Matches 401 - 450 out of 613 < 1 2 3 4 5 6 7 8 9 10 11 12 13 >
Match Document Document Title
5514682 Fused imidazole and triazole derivatives as 5-HT1 receptor agonists  
Compounds of formula (I) wherein F represents a Group of the formula (a) ; E represents a bond or a straight or branched alkylene chain containing from 1 to 4 carbon atoms; and the rest of the...
5512590 5,6-dihydro-4h-imidazo 2',1':2,3!imidazo- 4,5,1-ij!quinoline and 4,5-dihydroimidazo- 1,2-a!pyrolo 1,2,3-cd!benzimidazole derivatives, their preparation and application in therapeutics  
The invention discloses compounds formula (I) ##STR1## in which n represents the number 1 or 2, X represents a hydrogen atom or indicates that the phenyl ring to which it is attached is substituted...
5510364 2-cyanobenzimidazoles and their use, and new precursors  
New 2-cyanobenzimidazoles of the formula (I) ##STR1## in which R 1 , R 2 and A have the meaning given in the description, a preparation process, their use in agriculture, for example against...
5508297 Vascular hypertrophy suppression treatment  
This invention relates to a method for the prophylaxis or treatment of vascular hypertropy in a mammal by administering a pharmaceutically effective amount of a compound represented by the formula...
5502040 Anticoccidial method  
The present invention is directed to anticoccidial methods, animal feed premixes, and animal feeds, employing a specified o-phenylenediamine or benzimidazole. The present invention is also directed...
5500435 Method of treating epithelial disorders  
A method for treating skin disorders in warm-blooded animals, said method comprising administering to said warm-blooded animals an effective amount of an appropriately substituted benzimidazole or...
5500443 New benzodioxane compounds  
A compound of formula (I): ##STR1## in which: X represents oxygen or methylene, n represents 1, 2 or 3, R 1 represents hydrogen, aminocarbonyl or hydroxymethyl, R 2 represents: ##STR2##...
5496826 Pharmaceutical methods of using heterocyclic derivatives of N-phenylamides  
New central nervous system agents conform to formula I: ##STR1## wherein R=H or C 1 -4 alkoxy; X=CH or N; Y=NH, O or S; Z=C 1 -4 alkyl, C 3 -6 cycloalkyl, C 2 -3 alkenyl, NH 2 , C 1 -4...
5494919 2-substituted piperidines, pyrrolidines and hexahydro-1H-azepines promote release of growth hormone  
The present invention is directed to certain piperidine, pyrrolidine, and hexahydro-1H-azepine compounds of the general structural formula: ##STR1## wherein R 1 , R 3 , R 4 , R 5 , A, W, X, Y, and...
5494926 2/3-(heterocyclic alkyl amino)-1-(subst.-phenyl-methoxy)-ethanes/propanes as tachykinin-receptor antagonists  
Compounds of formula (I), and salts and prodrugs thereof, wherein Q represents phenyl or benzhydryl; X and Y each represent H or X and Y together form a group =0; Z is O, S or NR 8 (R 8 is H or C...
5491161 Pyrroloimidazolyl and imidazopyridinyl substituted 1H-benzimidazole derivatives  
Pyrroloimidazolyl and imidazopyridinyl substituted 1H-benzimidazole derivatives having the formula ##STR1## wherein n is 0 or 1; R 1 is hydrogen, nitro, amino, mono- or di(C 1 -6 alkyl)amino,...
5491149 Dihydroxypropylamine containing retroviral protease inhibitors  
This invention relates to substituted dihydroxypropylamines, a process to prepare intermediates useful for the synthesis of these compounds, compositions comprising such compounds, and a method of...
5486525 Platelet activating factor antagonists: imidazopyridine indoles  
The present invention relates to compounds of formula ##STR1## and the pharmaceutically acceptable salts thereof which are potent antagonists of PAF and are useful in the treatment of PAF-related...
5482942 (3,4-dioxocyclobuten-1-yl)chromene, indene, and dihydronaphthalenone derivatives as smooth muscle relaxants  
This invention relates to novel 4-(3,4-dioxocyclobuten-1-yl)chromenes and dihydronaphthalenones and 3-(3,4-dioxocyclobuten-1-yl)indenes and salts thereof having smooth muscle relaxing activity, to...
5482956 Method of treating parastic protozoa with substituted benzimidazoles  
The present invention relates to the use of benzimidazoles of the formula (I) ##STR1## in which X 1 , X 2 , X 3 , X 4 , R 3 and R 5 are described herein and these compounds are agents for...
5466696 Tacrine and cytochrome P450 oxidase inhibitors and methods of use  
Described is a method of treating Alzheimer's disease in a patient comprising administering to said patient an effective amount of tacrine in combination with a P450 1A2 oxidase inhibitor....
5466706 9H-imidazo[1,2-A]benzimidazole-3-acetamide derivatives, their preparation and their therapeutic application  
Compound corresponding to the formula: ##STR1## in which X represents one or more of hydrogen, halogen, alkyl, trifluoromethyl, alkoxy, alkylthio, methylsulphonyl, cyano, ethoxycarbonyl,...
5464854 Method of modifying ovarian hormone-regulated AT1 receptor activity as treatment of incapacitating symptom(s) of P.M.S.  
The method of treatment moderating, blocking and/or eliminating premenstrual syndrome embodies the intermittent administering of an AT1 antagonist to a female having menstrual cycles characterized...
5459148 Biphenyl derivatives and their use for the treatment of hypertension and cardiac disease  
Compounds of formula (I): ##STR1## [wherein: A represents a group (IIa), (IIb) or (IIc): ##STR2## R 1 is alkyl, alkenyl, cycloalkyl or a group of formula R 4 --Y--R 5 --, where: R 4 is...
5459147 Substituted benzimidazolyl derivatives and pharmaceutical compositions containing these compounds  
The invention relates to substituted benzimidazolyl derivatives of the general formula ##STR1## wherein A and R a to R c are defined as in claim 1, the mixtures of position isomers thereof and...
5451583 Substituted benzimidazoles and quinazolines as antihypertensives  
There are disclosed compounds of the formula ##STR1## wherein R 1 and R 2 are defined in the specification; n is 1 to 3; Y is ##STR2## wherein R 3 is hydrogen, perfluoro alkyl of 1-6 carbon...
5449682 Angiotensin II antagonists incorporating a substituted benzyl element  
Substituted heterocycles attached through a methylene bridge to novel substituted phenyl derivatives of the Formula I are useful as angiotensin II antagonists. ##STR1## wherein the substituents are...
5436262 Pharmacologically active derivatives of 2-(benzimidazol-2-yl)-1,3-diaminopropane  
Derivatives of 2-(benzimidazol-2-yl)-1,3-diaminopropane, the process for their preparation as well as the pharmaceutical compositions containing them as active ingredients are described. The...
5434150 Condensed 5-membered heterocyclic compounds, processes for preparing them and pharmaceutical preparations containing these compounds  
The invention relates to cyclic imino derivatives of general formula ##STR1## wherein A to G, R 1 , Z 1 to Z 6 , X and Y are defined as in claim 1, the tautomers, stereoisomers and mixtures...
5414010 Dimeric benzimidazoles as central nervous system agents  
Dimeric benzimidazoles are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as...
5409937 Hexahydrofuro(2,3-b)furans as PAF antagonists  
The invention concerns compounds of the formula I: ##STR1## wherein the variables are described in the specification which are antagonists of platelet activity factor.
5393771 4-substituted benzopyran and related compounds  
Compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof. These compounds have potassium channel activating activity and are useful, therefore for example, as...
5389634 Imidazole derivatives having angiotensin II receptor antagonistic activity  
Imidazoles of the formula ##STR1## and their non-toxic, pharmaceutically acceptable salts with acids and bases having an antagonistic activity against angiotensin II receptors.
5389664 Alleviating stomach ulcers in swine  
Alleviation of stomach ulcers in swine which are being administered exogenous somatotropin, by administering to the swine a benzimidazole compound selected from heterocyclylalkyl(sulfinyl or...
5387600 Treating arteriosclerosis using benzimidazole compositions  
Disclosed are an antihyperlipidemia or antiarteriosclerosis agent comprising a certain benzimidazole or 2,2'-methylenebisphenol derivative such as 5-dodecanoylamino-2-mercaptobenzimidazole or...
5374615 Indole- and benzimidazole-substituted imidazole and benzimidazole derivatives  
Novel compounds are disclosed having the formula ##STR1## wherein X, R 1 , R 2 , R 3 , R 4 , and R 5 are substituents. These compounds inhibit the action of angiotensin II and are useful,...
5373017 Imidazolyl/benzimidazolyl-terminated alkylamino ethynyl alanine amino diol compounds for treatment of hypertension  
Compounds characterized generally as imidazolyl/benzimidazolyl-terminated alkylamino ethynyl alanine amino diol derivatives are useful as renin inhibitors for the treatment of hypertension....
5360809 Imidazole compounds and their use as calcium channel blockers  
The present invention discloses compounds of the formula ##STR1## wherein X is C; Y is C; R 4 to R 7 and R 11 to R 13 are as defined herein; or a pharmaceutically-acceptable addition salt...
5358946 Heterocycle-substituted amides, carbamates and ureas as agents for the treatment of atherosclerosis  
This invention relates to imidazoles, namely, heterocycle-substituted amides, carbamates and ureas as inhibitors of acyl-CoA: cholesterol acyltransferase (ACAT), pharmaceutical compositions...
5338756 Benzimidazole compounds  
Novel imidazoles of the formula ##STR1## and their non-toxic, pharmaceutically acceptable salts with acids and bases having an antagonistic activity against angiotensin II receptors.
5330997 1H-indazole-3-acetic acids as aldose reductase inhibitors  
Certain 1H-indazole-3-acetic acid derivatives, and their pharmaceutically-acceptable esters and salts, are inhibitors of the aldose reductase enzyme, and so are useful in the treatment of diabetic...
5331003 Anticoccidial methods  
The present invention is directed to anticoccidial methods, animal feed premixes, and animal feeds, employing a specified o-phenylenediamine or benzimidazole. The present invention is also directed...
5317021 3-mercapto-glutamic acid derivatives  
Amino acid compounds of the formula: ##STR1## wherein the various symbols are as hereinafter described, which have inhibiting effect on enkephalinase.
5314880 Benzimidazole derivatives  
Compounds of general formula I: ##STR1## wherein: each of R 1 -R 8 , k, and V represent disclosed functional groups that have been chosen such that all disclosed variations of compound I and their...
5312820 Substituted carbamoyl and oxycarbonyl derivatives of biphenylmethylamines  
Carbamoyl and oxycarbonyl derivatives of biphenylmethylamines of structure I are angiotensin-II antagonists with balanced AT 1 and AT 2 activity useful in the treatment of hypertension and...
5304604 Hydroxamic acid collagenase inhibotors  
Compounds of general formula I: ##STR1## wherein: R 1 represents a hydrogen atom or a C 1 -C 6 alkyl, C 1 -C 6 alkenyl, phenyl, phenyl(C 1 -C 6 )alkyl, C 1 -C 6 alkylthiomethyl,...
5294631 Substituted benzimidazoles useful as angiotension II receptor antagonists  
Angiotensin II receptor antagonists having the formula: ##STR1## which are useful in regulating hypertension and in the treatment of congestive heart failure, renal failure, and glaucoma,...
5290801 Benzimidazoles for the treatment of atherosclerosis  
This invention relates to imidazoles, namely, fused-ring heterocycles as inhibitors of acyl-CoA: cholesterol acyltransferase (ACAT), pharmaceutical compositions containing them, processes for their...
5284868 Pharmaceutical compounds  
A pharmaceutical compound of the formula ##STR1## in which n is 0, 1 or 2 and R 1 is attached at any of the positions 5, 6, 7, 8, 9 or 10, and each R 1 is halo, trifluoromethyl, C 1 -4 alkoxy,...
5266320 Aminovinyl-substituted heterocyclic compounds as stabilizers for organic materials  
The use of an aminovinyl-substituted heterocyclic compound of the general formula I ##STR1## in which R 1 denotes hydrogen, C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy, or halogen, and, if more than one...
5254595 Aryloxypropanolaminotetralins, a process for their preparation and pharmaceutical compositions containing them  
Aryloxypropanolaminotetralins with beta-antagonist activity of the formula ##STR1## wherein R is hydrogen, hydroxy or methoxy and Ar is an optionally substituted aromatic or heteroaromatic group,...
5250554 Benzimidazole derivatives useful as angiotensin II inhibitors  
Novel imidazole derivatives of the formula (I): ##STR1## wherein R 1 is an optionally substituted alkyl group, R 2 and R 3 are independently a group capable of forming an anion or a group which...
5246955 Antineoplastic compounds and methods of using same  
New cytotoxic quionones, designated amamitosenes and iminoazamitosenes are found to have significant activity against ovarian tumors, colon cancer, myecloma and the like neoplastic diseases....
5240944 Cyclic guanidine derivatives, anti-ulceratives and method of manufacturing the same  
Derivatives of cyclic guanidine are disclosed, which are represented by the following formula: A--S--R wherein A is ##STR1## R 1 represent a lower alkyl or substituted phenyl or unsubstituted...
5234938 Benzimidazole derivative, its intermediate compounds and an agricultural and horticultural fungicide containing the benzimidazole derivative as an active ingredient  
A benzimidazole derivative having the formula, ##STR1## wherein X is halogen, is produced by reacting a compound having the formula, ##STR2## wherein X is halogen, with dimethylsulfamoyl chloride....
Matches 401 - 450 out of 613 < 1 2 3 4 5 6 7 8 9 10 11 12 13 >