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7618983 |
Bicyclic triazole α4 integrin inhibitors
The compounds of the present invention are novel bicyclic triazole amino acid-derivatives useful as α4 integrin receptor antagonists. The invention is further directed to methods for treating...
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7615555 |
Piperidine derivatives as modulators of chemokine receptor CCR5
Compounds of formula (I): compositions comprising them, processes for preparing them and their use in medical therapy (for example modulating CCR5 receptor activity in a warm blooded animal).
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7612105 |
3-arylphenyl sulfide derivative and insecticide and miticide
3-Arylphenyl sulfide derivatives represented by general formula (I):
(wherein R is a C 2 -C 6 alkyl group, a C 2 -C 6 alkenyl group, a C 2 -C 6 alkynyl group or the like, B 0 to B 2 and B...
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7612064 |
Sulfopyrroles
The invention relates to compounds of formula (I) wherein R 1 represents aryl, aralkyl or heteroaryl, R 2 is aryl or heteroaryl and R 3 is aryl, heteroaryl or optionally substituted aminomethyl,...
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7598280 |
Heterocyclic compounds, compositions comprising them and methods of their use
Heterocyclic compounds, compositions comprising them, and methods of their use for the treatment, prevention and management of inflammatory and autoimmune diseases and disorders are disclosed....
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7598245 |
Aminotriazole compounds useful as inhibitors of protein kinases
The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention, processes for preparing the...
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7592356 |
Triazoles as farnesyl transferase inhibitors
a prodrug, N-oxide, addition salt, quaternary amine or stereochemically isomeric form thereof, wherein L 1 and L 2 are R 1 —Y— wherein each (R 1 —Y)— substituent is defined independently...
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7579389 |
Antimicrobial acrylic polymer
An antimicrobial additive composition is provided which economically and efficiently imparts antimicrobial characteristics to acrylic polymers, and particularly thermoformable acrylic sheets made...
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7579352 |
Retinoic acid mimetic anilides
The present invention is concerned with compounds of formula
the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein X represents...
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7576113 |
Use of (E)-5-(4-chlorbenzyliden)-2,2-dimethyl-1-(1H-1,2,4-triazol-1-ylmethyl) cyclopentanol for combating rust attacks on soya plants
The invention relates to the use of triticonazole for controlling rust disease on soybeans and to a method for controlling rust disease in soybeans, in which the soybean plants and/or their seed...
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7576098 |
Heterocyclic compounds as inhibitors of factor VIIa
The present invention relates generally to compounds that inhibit serine proteases. In particular it is directed to novel heterocyclic compounds, or a stereoisomer or pharmaceutically acceptable...
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7572816 |
Therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders
The present invention is directed to compounds having the structure wherein R 1 , R 2 , R 3 , R 4 , R 5 and m are as defined herein. The compounds of this invention are novel therapeutic agents...
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7541374 |
Malononitrile compounds and use thereof
A nitrile compound shown by the formula (1) has an excellent pesticidal activity and it is useful as an active ingredient of pesticide.
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7538128 |
Dipeptidyl peptidase IV inhibitors, process for their preparation and compositions containing them
The present invention relates to novel compounds useful as dipeptidyl peptidase IV (DPP-IV) inhibitors of the formula:
wherein X, Y, a, R 1 , and R 2 are as defined herein.
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7531560 |
Anti-cytokine heterocyclic compounds
Disclosed are compounds of formula (I)
which inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving...
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7521470 |
Factor Xa inhibitors
The present invention is directed to compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof which are inhibitors of Factor Xa. The...
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7514459 |
Gamma-secretase inhibitors
Compounds of formula I:
are potent inhibitors of gamma-secretase and hence find use in treatment or prevention of diseases associated with deposition of β-amyloid.
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7511061 |
Triazoles as farnesyl transferase inhibitors
A prodrug, N-oxide, addition salt, quaternary amine or stereochemically isomeric form thereof, wherein L 1 and L 2 are R 1 —Y— wherein each (R 1 —Y)— substituent is defined independently...
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7507755 |
Inhibitors of cathepsin s
The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at...
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7504402 |
Triazole derivatives as inhibitors of 11-β-hydroxysteroid dehydrogenase-1
Triazole derivatives of structural formula I are selective inhibitors of the 11β-hydroxysteroid dehydrogenase-1. The compounds are useful for the treatment of diabetes, such as...
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7485656 |
Antifungal remedy formulation for external application
An antibacterial composition for external application, particularly, a remedial formulation for external use containing fluconazole is disclosed. The formulation comprises a base material, 0.1-5.0...
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7476763 |
Oxo-substituted cyclohexyl-1,4-diamine compounds
Novel cyclohexyl-1,4-diamine compounds corresponding to formula I:
methods for their production, pharmaceutical formulations containing these compounds, methods of producing such pharmaceutical...
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7473705 |
Hexafluoroisopropanol substituted ether derivatives
The invention is concerned with novel hexafluoroisopropanol substituted ether derivatives of formula (I):
wherein R 1 to R 3 are as defined in the description and in the claims, as well as...
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7473700 |
1,2,4-triazole derivatives, processes for the preparation thereof, and pharmaceutical compositions containing the same
A 1,2,4-triazole derivative of formula 1 or a non-toxic salt thereof, a preparation method thereof, and a pharmaceutical composition containing the derivative or the salt as an active ingredient...
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7470716 |
Imidazoles and triazoles, their preparation, and their use as pharmaceutical compositions
The present invention relates to imidazoles and triazoles of general formula
wherein R 1 to R 4 and X are defined as in claims 1 to 8, the tautomers, the enantiomers, the diastereomers, the...
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7470714 |
GM-95-containing antitumor effect potentiator, combined antitumor preparation and antitumor agent
An antitumor effect enhancer for enhancing the antitumor effects of an antitumor substance, which comprises a compound represented by the following formula (1):
wherein each R independently...
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7468385 |
Triazoles as oxytocin antagonists
The present invention relates to triazole derivatives of formula (I) notably for use as pharmaceutically active compounds, as well as pharmaceutical formulations containing such triazole...
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7465749 |
Letrozole purification process
Provided is a process for purifying a letrozole product that contains an isoletrozole impurity, which process preferably includes converting at least a portion of the isoletrozole impurity into...
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7465744 |
Triazole compounds and the therapeutic use thereof
The invention relates to triazole compounds of general formula (I), wherein A, B, R 1 , R 2 , R 3 and R 4 have the meaning cited in claim 1. The invention also relates to a pharmaceutical agent...
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7459475 |
Substituted triazoles as sodium channel blockers
Substituted triazole compounds represented by Formula I, II or III, or pharmaceutically acceptable salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds,...
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7459474 |
Modulators of the glucocorticoid receptor and method
Novel non-steroidal compounds are provided which are glucocorticoid receptor modulators which are useful in treating diseases requiring glucocorticoid receptor agonist or antagonist therapy such as...
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7459473 |
N-linked sulfonamides of N-heterocyclic carboxylic acids or carboxylic acid isosteres
This invention relates to novel N-linked sulfonamides of N-heterocyclic carboxylic acid and carboxylic acid isosteres, their preparation, and use for treating neurological disorders including...
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7446119 |
Miticidal triazolidine derivatives
A miticidal triazolidine derivative of the formula
wherein R is C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, or C 1 -C 6 haloalkyl; R 1 is hydrogen, C 1 -C 6 alkoxy, halogen, phenyl or C 1 -C 6 ...
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RE40558 |
Therapeutic uses of di-aryl acid derivatives
The use of diaryl acid derivatives of formula (I)
or pharmaceutically acceptable salts, N-oxides, hydrates or solvates thereof, wherein the variables shown are defined in the disclosure, and...
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7435752 |
N[S(4-aryl-triazol-3-yl)α-mercaptoacetyl]-p-amino benozioc acids as HIV reverse transcriptase inhibitors
A series of S-triazolyl α-mercaptoacetanilides having N-(α-mercaptoacetyl) p amino benzoic acid derivatives.
are provided, where Q is CO 2 H, or a salt or ester thereof, or a C(O)N-linked...
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7407979 |
Bioregulatory active ingredient combination
The present invention relates to the use of specific quaternized bioregulatory active ingredients in combination with triazole derivatives, in particular metconazole or an agriculturally utilizable...
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7405232 |
Long acting beta-2 agonists and their use as medicaments
A compound of formula 1
wherein the groups R 1 , R 2 , R 3 , R 4 and n may have the meanings given in the claims and in the specification, and methods for preparing a pharmaceutical...
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7390827 |
3-aminocarbonyl substituted benzoylpyrazolones
A description is given of derivatives of benzoylpyrazoles of the formula (I) and of their use as herbicides.
In this formula (I) R 1a , R 1b , R 1c , R 2 , R 3 , R 4 and R 5 stand for various...
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7378433 |
N-[4-(heteroarylmethyl)phenyl]-heteroarylamines
The present invention is concerned with compounds of formula
the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein R 1 is...
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7375081 |
Therapeutic combination of a pneumocandin derivative and an antifungal agent
There is described antifungal combination use of known antifungal agents such as the azoles or polyenes in combination with a lipopeptide compound antifungal agent. More particularly, the invention...
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7371772 |
Bicyclic compound, production and use thereof
The present invention provides a new cyclic compound having a CCR antagonist activity, especially a CCR5 antagonist activity, and the use thereof. The compound of the present invention is...
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7368464 |
Preparation for the production of 1,2,4-triazolylmethyl-oxiranes
The present invention relates to a process for the preparation of 1,2,4-triazol-1-ylmethyloxiranes of the formula I
in which A and B are identical or different and, independently of one...
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7365089 |
Triazolo-quinolin derivatives useful as adenosine receptor ligands
The present invention relates to adenosine A 3? receptor ligands of the general formula (I), within those preferably antagonists, as well as their salts, solvates and isomers, and the...
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7365085 |
Compounds and methods
Disclosed is a compound having the formula:
pharmaceutically acceptable salts or solvates thereof and pharmaceutical compositions containing the same, wherein the structural variables are...
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7361677 |
Polycyclic sulphamate compounds suitable for use as inhibitors of aromatase and/or sulphatase
There is provided a compound of Formula I
wherein each T is independently selected from H, hydrocarbyl, —F—R, and a bond with one of D, E, P or Q, or together with one of P and Q forms a...
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7361672 |
Heteroarylacetamide inhibitors of factor Xa
The invention is concerned with novel heteroarylacetamides of formula (I)
R d —C(O)—N(R e )—R c —CH 2 —C(O)—N(R a )(R b ) ...
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7361654 |
Substituted heteroaryl amide modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
The present invention relates to new class of non-steroidal compounds which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity...
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7351731 |
Azole derivatives and methods for making the same
The present invention is broadly directed to azole derivatives that exhibit antifungal activity and methods for making the same. In one aspect, the invention includes carboxylic acid and phosphate...
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7351729 |
JNK inhibitors for use in combination therapy for treating or managing proliferative disorders and cancers
The present invention relates to methods and compositions designed for the treatment, management or prevention of cancer. The methods of the invention comprise the administration of an effective...
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7348333 |
Cycloalkyl derivatives as inhibitors of bone resorption and vitronectin receptor antagonists
There are described cycloalkyl derivatives of the formula (I)
R 1 —Y-A-B-D-E-F-G (I)
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