceptable salt or N-oxide thereof, are useful in the treatment of tumors. Combinatorial libraries composed of compounds represented...
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7414138 |
Benzoxazole and benzodiazole UV-A sunscreens
The present invention relates to 1,3-benzoxazole or benzodiazole UV-A sunscreens and to compositions, in particular topical compositions, containing the above UV-A sunscreens.
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7407968 |
Compounds
Compounds of formula (I) wherein R F1 , R F2 , Z, R 1 , R 2 , Ar, X and Y are as defined in the specification as well as salts and pharmaceutical compositions including the compounds were prepared....
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7405235 |
Transcription factor modulating compounds and methods of use thereof
Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole...
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7393857 |
Use of 5-HT3 receptor antagonists for treating musculoskeletal diseases
The present invention relates to a new use for compounds having 5-HT 3 (serotonin M) receptor antagonist activity, especially tropisetron, for the manufacture of a pharmaceutical composition for...
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7358270 |
Treating agent for irritable bowel syndrome
A therapeutic method and pharmaceutical compositions for treatment of irritable bowel syndrome including non-constipated irritable bowel syndrome such as diarrhea-predominant irritable bowel...
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