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7605156 |
Methods for the use of inhibitors of cytosolic phospholipase A2
This invention provides methods for the use of substituted indole compounds of the general formula:
and pharmaceutically acceptable salt forms thereof. The invention provides methods for the...
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7582667 |
Dihydrospiro[dibenzo[a,d][7]annulene-5,4′-imidazol] compounds for the inhibition of beta-secretase
The present invention provides a 10,11-dihydrospiro[dibenzo[a,d][7]annulene -5,4′-imidazol]-5′(1′H)-one compound of formula I
Also provided are methods and compositions for the inhibition...
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7569595 |
2-((2-thioxo-2,3-dihydro-1H-imidazol-4-yl)methyl)-3,4-dihydronaphthalen-1(2H)-one
A compound of the formula
or a pharmaceutically acceptable salt thereof, is disclosed herein. Methods and compositions related thereto are also disclosed.
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7550494 |
Small molecules useful in the treatment of inflammatory disease
Compounds of the formula I
which are useful for treating or preventing inflammatory and immune cell-mediated diseases. Exemplary are:
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7544705 |
Pyrroloimidazole derivatives, their preparation, pharmaceutical composition containing them, and their use as nootropic agents
Described herein are new bicyclic arylimidazolones having nootropic action (i.e., protecting and stimulating cerebral functions), analgesic action and anti hyperalgesic action; also described is...
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7531565 |
Imidazolidin-2-one derivatives as selective androgen receptor modulators (SARMS)
The present invention is directed to novel imidazolidin-2-one derivatives having a structure according to Formula I
wherein a, b, R 1 , R 2 , R 3 , and R 4 are as defined above, pharmaceutical...
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7511068 |
Mercaptoimidazoles as CCR2 receptor antagonists
The present invention relates to a compound of formula (I) having CCR2 receptor antagonistic properties, particularly anti-inflammatory properties.
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7417047 |
Amino-5-(5-membered)hetero-arylimidazolone compounds and the use thereof for β-secretase modulation
The present invention provides a 2-amino-5-heteroaryl-5-phenylimidazolone compound of formula I
The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and...
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7407963 |
Cyclopropane CGRP antagonists, medicaments containing these compounds, and method for the production thereof
A compound of general formula (I)
wherein R and R 1 are as defined herein, or a tautomer, diastereomer, enantiomer, or salt thereof, particularly the physiologically acceptable salts thereof,...
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7405233 |
Ureido substituted benzoic acid compounds and their use for nonsense suppression and the treatment of disease
The invention encompasses ureido substituted benzoic acid compounds, compositions comprising the compounds and methods for treating or preventing diseases associated with nonsense mutations of mRNA...
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7396849 |
4-(Condensed cyclicmethyl)-imidazole-2-thiones acting as α2 adrenergic agonists
Compounds of Formula 1
where the variables have the meaning defined in the specification are agonists of alpha 2 adrenergic receptors. Several compounds of the disclosure are specific or...
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7390829 |
Alpha-2 adrenergic agonists
A compound is disclosed herein comprising
or a pharmaceutically acceptable salt or a prodrug thereof;
wherein R is OH or NH 2 .
Methods, compositions, and medicaments related thereto are...
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7390821 |
Methods of reducing angiogenesis
The present invention provides methods of reducing angiogenesis in an individual. The methods generally involve administering to the individual an effective amount of a nicotinic acetyl choline...
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7390798 |
Carboxamide spirolactam CGRP receptor antagonists
The present invention is directed to compounds of Formula I: I (where variables A 1 , A 2 , B, J, K, m, n, R 4 , R 5a , R 5b and R 5c are as defined herein) useful as antagonists of CGRP...
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7358269 |
2-((2-Thioxo-2,3-dihydro-1H-imidazol-4-yl)methyl)-3,4-dihydronapthalen-1(2H)-one
A compound of the formula
or a pharmaceutically acceptable salt thereof, is disclosed herein. Methods and compositions related thereto are also disclosed.
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7358239 |
Pyrrolidinyl, piperidinyl or homopiperidinyl substituted (benzodioxan, benzofuran or benzopyran) derivatives
The present invention concerns compounds of formula (I)
a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, wherein -Z...
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7304083 |
2-iminoimidazole derivatives (2)
A 2-iminoimidazole derivative represented by the formula:
{wherein R 1 , R 2 and R 3 represent hydrogen, optionally substituted C 1-6 alkyl, etc.; R 6 represents hydrogen, C 1-6 alkyl, C...
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7288559 |
Carboxamide spirohydantoin CGRP receptor antagonists
The present invention is directed to compounds that are antagonists of CGRP receptors and that are useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache,...
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7141561 |
Substituted diaryl heterocycles, process for their preparation and their use as medicaments
This invention discloses and claims diary heterocycles of formula (I)
and their pharmaceutically acceptable salts, pharmaceutical compositions thereof, and methods of using said compounds of...
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7125904 |
Peripherally-selective inhibitors of dopamine-β-hydroxylase and method of their preparation
Compounds of formula I:
where R 1 , R 2 and R 3 are the same or different and signify hydrogens, halogens, alkyl, alkylaryl, alkyloxy, hydroxy, nitro, amino, alkylcarbonylamino, alkylamino or...
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7109227 |
Imidazolamino compounds
The invention relates to novel imidazolamino compounds. Also disclosed are methods of treating cancer by using one of these compounds and pharmaceutical compositions containing one of these compounds.
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7101875 |
Methods for treating arthritic disorders
This invention provides methods for treating in mammals arthritic or rheumatic disorders using substituted indole compounds of the general formula:
and pharmaceutically acceptable salt forms...
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7091232 |
4-(substituted cycloalkylmethyl) imidazole-2-thiones, 4-(substituted cycloalkenylmethyl) imidazole-2-thiones, 4-(substituted cycloalkylmethyl) imidazol-2-ones and 4-(substituted cycloalkenylmethyl) imidazol-2-ones and related compounds
Compounds of Formula 1
where X is S and the variables have the meaning defined in the specification are specific or selective to alpha 2B and/or alpha 2C adrenergic receptors in...
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7049332 |
HIV inhibiting N-aminoimidazole derivatives
An N-aminoimidazole or N-aminoimidazolethione derivative, a pharmaceutically acceptable salt, a tautomer, an isomer, an ester or glycosylation product thereof, said derivative being represented by...
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7045534 |
Methods of reducing angiogenesis
The present invention provides methods of reducing angiogenesis in an individual. The methods generally involve administering to the individual an effective amount of a nicotinic acetyl choline...
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7025978 |
Use of polysiloxanes containing quarternary amino groups as formulation auxiliary agents, and agents containing the same
The present invention relates to the use of polysiloxanes containing at least one quaternary ammonium group as formulation auxiliaries in formulations of pharmaceutically and veterinary active...
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6974829 |
Succinoyl aminopyrazoles and related compounds
This invention is directed to a class of compounds (Formula I) including succinoyl amino pyrazoles, succinoyl amino thiadiazoles, succinoyl amino acid esters, succinoyl amino acid amides, succinoyl...
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6943149 |
Benzimidazolone peptidomimetics as thrombin receptor antagonists
The invention is directed to novel benzimidazolone peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis,...
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6930076 |
Nematicidal trifluorobutenyl imidazole thioether derivatives
The present invention relates to novel trifluorobutenyl imidazole thioether derivatives of the following formula (I)
wherein R 1 represents hydrogen or halogen, R 2 represents hydrogen,...
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6927231 |
Use of creatine for the amelioration of oxidative stress
The present invention relates to a method of amelioring oxidative stress and stress-related degenerative processes associated with aging or various disease conditions such as cancer,...
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6881747 |
Small molecules for inhibition of function and drug delivery to leukocytes
The present invention provides a compound and a method of making a compound according to the following formula:
where R 1 is an alkyl group having 1 to 12 carbons; R 2 is a urea group; R 3 ...
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6878732 |
NK1 antagonists
A NK 1 antagonist having the formula (I), with the variables defined herein, which is useful for treating a number of disorders, including emesis, depression, anxiety and cough:
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6797708 |
Inhibitors of cytosolic phospholipase A2
This invention provides substituted indole compounds of the general formula: and pharmaceutically acceptable salt forms thereof, and methods for using the compounds as inhibitors of the activity...
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6713507 |
Ether compounds and compositions for cholesterol management and related uses
The present invention relates to novel ether compounds, compositions comprising ether compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias,...
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6673780 |
Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses
The present invention relates to novel sulfoxide and bis-sulfoxide compounds, compositions comprising sulfoxide and bis-sulfoxide compounds, and methods useful for treating and preventing...
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6630451 |
Benzimidazolone peptidometics as thrombin receptor antagonist
The invention is directed to novel benzimidazolone peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis,...
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6620834 |
Medicinal compositions for treating colorectal cancer
Medicinal compositions for colorectal cancer to be administered to the large intestine by taking advantage of preparations disintegrating in the large intestine, characterized by containing a...
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6552051 |
Energetic nitramine-linked azoles and related compounds as oxidizers, initiators and gas generators
Novel compounds are provided having the structural formula R[—N(NO 2 )—L—R 1 ] n wherein R, L, R 1 and n are defined herein. The compounds are useful in a variety of contexts, but are...
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6544998 |
Combination of gaba agonists and sorbitol dehydrogenase inhibitors
This invention relates to pharmaceutical compositions comprising combinations of a GABA agonist, a prodrug thereof or a pharmaceutically acceptable salt of said GABA agonist or said prodrug and a...
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6518293 |
Anti-HIV imidazolone derivatives
The invention is concerned with novel imidazolone derivatives, a process for their manufacture, pharmaceutical compositions and the use of such compounds in medicine. In particular, the compounds...
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6518268 |
Telomerase inhibitors and methods of their use
Thiazolidinedione compounds, compositions, and methods of inhibiting telomerase activity in vitro and treatment of telomerase mediated conditions or diseases ex vivo and in vivo are provided. The...
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6511968 |
Combination therapy for treating, preventing, or reducing the risks associated with acute coronary ischemic syndrome and related conditions
The invention provides a method for treating, preventing, or reducing the risk of developing a condition selected from the group consisting of acute coronary ischemic syndrome, thrombosis,...
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6486189 |
Five-membered heterocycles having biphenylsulfonyl substitution, process for their preparation, their use as a medicament or diagnostic, and medicament comprising them
Five-membered heterocycles having biphenylsulfonyl substitution, process for their preparation, their use as a medicament or diagnostic, and medicament comprising them. Compounds of the formula I ...
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6455550 |
N-alkanoylphenylalanine derivatives
Compounds of the formula: are disclosed which have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4. Such compounds are useful for treating diseases whose symptoms...
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6444693 |
Fungicidal active substance combinations
The invention relates to novel active substance combinations of valinamide derivatives of formula (I), wherein R 1 and R 2 have the meaning cited in the description, and fenamidone. The invention...
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6432935 |
Pharmaceutical compositions, mainly vaginal suppository, containing many different active ingredients
Compositions comprising an antibiotic, sulphonamide, at least one an antiquagul agent, e.g., clotrimazol (bis-phenyl-(2-chlorophenyl)-1-imidazolyl-methane), natamycin, or nystatin,and...
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6410576 |
Thiazolidine derivatives
An object of the present invention is to provide novel thiazolidine derivatives which are useful as drugs. The thiazolidine derivatives according to the present invention are compounds represented...
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6384067 |
Fungicidal compositions comprising a 2-imidazolin-5-one
1) Fungicidal compositions comprising a compound (I) which is (4S)-4-methyl-2-methylthio-4-phenyl-1-phenylamino-2-imidazol
in-5-one and a compound (II) chosen from the group comprising: (IIA)...
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6380235 |
Benzimidazolones and analogues
The present invention provides compounds and pharmaceutical formulations useful as progesterone receptor agonists and antagonists and having the general formula: wherein: A is O, S, or NR 4 ; B...
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6365615 |
Small molecules useful in the treatment of inflammatory disease
Novel compounds of the formula I which are useful for treating or preventing inflammatory and immune cell-mediated diseases. Exemplary compounds are:...
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