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6284770 |
Medicaments for the treatment of non-constipated female irritable bowel syndrome
This invention relates to the use of 5-HT3 receptor antagonists in the treatment of nonconstipated female IBS patients.
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6277849 |
N-sulphonyl and N-sulphinyl amino acid amides as microbiocides
The invention relates to novel pesticidally active compounds of the general formula I ##STR1## as well as possible isomers and isomeric mixtures thereof, wherein n is a number zero or one; and ...
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6271256 |
Methods for controlling gram negative bacteria in mammals with bicyclo spiroether compounds
Methods for controlling growth of gram negative bacteria, such as Helicobacter pylori, which are agents associated with disorders of the gastrointestinal tract of a mammal are described. They...
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6271241 |
Cycloalkyl and aryl fused aminoalkyl-imidazole derivatives: modulators and GLP-1 receptors
Disclosed are compounds of the formula: ##STR1## or the pharmaceutically acceptable non-toxic salts thereof wherein X, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , A, B, C, and D are variables defined...
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6255331 |
Stable biocidal compositions
Disclosed are biocidal compositions comprising mixtures of formaldehyde-releasing imidazolidines, such as 1,3-dimethylol-5,3-dimethylhydantoin, and 3-isothiazolones stabilized with low levels of...
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6248768 |
Benzimidazole derivatives and pharmacologically acceptable salts thereof
This invention provides a compound having both IL-4 production inhibitory activity and PDE (IV) inhibitory activity, represented by formula (I): ##STR1## and a pharmaceutical composition or a...
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6235765 |
Benzimidazole derivatives
Novel benzimidazole derivatives of the formula ##STR1## in which R 1 , R 2 , X 1 , X 2 , X 3 , X 4 and Y are each as defined in the description, and acid addition salts and metal salt...
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6218388 |
Benzimidazoles for inhibiting protein tyrosine kinase mediated cellular proliferation
Benzimidazoles of Formula I below are inhibitors of protein tyrosine kinases, and are useful in treating cellular proliferation. ##STR1## The compounds are especially useful in treating cancer,...
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6214881 |
IL-8 receptor antagonists
The present invention relates to the novel use of phenyl ureas in the treatment of disease states mediated by the chemokine, Interleukin-8 (I-8).
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6207693 |
Benzamide derivatives having a vasopressin antagonistic activity
This invention relates to new benzamide derivatives having a vasopressin antagonistic activity, etc. and represented by general formula (I): ##STR1## wherein R 1 is aryl optionally substituted...
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6204264 |
Benzimidazole derivative, hair growth promoter and external composition for skin using the same
A benzimidazole derivative or a salt thereof expressed by the following Formula (I): ##STR1## wherein one of A and B is a hydrocarbon group of C 10 -30 expressed by R 1 and the other is --(CH 2 )...
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6204249 |
L-benzimidazole nucleosides
The present invention relates to benzimidazole derivatives and their use in medical therapy particularly for the treatment or prophylaxis of virus infections such as those caused by herpes viruses....
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6204282 |
Benzimidazole compounds that are vitronectin receptor antagonists
The present invention provides compounds having the formula ##STR1## wherein n, p, q and r are each independently selected from 0 or 1; a, b, c, and d each independently represents a carbon...
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6194396 |
Benzimidazole compounds as bradykinin antagonists
This invention relates to a heterocyclic compound of the formula ##STR1## wherein a group of the formula: ##STR2## is a group of the formula ##STR3## X is O, S or N-R 5 , R 1 is lower...
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6177454 |
Amide derivatives and medicinal compositions thereof
An amide derivative represented by the following general formula (I) or a salt thereof and a pharmaceutical composition containing the amide derivative and a pharmaceutically acceptable vehicle....
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6174910 |
AT1 receptor antagonist for the stimulation of apoptosis
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6169105 |
Potentiation of drug response
The power of citalopram, fluvoxamine and paroxetine to increase the availability of sarotonin, norepinephrine and dopamine, particularly serotonin, is augmented by administration in combination...
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6156779 |
Methods of combating infectious diseases using dicatoni bis-benzimidazoles
The present invention provides methods for treating Cryptococcus neoformans and Candida albicans in a subject in need of such treatment. The methods comprises administering to the subject a...
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6150371 |
Method for preventing and for treating autoimmune disease
A method for preventing or treating autoimmune diseases (excluding type I diabetes) by administering an insulin resistance improving substance as an active ingredient.
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6143788 |
Bis-amino acid hydroxyethlamino sulfonamide retroviral protease inhibitors
Selected bis-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to...
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6140355 |
Pharmaceutical compositions containing rifaximin for treatment of vaginal infections
Vaginal pharmaceutical compositions administrable through the topical route, particularly in the form of foams and creams containing a therapeutically effective amount of rifaximin (Common...
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6136836 |
Compositions for the systemic control of parasites of warm-blooded animals
A composition and method for controlling warm-blooded animal parasites comprising 1-[3-chloro-4-(1,1,2-trifluoro-2-trifluoromethoxyethoxy)phen
yl]-3-(2,6,dif luorobenzoyl)urea.
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6136831 |
Pyrazole derivatives and COX inhibitors containing them
The purpose is to provide anti-inflammatory agents which have potent pharmacological actions and exert a selective inhibitory activity on COX-2, thereby being expected to reduce adverse effects...
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6127395 |
Substituted aryl and cycloalkyl imidazolones; a new class of GABA brain receptor ligands
Disclosed are compounds of the formula: ##STR1## wherein: T is NH, O, or S; X is hydrogen, hydroxyl, lower alkyl, or an optionally substituted amide; the W ring is an optionally substituted...
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6127380 |
4-aminoalkoxy-1H-benzoimidazoles
This invention relates to D 2 dopaminergic compounds of the formula ##STR1## wherein: R 1 is hydrogen, trifluoromethyl, pentafluoroethyl, heptafluoropropyl, straight-chain or branched alkyl group...
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6127389 |
Benzimidazole derivatives as bradykinin agonists
This invention relates to compounds of formula: ##STR1## wherein R 6 , R 7 , R 2 , R 2 , R 3 and A 1 are as defined in the disclosure; and pharmaceutically acceptable salts thereof, to processes...
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6123962 |
Process for producing stabilized pharmaceutical composition
The pharmaceutical composition of the invention, which comprises a benzimidazole compound of the formula ##STR1## wherein R 1 is hydrogen, alkyl, halogen, cyano, carboxy, carboalkoxy,...
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6114369 |
Benzimidazole compound
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6110967 |
Epoxysuccinamide derivative or salt thereof
The invention relates an epoxysuccinamide derivative represented by a formula (I): ##STR1## wherein R 1 represents a hydrogen atom, an alkyl or aminoalkyl group, R 2 represents an aminoalkyl...
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6110963 |
Aryl-oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia
This invention provides compounds of Formula I having the structure ##STR1## wherein A is C or N; B is O, S, N, or CHCH; E is ##STR2## or --X--D; D is ##STR3## or alkyl of 1-12 carbon...
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6103768 |
Fatty acid based compositions and methods for the control of plant infections and pests
The invention described here concerns the unique utility of fatty acids and their derivatives to eradicate existing fungal and bacterial infections in plants. Also, described herein are combination...
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6100252 |
Heterocyclic compounds and their use as angiotensin antagonists
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6096766 |
3-benzylaminopiperidines as tachykinin receptor antagonists
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6096755 |
N-substituted azabicycloalkane derivatives, their preparation and use
Compounds of the formula I ##STR1## where B, R 1 , R 2 , n, R 3 , A, X, Y and Z have the meanings stated in the description, and their preparation are described. The novel compounds are suitable...
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6083973 |
Methods for inhibiting mucin secretion using RAR α selective antagonists
This invention provides methods of of inhibiting mucin production in a mammal comprising administering to the mammal an RAR antagonist. Preferably, the RAR antagonist is an RARα selective...
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6071909 |
Phenylbenzimidazole derivatives as ligands for GABA receptors
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6071931 |
AT.sub.1 -receptor antagonists for preventing and treating postischemic renal failure and for protecting ischemic kidneys
The compound (S)-N-(1-carboxy-2-methylprop-1-yl)-N-pentanoyl-N-[2'(1H-tet
razol-5-yl)bip henyl-4-yl-methyl]amine (valsartan) of formula ##STR1## or a salt thereof, in particular a pharmaceutically...
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6069126 |
Antifungal combination therapy
There is described antifungal combination therapy comprising the use of known antifungal agents such as the azoles or polyenes in combination with a pneumocandin derivative antifungal agent. More...
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6040327 |
Benzimidazole, benzoxazole and benzothiazole compounds
A compound of formula (I): ##STR1## wherein: R 1 represents halogen or a different group as defined in the description, Ra and Rb, which mnay be identical or different, represent hydrogen,...
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6034116 |
Mixtures of substituted benzimidazoles with polyether antibiotics or synthetic coccidiostats as agents for use against parasitic protozoa
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6030992 |
Methods of treating or preventing sleep apnea
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6017941 |
Method of combatting infectious diseases using dicationic bis-benzimidazoles
The present invention provides methods for treating Cryptococcus neoformans and Candida albicans in a subject in need of such treatment. The methods comprises administering to the subject a...
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6017923 |
Carbo-acyclic nucleoside derivatives as antiviral and antineoplastic agents
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6015827 |
Benzoxazole-4-carboxamides and their use in inhibiting poly (adp-ribose) polymerase activity and improving cytotoxic effectiveness of cytotoxic drugs or radiotherapy
Benzoxazole carboxamides are disclosed which can act as potent inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase or PARP enzyme (EC 2.4.2.30), and which thereby can provide useful...
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6013644 |
Spiro-substituted azacycles as modulators of chemokine receptor activity
The present invention is directed spiro-substituted azacycles of formula I: (wherein R 1 , R 2 , R 3 , R 4 , R 5 , k, l and m are defined herein) which are useful as modulators of chemokine...
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6001866 |
Method for treating and preventing inflammation and atherosclerosis
This invention provides a method for treating or preventing inflammation or atherosclerosis in mammals comprising administering an effective amount of a 15-LO inhibitor of Formula I: ##STR1##...
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5998398 |
2-amino-5,6-dichlorobenzimidazole derivatives having antiviral activity
The present invention relates to benzimidazole derivatives of formula (I) wherein: R 1 represents H, C 1 -4 alkyl, C 3 -5 cycloalkyl; R 2 represents H, C 1 -4 alkyl; or R 1 and R 2 together...
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5977154 |
Selective β3 adrenergic agonist
The present invention is in the field of medicine, particularly in the treatment of Type II diabetes and obesity. More specifically, the present invention relates to selective β3 adrenergic...
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5965565 |
Piperidines promote release of growth hormone
The present invention is directed to certain piperidines, pyrrolidines, and hexahydro-1H-azepines of the general structural formula: ##STR1## wherein B is selected from: ##STR2## and R 1 , R 1a , R...
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5962492 |
2 cyclo(alkyl and alkenyl) phenyl-alkenylyl heteroaryl compounds and pharmaceutical compositions containing same
Compounds of general formula (1) ##STR1## are described wherein Y is a halogen atom or a group --OR 1 , wherein R 1 is an optionally substituted alkyl group; X is --O--, --S--, or --N(R 6 ),...
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