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7569701 |
Crystal form of 5-hydroxy-1-methylimidazolidin-2,4-dione
Conventional I-form crystals of 5-hydroxy-1-methylhydantoin contain, remaining therein in a considerable amount, the organic solvent used in a purification step. In contrast, in II-form crystals,...
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7358266 |
Cyclopropyl and cyclobutyl epothilone analogs
The invention relates to cis- and trans-12, 13-cyclopropyl and 12,13-cyclobutyl epothilones of formula I to IV
wherein Ar is a radical represented by the following structure:
and the other...
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7135492 |
1,3-disubstituted-2- thioxo-imidazolidine-4,5-dione derivatives useful in the treatment of atherosclerosis
Antiatherosclerotic compounds of Formula I are provided:
wherein:
R is lower alkyl, alkenyl, alkynyl, or —O—(CH 2 ) n —COOR′; R′ is lower alkyl; n is an integer of 1–3; Ar is...
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7125863 |
Inhibitors of dipeptidyl peptidase IV
Compounds according to formula (1), wherein R 1 is H or CN, X 1 is S, O, SO 2 or CH 2 , X 2 is CO, CH 2 or a covalent bond, Het is a nitrogen-containing heterocycle and n is 1–5 are new. The...
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7101902 |
2-guanidinylimidazolidinedione compounds and methods of making and using thereof
Disclosed herein are 2-guanidinylimidazolidinedione compounds having the structural formula A or B
wherein R 1 and R 2 are each independently a hydrogen, halogen, alkyl, alkoxyl, amino,...
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7094431 |
Method of healing skin wounds in mammals and a composition therefor
This invention pertains to therapeutic antibacterial/antifungal-wound healing compositions comprising a therapeutically effective amount of antibacterial agents and/or antifungal agents and/or...
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7034015 |
Aminobenzoephenones
The invention relates to a novel class of aminobenzophenones derivatives, to pharmaceutical preparations comprising said compounds, to dosage units of such preparations, to methods of treating...
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6982097 |
Biocidal compositions and methods of using same
This invention relates to biocidal compositions and methods of using same. Also provided is a process for the manufacturing of a biocidal composition in the form of a tablet and a method of using...
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6977081 |
Facial cream composition containing allantoin
The present invention provides emollient creams composed of sulfur, sodium sulfacetamide and a botanically-derived anti-inflammatory ingredient. The creams are alcohol-free and have a pH at or...
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6919365 |
Imidazolidinedione derivatives and use thereof as drugs
The present invention is to provide an imidazolidinedione derivative and oxazolidinedione derivative represented by the following general Formula (I) having the chymase and/or tryptase inhibition...
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6896897 |
Flexible applicator for applying oil-in-water emulsion with improved stability
A flexible applicator for applying an oil-in-water emulsion comprises: (1) an allantoin-containing oil-in-water emulsion; and (2) a flexible element that adsorbs or absorbs the emulsion such that...
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6864274 |
Allantoin-containing skin cream
An allantoin-containing skin cream composition can comprise allantoin and at least one anionic or nonionic emulsifier that is substantially hydrophilic and is soluble in water. The pH of the...
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6794373 |
Contraceptive methods using benzimidazolones
This invention relates to cyclic combination therapies and regimens utilizing indoline compounds which are antagonists of the progesterone receptor and having the general structure: A is O, S,...
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6765003 |
3-Arylsulfonyl-2 (substituted methyl) propanoic acid derivatives as matrix metalloproteinase inhibitors
Compounds which are 3-arylsulfonyl-2-methyl propanoic acid derivatives of formula (I): wherein X is HO—NH— or HO—, R1 is selected from phenyl, 4-chlorophenyl, 4-florophenyl, 4-cyanophenyl,...
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6743434 |
Carbonic emulsion skin care compositions and method for removing chemically bound residues and mineral deposits from hair
The invention, in part, relates to skin care or hair care compositions containing a source of carbon dioxide. The carbon dioxide is conveniently entrained in a gel-network, or liquid crystalline...
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6706290 |
Methods for eradication of nanobacteria
Nanobacteria contribute to pathological calcification in the human and animal body, including diseases such as kidney stones, salivary gland stones, dental pulp stones and atherosclerosis. The...
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6673826 |
Methods for treatment of inflammatory diseases
An improved method of treating skin diseases comprises applying to the skin of a patient suffering such a skin disease an allantoin-containing composition in a therapeutically effective quantity....
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6585967 |
Adhesive treatment for tinea cruris
A method of treating or preventing tinea cruris, commonly known as Jock Itch, includes applying a polymerizable monomer adhesive composition to an area of skin afflicted with or susceptible to...
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6566384 |
Hydroxamic and carboxylic acid derivatives having MMP and TNF inhibitory activity
Hydroxamic and carboxylic acid derivatives having MMP and TNF inhibitory activity.
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6531497 |
Epothilone derivatives and their synthesis and use
The invention relates to epothilone analog represented by formula (I) wherein (i) R 2 is absent or oxygen; “a” can be either a single or double bond; “b” can be either absent or a single...
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6451831 |
Agent for hypoalbuminaemia
A highly safe and useful therapeutic agent for hypoalbuminaemia contains a hydantoin derivative represented by the formula (I) or a pharmaceutically acceptable salt thereof as an effective...
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6423699 |
Combination therapies using benzimidazolones
This invention relates to cyclic combination therapies and regimens utilizing substituted indoline derivative compounds which are antagonists of the progesterone receptor having the general...
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6353021 |
Stabilized composition containing halopropynyl compounds
This invention is directed to a stabilized biocidal composition which comprises a mixture of at least one halopropynyl compound, and particularly a halopropynyl carbamate fungicide such as IPBC, a...
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6281236 |
Oil-in-water emulsion with improved stability
A skin cream composition containing allantoin and an emulsifier has improved stability coming from the adjustment of the pH to a range of 4.5 to 5.8. The lower pH preserves the stability of the...
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6255331 |
Stable biocidal compositions
Disclosed are biocidal compositions comprising mixtures of formaldehyde-releasing imidazolidines, such as 1,3-dimethylol-5,3-dimethylhydantoin, and 3-isothiazolones stabilized with low levels of...
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6251929 |
Therapeutic agent for intractable vasculitis
A highly safe therapeutic agent for intractable vasculitis such as malignant rheumatoid arthritis contains a hydantoin derivative represented by the formula (I) or a pharmaceutically acceptable...
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6174910 |
AT1 receptor antagonist for the stimulation of apoptosis
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6127363 |
Local administration of Type IV phosphodiesterase inhibitors for the treatment of erectile dysfunction
A method is provided for treating erectile dysfunction, e.g., vasculogenic erectile dysfunction such as vasculogenic impotence. The method involves the administration of a Type IV phosphodiesterase...
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6040326 |
3-deoxyglucosone production inhibitor
The production of 3-deoxyglucosone, which is an intermediate in the Maillard reaction and induces a crosslinking glycation of proteins participating in various diseases, is inhibited with an...
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5994383 |
Surfactant-based antimicrobial compositions and methods for using the same
Antimicrobial compositions and methods for preparing and using same are provided. The antimicrobial compositions are surfactant-based and contain certain benzalkonium chloride homologs. The...
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5977153 |
Solid aldehyde and antimicrobial compositions useful as fixatives, preservatives and embalming agents
Stable solid forms of preservative and embalming compositions are described which can be prepared by adding a sufficient amount of a chemical or chemicals containing at least one polar group...
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5965594 |
Antimicrobial liquid preservative solutions and process for preparation
Improved liquid antimicrobial solutions useful as preservative additives to personal care preparations, particularly cosmetic formulations and the like, are provided which comprise...
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5942240 |
Antimicrobial preservative composition
The antimicrobial preservative composition consisting essentially of (a) from 0.5 to 20 wt. % dihalogenated butane having terminal cyano groups and (b) from 80 to 99.5 wt. % of a heterocyclic...
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5863548 |
Light stable antimicrobial product which is a silver-allantoin complex encapsulated with allantoin
What is described is a light stable, whitish antimicrobial product which is a silver-allantoin complex encapsulated with allantoin. The molar ratio of silver-to-allantoin in the product is between...
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5851406 |
Process for preventing the degradation of water soluble packaging films by halogenated hydantoins or chlorinated cyanuric acid and apparatus for disinfecting a water system
A method to prevent the degradation of water soluble film placed in contact with halogenated hydantoin or chlorinated cyanuric acid and an apparatus for disinfecting water systems. Halogenated...
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5827870 |
Antimicrobial compositions and methods for using the same
Antimicrobial compositions useful in the treatment of microbial infections and as general cleansers are provided along with methods for their administration. The antimicrobial compositions are...
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5827543 |
Methods and compositions for the prevention and treatment of urogenital disorders
The subject invention encompasses methods for prevention and treatment of a human or lower animal subject having a urogenital disorder caused or mediated by one or more parasitic protozoa...
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5674858 |
Medicaments for treating gastrointestinal disorders
The use is described of both (i) ranitidine bismuth citrate and (ii) one or more Helicobacter pylori-inhibiting antibiotics in treating or preventing gastrointestinal disorders. Pharmaceutical...
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5631273 |
Synergistic water soluble preservative compositions of biocidal mixtures
A water soluble preservative antimicrobial composition for addition to commercial use products at predetermined use levels to provide synergistic biocidal activity against a wide range of fungi and...
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5616347 |
Chlorine dioxide skin medicating compositions for preventing irritation
The present invention relates to the discovery that the inclusion of effective amounts of an irritation reducing compound selected from the group consisting of allantoin, glycerine, aloe vera and...
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5591748 |
Immunomodulatory azaspiranes
Invented are substituted azaspirane compounds, pharmaceutical compositions containing these compounds, and methods for using these compounds to induce an immunosuppressive effect in a mammal in...
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5574057 |
Naamidine A extracted from sea sponges and methods for its use as an anti-tumor agent
Naamidine A isolated from marine sponges is found to be selective in inhibiting the growth of tumor cells which are dependent upon epidermal growth factor for their growth, while showing acceptably...
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RE35279 |
Hydantoin derivatives
The present invention relates to novel hydantoin derivatives, processes for producing said hydantoin derivatives, pharmaceutical compositions containing at least one of said hydantoin derivatives...
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5484802 |
Fungicidal α-(dioxoimidazolidine)acetanilide compounds
There are provided α-(dioxoimidazolidine)acetanilide compounds which are effective for the control of phytopathogenic fungi, the control and prevention of disease caused thereby and the protection...
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5455243 |
Fibrinogen receptor antagonists for inhibiting aggregation of blood platelets
Fibrinogen receptor antagonists of the formula: ##STR1## such as ##STR2## are disclosed for use in inhibiting the binding of fibrinogen to blood platelets and for inhibiting the aggregation of...
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5436260 |
Angiotensin II receptor antagonists
Substituted 1-benzylimidazole-5-methylidene hydantoins are disclosed as well as methods of preparing them, pharmaceutical compositions containing them, and methods of using them. Intermediates...
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5422360 |
Maillard reaction inhibitor
A novel Maillard reaction inhibitor containing at least one compound represented by formula (1) and the salts thereof; methods for producing the compounds of formula (1) and the salts thereof; a...
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5272166 |
Method for selective reduction of Lp(a)
The present invention relates to methods and corresponding agents for lowering plasma Lp(a) levels by the administration of agents that reduce Lp(a) and selectively separate therefrom the apo(a)...
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5256684 |
Methods and compositions for the treatment of gastrointestinal disorders
Methods, for the treatment of humans and lower animal subjects having a gastrointestinal disorder, comprising administering bismuth and administering an antimicrobial. From about 50 to about 5000...
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5122533 |
Topical pharmaceutical compositions
The invention relates to a pharmaceutical composition for removing necrotic skin tissue in mammals, including humans. The composition comprises in combination a substituted thiol in which the...
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