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7622497 |
Derivatives of gambogic acid and analogs as activators of caspases and inducers of apoptosis
The present invention is directed to novel derivatives of gambogic acid and analogs thereof. The present invention also relates to the discovery that novel derivatives of gambogic acid are...
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7622482 |
Chemical compounds
This invention relates to novel compounds having the formula (I): and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment for cancer.
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7618993 |
Compounds
The present invention relates to new compounds
or salts, solvates or solvated salts thereof, processes for their preparation and to new intermediates used in the preparation thereof,...
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7618992 |
Method of treating cancer by co-administration of anticancer agents
The present invention relates to a method of treating cancer by co-administration of an effective amount of...
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7605145 |
Micronutrient formulations for treatment of diabetes mellitus
Formulations for minimizing damage to at least one of cells, organs and systems within the body of a subject afflicted with Diabetes Mellitus. The invention additionally encompasses methods for...
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7589070 |
Surface modification for improving biocompatibility
A therapeutic delivery system efficiently introduces biologically active molecules to mammalian cells without the use of synthetic polymers or biopolymer coatings. Surface modification of a metal...
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7582770 |
Viral polymerase inhibitors
An enantiomer, diastereoisomer or tautomer of a compound, represented by formula I:
wherein A, B, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , and R 10 are as defined herein, or a...
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7550602 |
Small molecule compositions for sexual dysfunction
Compounds of the general formula:
or a pharmaceutically acceptable salt thereof, wherein R 1 , R 2 , R 3 , and X are as defined. Further provided are methods for treatment of sexual...
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7517897 |
Derivatives of 6,7-dihydro-5h -imidazo[1,2-a] imidazole-3-sulfonic acid
Derivatives of 6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonic acid which exhibit good inhibitory effect upon the interaction of CAMs and Leukointegrins and are thus useful in the treatment of...
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7498354 |
Pyrrolo[2,3-D]imidazoles for the treatment of hyperproliferative disorders
or a pharmaceutically acceptable salt or N-oxide thereof, are useful in the treatment of tumors and cancers.
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7482372 |
Hydantoins and related heterocycles as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme (TACE)
The present application describes novel hydantoin derivatives of formula (I):
or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, B, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7...
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7456204 |
Cyclohexylglycine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
The present invention is directed to novel cyclohexylglycine derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or...
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7449451 |
Use of multiple antioxidant micronutrients as systemic biological radioprotective agents against potential ionizing radiation risks
Disclosed herein is a method for protecting humans in need of such protection from physical damage caused by ionizing radiation comprising administering to said humans on a defined basis prior to...
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7442717 |
Substituted 2-aminoimidazoles, process for their preparation, their use as medicament or diagnostic aid
Novel substituted 2-aminoimidazoles of formula I, process for their preparation, their use as medicament or diagnostic aid, and medicament containing them. The compounds of this type are useful in...
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7419995 |
N-substituted benzimidazoyl c-Kit inhibitors and combinatorial benzimidazole library
Compounds represented by Formula (I):
or a pharmaceutically acceptable salt or N-oxide thereof, are useful in the treatment of tumors. Combinatorial libraries composed of compounds represented...
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7407968 |
Compounds
Compounds of formula (I) wherein R F1 , R F2 , Z, R 1 , R 2 , Ar, X and Y are as defined in the specification as well as salts and pharmaceutical compositions including the compounds were prepared....
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7405234 |
Bicyclic modulators of androgen receptor function
The invention provides compounds according to formula I
wherein the substitutents are as described herein.
Further provided are methods of using such compounds for the treatment of...
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7399755 |
Formulations comprising multiple dietary and endogenously made antioxidants and B-vitamins and use of same
The invention is directed to formulations comprised of multiple dietary and endogenously made antioxidants and B-vitamins and the use of these formulations in preventing and treating coronary...
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7345090 |
Galenical formulation
The invention relates to compounds of the formula I
where R 1 , R 2 , R 3 , R 4 and R 5 have the meanings given in claim 1. The compound is suitable in particular for use in skin care...
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7285551 |
Fused-ring compounds and use thereof as drugs
The present invention provides a fused ring compound of the following formula [I]
wherein each symbol is as defined in the specification, a pharmaceutically acceptable salt thereof, and a...
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7282503 |
Fungicidal mixtures based on imidazole derivatives
Disclosed are fungicidal mixtures containing a synergistically effective amount of A) a triazolopyrimidine of formula I, and B) imidazole derivatives of formula II, wherein X 1 and X 2 represent...
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7271187 |
Compositions and methods for promoting tissue regeneration
The present invention relates to compositions and methods for promoting tissue regeneration, preferably neural tissue regeneration. Compositions of the invention include (i) certain diphenyl...
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7244746 |
Imidazolyl derivatives as corticotropin releasing factor inhibitors
The present invention relates to novel heterocyclic antagonists of Formula (I) and pharmaceutical compositions comprising said antagonists of the corticotropin releasing factor receptor (“CRF...
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7241741 |
Methods and compositions for the treatment of asthma and related disorders
The present invention provides methods for the treatment of respiratory tract mucositis in individuals in need of such treatment, the method comprising the systemic administration to the individual...
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7238699 |
Imidazolyl derivatives as corticotropin releasing factor inhibitors
The present invention relates to novel heterocyclic antagonists of Formula (I) and pharmaceutical compositions comprising said antagonists of the corticotropin releasing factor receptor (“CRF...
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7230021 |
Potent, simplified derivatives of pateamine A
The present invention provides a compound of Formula I, all of its related stereoisomers, and their pharmaceutically acceptable salts, wherein A—B, K, Q, X, Y, Z, R and R1 are as defined in Claim...
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7220769 |
Azolylbenzamides and analogues and their use for treating osteoporosis
A compound of formula (I) or a salt thereof, or a solvate thereof, wherein: X represents oxygen, sulphur, or NR b ; Y and Z each independently represent nitrogen, CH, CR 1 or CR 2 ; A represents...
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7220757 |
Compositions and methods for topical administration of 2-NH-heteroarylimidazoles
Compounds of formula (I):
are inhibitors of bacterial methionyl tRNA synthetase and are of use in treating bacterial infections.
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7186739 |
Stabilized activated derivatives of carbamic acid, their process of preparation and their use for the preparation of ureas
A carbamate compound is disclosed.
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7173053 |
N-formyl hydroxylamine derivatives as inhibitors of bacterial polypeptide formylase for treating microbial infections
Compounds of formula (I) are antibacterial or antiprotozoal agents for treatment of infections in humans and non-human mammals, wherein: Z represents a radical of formula —N(OH)CH(═O) or...
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7169793 |
Process for preparation of optically pure or optically enriched sulfoxide compounds, including amorphous esomeprazole and salts thereof
A process of preparation of optically pure or optically enriched isomers of omeprazole and structurally related sulfoxides is provided. Also provided are an amorphous form of esomeprazole, as well...
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7166583 |
1,3-diaza-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof
The present invention relates to 1,3-diaza-dibenzoazulene derivatives, to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well...
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7160914 |
Compounds that exhibit specific molecular recognition of mixed nucleic acid sequences and bind in the DNA minor groove as a dimer
Asymmetric derivatives of furamidines with one of the phenyl rings of furamidine replaced with a benzimidazole have been found by quantitative footprinting analyses to bind GC containing sites on...
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7153873 |
Salts of bicyclic, N-acylated imidazo-3-amines and imidazo-5-amines
Salts of a bicyclic, N-acylated imidazo-3-amine or an imidazo-5-amine of the formula:
addition products thereof with acids, and methods for preparing the salts and addition products. Also...
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7148234 |
Use of EP4 receptor ligands in the treatment of IL-6 involved diseases
Methods of treating IL-6 involved diseases with EP4 receptor ligands, including EP4 receptor antagonists. Assays to determine the effect of test compounds on PGE2-induced whole blood cells activation.
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7148215 |
Chemical compounds
The present invention concerns compounds of general formula (I):
in which the substituents are as described herein.
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7144883 |
Bicyclic sulfonamide compounds
The present invention relates to substituted sulfonamide compounds of the general formula (I), wherein P is sulfonamide or amide-substituted sulfonic acid, which compounds are potentially useful...
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7141598 |
Imidazole derivatives, production method thereof and use thereof
The present invention provides a compound having a steroid C 17,20 -lyase-inhibitory activity and useful for the therapy and prophylaxis of tumor such as prostatism, breast cancer and the like, and...
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7132439 |
Bis-benzimidazoles and related compounds as potassium channel modulators
The present invention provides a genus of bis-benzimidazole compounds, methods and pharmaceutical compositions that are useful as modulators of potassium ion channels. The compounds of the...
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7122567 |
Heterocyclic amide derivatives having glycogen phosphorylase inhibitory activity
Heterocyclic amides of formula (1)
wherein:
Z is CH or nitrogen; R 4 and R 5 together are either —S—C(R 6 )═C(R 7 )— or —C(R 7 )═C(R 6 )—S—; R 6 and R 7 are selected from...
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7105564 |
Pharmaceutical composition comprising a dual antagonist against PGD2/TXA2 receptors having a [2.2.1] or [3.1.1] bicyclic skeleton
The present invention provides novel compounds having a dual antagonistic activity against thromboxane A2 receptor and prostaglandin D 2 receptor and pharmaceutical compositions comprising them. ...
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7105550 |
2,4-disubstituted thiazolyl derivatives
This invention concerns the use of a compound of formula (I′)
a N-oxide, pharmaceutically acceptable addition salt, quaternary amine and stereochemically isomeric form thereof, wherein Q is...
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7105513 |
Acylated, heteroaryl-condensed cycloalkenylamines and their use as pharmaceuticals
The present invention relates to acylated, heteroaryl-condensed cycloalkenylamines, to pharmaceutical compositions comprising such compounds, to methods for the stimulation of the expression of...
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7041303 |
Use of moxonidine for postmyocardial infarction treatment
A method of treating myocardial damage secondary to myocardial infarction using moxonidine or a physiologically compatible salt thereof. Pharmaceutical preparations containing moxonidine and its...
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7034034 |
Substituted 2-cyclohexyl-4-phenyl-1H-imidazole derivatives
Substituted 2-cyclohexyl-4-phenyl-1H-imidazole derivatives capable of modulating NPY5 receptor activity, are provided. Such compounds may be used to modulate NPY binding to NPY5 receptors in vivo...
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7030149 |
Combination of brimonidine timolol for topical ophthalmic use
Disclosed are pharmaceutical compositions comprising brimondine and timolol for topical ophthalmic delivery and a method of treatment comprising administering said composition when indicated for...
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7030139 |
Compounds
Compounds of general formula (I), are disclosed and claimed in the present application, as well as salts and pharmaceutical compositions comprising the novel compounds and their use in therapy, in...
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7022728 |
Benzimidazoles that are useful in treating male sexual dysfunction
The present invention relates to the use of compounds of formula (I)
for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual...
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7012087 |
p53 inhibitors and therapeutic use of the same
The therapeutic use of temporary p53 inhibitors in the treatment of p53-mediated diseases, conditions, and injuries is disclosed.
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6962942 |
Azacycloalkanone serine protease inhibitors
The present invention is directed to non-peptidic factor Xa inhibitors which are useful for the treatment of arterial and venous thrombotic occlusive disorders, inflammation, cancer, and...
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