Patents in Class 514/385

Matches 1 - 50 out of 285

1 2 3 4 5 6 >

Match	Document	Document Title
1	7629340	N-(6-membered aromatic ring)-amido anti-viral compounds Disclosed are compounds having Formula (I) and the compositions and methods relating to these compounds, for treating or preventing a viral infection mediated at least in part by a virus in the...
2	7625934	Metalloproteinase inhibitors Compounds of the formula (I) wherein z is SO 2 or SO, useful as metalloproteinase inhibitors, especially as inhibitors of MMP12.
3	7622491	Modulators of PPAR and methods of their preparation The present invention is directed to certain novel compounds represented by Formula (I) and pharmaceutically acceptable salts, solvates, hydrates and prodrugs thereof. The present invention is also...
4	7618993	Compounds The present invention relates to new compounds or salts, solvates or solvated salts thereof, processes for their preparation and to new intermediates used in the preparation thereof,...
5	7589115	Derivatives of [6,7-dihydro-5H-imidazo[1,2-α]imidazole-3-sulfonylamino]-propionamide Derivatives of [6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonylamino]-pro pionamide which exhibit good inhibitory effect upon the interaction of CAMs and Leukointegrins and are thus useful in the...
6	7582770	Viral polymerase inhibitors An enantiomer, diastereoisomer or tautomer of a compound, represented by formula I: wherein A, B, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , and R 10 are as defined herein, or a...
7	7579389	Antimicrobial acrylic polymer An antimicrobial additive composition is provided which economically and efficiently imparts antimicrobial characteristics to acrylic polymers, and particularly thermoformable acrylic sheets made...
8	7579368	Cis-imidazolines There are presented compounds of the formula or pharmaceutically acceptable salts thereof, wherein Y 1 , Y 2 , X 1 , X 2 , X 3 and R are as described in this application. These compounds are...
9	7576114	N3 alkylated benzimidazole derivatives as MEK inhibitors Disclosed are compounds of the Formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein W, R 1 , R 2 , R 7 , R 8 , R 9 and R 10 are as defined in the specification. Such...
10	7572816	Therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders The present invention is directed to compounds having the structure wherein R 1 , R 2 , R 3 , R 4 , R 5 and m are as defined herein. The compounds of this invention are novel therapeutic agents...
11	7569595	2-((2-thioxo-2,3-dihydro-1H-imidazol-4-yl)methyl)-3,4-dihydronaphthalen-1(2H)-one A compound of the formula or a pharmaceutically acceptable salt thereof, is disclosed herein. Methods and compositions related thereto are also disclosed.
12	7563814	Olmesartan medoxomil with reduced levels of impurities The present invention provides the preparation of olmesartan medoxomil containing less than about 0.1% of one or more of the impurities OLM-Me, OLM-Cl, and OLM-eliminate.
13	7557136	Pyrrolidine derivatives as oxytocin antagonists The present invention relates to novel pyrrolidine derivatives of Formula (I), its geometrical isomers, its optically active forms as enantiomers, diastercomers, mixtures of these and its racemate...
14	7547718	Substituted imidazoles This invention relates to a range of alpha substituted 2-benzyl substituted imidazole compounds and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such...
15	7544705	Pyrroloimidazole derivatives, their preparation, pharmaceutical composition containing them, and their use as nootropic agents Described herein are new bicyclic arylimidazolones having nootropic action (i.e., protecting and stimulating cerebral functions), analgesic action and anti hyperalgesic action; also described is...
16	7541375	Azole derivatives and pharmaceutical compositions containing them The invention provides substituted pyrazolidinone compounds, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention...
17	7531560	Anti-cytokine heterocyclic compounds Disclosed are compounds of formula (I) which inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving...
18	7524875	Modified bio-related substance, process for producing the same, and intermediate A modified bio-related substance, wherein at least one poly(alkylene glycol)oxy group represented by the following formula (1) is combined in a molecule: wherein R is a hydrocarbon group having...
19	7524867	Tetrasubstituted imidazole derivatives as cannabinoid CB₁ receptor modulators with a high CB₁/CB₂receptor subtype selectivity The present invention relates to 1,2,4,5-tetrasubstituted imidazole derivatives as selective cannabinoid CB 1 receptor modulators, in particular CB 1 receptor antagonists or inverse agonists...
20	7521470	Factor Xa inhibitors The present invention is directed to compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof which are inhibitors of Factor Xa. The...
21	7514459	Gamma-secretase inhibitors Compounds of formula I: are potent inhibitors of gamma-secretase and hence find use in treatment or prevention of diseases associated with deposition of β-amyloid.
22	7511068	Mercaptoimidazoles as CCR2 receptor antagonists The present invention relates to a compound of formula (I) having CCR2 receptor antagonistic properties, particularly anti-inflammatory properties.
23	7511067	3-hydroxymethyl-4-hydroxy-phenyl-derivatives for the treatment of respiratory diseases The present invention relates to the use of the compounds of general formula 1 wherein the groups R 1 , X and Y may have the meanings given in the claims and in the specification, for preparing...
24	7507755	Inhibitors of cathepsin s The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at...
25	7507756	Scalable synthesis of imidazole derivatives Imidazole derivatives, compositions containing them, methods of preparing them, including regioselective scale-up synthetic methods, and methods of using them.
26	7504425	Compounds useful in the treatment of anthrax and inhibiting lethal factor This invention relates to compounds of formula (I), and a method for treating anthrax or inhibiting lethal factor by administrating a composition containing a compound of formula (I) and a...
27	7501447	Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof Compounds of formula (I) or pharmaceutically acceptable salts thereof: wherein R1, R2, R3, R4 and Z are as defined in the specification as well as salts and pharmaceutical compositions including...
28	7501448	Process for preparing telmisartan Provided are processes for preparing telmisartan alkyl ester and telmisartan using environmentally friendly organic solvents that are easily removed from the reaction mixture, wherein a telmisartan...
29	7498354	Pyrrolo[2,3-D]imidazoles for the treatment of hyperproliferative disorders or a pharmaceutically acceptable salt or N-oxide thereof, are useful in the treatment of tumors and cancers.
30	7470716	Imidazoles and triazoles, their preparation, and their use as pharmaceutical compositions The present invention relates to imidazoles and triazoles of general formula wherein R 1 to R 4 and X are defined as in claims 1 to 8, the tautomers, the enantiomers, the diastereomers, the...
31	7465811	Indoline compounds Sulfonylindoline compounds of formula I, wherein R1 through R4, Y and Z have defined meanings, a process for preparation of such compounds, and the use as pharmaceutically active substances,...
32	7456204	Cyclohexylglycine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes The present invention is directed to novel cyclohexylglycine derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or...
33	7449195	Fungicide mixtures Fungicidal mixtures, comprising A) imidazole derivatives of the formula I in which R 1 and R 2 are halogen or phenyl, which may be substituted by halogen or alkyl, or R 1...
34	7442716	2-(phenyl or heterocyclic)-1H-phenantrho[9,10-d]imidazoles as mPGES-1 inhibitors The invention encompasses novel compounds of Formula I or pharmaceutically acceptable salts thereof. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme...
35	7427631	Metalloproteinase inhibitors Compounds of the formula (I) wherein z is SO 2 or SO, useful as metalloproteinase inhibitors, especially as inhibitors of MMP12.
36	7419995	N-substituted benzimidazoyl c-Kit inhibitors and combinatorial benzimidazole library Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, are useful in the treatment of tumors. Combinatorial libraries composed of compounds represented...
37	7417030	Indazole peptidomimetics as thrombin receptor antagonists The invention is directed to novel indazole peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis,...
38	7390506	Lipophilic drug compositions The invention is directed to biologically active lipophilic compositions comprising a biologically active covalently attached to, or encapsulated within, a lipid. Preferably, a biologically active...
39	7390824	Method for treating diabetes employing an aP2 inhibitor and combination A method is provided for treating diabetes and related diseases, especially Type II diabetes, employing an aP2 inhibitor or a combination of an aP2 inhibitor and another antidiabetic agent such as...
40	7390829	Alpha-2 adrenergic agonists A compound is disclosed herein comprising or a pharmaceutically acceptable salt or a prodrug thereof; wherein R is OH or NH 2 . Methods, compositions, and medicaments related thereto are...
41	7368467	Ion channel modulators The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein...
42	7361663	N-acylpyrrolidin-2-ylalkylbenzamidine derivatives as inhibitors of factor Xa This invention is directed to N-acylpyrrolidin-2-ylalkylbenzamidine derivatives which useful for inhibiting the activity of Factor Xa, by contacting said derivatives with a composition containing...
43	7358239	Pyrrolidinyl, piperidinyl or homopiperidinyl substituted (benzodioxan, benzofuran or benzopyran) derivatives The present invention concerns compounds of formula (I) a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, wherein -Z...
44	7358269	2-((2-Thioxo-2,3-dihydro-1H-imidazol-4-yl)methyl)-3,4-dihydronapthalen-1(2H)-one A compound of the formula or a pharmaceutically acceptable salt thereof, is disclosed herein. Methods and compositions related thereto are also disclosed.
45	7345072	Phenyltetrazole compounds Novel phenyltetrazole compounds useful as intermediates in the preparation of angiotensin II antagonists and the processes for the conversion thereof to biologically active molecules.
46	7326696	Amino-methyl substituted tetracycline compounds Aminomethyl substituted tetracycline compounds, pharmaceutical compositions, and methods of use thereof are discussed.
47	7323485	4-(substituted cycloalkylmethyl) imidazole-2-thiones, 4-(substituted cycloalkenylmethyl) imidazole-2-thiones, 4-(substituted cycloalkylmethyl) imidazol-2-ones and 4-(substituted cycloalkenylmethyl) imidazol-2-ones and related compounds Compounds of Formula 1 where X is S and the variables have the meaning defined in the specification are specific or selective to alpha 2B and/or alpha 2C adrenergic receptors in...
48	7323433	R-(-)-1-[2-(7-chlorobenzo[b]thiopen-3-yl-methoxy)-2-(2,4-dichlorophenyl)-ethyl]-1H-imidazole The invention relates to R-(−)-1-[2-(7-Chloro-benzo[b]thiophen-3-yl-methoxy)-2-(2,4 -dichloro-phenyl)-ethyl]-1H-imidazole and the salts thereof. The invention also relates to compositions thereof...
49	7317032	Imidazolyl inhibitors of 15-lipoxygenase The present invention provides imidazolyl inhibitors of 15-LO, pharmaceutical compositions containing such inhibitors and methods for treating diseases related to the 15-LO cascade using such...
50	7288541	Propylcarbamate derivatives as inhibitors of serine and cysteine proteases The present invention includes ketone derivatives (I) and (II), which are useful as cathepsin K inhibitors. The described invention also includes methods of making such ketone derivatives as well...

Matches 1 - 50 out of 285

1 2 3 4 5 6 >