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7612045 |
Compounds, compositions and methods for controlling biofilms and bacterial infections
The present invention provides compounds and compositions useful for controlling bacterial biofilms as well as for controlling and/or preventing bacterial infections. The compounds of the invention...
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7404964 |
Injectable compositions for the controlled delivery of pharmacologically active compound
The present invention provides compositions and methods for extending the release times and lowering the toxicity of pharmacologically active compounds. The compounds comprise a salt of the...
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7368102 |
Pulmonary delivery of aminoglycosides
The present invention is directed to the administration of aminoglycosides. In particular, the present invention is directed to compositions and methods for the pulmonary administration of...
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7345024 |
Pharmaceutical preparation, method for its production as well as its use
The invention relates to hardly soluble antiphlogistic salts and antiphlogistic-antibiotic pharmaceutical preparations and their use. The hardly water soluble antiphlogistic antibiotics salts have...
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7244712 |
Aminoglycoside antibiotics and methods of using same
The present invention relates to aminoglycoside compounds having antibiotic activity. Moreover, the present invention relates to L-aminoglycoside compounds and diastereomers thereof which posses...
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7115577 |
Colorectal neoplasia prophylaxis
Development of colorectal neoplasia in a patient subject or predisposed to colorectal neoplasia is reduced by the steps of (a) determining a patient is subject or predisposed to colorectal...
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7094431 |
Method of healing skin wounds in mammals and a composition therefor
This invention pertains to therapeutic antibacterial/antifungal-wound healing compositions comprising a therapeutically effective amount of antibacterial agents and/or antifungal agents and/or...
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6946137 |
Methods for the controlled delivery of pharmacologically active compounds
The present invention provides compositions and methods for extending the release times and lowering the toxicity of pharmacologically active compounds. The compounds comprise a salt of the...
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6858589 |
Methods of and compositions for potentiating the action of agents active on cell wall sites of the susceptible bacteria
The invention provides a method of potentiating the activity of antibacterial agents that act on bacterial cell walls, comprising the step of administering to a subject an antibacterial agent and...
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6846807 |
Colorectal neoplasia prophylaxis
Development of colorectal neoplasia in a patient subject or predisposed to colorectal neoplasia is reduced by the steps of (a) determining a patient is subject or predisposed to colorectal...
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6818625 |
Method for increasing survival rate of cells in animal cell culture under hypoxia condition
The present invention relates to a method for increasing survival rate of cells in animal cell culture under hypoxia condition by adding antibiotics to the culture media. The method of present...
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6737411 |
Racemization and enantiomer separation of clopidogrel
Processes for separation of enantiomers of clopidogrel, and converting one enantiomer of clopidogrel to another enantiomer of clopidogrel are provided. The enantiomers are separated by...
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6716822 |
Therapeutic agent for ischemia which inhibits apoptosis under ischemic condition
The present invention relates to a therapeutic agent for ischemia which inhibits apoptosis under ischemic condition. The therapeutic agent of the present invention comprises antibacterial agents of...
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6706290 |
Methods for eradication of nanobacteria
Nanobacteria contribute to pathological calcification in the human and animal body, including diseases such as kidney stones, salivary gland stones, dental pulp stones and atherosclerosis. The...
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6664233 |
Combination therapy including 9-nitro-20(S)-camptothecin and bleomycin
A method for treating a patient having a disease associated with undesirable or uncontrolled cell proliferation such as cancer and restenosis is provided. The method comprises: delivering to the...
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6645508 |
Stable L-ascorbic acid composition
A stable composition including a water-sensitive pharmacologically active agent, such as an enzyme, an antibiotic or a vitamin, a hydrophilic non-polar primary solvent, an optional hydrophilic...
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6482802 |
Use of neomycin for treating angiogenesis-related diseases
The present invention is directed to using neomycin or an analogue thereof as an therapeutic agent to treat angiogenesis-related diseases, which are characterized by excessive, undesired or...
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6475993 |
Treatment of hereditary diseases with gentamicin
This invention relates to a method of treating an inherited disease due to a point mutation producing a stop codon by administering an effective dose of an aminoglycoside antibiotic or a derivative...
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6387886 |
Method for the treatment of severe chronic bronchitis (bronchietasis) with an aerosolized antibiotic
The present invention is directed to a method for the treatment of severe chronic bronchitis, i.e., bronchiectasis, using a concentrated aminoglycoside antibiotic formulation delivering the...
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6337325 |
Combined preparation for the therapy of immune diseases
A combination preparation comprising a compound which has a phosphodiesterase-inhibiting action, and a compound which reduces the biologically effective intracellular Ca 2+ content, is suitable...
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6284739 |
Antileishmanial composition for topical application
The instant invention provides compositions containing as active agents paromomycin in combination with gentamicin. When given in combination, the compositions appear much more effective than when...
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6274555 |
Composition and method for topical animal medication
A composition for topically treating epidermal abrasions in animals is provided consisting of bacitracin zinc utilized in a ratio of 300 milligrams, neomycin utilized in a ratio of 35 milligrams,...
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6248718 |
Lesion-directed dry dosage forms of antibacterial agents for the treatment of acute mucosal infections of the oral cavity
The invention provides a medicament for topically treating acute bacterial infections in the oral mucosa, and methods of use. The medicament comprises a dry dosage (such as a troche or powder) of...
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6066676 |
Pharmaceutical composition and methods for using it
Disclosed is a method of treating problems or disorders of the human nervous system or a method of imparting an anaesthetic effect, by applying to a patient in need of such treatment a...
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6037140 |
Selective media for the culture and isolation of gram bacteria, antibiotic composition
This invention relates to a selective medium for the culture and isolation of Gram - bacteria comprising at least one antibiotic specifically active against Gram + bacteria and at least one...
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5981499 |
Lesion-directed antibiotics in dry dosage forms for the treatment of shallow ulcers of the oral mucosa
The invention provides a medicament for topically treating aphthous ulcers in the oral mucosa, and methods of use. The medicament comprises a troche or powder comprising a dry dosage of one or more...
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5929039 |
Method for treating cardiac dysfunction and pharmaceutical compositions useful therefor
The present invention relates generally to a method for, and pharmaceutical compositions useful in, the prophylaxis and/or treatment of cardiac dysfunction in a mammal by the administration of an...
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5900406 |
Use of antibiotics of the type 2-deoxystreptamine substituted with aminosugars to inhibit growth of microorganisms containing group I introns
The invention described herein provides for methods of screening for compounds that can be used to prevent or inhibit the growth of microbial eukaryotes, particularly plant or animal pathogens. The...
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5883074 |
Potentiators of antibacterial agents
Methods for screening for compounds which potentiate the activity of antibacterial agents against bacteria resistant to the antibacterial agent alone, pharmaceutical compositions including such...
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5827543 |
Methods and compositions for the prevention and treatment of urogenital disorders
The subject invention encompasses methods for prevention and treatment of a human or lower animal subject having a urogenital disorder caused or mediated by one or more parasitic protozoa...
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5801153 |
Method of enhancing the antimicrobial properties of antibacterial antibiotics to massively control and prevent bacterial, fungal, and viral diseases in plants
A method for controlling plant diseases utilizes a mixture of antibiotics and food additives or food preservatives. The mixture is sprayed on the plants twice per week for three weeks, then once...
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5753713 |
Method for promoting hair growth
Disclosed is a pharmaceutical composition intended for the topical application to human skin, comprising (A) as an effective ingredient, a mixture comprising (1) an antibiotic medication; ...
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5753247 |
Method of treating fungal infections
Disclosed is a pharmaceutical composition intended for the topical application to human skin, comprising (A) as an effective ingredient, a mixture comprising (1) an antibiotic medication; ...
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5712261 |
Method for preventing or treating hypertriglyceridemia
A method is provided for preventing and/or treating hypertriglyceridemia, and/or atherosclerosis and/or pancreatitis resulting from hypertriglyceridemia, employing a squalene synthetase inhibitor.
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5677288 |
Use of aminoglycosides to protect against excitotoxic neuron damage
A method is disclosed for reducing excitotoxic damage to neurons, which can occur as a result of stroke, cardiac arrest, or other events or conditions. This method involves administering an...
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5663152 |
Potentiators for aminoglycosides
The present invention provides antimicrobial compositions, especially compositions comprising an antimicrobial (microbiocidal or microbiostatic) compound and a potentiator of antimicrobial...
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5662929 |
Therapeutic liposomal formulation
The invention relates to a liposomal formulation containing a therapeutic agent. The formulation of the invention when administered to animals, allows a substantial increase in antibacterial...
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5643887 |
Daunomycin derivative with reduced cytotoxicity toward normal cells
Chemotherapeutic agents that exhibit cytotoxicity similar to that of daunomycin against cancer cells, but exhibit lessened cytotoxicity against normal, non-transformed cells are disclosed, as are...
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5595977 |
Salts of amino glycosides
The present invention relates to novel amino glycoside salts of sucrose-octa-O-sulfonic acid of formula I: ([sucrose-octa-O-sulfonic acid 8 - ]-[R-(NH 3 + ) x ] y -M z n +) ...
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5593971 |
Method for preventing onset of hypertension employing a cholesterol lowering drug
A method is provided for preventing or reducing the risk of hypertension in normotensive patients having insulin resistance by administering a cholesterol lowering drug, such as pravastatin, alone...
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5534408 |
2-deoxystreptamine aminoglycoside inhibition of HIV RRE/Rev binding
Disclosed is a method for the inhibition of binding of a ligand to an RNA, the inhibition being mediated by a small organic molecule which binds to the RNA, thereby inhibiting ligand binding. A...
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5534253 |
Method of treating enteropathogenic bacterial infections in poultry
A method of improving animal health including selecting at least one L. reuteri strain, characterized by the production of β-hydroxypropionaldehyde, and using the selected strain(s) along with the...
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5525349 |
Compositions and methods for treating the cornea inconjunction with laser irradiation
Methods for preventing and treating corneal haze resulting from exposure of the eye to laser irradiation are disclosed. The methods include administration of compositions of wound healing...
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5312814 |
α-phosphonocarboxylate squalene synthetase inhibitors
α- Phosphonocarboxylate compounds are provided which inhibit the enzyme squalene synthetase and thereby inhibit cholesterol biosynthesis. These compounds have the formula ##STR1## wherein R 1 is...
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5312813 |
Biofilm reduction method
A method of killing microorganisms which form a biofilm on a tissue or implant surfaces in a patient, and which are refractory to a biocide at a dose which is effective to kill the microorganism in...
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5273969 |
Phosphorus-containing squalene synthetase inhibitors and method
Compounds which are inhibitors of cholesterol biosynthesis (by inhibiting de novo squalene biosynthesis), and thus are useful as hypocholesterolemic agents and antiatherosclerotic agents are...
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5256684 |
Methods and compositions for the treatment of gastrointestinal disorders
Methods, for the treatment of humans and lower animal subjects having a gastrointestinal disorder, comprising administering bismuth and administering an antimicrobial. From about 50 to about 5000...
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5254544 |
Hydroxyphosphinyl phosphonate squalene synthetase inhibitors and method
Hydroxyphosphinyl phosphonate compounds are provided which inhibit the enzyme squalene synthetase and thereby inhibit cholesterol biosynthesis. These compounds have the formula ##STR1## wherein R 2...
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5211955 |
Pharmaceutical composition containing a hydrophilic active compound, treated with an organic acid and encapsulated in a liposome
A pharmaceutical composition containing an hydrophilic aminoglucoside antibiotic coupled with an organic acid. The coupled aminoglucoside antibiotic and organic acid are encapsulated in a liposome....
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5182268 |
Pharmaceutical composition comprising daunorubicin potentiated with 2,4,5-tri (4-methoxyphenyl)-4,5-dihydroimidazole
2,4,5-Tri(4-methoxyphenyl)-4,5-dihydroimidazole, or a pharmaceutically acceptable salt thereof, is employed as a cancer drug potentiator or as an antimetastis drug.
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